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1. 发明授权

US5749968A Device for priming for improved adherence of gels to substrates 失效
标题翻译：用于引发凝胶的装置用于改善凝胶对底物的附着力
公开(公告)号：US5749968A
公开(公告)日：1998-05-12
申请号：US472745
申请日：1995-06-07
申请人： David A. Melanson , Marc Alan Levine , John C. Spiridigliozzi , Thomas S. Bromander , Dean M. Pichon , George Selecman , David J. Nedder
发明人： David A. Melanson , Marc Alan Levine , John C. Spiridigliozzi , Thomas S. Bromander , Dean M. Pichon , George Selecman , David J. Nedder
IPC分类号： A61K38/42 , A61K38/44 , A61L24/00 , A61L24/04 , A61L24/06 , A61L26/00 , A61L27/34 , A61L27/38 , A61L27/52 , A61L29/08 , A61L31/14 , C08F2/48 , C08F265/04 , C08F271/00 , C08F283/00 , C08F289/00 , C08F290/00 , C08F290/02 , C08F290/06 , C08F290/14 , C08F291/00 , C09D153/00 , C09J151/00 , C12N5/00 , C12N11/04 , B05C5/00
CPC分类号： C12N11/04 , A61K38/42 , A61K38/44 , C08F2/48 , C08F265/04 , C08F271/00 , C08F283/00 , C08F289/00 , C08F290/00 , C08F290/02 , C08F290/06 , C08F290/062 , C08F290/14 , C08F291/00 , C09D153/00 , C09J151/00 , C12N5/0012 , C12N2533/30 , C12N2533/32 , C12N2533/40 , C12N2533/74
摘要： An improved barrier or drug delivery system which is highly adherent to the surface to which it is applied is disclosed, along with methods for making the barrier. In the preferred embodiment, tissue is stained with a photoinitiator, then the polymer solution or gel having added thereto a defined amount of the same or a different photoinitator is applied to the tissue. On exposure to light, the resulting system polymerizes at the surface, giving excellent adherence, and also forms a gel in the rest of the applied volume. Thus a gel barrier of arbitrary thickness can be applied to a surface while maintaining high adherence at the interface. This process is referred to herein as "priming". The polymerizable barrier materials are highly useful for sealing tissue surfaces and junctions against leaks of fluids. In another embodiment, "priming" can be used to reliably adhere preformed barriers to tissue or other surfaces, or to adhere tissue surfaces to each other. A first surface and a barrier, or another surface, are prestained with initiator, and a thin layer of gellable monomer containing initiator is placed between them. Strong adhesion is obtained between the two surfaces on gelation of the monomer. In a similar fashion, tissue surfaces can be adhered to each other in repair of wounds and formation of anastomoses. Methods for use of non-photochemical systems and combined chemical/photochemical systems are described.
摘要翻译：公开了与施加的表面高度附着的改进的屏障或药物递送系统，以及用于制造屏障的方法。在优选的实施方案中，用光引发剂对组织进行染色，然后将向其中加入定量的相同或不同的光引发剂的聚合物溶液或凝胶施加到组织上。在暴露于光下时，所得体系在表面聚合，赋予优异的粘附性，并且在所施加的体积的其余部分中也形成凝胶。因此，可以在表面上施加任意厚度的凝胶屏障，同时在界面处保持高粘附性。该方法在本文中称为“起动”。可聚合的阻挡材料对于密封组织表面和防止流体泄漏的接头非常有用。在另一个实施例中，可以使用“起动”来将预先形成的障碍物可靠地粘附到组织或其它表面，或者将组织表面彼此附着。第一表面和屏障或另一表面用引发剂预浸渍，并且在它们之间放置含有可凝胶单体的引发剂的薄层。在单体凝胶化时，在两个表面之间获得强粘合性。以类似的方式，组织表面可以在伤口的修复和吻合的形成中彼此粘合。描述了使用非光化学体系和组合化学/光化学体系的方法。

