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1. 发明授权

US08323306B2 Microcoil vaso-occlusive device with multi-axis secondary configuration 有权
标题翻译：具有多轴二次配置的微线圈血管闭塞装置
公开(公告)号：US08323306B2
公开(公告)日：2012-12-04
申请号：US11398081
申请日：2006-04-05
申请人： Dean Schaefer , Brian J. Cox , George R. Greene, Jr. , David A. Ferrera , Matthew Fitz , Robert F. Rosenbluth
发明人： Dean Schaefer , Brian J. Cox , George R. Greene, Jr. , David A. Ferrera , Matthew Fitz , Robert F. Rosenbluth
IPC分类号： A61M29/00 , A61F2/06
CPC分类号： A61B17/12022 , A61B17/12113 , A61B17/12145 , A61B2017/00867
摘要： A vaso-occlusive device includes a microcoil formed into a minimum energy state secondary configuration comprising a plurality of curved segments, each defining a discrete axis, whereby the device, in its minimum energy state configuration, defines multiple axes. Confinement of the device within an aneurysm causes it to assume a three-dimensional configuration with a higher energy state than the minimum energy state. Because the minimum energy state configuration of the device is larger (in at least one dimension) than the aneurysm, the deployed device is constrained by its contact with the walls of the aneurysm from returning to its minimum energy state configuration. The engagement of the device with the aneurysm wall minimizes shifting or tumbling due to blood flow.
摘要翻译：血管闭塞装置包括形成为最小能量状态次级构造的微线圈，其包括多个弯曲段，每个弯曲段限定离散轴线，由此该装置在其最小能量状态构造中限定多个轴线。动脉瘤内装置的限制使其呈现具有比最小能量状态更高的能量状态的三维构型。由于装置的最小能量状态构造比动脉瘤更大（至少一个维度），因此部署的装置受到与动脉瘤壁的接触的约束，从而返回到其最小能量状态。该装置与动脉瘤壁的接合最小化由于血流引起的移动或翻滚。

2. 发明授权

US07033374B2 Microcoil vaso-occlusive device with multi-axis secondary configuration 有权
公开(公告)号：US07033374B2
公开(公告)日：2006-04-25
申请号：US10043947
申请日：2002-01-11
申请人： Dean Schaefer , Brian J. Cox , George R. Greene, Jr. , David A. Ferrera , Matthew Fitz , Robert F. Rosenbluth
发明人： Dean Schaefer , Brian J. Cox , George R. Greene, Jr. , David A. Ferrera , Matthew Fitz , Robert F. Rosenbluth
IPC分类号： A61M29/00
CPC分类号： A61B17/12022 , A61B17/12113 , A61B17/12145 , A61B2017/00526 , A61B2017/00867
摘要： A vaso-occlusive device includes a microcoil formed into a minimum energy state secondary configuration comprising a plurality of curved segments, each defining a discrete axis, whereby the device, in its minimum energy state configuration, defines multiple axes. In a preferred embodiment, the secondary configuration-comprises a plurality of interconnected closed loops defining a plurality of discrete axes. In a second embodiment, the secondary configuration defines a wave-form like structure comprising an array of laterally-alternating open loops defining a plurality of separate axes. In a third embodiment, the secondary configuration forms a series of tangential closed loops, wherein the entire structure subtends a first angle of arc, and wherein each adjacent pair of loops defines a second angle of arc. In a fourth embodiment, the secondary configuration forms a logarithmic spiral. In all embodiments, the device, in its secondary configuration, has a dimension that is substantially larger than the largest dimension of the vascular site (i.e., aneurysm) in which it is to be deployed. Thus, confinement of the device within an aneurysm causes it to assume a three-dimensional configuration with a higher energy state than the minimum energy state. Because the minimum energy state configuration of the device is larger (in at least one dimension) than the aneurysm, the deployed device is constrained by its contact with the walls of the aneurysm from returning to its minimum energy state configuration. The engagement of the device with the aneurysm wall minimizes shifting or tumbling due to blood flow. Furthermore, the secondary configuration is not conducive to “coin stacking,” thereby minimizing the compaction experienced.

