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1. 发明申请

US20140106368A1 FLUIDIZED BED DETECTOR FOR CONTINUOUS, ULTRA-SENSITIVE DETECTION OF BIOLOGICAL AND CHEMICAL MATERIALS 审中-公开
标题翻译：流化床检测仪用于连续，超敏感检测生物和化学材料
公开(公告)号：US20140106368A1
公开(公告)日：2014-04-17
申请号：US14108538
申请日：2013-12-17
申请人： David A. Kidwell
发明人： David A. Kidwell
IPC分类号： G01N33/52 , G01N33/53
CPC分类号： G01N33/52 , G01N21/6428 , G01N33/53 , G01N33/54313
摘要： The present invention is generally directed to a fluidized bed detector for continuous detection of biological and chemical materials comprising a fluidized bed of detecting elements suspended in a continuous flow system wherein the detecting elements remain in the system when a first force trying to move the detecting elements to the bottom of the system is balanced with a second opposing force of a flowing gas or liquid trying to move detecting elements to the top of the system and wherein the presence of a target molecule in the flowing gas or liquid disrupts the balance of the first and second forces causing the detecting element to exit the system. The release of the detecting element indicates the presence of the target molecule and may be captured, concentrated, or both for further evaluation by other assays or other means. Also disclosed is the related method of detecting biological and chemical materials using a fluidized bed detector.
摘要翻译：本发明一般涉及用于连续检测生物和化学材料的流化床检测器，其包括悬浮在连续流动系统中的检测元件的流化床，其中当试图移动检测元件的第一力时，检测元件保留在系统中系统的底部与试图将检测元件移动到系统的顶部的流动气体或液体的第二相反的力平衡，并且其中流动气体或液体中目标分子的存在破坏了第一以及使检测元件离开系统的第二力。检测元件的释放指示靶分子的存在并且可被捕获，浓缩或两者用于通过其它测定或其它方法进一步评估。还公开了使用流化床检测器检测生物和化学材料的相关方法。

2. 发明授权

US5314802A Light emission- or absorbance-based binding assays 失效
标题翻译：基于光发射或吸光度的结合测定
公开(公告)号：US5314802A
公开(公告)日：1994-05-24
申请号：US865526
申请日：1992-04-09
申请人： David A. Kidwell
发明人： David A. Kidwell
IPC分类号： C12Q1/68 , G01N33/542 , G01N33/94 , G01N33/533
CPC分类号： C12Q1/6818 , G01N33/542 , G01N33/946 , Y10S435/962 , Y10S436/80
摘要： A substance having binding sites for at least two molecules may be detected within a sample. A molecule which can be recognized by the substance is labelled such that when at least two of the labelled molecules are bound the binding sites on the substance, the labels on the molecules electronically interact with each other and vary the wavelength dependance of their spectra. This variation in the spectra of the label can be detected. If the sample is suspected of containing the unlabelled form of a molecule, such as biotin or cocaine, a known amount of the above substance, along with a known amount of the corresponding labelled biotin or cocaine is added to the sample. In this instance, the amount of the suspect molecule in the sample is then determined by the extent to which the variation in the spectra of the label has been reduced. Alternatively, the present invention can be used to determine the binding characteristics of the substance within the sample. The method of the present invention is useful in immunoassays or other bioassays as well as in studies of surface interactions.
摘要翻译：可以在样品内检测到具有至少两个分子的结合位点的物质。可以被该物质识别的分子被标记为使得当至少两个标记分子与物质上的结合位点结合时，分子上的标记物彼此电子相互作用并改变其光谱的波长依赖性。可以检测标签光谱的这种变化。如果样品被怀疑含有未标记形式的分子，例如生物素或可卡因，将已知量的上述物质连同已知量的相应标记的生物素或可卡因一起加入到样品中。在这种情况下，样品中的可疑分子的量然后通过标记的光谱变化已被降低的程度确定。或者，本发明可用于确定样品中物质的结合特性。本发明的方法可用于免疫测定或其他生物测定以及表面相互作用研究。

