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1. 发明授权

US4367648A Dark field viewing apparatus 失效
标题翻译：暗场观察装置
公开(公告)号：US4367648A
公开(公告)日：1983-01-11
申请号：US245547
申请日：1981-03-19
申请人： David A. Sinclair , Ian R. Smith
发明人： David A. Sinclair , Ian R. Smith
IPC分类号： G01H3/12 , G01N29/06 , G02B27/50 , G01N29/00
CPC分类号： G02B27/50 , G01H3/125 , G01N29/06 , G01N29/0609
摘要： Dark field viewing apparatus comprises either (a) a source of coherent plane wave radiation and focused coherent receiving means, or (b) a source of focused coherent radiation and a coherent receiver of plane wave radiation, the source and receiver being axially aligned in both cases; and elimination means to eliminate any radiation which in the region of the focus would travel substantially parallel to the axis of the apparatus. The apparatus may be a transmission or a reflection scanning acoustic microscope or a holographic recording system, and the elimination means may be a small acoustically-absorbent stop.
摘要翻译：暗场观察装置包括（a）相干平面波辐射源和聚焦相干接收装置，或（b）聚焦相干辐射源和平面波辐射的相干接收器，源和接收器在两者中轴向对准案件; 以及消除装置，以消除焦点区域中基本上平行于设备轴线移动的任何辐射。该装置可以是透射或反射扫描声学显微镜或全息记录系统，并且消除装置可以是小的吸声止挡件。

2. 发明申请

US20170189434A1 NICOTINAMIDE MONONUCLEOTIDE DERIVATIVES AND THEIR USES 有权
公开(公告)号：US20170189434A1
公开(公告)日：2017-07-06
申请号：US15463683
申请日：2017-03-20
申请人： Karl D. Normington , David A. Sinclair , David J. Livingston , James M. McKearin , Bruce Szczpankiewicz , Jonathan N. Kremsky
发明人： Karl D. Normington , David A. Sinclair , David J. Livingston , James M. McKearin , Bruce Szczpankiewicz , Jonathan N. Kremsky
IPC分类号： A61K31/706
CPC分类号： A61K31/706 , A61K31/443 , A61K31/661 , A61K31/665 , A61K31/7052 , C07F9/06 , C07F9/547 , C07F9/65586 , C07F9/6561 , C07F9/65742 , C07H11/04 , C07H19/04 , C07H19/048
摘要： The invention relates to compositions of nicotinamide mononucleotide derivatives and their methods of use. The invention also relates to methods of preparing nicotinamide mononucleotide derivatives. The invention relates to pharmaceutical compositions and nutritional supplements containing a nicotinamide mononucleotide derivative. The invention relates to methods of using nicotinamide mononucleotide derivatives that promote the increase of intracellular levels of nicotinamide adenine dinucleotide (NAD+) in cells and tissues for treating diseases and improving cell and tissue survival.

3. 发明申请

US20120029065A1 COMPOSITIONS FOR TREATING OR PREVENTING OBESITY AND INSULIN RESISTANCE DISORDERS 有权
标题翻译：用于治疗或预防肥胖和胰岛素抵抗障碍的组合物
公开(公告)号：US20120029065A1
公开(公告)日：2012-02-02
申请号：US13192011
申请日：2011-07-27
申请人： David A. Sinclair , Maria Alexander-Bridges
发明人： David A. Sinclair , Maria Alexander-Bridges
IPC分类号： A61K31/352 , A61P3/00 , A61P3/10 , A61P3/04 , A61K31/05 , A61K31/12
CPC分类号： A61K31/455 , A61K31/00 , A61K31/05 , A61K31/12 , A61K31/353 , A61K31/7048 , A61K31/7052 , A61K31/706 , A61K45/06 , Y10S514/866 , Y10S514/909
摘要： Provided herein are methods and compositions for modulating the activity or level of a sirtuin, thereby treating or preventing obesity or an insulin resistance disorder, such as diabetes in a subject. Exemplary methods comprise contacting a cell with a sirtuin activating compound or an inhibitory compound to thereby increase or decrease fat accumulation, respectively.
摘要翻译：本文提供了用于调节沉默调节蛋白的活性或水平的方法和组合物，从而治疗或预防肥胖或胰岛素抵抗障碍，例如受试者中的糖尿病。示例性方法包括使细胞与沉默调节蛋白的活化化合物或抑制化合物接触，从而分别增加或减少脂肪蓄积。