3. 发明授权

US06607538B1 Mechanism for the deployment of endovascular implants 有权
标题翻译：部署血管内植入物的机制
公开(公告)号：US06607538B1
公开(公告)日：2003-08-19
申请号：US09692248
申请日：2000-10-18
申请人： David A. Ferrera , George R. Greene, Jr. , Brian J. Cox , Robert F. Rosenbluth
发明人： David A. Ferrera , George R. Greene, Jr. , Brian J. Cox , Robert F. Rosenbluth
IPC分类号： A61F1100
CPC分类号： A61B17/1214 , A61B17/12022 , A61B17/1215 , A61B17/12163 , A61B17/1219 , A61B2017/00477 , A61B2017/00535 , A61B2017/00539 , A61B2017/00867 , A61B2017/1205 , A61B2017/12054
摘要： A mechanism for the deployment of an endovascular device having a coupling element attached to its proximal end, includes a deployment tube having a proximal end, a distal section, open distal end, and a lumen extending between the proximal and distal ends. A retention sleeve, fixed around the distal section, includes an extension extending past the distal end of the tube. The retention sleeve is fixed around the coupling element, so that the coupling element is releasably held within the extension. In use, the deployment tube, with the implant attached to its distal end, is passed intravascularly until the device is deployed within a target site. A liquid is injected through the lumen so as to push the coupling element out of the retention sleeve by fluid pressure, thereby detaching the endovascular device from the deployment tube.
摘要翻译：一种用于部署具有附接到其近端的联接元件的血管内装置的机构，包括具有近端，远端部分，开放远端以及在近端和远端之间延伸的内腔的展开管。围绕远端部分固定的保持套筒包括延伸穿过管的远端的延伸部分。保持套固定在联接元件周围，使得联接元件可释放地保持在延伸部内。在使用中，将植入物连接到其远端的展开管通过血管内直到装置部署在目标部位内。通过内腔注入液体，以便通过流体压力将联接元件推出保持套筒，从而将血管内装置与展开管分开。

4. 发明授权

US06689141B2 Mechanism for the deployment of endovascular implants 有权
标题翻译：部署血管内植入物的机制
公开(公告)号：US06689141B2
公开(公告)日：2004-02-10
申请号：US10143724
申请日：2002-05-10
申请人： David A. Ferrera , George R. Greene, Jr. , Brian J. Cox , Robert F. Rosenbluth
发明人： David A. Ferrera , George R. Greene, Jr. , Brian J. Cox , Robert F. Rosenbluth
IPC分类号： A61F1100
CPC分类号： A61B17/1215 , A61B17/12022 , A61B17/1214 , A61B17/12163 , A61B17/1219 , A61B2017/00477 , A61B2017/00535 , A61B2017/00539 , A61B2017/00867 , A61B2017/1205 , A61B2017/12054
摘要： A mechanism for the deployment of a filamentous endovascular device includes a flexible deployment tube having an open proximal end, and a coupling element attached to the proximal end of the endovascular device. The deployment tube includes a distal section terminating in an open distal end, with a lumen defined between the proximal and distal ends. A retention sleeve is fixed around the distal section and includes a distal extension extending a short distance past the distal end of the deployment tube. The endovascular device is attached to the distal end of the deployment tube by fixing the retention sleeve around the coupling element, so that the coupling element is releasably held within the distal extension of the deployment tube. In use, the deployment tube, with the implant attached to its distal end, is passed intravascularly through a microcatheter to a target vascular site until the endovascular device is located within the site. To detach the endovascular device from the deployment tube, a liquid is injected through the lumen of the deployment tube so as to apply pressure to the upstream side of the coupling element, which is thus pushed out of the retention sleeve by the fluid pressure. The coupling element may include an internal or peripheral purge passage that allows air to be purged from the microcatheter prior to the intravascular passage of the endovascular device.
摘要翻译：用于部署丝状血管内装置的机构包括具有开口近端的柔性展开管和附接到血管内装置的近端的联接元件。展开管包括终止于开放远端的远侧部分，其中限定在近端和远端之间的内腔。保持套固定在远端部分周围，并且包括远离展开管远端延伸的远端延伸部。血管内装置通过将保持套固定在联接元件周围而附接到展开管的远端，使得联接元件可释放地保持在展开管的远侧延伸部内。在使用中，将植入物连接到其远端的展开管通过血管内通过微导管至目标血管部位，直到血管内装置位于部位内。为了将血管内装置从展开管中分离出来，液体通过展开管的内腔被注入，以便向耦合元件的上游侧施加压力，由此通过流体压力将其推出保持套筒。联接元件可以包括内部或周边清洗通道，其允许空气在血管内装置的血管内通过之前从微导管清除。