2. 发明授权

US6121341A Redox and photoinitiator systems for priming and improved adherence of gels to substrates 失效
标题翻译：氧化还原和光引发剂体系，用于引发和改善凝胶对底物的粘附
公开(公告)号：US6121341A
公开(公告)日：2000-09-19
申请号：US973077
申请日：1997-10-10
申请人： Amarpreet S. Sawhney , David A. Melanson , Chandrashekar P. Pathak , Jeffrey A. Hubbell , Luis Z. Avila , Mark T. Kieras , Stephen D. Goodrich , Shikha P. Barman , Arthur J. Coury , Ronald S. Rudowsky , Douglas J. K. Weaver , Marc A. Levine , John C. Spiridigliozzi , Thomas S. Bromander , Dean M. Pichon , George Selecman , David J. Nedder , Bradley C. Poff , Donald L. Elbert
发明人： Amarpreet S. Sawhney , David A. Melanson , Chandrashekar P. Pathak , Jeffrey A. Hubbell , Luis Z. Avila , Mark T. Kieras , Stephen D. Goodrich , Shikha P. Barman , Arthur J. Coury , Ronald S. Rudowsky , Douglas J. K. Weaver , Marc A. Levine , John C. Spiridigliozzi , Thomas S. Bromander , Dean M. Pichon , George Selecman , David J. Nedder , Bradley C. Poff , Donald L. Elbert
IPC分类号： A61B17/00 , A61B17/08 , A61L24/00 , A61L24/04 , A61L24/06 , A61L29/00 , A61L31/00 , C08F2/48 , C08F4/40 , C08F265/04 , C08F271/00 , C08F283/00 , C08F289/00 , C08F290/06 , C08F290/14 , C08F291/00 , C09D4/00 , C09D7/00 , C09D171/00 , C09J151/00 , C08K1/00 , A61F2/00
CPC分类号： C09D4/00 , A61L24/0015 , A61L24/0031 , A61L24/0042 , A61L24/046 , A61L24/06 , C08F2/48 , C08F265/04 , C08F271/00 , C08F283/00 , C08F289/00 , C08F290/06 , C08F290/062 , C08F290/14 , C08F291/00 , C09J151/00 , A61B17/00491 , A61B17/085 , A61B2017/00495 , A61L2300/00 , Y10S602/904
摘要： An impoved barrier or drug delivery system which is highly adherent to the surface to which it is applied is disclosed, along with methods for making the barrier. In the preferred embodiment, tissue is stained with a photoinitiator, then the polymer solution or gel having added thereto a defined amount of the same or a different photoinitiator is applied to the tissue. On exposure to light, the resulting system polymerizes at the surface, giving excellent adherence, and also forms a gel in the rest of the applied volume. Thus a gel barrier of arbitrary thickness can be applied to a surface while maintaining high adherence at the interface. This process is referred to herein as "priming". the polymerizable barrier materials are highly useful for sealing tissue surfaces and junctions against leaks of fluids. In another embodiment, "priming" can be used to reliably adhere preformed barriers to tissue or other surfaces, or to adhere tissue surfaces to each other. A first surface and a barrier, or another surface, are prestained with initiator, and a thin layer of gelable monomer containing initiator is placed between them. Strong adhesion is obtained between the two surfaces on gelation of the monomer. In a similar fashion, tissue surfaces can be adhered to each other in repair of wounds and formation of anastomoses. Methods for use of non-photochemical systems and combined chemical/photochemical systems are described.
摘要翻译： PCT No.PCT / US96 / 03834 Sec。 371日期：1997年10月10日 102（e）日期1997年10月10日PCT提交1996年3月22日PCT公布。出版物WO96 / 29370 日期1996年9月26日披露了与施加的表面高粘附性的阻挡或药物递送系统，以及制造屏障的方法。在优选的实施方案中，用光引发剂对组织进行染色，然后将向其中加入定量的相同或不同的光引发剂的聚合物溶液或凝胶施加到组织上。在暴露于光下时，所得体系在表面聚合，赋予优异的粘附性，并且在所施加的体积的其余部分中也形成凝胶。因此，可以在表面上施加任意厚度的凝胶屏障，同时在界面处保持高粘附性。该方法在本文中称为“起动”。可聚合的阻挡材料对于密封组织表面和防止流体泄漏的接头非常有用。在另一个实施例中，可以使用“起动”来将预先形成的障碍物可靠地粘附到组织或其它表面，或者将组织表面彼此附着。第一表面和屏障或另一个表面用引发剂预处理，并且在它们之间放置一层含有起泡剂的可凝胶单体。在单体凝胶化时，在两个表面之间获得强粘合性。以类似的方式，组织表面可以在伤口的修复和吻合的形成中彼此粘合。描述了使用非光化学体系和组合化学/光化学体系的方法。