4. 发明申请

US20120021924A1 DETECTION AND MODULATION OF CYTOCHROME C ACETYLATION 审中-公开
标题翻译：细胞色素C乙酰化的检测与调控
公开(公告)号：US20120021924A1
公开(公告)日：2012-01-26
申请号：US13125405
申请日：2009-10-23
申请人： Angela Valeska Hafner , David A. Sinclair
发明人： Angela Valeska Hafner , David A. Sinclair
IPC分类号： C40B30/00 , G01N33/566 , H01J49/26 , C12Q1/34
CPC分类号： G01N33/6896 , C12Q1/34 , G01N33/573 , G01N33/57496 , G01N2333/47 , G01N2333/80 , G01N2333/98 , G01N2440/10 , G01N2500/02 , G01N2500/20 , G01N2800/28 , G01N2800/52
摘要： The invention relates to detection and modulation of cytochrome c acetylation. The invention has diagnostic and therapeutic applications for neurodegenerative disorders and cancer.
摘要翻译：本发明涉及细胞色素c乙酰化的检测和调节。本发明具有用于神经变性疾病和癌症的诊断和治疗应用。

5. 发明申请

US20100316679A1 COMPOSITIONS FOR TREATING OR PREVENTING OBESITY AND INSULIN RESISTANCE DISORDERS 有权
标题翻译：用于治疗或预防肥胖和胰岛素抵抗障碍的组合物
公开(公告)号：US20100316679A1
公开(公告)日：2010-12-16
申请号：US12683998
申请日：2010-01-07
申请人： David A. Sinclair , Maria Alexander-Bridges
发明人： David A. Sinclair , Maria Alexander-Bridges
IPC分类号： A61K31/05 , A61K9/00 , A61K31/155 , A61P3/10 , A61P3/04 , C12N5/077 , C12N5/071
CPC分类号： A61K31/05 , A61K31/00 , A61K31/12 , A61K31/353
摘要： Provided herein are methods and compositions for modulating the activity or level of a sirtuin, thereby treating or preventing obesity or an insulin resistance disorder, such as diabetes in a subject. Exemplary methods comprise contacting a cell with a sirtuin activating compound or an inhibitory compound to thereby increase or decrease fat accumulation, respectively.
摘要翻译：本文提供了用于调节沉默调节蛋白的活性或水平的方法和组合物，从而治疗或预防肥胖或胰岛素抵抗障碍，例如受试者中的糖尿病。示例性方法包括使细胞与沉默调节蛋白的活化化合物或抑制化合物接触，从而分别增加或减少脂肪蓄积。

6. 发明授权

US07702829B2 Method, system, and computer program product for reading data from a storage controller in a storage area network 失效
标题翻译：用于从存储区域网络中的存储控制器读取数据的方法，系统和计算机程序产品
公开(公告)号：US07702829B2
公开(公告)日：2010-04-20
申请号：US11753718
申请日：2007-05-25
申请人： Thomas W. Rickard , William J. Scales , David A. Sinclair , Alistair L. Symon
发明人： Thomas W. Rickard , William J. Scales , David A. Sinclair , Alistair L. Symon
IPC分类号： G06F3/00 , G06F5/00 , G06F13/12 , G06F13/38
CPC分类号： G06F3/0635 , G06F3/061 , G06F3/067 , G06F11/2005 , G06F11/2007
摘要： This invention relates to a method, system and computer program product for reading data from a storage controller in storage area network. A read data instruction is received from an application requesting data from the storage controller using a primary data path. If the data on the primary data path is not transferred in a defined time interval using the primary data path, data is requested from the storage controller using one or more alternative data paths. Data is received from the storage controller on one of data paths and into a buffer. When the read instruction has completed and that the data is in the buffer, the application is notified. Each data path is associated with a buffer and the data is received into a buffer associated with the path. The application is informed which buffer holds the data and the application accesses the data from this buffer.
摘要翻译：本发明涉及一种用于从存储区域网络中的存储控制器读取数据的方法，系统和计算机程序产品。从应用程序使用主要数据路径从存储控制器请求数据的应用程序接收读取数据指令。如果主数据路径上的数据没有使用主数据路径在规定的时间间隔内传输，则使用一个或多个替代数据路径从存储控制器请求数据。在数据路径之一上从存储控制器接收数据并进入缓冲器。当读取指令完成并且数据在缓冲器中时，通知应用程序。每个数据路径与缓冲区相关联，数据被接收到与该路径相关联的缓冲器中。通知应用程序哪个缓冲区保存数据，应用程序访问此缓冲区的数据。