5. 发明授权

US07029486B2 Microcoil vaso-occlusive device with multi-axis secondary configuration 有权
标题翻译：具有多轴二次配置的微线圈血管闭塞装置
公开(公告)号：US07029486B2
公开(公告)日：2006-04-18
申请号：US10247231
申请日：2002-09-19
申请人： Dean Schaefer , Brian J. Cox , George R. Greene, Jr. , David A. Ferrera , Matthew Fitz , Robert F. Rosenbluth
发明人： Dean Schaefer , Brian J. Cox , George R. Greene, Jr. , David A. Ferrera , Matthew Fitz , Robert F. Rosenbluth
IPC分类号： A61M29/00
CPC分类号： A61B17/12022 , A61B17/12113 , A61B17/12145 , A61B2017/00867
摘要： A microcoil vaso-occlusive device has a minimum energy state secondary configuration having a plurality of curved segments, each defining a discrete axis. The secondary configuration may be a plurality of interconnected closed loops; an array of laterally-alternating open loops; a series of tangential closed loops; or a logarithmic spiral. The device, in its secondary cofiguration, has a dimension that is substantially larger than the largest dimension of the vascular site in which it is to be deployed. Thus, confinement of the device within the site causes it to assume a configuration with a higher energy state than the minimum energy state. Because the secondary configuration is larger (in at least one dimension) than the site, the device is constrained, by contact with the walls of the site, from returning to its secondary configuration, and shifting of the device due to blood flow is minimized.
摘要翻译：微线圈血管闭塞装置具有最小能量状态次级构型，其具有多个弯曲段，每个限定离散轴。二次配置可以是多个互连的闭环; 横向交替的开环阵列; 一系列切向闭环; 或对数螺旋。该装置在其二次配置中具有的尺寸基本上大于其将被部署的血管部位的最大尺寸。因此，在站点内的设备的限制使其呈现具有比最小能量状态更高的能量状态的配置。由于二次配置比现场更大（至少一个维度），所以通过与现场的墙壁接触来限制设备从返回到其次要配置，并且由于血液流动而使设备的移动被最小化。

6. 发明授权

US07201762B2 Vascular embolization with an expansible implant 有权
标题翻译：血管栓塞与可扩展植入物
公开(公告)号：US07201762B2
公开(公告)日：2007-04-10
申请号：US10320033
申请日：2002-12-16
申请人： George R. Greene, Jr. , Robert F. Rosenbluth , Brian J. Cox
发明人： George R. Greene, Jr. , Robert F. Rosenbluth , Brian J. Cox
IPC分类号： A61B19/00 , A61F2/06
CPC分类号： A61L31/146 , A61B17/12022 , A61B17/12113 , A61B17/12186 , A61B17/1219 , A61B34/10 , A61B2017/00526 , A61B2017/1205 , A61F2/06 , A61L31/145 , A61L31/18 , A61L2430/36 , B33Y50/00 , B33Y80/00 , Y10S623/901 , Y10S623/903 , Y10T29/49
摘要： A vascular implant formed of a compressible foam material has a compressed configuration from which it is expansible into a configuration substantially conforming to the shape and size of a vascular site to be embolized. Preferably, the implant is formed of a hydrophilic, macroporous foam material, having an initial configuration of a scaled-down model of the vascular site, from which it is compressible into the compressed configuration. The implant is made by scanning the vascular site to create a digitized scan data set; using the scan data set to create a three-dimensional digitized virtual model of the vascular site; using the virtual model to create a scaled-down physical mold of the vascular site; and using the mold to create a vascular implant in the form of a scaled-down model of the vascular site. To embolize a vascular site, the implant is compressed and passed through a microcatheter, the distal end of which has been passed into a vascular site. Upon entering the vascular site, the implant expands in situ substantially to fill the vascular site. A retention element is contained within the microcatheter and has a distal end detachably connected to the implant. A flexible, tubular deployment element is used to pass the implant and the retention element through the microcatheter, and then to separate the implant from the retention element when the implant has been passed out of the microcatheter and into the vascular site.
摘要翻译：由可压缩泡沫材料形成的血管植入物具有压缩构型，其可膨胀到基本上符合要栓塞的血管部位的形状和尺寸的构造。优选地，植入物由亲水的大孔泡沫材料形成，具有血管部位的缩小模型的初始构型，从而可压缩成压缩构型。通过扫描血管部位来创建植入物以产生数字化的扫描数据集; 使用扫描数据集创建血管部位的三维数字化虚拟模型; 使用虚拟模型创建血管部位的缩小物理模具; 并使用模具以血管部位的缩小模型的形式产生血管植入物。为了栓塞血管部位，植入物被压缩并通过微导管，其远端已经进入血管部位。在进入血管部位时，植入物基本上扩张以填充血管部位。保持元件容纳在微导管内并且具有可拆卸地连接到植入物的远端。使用柔性的管状展开元件将植入物和保持元件通过微导管，然后当植入物从微导管通过并进入血管部位时，将植入物与保留元件分离。