3. 发明授权

US06387977B1 Redox and photoinitiator systems for priming for improved adherence of gels to substrates 有权
标题翻译：氧化还原和光引发剂体系，用于引发凝胶以增强凝胶对底物的粘附性
公开(公告)号：US06387977B1
公开(公告)日：2002-05-14
申请号：US09616256
申请日：2000-07-14
申请人： Amarpreet S. Sawhney , David A. Melanson , Chandrashekar P. Pathak , Jeffrey A. Hubbell , Luis Z. Avila , Mark T. Kieras , Stephen D. Goodrich , Shikha P. Barman , Arthur J. Coury , Ronald S. Rudowsky , Douglas J. K. Weaver , Marc A. Levine , John C. Spiridigliozzi , Thomas S. Bromander , Dean M. Pichon , George Selecman , David J. Nedder , Bradley C. Poff , Donald L. Elbert
发明人： Amarpreet S. Sawhney , David A. Melanson , Chandrashekar P. Pathak , Jeffrey A. Hubbell , Luis Z. Avila , Mark T. Kieras , Stephen D. Goodrich , Shikha P. Barman , Arthur J. Coury , Ronald S. Rudowsky , Douglas J. K. Weaver , Marc A. Levine , John C. Spiridigliozzi , Thomas S. Bromander , Dean M. Pichon , George Selecman , David J. Nedder , Bradley C. Poff , Donald L. Elbert
IPC分类号： C09D400
CPC分类号： C09D4/00 , A61B17/00491 , A61B17/085 , A61B2017/00495 , A61L24/0015 , A61L24/0031 , A61L24/0042 , A61L24/046 , A61L24/06 , A61L2300/00 , C08F2/48 , C08F265/04 , C08F271/00 , C08F283/00 , C08F289/00 , C08F290/06 , C08F290/062 , C08F290/14 , C08F291/00 , C08L2666/02 , C09J151/00 , Y10S602/904 , C08L71/02 , C08L33/04 , C08F220/00
摘要： An impoved barrier or drug delivery system which is highly adherent to the surface to which it is applied is disclosed, along with methods for making the barrier. In the preferred embodiment, tissue is stained with a photoinitiator, then the polymer solution or gel having added thereto a defined amount of the same or a different photoinitiator is applied to the tissue. On exposure to light, the resulting system polymerizes at the surface, giving excellent adherence, and also forms a gel in the rest of the applied volume. Thus a gel barrier of arbitrary thickness can be applied to a surface while maintaining high adherence at the interface. This process is referred to herein as “priming”. The polymerizable barrier materials are highly useful for sealing tissue surfaces and junctions against leaks of fluids. In another embodiment, “priming” can be used to reliably adhere preformed barriers to tissue or other surfaces, or to adhere tissue surfaces to each other. A first surface and a barrier, or another surface, are prestained with initiator, and a thin layer of gelable monomer containing initiator is placed between them. Strong adhesion is obtained between the two surfaces on gelation of the monomer. In a similar fashion, tissue surfaces can be adhered to each other in repair of wounds and formation of anastomoses. Methods for use of non-photochemical systems and combined chemical/photochemical systems are described.
摘要翻译：公开了一种与其所施加的表面高粘附性的经阻挡或药物递送系统，以及用于制备屏障的方法。在优选的实施方案中，用光引发剂对组织进行染色，然后将向其中加入定量的相同或不同的光引发剂的聚合物溶液或凝胶施加到组织上。在暴露于光下时，所得体系在表面聚合，赋予优异的粘附性，并且在所施加的体积的其余部分中也形成凝胶。因此，可以在表面上施加任意厚度的凝胶屏障，同时在界面处保持高粘附性。该方法在本文中称为“起动”。可聚合的阻挡材料对于密封组织表面和防止流体泄漏的接头非常有用。在另一个实施例中，可以使用“起动”来将预先形成的障碍物可靠地粘附到组织或其它表面，或者将组织表面彼此附着。第一表面和屏障或另一个表面用引发剂预处理，并且在它们之间放置一层含有起泡剂的可凝胶单体。在单体凝胶化时，在两个表面之间获得强粘合性。以类似的方式，组织表面可以在伤口的修复和吻合的形成中彼此粘合。描述了使用非光化学体系和组合化学/光化学体系的方法。