7. 发明授权

US06208979B1 Computer-driven information management system for selectively matching credit applicants with money lenders through a global communications network 有权
标题翻译：计算机驱动的信息管理系统，用于通过全球通信网络选择性地将信贷申请人与放款人相匹配
公开(公告)号：US06208979B1
公开(公告)日：2001-03-27
申请号：US09454095
申请日：1999-12-03
申请人： David A. Sinclair
发明人： David A. Sinclair
IPC分类号： G06F1760
CPC分类号： G06Q30/02 , G06Q30/06 , G06Q40/02 , G06Q40/025 , G06Q40/08
摘要： A computer-driven information management system selectively matches credit applicants with money lenders through a global communications network. The system includes an applicant data entry device for entering applicant data into the system. The applicant data defines an electronic applicant profile of a credit applicant seeking financing. A model data entry device is provided for entering model data into the system. The model data is established by the lender and defines an electronic model profile representing characteristics of a desired applicant. A filter electronically compares the applicant profile with the model profile, such that for those credit applicants matching the model profile, the applicant data is made available through the system to lender. For those credit applicants not matching the model profile, no applicant data is made available through the system to the lender.
摘要翻译：计算机驱动的信息管理系统通过全球通信网络选择性地将信用申请人与放款人进行匹配。该系统包括用于将申请人数据输入到系统中的申请者数据输入装置。申请人资料定义了寻求融资的信用申请人的电子申请人简介。提供模型数据输入装置，用于将模型数据输入到系统中。模型数据由贷款人建立，并且定义了表示期望申请人特征的电子模型简档。过滤器将申请人简介与模型资料进行电子比较，使得对于符合模型资料的信用申请人，通过系统向申请人提供资料。对于不符合模特资料的信用申请人，没有通过系统向贷方提供申请人资料。

8. 发明授权

US5079720A Display system for representing an array of data values in a display field 失效
标题翻译：用于在显示区域中表示数据值的阵列的显示系统
公开(公告)号：US5079720A
公开(公告)日：1992-01-07
申请号：US310808
申请日：1989-02-14
申请人： David A. Sinclair
发明人： David A. Sinclair
IPC分类号： G06F3/14 , G09G1/16
CPC分类号： G09G1/162
摘要： In a display system an array of data values such as, for example, an array of speech waveform samples, is represented in a display field by logically dividing the display field into a number of display areas and determining (e.g. in 16), for each value of the data array, the area of the display field within which that value should be displayed, comparing that value to a range for the area in question and updating the range to include that value if it lies outside the range previously defined for that area and then plotting, within each area of the display field, a line joining display screen positions defined by the range in the range storage for that area.

9. 发明申请

US20180125871A1 Targeting NAD+ to Treat Chemotherapy and Radiotherapy Induced Cognitive Impairment, Neuropathies and Inactivity 审中-公开
公开(公告)号：US20180125871A1
公开(公告)日：2018-05-10
申请号：US15570210
申请日：2016-04-28
申请人： David A. Sinclair , NewSouth Innovation Pty Limited
发明人： Lindsay Wu , David A. Sinclair
IPC分类号： A61K31/706 , A61P25/02
CPC分类号： A61K31/706 , A61K31/443 , A61K31/455 , A61K31/52 , A61K31/7076 , A61K38/45 , A61P25/02 , C12Y204/02012 , C12Y207/07001
摘要： Methods and compositions for preventing or treating peripheral neuropathy, cognitive deficits, inactivity, depression, chemotherapy and/or radiotherapy induced peripheral neuropathy and cognitive deficits, and improving cognitive performance, in a subject in need thereof are disclosed. The disclosed methods include the step of administering to the subject an effective amount of an agent that increases the level of NAD+ in the subject.

10. 发明授权

US08242171B2 Method for reducing the weight of a subject or inhibiting weight gain in a subject 有权
标题翻译：用于减轻受试者体重或抑制受试者体重增加的方法
公开(公告)号：US08242171B2
公开(公告)日：2012-08-14
申请号：US12683998
申请日：2010-01-07
申请人： David A. Sinclair , Maria Alexander-Bridges
发明人： David A. Sinclair , Maria Alexander-Bridges
IPC分类号： A61K31/22 , A61K36/00
CPC分类号： A61K31/05 , A61K31/00 , A61K31/12 , A61K31/353
摘要： Provided herein are methods and compositions for modulating the activity or level of a sirtuin, thereby treating or preventing obesity or an insulin resistance disorder, such as diabetes in a subject. Exemplary methods comprise contacting a cell with a sirtuin activating compound or an inhibitory compound to thereby increase or decrease fat accumulation, respectively.
摘要翻译：本文提供了用于调节沉默调节蛋白的活性或水平的方法和组合物，从而治疗或预防肥胖或胰岛素抵抗障碍，例如受试者中的糖尿病。示例性方法包括使细胞与沉默调节蛋白的活化化合物或抑制化合物接触，从而分别增加或减少脂肪蓄积。

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