7. 发明授权

US6165193A Vascular embolization with an expansible implant 失效
公开(公告)号：US6165193A
公开(公告)日：2000-12-26
申请号：US110816
申请日：1998-07-06
申请人： George R. Greene, Jr. , Robert F. Rosenbluth , Brian J. Cox
发明人： George R. Greene, Jr. , Robert F. Rosenbluth , Brian J. Cox
IPC分类号： A61B19/00 , A61B17/12 , A61F2/02 , A61L31/14 , A61L31/18
CPC分类号： A61L31/146 , A61B17/12022 , A61B17/12113 , A61B17/12186 , A61B17/1219 , A61B34/10 , A61B2017/00526 , A61B2017/1205 , A61F2/06 , A61L31/145 , A61L31/18 , A61L2430/36 , B33Y50/00 , B33Y80/00 , Y10S623/901 , Y10S623/903 , Y10T29/49
摘要： A vascular implant formed of a compressible foam material has a compressed configuration from which it is expansible into a configuration substantially conforming to the shape and size of a vascular site to be embolized. Preferably, the implant is formed of a hydrophilic, macroporous foam material, having an initial configuration of a scaled-down model of the vascular site, from which it is compressible into the compressed configuration. The implant is made by scanning the vascular site to create a digitized scan data set; using the scan data set to create a three-dimensional digitized virtual model of the vascular site; using the virtual model to create a scaled-down physical mold of the vascular site; and using the mold to create a vascular implant in the form of a scaled-down model of the vascular site. To embolize a vascular site, the implant is compressed and passed through a microcatheter, the distal end of which has been passed into a vascular site. Upon entering the vascular site, the implant expands in situ substantially to fill the vascular site. A retention element is contained within the microcatheter and has a distal end detachably connected to the implant. A flexible, tubular deployment element is used to pass the implant and the retention element through the microcatheter, and then to separate the implant from the retention element when the implant has been passed out of the microcatheter and into the vascular site.

8. 发明授权

US07483558B2 Vascular embolization with an expansible implant 有权
标题翻译：血管栓塞与可扩展植入物
公开(公告)号：US07483558B2
公开(公告)日：2009-01-27
申请号：US11733697
申请日：2007-04-10
申请人： George R. Greene, Jr. , Robert F. Rosenbluth , Brian J. Cox
发明人： George R. Greene, Jr. , Robert F. Rosenbluth , Brian J. Cox
IPC分类号： G06T7/60 , A61F2/06 , B22C7/02
CPC分类号： A61L31/146 , A61B17/12022 , A61B17/12113 , A61B17/12186 , A61B17/1219 , A61B34/10 , A61B2017/00526 , A61B2017/1205 , A61F2/06 , A61L31/145 , A61L31/18 , A61L2430/36 , B33Y50/00 , B33Y80/00 , Y10S623/901 , Y10S623/903 , Y10T29/49
摘要： A vascular implant formed of a compressible foam material has a compressed configuration from which it is expansible into a configuration substantially conforming to the shape and size of a vascular site to be embolized. Preferably, the implant is formed of a hydrophilic, macroporous foam material, having an initial configuration of a scaled-down model of the vascular site, from which it is compressible into the compressed configuration. The implant is made by scanning the vascular site to create a digitized scan data set; using the scan data set to create a three-dimensional digitized virtual model of the vascular site; using the virtual model to create a scaled-down physical mold of the vascular site; and using the mold to create a vascular implant in the form of a scaled-down model of the vascular site. To embolize a vascular site, the implant is compressed and passed through a microcatheter, the distal end of which has been passed into a vascular site. Upon entering the vascular site, the implant expands in situ substantially to fill the vascular site. A retention element is contained within the microcatheter and has a distal end detachably connected to the implant. A flexible, tubular deployment element is used to pass the implant and the retention element through the microcatheter, and then to separate the implant from the retention element when the implant has been passed out of the microcatheter and into the vascular site.
摘要翻译：由可压缩泡沫材料形成的血管植入物具有压缩构型，其可膨胀到基本上符合要栓塞的血管部位的形状和尺寸的构造。优选地，植入物由亲水的大孔泡沫材料形成，具有血管部位的缩小模型的初始构型，从而可压缩成压缩构型。通过扫描血管部位来创建植入物以产生数字化的扫描数据集; 使用扫描数据集创建血管部位的三维数字化虚拟模型; 使用虚拟模型创建血管部位的缩小物理模具; 并使用模具以血管部位的缩小模型的形式产生血管植入物。为了栓塞血管部位，植入物被压缩并通过微导管，其远端已经进入血管部位。在进入血管部位时，植入物基本上扩张以填充血管部位。保持元件容纳在微导管内并且具有可拆卸地连接到植入物的远端。使用柔性的管状展开元件将植入物和保持元件通过微导管，然后当植入物从微导管通过并进入血管部位时，将植入物与保留元件分离。