3. 发明授权

US06443892B1 Sweat collecting device and methods for use and detection of tampering 失效
标题翻译：汗液收集装置和使用和检测篡改的方法
公开(公告)号：US06443892B1
公开(公告)日：2002-09-03
申请号：US09671167
申请日：2000-09-28
申请人： David A. Kidwell
发明人： David A. Kidwell
IPC分类号： A61B500
CPC分类号： A61B10/0064 , A61B2010/0006
摘要： The invention is useful for providing sweat collecting devices for the detection of chemicals or biochemicals in the perspiration of a living subject while reducing drug contamination from without (external sources), and for detecting tampering of the sweat collection device. The invention also provides a method for using the sweat collecting device which reduces and identifies prior chemical or biochemical contamination on the skin of the tested subject.
摘要翻译：本发明可用于提供汗液收集装置，用于在不影响（外部来源）的同时减少药物污染以及用于检测汗液收集装置的篡改的情况下，检测活体中出汗的化学物质或生物化学物质。本发明还提供了一种使用汗液收集装置的方法，其减少并识别被测试对象的皮肤上的先前的化学或生物化学污染。

4. 发明授权

US5200321A Microassay on a card 失效
标题翻译：一张卡上的Microassay
公开(公告)号：US5200321A
公开(公告)日：1993-04-06
申请号：US578390
申请日：1990-09-07
申请人： David A. Kidwell
发明人： David A. Kidwell
IPC分类号： G01N33/53 , B01L3/00 , G01N21/03 , G01N21/29 , G01N21/76 , G01N21/78 , G01N31/20 , G01N33/52 , G01N33/543 , G01N33/545 , G01N33/552 , G01N33/94
CPC分类号： G01N33/54386 , B01L3/5023 , G01N21/78 , G01N33/525 , B01L2200/0621 , B01L2300/0681 , B01L2300/069 , B01L2300/0819 , B01L2300/0822 , B01L2300/087 , B01L2300/0887 , B01L2400/0406 , G01N21/29 , G01N21/76 , G01N2201/04 , Y10S435/805 , Y10S435/81 , Y10S435/967 , Y10S435/969 , Y10S435/97 , Y10S436/805 , Y10S436/808 , Y10S436/81
摘要： A microassay card for a includes an upper layer containing wells for receiving a liquid sample. A second layer of the card, beneath the first layer, includes a supporting surface bound to a reactive species. A third layer includes a superabsorbent support impregnated with an indicator. Typically, the indicator is a substrate for an enzyme, such as a reduced dye precursor and a source of hydrogen peroxide necessary for the action of the enzyme upon the substrate to cause a spectral change in the absorbent layer. By selecting the structure of the first and second layers, the card can be formatted for a displacement assay or a competitive assay. The microassay card of the present invention is particularly useful for drug testing.
摘要翻译：用于a的微型卡片包括含有用于接收液体样品的孔的上层。在第一层下方的卡的第二层包括与活性物质结合的支撑表面。第三层包括浸渍有指示剂的超吸收剂载体。通常，指示剂是用于酶的底物，例如还原的染料前体和过氧化氢源，用于酶在底物上起作用以引起吸收层中的光谱变化。通过选择第一层和第二层的结构，可以将卡格式化为位移测定或竞争性测定。本发明的微量测定卡对于药物测试特别有用。

5. 发明授权

US08728197B2 Metal nanoparticles with a pre-selected number of atoms 有权
标题翻译：具有预选数目原子的金属纳米粒子
公开(公告)号：US08728197B2
公开(公告)日：2014-05-20
申请号：US13323287
申请日：2011-12-12
申请人： David A. Kidwell , Albert Epshteyn
发明人： David A. Kidwell , Albert Epshteyn
IPC分类号： B22F9/18 , C08K3/10
CPC分类号： B22F9/24 , B22F2999/00 , B82Y30/00 , B82Y40/00 , B22F1/0018 , B22F2301/25
摘要： A metron refers to a molecule which contains a pre-defined number of high affinity binding sites for metal ions. Metrons may be used to prepare homogenous populations of nanoparticles each composed of a same, specific number of atoms, wherein each particle has the same size ranging from 2 atoms to about ten nanometers.
摘要翻译：指甲是指含有预定数量的金属离子的高亲合力结合位点的分子。 Metron可以用于制备均匀的纳米粒子群，每个纳米粒子由相同的特定数量的原子组成，其中每个粒子具有从2个原子到约10纳米的相同的大小。