4. 发明授权

US5800373A Initiator priming for improved adherence of gels to substrates 失效
标题翻译：引发剂引发，用于提高凝胶对底物的粘附性
公开(公告)号：US5800373A
公开(公告)日：1998-09-01
申请号：US410037
申请日：1995-03-23
申请人： David A. Melanson , Amarpreet S. Sawhney , Marc Alan Levine , John C. Spiridigliozzi , Thomas S. Bromander
发明人： David A. Melanson , Amarpreet S. Sawhney , Marc Alan Levine , John C. Spiridigliozzi , Thomas S. Bromander
IPC分类号： A61B17/00 , A61B17/08 , A61L24/00 , A61L24/04 , A61L24/06 , A61L29/00 , A61L31/00 , C08F2/48 , C08F2/50 , C08F4/00 , C08F4/40 , C08F265/04 , C08F271/00 , C08F283/00 , C08F289/00 , C08F290/06 , C08F290/14 , C08F291/00 , C09D4/00 , C09D7/00 , C09D171/00 , C09J151/00 , A61F13/00
CPC分类号： A61L24/0031 , A61L24/0015 , A61L24/0042 , A61L24/046 , A61L24/06 , C08F2/48 , C08F265/04 , C08F271/00 , C08F283/00 , C08F289/00 , C08F290/06 , C08F290/062 , C08F290/14 , C08F291/00 , C09D4/00 , C09J151/00 , A61B17/00491 , A61B17/085 , A61B2017/00495 , A61L2300/00 , Y10S602/90 , Y10S602/904
摘要： An improved barrier or drug delivery system which is highly adherent to the surface to which it is applied is disclosed, along with methods for making for making the barrier. In the preferred embodiment, tissue is stained with a photoinitiator, then the polymer solution or gel having added thereto a defined amount of the same or a different photoinitator is applied to the tissue. On exposure to light, the resulting system polymerizes at the surface, giving excellent adherence, and also forms a gel in the rest of the applied volume. Thus a gel barrier of arbitrary thickness can be applied to a surface while maintaining high adherence at the interface. This process is referred to herein as "priming". The polymerizable barrier materials are highly useful for sealing tissue surfaces and junctions against leaks of fluids. In another embodiment, "priming" can be used to reliably adhere preformed barriers to tissue or other surfaces, or to adhere tissue surfaces to each other. A first surface and a barrier, or another surface, are prestained with initiator, and a thin layer of gellable monomer containing initiator is placed between them. Strong adhesion is obtained between the two surfaces on gelation of the monomer. In a similar fashion, tissue surfaces can be adhered to each other in repair of wounds and formation of anastomoses.
摘要翻译：公开了一种改进的屏障或药物递送系统，其与其所应用的表面高粘附，以及用于制造屏障的方法。在优选的实施方案中，用光引发剂对组织进行染色，然后将向其中加入定量的相同或不同的光引发剂的聚合物溶液或凝胶施加到组织上。在暴露于光下时，所得体系在表面聚合，赋予优异的粘附性，并且在所施加的体积的其余部分中也形成凝胶。因此，可以在表面上施加任意厚度的凝胶屏障，同时在界面处保持高粘附性。该方法在本文中称为“起动”。可聚合的阻挡材料对于密封组织表面和防止流体泄漏的接头非常有用。在另一个实施例中，可以使用“起动”来将预先形成的障碍物可靠地粘附到组织或其它表面，或者将组织表面彼此附着。第一表面和屏障或另一表面用引发剂预浸渍，并且在它们之间放置含有可凝胶单体的引发剂的薄层。在单体凝胶化时，在两个表面之间获得强粘合性。以类似的方式，组织表面可以在伤口的修复和吻合的形成中彼此粘合。

5. 发明授权

US07044937B1 Universal modular surgical applicator systems 有权
标题翻译：通用模块化手术敷贴器系统
公开(公告)号：US07044937B1
公开(公告)日：2006-05-16
申请号：US09744698
申请日：1999-07-27
申请人： John M. Kirwan , Dean M. Pichon , J. Jeffrey Kablik , Stephen J. Herman , Thomas S. Bromander
发明人： John M. Kirwan , Dean M. Pichon , J. Jeffrey Kablik , Stephen J. Herman , Thomas S. Bromander
IPC分类号： A61M5/178 , A61M5/00 , A61B17/00
CPC分类号： A61B17/00491 , A61B2017/0046 , A61B2017/00477 , A61B2017/00495
摘要： A modular system is described for construction of fluid applicators for open or endoscopic surgery from modular components. Lengths of tubing of various lengths, and devices to be carried by said tubing, are pre-fitted with standard adapters to mate with each other, thereby forming cannula sections and applicator sections. Interconnectors may also be provided, particularly for provision of articulation. The tubing is preferably rigid, but may also be either flexible or permanently bendable. A device can then be constructed by selection of a suitable set of tubing lengths, adapters and applicators. Devices customizable for particular uses can be created with minimal expense. The system is especially suitable for delivery of fluids to tissue in endoscopic or other minimally invasive surgical procedures. Delivery of fluids forming structure at a tissue site, especially as a hydrogel, is a preferred use of the devices.
摘要翻译：描述了用于从模块化组件构建用于开放式或内窥镜手术的流体施放器的模块化系统。各种长度的管道的长度以及由所述管道承载的装置预先安装有标准适配器以彼此配合，从而形成插管部分和施用器部分。也可以提供互连器，特别是提供发音。管道优选是刚性的，但也可以是柔性的或永久可弯曲的。然后可以通过选择合适的一组管道长度，适配器和施加器来构造设备。可以以最少的费用创建可针对特定用途定制的设备。该系统特别适用于在内窥镜或其他微创外科手术中将液体递送至组织。在组织部位，特别是作为水凝胶的流体形成结构的递送是装置的优选用途。

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