9. 发明授权

US6015424A Apparatus and method for vascular embolization 失效
公开(公告)号：US6015424A
公开(公告)日：2000-01-18
申请号：US69008
申请日：1998-04-28
申请人： Robert F. Rosenbluth , Brian J. Cox , George R. Greene, Jr.
发明人： Robert F. Rosenbluth , Brian J. Cox , George R. Greene, Jr.
IPC分类号： A61B17/12 , A61M29/00
CPC分类号： A61B17/12022 , A61B17/12113 , A61B17/1214 , A61B17/12163 , A61B17/12186 , A61B17/12195 , A61B2017/1205 , A61B2017/12063
摘要： Apparatus for vascular embolization, deployable through a microcatheter, includes a flexible, elongate deployment tube dimensioned for insertion through the microcatheter, and a filamentous embolic device releasably attached to the distal end of the tube. The embolic device is controllably transformable from a soft, compliant state to a rigid or semi-rigid state. The embolic device may include a polymeric material that is transformable by contact with vascular blood or with a liquid that is cooler than vascular blood, or it may include a metallic material that is transformable by electrolytic corrosion. The embolic device may be a continuous filamentous polymeric extrusion; an elongate microcoil filled with polymeric material; an elongate, multi-segmented chain including polymeric interconnecting portions; or an elongate chain of metal segments that are fused together by electrolytic corrosion. An aneurysm is embolized with this apparatus by deploying a microcatheter so that its distal end is adjacent the aneurysm; deploying the embolic device through the microcatheter and into the aneurysm so that the embolic device forms a web-like mass in the aneurysm; and transforming the embolic device from its soft, compliant state to its rigid or semi-rigid state. The embolic device is advantageously deployed by releasably attaching it to a flexible, elongate deployment tube that is passed through the microcatheter, and then detaching the embolic device from the tube when the embolic device is suitably situated.

10. 发明授权

US09034005B2 Vascular embolization with an expansible implant 有权
公开(公告)号：US09034005B2
公开(公告)日：2015-05-19
申请号：US12877906
申请日：2010-09-08
申请人： George R. Greene, Jr. , Robert F. Rosenbluth , Brian J. Cox
发明人： George R. Greene, Jr. , Robert F. Rosenbluth , Brian J. Cox
IPC分类号： A61F2/06 , A61L31/14 , A61B17/12 , A61B19/00 , A61L31/18 , A61B17/00
CPC分类号： A61L31/146 , A61B17/12022 , A61B17/12113 , A61B17/12186 , A61B17/1219 , A61B34/10 , A61B2017/00526 , A61B2017/1205 , A61F2/06 , A61L31/145 , A61L31/18 , A61L2430/36 , B33Y50/00 , B33Y80/00 , Y10S623/901 , Y10S623/903 , Y10T29/49
摘要： A vascular implant formed of a compressible foam material has a compressed configuration from which it is expansible into a configuration substantially conforming to the shape and size of a vascular site to be embolized. Preferably, the implant is formed of a hydrophilic, macroporous foam material, having an initial configuration of a scaled-down model of the vascular site, from which it is compressible into the compressed configuration. The implant is made by scanning the vascular site to create a digitized scan data set; using the scan data set to create a three-dimensional digitized virtual model of the vascular site; using the virtual model to create a scaled-down physical mold of the vascular site; and using the mold to create a vascular implant in the form of a scaled-down model of the vascular site. To embolize a vascular site, the implant is compressed and passed through a microcatheter, the distal end of which has been passed into a vascular site. Upon entering the vascular site, the implant expands in situ substantially to fill the vascular site. A retention element is contained within the microcatheter and has a distal end detachably connected to the implant. A flexible, tubular deployment element is used to pass the implant and the retention element through the microcatheter, and then to separate the implant from the retention element when the implant has been passed out of the microcatheter and into the vascular site.

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