6. 发明申请

US20110077145A1 EXCESS ENTHALPY UPON PRESSURIZATION OF NANOSIZED METALS WITH DEUTERIUM 审中-公开
标题翻译：纳米金属与脱氧核糖核酸的加压过程
公开(公告)号：US20110077145A1
公开(公告)日：2011-03-31
申请号：US12893325
申请日：2010-09-29
申请人： David A. Kidwell
发明人： David A. Kidwell
IPC分类号： B01J23/00 , B01J23/44 , B01J23/42 , B01J29/04 , B01J21/04 , B01J8/02
CPC分类号： G01N25/48 , B01J21/04 , B01J23/42 , B01J23/44 , B01J23/63 , B01J29/04
摘要： A method for producing excess enthalpy by impregnating metallic precursors on an oxide support that reduces sintering and particle growth; drying the impregnated support at a temperature where the particle growth is minimal; reducing the metallic precursors at a second temperature where the particle growth results in supported metallic particles 2 nm or less in size; and pressurizing the supported metallic particles in the presence of deuterium. The metal particles may comprise palladium, platinum, mixtures thereof, or mixtures of palladium and/or platinum with other elements. Also disclosed is a method for measuring excess enthalpy by placing a test material in a pressure vessel; heating the pressure vessel; evacuating the pressure vessel; introducing deuterium, hydrogen, or both into the pressure vessel; measuring the enthalpy generated during pressurization; again evacuating the pressure vessel; and measuring the enthalpy used during depressurization.
摘要翻译：通过将金属前体浸渍在减少烧结和颗粒生长的氧化物载体上来产生过量焓的方法; 在颗粒生长最小的温度下干燥浸渍的载体; 在第二温度下还原金属前体，其中颗粒生长导致尺寸为2nm或更小的负载金属颗粒; 并在氘存在下对负载的金属颗粒加压。金属颗粒可以包括钯，铂，其混合物，或钯和/或铂与其它元素的混合物。还公开了一种通过将测试材料放置在压力容器中来测量过量焓的方法; 加热压力容器; 排空压力容器; 将氘，氢或二者引入压力容器中; 测量加压过程中产生的焓; 再次抽空压力容器; 并测量在减压期间使用的焓。

7. 发明授权

US5807758A Chemical and biological sensor using an ultra-sensitive force transducer 失效
标题翻译：化学和生物传感器使用超灵敏力传感器
公开(公告)号：US5807758A
公开(公告)日：1998-09-15
申请号：US505547
申请日：1995-07-21
申请人： Gil U. Lee , David A. Kidwell , Richard J. Colton
发明人： Gil U. Lee , David A. Kidwell , Richard J. Colton
IPC分类号： B81B3/00 , C12Q1/68 , C12Q1/70 , G01N33/543 , G01Q90/00 , G01N27/00 , G01N33/573 , C01N33/573
CPC分类号： G01Q60/42 , B82Y35/00 , G01N27/745 , G01N33/54373
摘要： The present invention is a method and apparatus for detecting a target species. The target molecule may be in liquid phase (in solution) or (for some embodiments of the invention) in vapor phase. A sensor according to the present invention monitors whether a target species has selectively bound to groups on the cantilever surface by monitoring the displacement of the cantilever, and hence the force acting on the cantilever. This force acting on the cantilever arises from the force acting on a structure that moves in electric or magnetic field, and that may be selectively bound to the cantilever. In the case of target species having a sufficiently large net electric charge or dipole moment, the target species itself may serve as the structure that moves in an electric field. More typically however, separate modified structures, such as modified magnetic beads or modified beads having a net charge or a dipole moment, will, when selectively bound to the cantilever, exert a force on the cantilever that relates to the presence of the target species.
摘要翻译：本发明是用于检测目标物种的方法和装置。靶分子在气相中可以是液相（溶液中）或（对于本发明的一些实施方案）。根据本发明的传感器通过监测悬臂的位移以及因此作用在悬臂上的力来监视目标物种是否选择性地结合到悬臂表面上的组。作用在悬臂上的力源自作用在电场或磁场中移动的结构上的力，并且可以选择性地结合到悬臂。在具有足够大的净电荷或偶极矩的目标物种的情况下，目标物质本身可以用作在电场中移动的结构。然而，更典型地，单独的改性结构，例如具有净电荷或偶极矩的改性磁珠或改性珠粒，当选择性地结合到悬臂时，将在悬臂上施加与靶物种的存在有关的力。

8. 发明授权

US5466578A Surfactant-enhanced light emission- or absorbance-based binding assays for polynucleic acids 失效
标题翻译：用于多核酸的表面活性剂增强的光发射或基于吸光度的结合测定
公开(公告)号：US5466578A
公开(公告)日：1995-11-14
申请号：US280537
申请日：1994-07-26
申请人： David A. Kidwell
发明人： David A. Kidwell
IPC分类号： C12Q1/68 , G01N33/542 , G01N33/94 , G01N21/64
CPC分类号： C12Q1/6818 , G01N33/542 , G01N33/946
摘要： The fluorescence of polycyclic aromatic labels, and excimers of these lab, attached to nucleic acids is greatly enhanced by the presence of quaternary ammonium surfactants having at least one long chain (C4 or greater) alkyl group. This enchancement may be advantageously used in Pi Overlapping Rings Systems Contained in a Homogeneous Assay (PORSCHA) and in conventional assays.
摘要翻译：通过存在具有至少一个长链（C4或更高）烷基的季铵表面活性剂，大量增加了附着于核酸的多环芳族标记物和这些标记物的取代基的荧光。这种增强可以有利地用于均匀测定（PORSCHA）中包含的Pi重叠环系统和常规测定中。

9. 发明授权

US5369007A Microassay on a card 失效
标题翻译：一张卡上的Microassay
公开(公告)号：US5369007A
公开(公告)日：1994-11-29
申请号：US981857
申请日：1992-08-26
申请人： David A. Kidwell
发明人： David A. Kidwell
IPC分类号： G01N33/53 , B01L3/00 , G01N21/03 , G01N21/29 , G01N21/76 , G01N21/78 , G01N31/20 , G01N33/52 , G01N33/543 , G01N33/545 , G01N33/552 , G01N33/94
CPC分类号： G01N33/54386 , B01L3/5023 , G01N21/78 , G01N33/525 , B01L2200/0621 , B01L2300/0681 , B01L2300/069 , B01L2300/0819 , B01L2300/0822 , B01L2300/087 , B01L2300/0887 , B01L2400/0406 , G01N21/29 , G01N21/76 , G01N2201/04 , Y10S435/805 , Y10S435/81 , Y10S435/967 , Y10S435/969 , Y10S435/97 , Y10S436/805 , Y10S436/808 , Y10S436/81
摘要： A microassay card includes an upper layer containing wells for receiving a liquid sample. A second layer of the card, beneath the first layer, includes a supporting surface bound to a reactive species. A third layer includes a superabsorbent support impregnated with an indicator. Typically, the indicator is a substrate for an enzyme, such as a reduced dye precursor and a source of hydrogen peroxide necessary for the action of the enzyme upon the substrate to cause a spectral change in the absorbent layer. By selecting the structure of the first and second layers, the card can be formatted for a displacement assay or a competitive assay. The microassay card of the present invention is particularly useful for drug testing.
摘要翻译：微型卡片包括含有用于接收液体样品的孔的上层。在第一层下方的卡的第二层包括与活性物质结合的支撑表面。第三层包括浸渍有指示剂的超吸收剂载体。通常，指示剂是用于酶的底物，例如还原的染料前体和过氧化氢源，用于酶在底物上起作用以引起吸收层中的光谱变化。通过选择第一层和第二层的结构，可以将卡格式化为位移测定或竞争性测定。本发明的微量测定卡对于药物测试特别有用。

10. 发明授权

US5637508A Biomolecules bound to polymer or copolymer coated catalytic inorganic particles, immunoassays using the same and kits containing the same 失效
标题翻译：生物分子结合聚合物或共聚物涂覆的催化无机颗粒，使用相同的免疫测定法和含有该颗粒的试剂盒
公开(公告)号：US5637508A
公开(公告)日：1997-06-10
申请号：US376396
申请日：1995-01-23
申请人： David A. Kidwell , Susan M. Conyers
发明人： David A. Kidwell , Susan M. Conyers
IPC分类号： G01N33/553 , G01N33/58 , G01N33/551
CPC分类号： G01N33/553 , G01N33/587 , Y10S435/975 , Y10S436/805 , Y10S436/808
摘要： Polymer or copolymer coated catalytic colloidal metal particles bound to a biomolecule such as an antibody, avidin, or streptavidin and kits containing such polymer or copolymer coated catalytic metal particles are useful for detecting the presence of the biomolecule in an assay such as an immunoassay.
摘要翻译：与生物分子如抗体，抗生物素蛋白或链霉亲和素结合的聚合物或共聚物涂覆的催化胶体金属颗粒和含有这种聚合物或共聚物涂覆的催化金属颗粒的试剂盒可用于在诸如免疫测定的测定中检测生物分子的存在。

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