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1. 发明授权

US08070665B2 Method for separating discrete volumes of a composite liquid 有权
标题翻译：用于分离复合液体的离散体积的方法
公开(公告)号：US08070665B2
公开(公告)日：2011-12-06
申请号：US12832101
申请日：2010-07-08
申请人： Victor D. Dolecek , Daniel A. Joseph , Darryl Hudock
发明人： Victor D. Dolecek , Daniel A. Joseph , Darryl Hudock
IPC分类号： B01D43/00 , B04B11/00
CPC分类号： A61M1/3693 , A61M1/0218 , A61M1/3696 , A61M1/3698 , A61M2202/0429 , A61M2202/0439 , A61M2205/3365 , B04B5/0428 , B04B9/14 , B04B2009/143 , B04B2013/006
摘要： A method for separating at least two discrete volumes of a composite liquid into at least a first component and a second component, comprising centrifuging at least two separation bags containing two discrete volumes of a composite liquid respectively, so as to separate therein the first and second components; transferring at least one fraction of a first separated component from the separation bags into satellite bags connected thereto respectively; detecting a characteristic of a component at determined location in each separation bag; and stopping transferring the at least one fraction of the first component from each separation bag into the first satellite bag connected thereto, upon detection of the characteristic of a component at the determined location.
摘要翻译：一种用于将至少两个离散体积的复合液体分离成至少第一组分和第二组分的方法，包括分别离心分离含有两个离散体积的复合液体的至少两个分离袋，以便在其中分离第一和第二组分组件; 将来自分离袋的至少一部分第一分离组分转移到分别与其连接的卫星袋中; 检测每个分离袋中的确定位置处的部件的特性; 并且在检测到所确定的位置处的部件的特性时，停止将来自每个分离袋的第一部件的至少一部分转移到与其连接的第一卫星袋中。

2. 发明授权

US07766809B2 Apparatus for separating discrete volumes of a composite liquid 有权
标题翻译：用于分离离散体积的复合液体的装置
公开(公告)号：US07766809B2
公开(公告)日：2010-08-03
申请号：US11954360
申请日：2007-12-12
申请人： Victor D. Dolecek , Daniel A. Joseph , Darryl Hudock
发明人： Victor D. Dolecek , Daniel A. Joseph , Darryl Hudock
IPC分类号： B04B9/14 , B04B13/00
CPC分类号： A61M1/3693 , A61M1/0218 , A61M1/3696 , A61M1/3698 , A61M2202/0429 , A61M2202/0439 , A61M2205/3365 , B04B5/0428 , B04B9/14 , B04B2009/143 , B04B2013/006
摘要： A method for separating at least two discrete volumes of a composite liquid into at least a first component and a second component, comprising centrifuging at least two separation bags containing two discrete volumes of a composite liquid respectively, so as to separate therein the first and second components; transferring at least one fraction of a first separated component from the separation bags into satellite bags connected thereto respectively; detecting a characteristic of a component at determined location in each separation bag; and stopping transferring the at least one fraction of the first component from each separation bag into the first satellite bag connected thereto, upon detection of the characteristic of a component at the determined location.
摘要翻译：一种用于将至少两个离散体积的复合液体分离成至少第一组分和第二组分的方法，包括分别离心分离含有两个离散体积的复合液体的至少两个分离袋，以便在其中分离第一和第二组分组件; 将来自分离袋的至少一部分第一分离组分转移到分别与其连接的卫星袋中; 检测每个分离袋中的确定位置处的部件的特性; 并且在检测到所确定的位置处的部件的特性时，停止将来自每个分离袋的第一部件的至少一部分转移到与其连接的第一卫星袋中。

3. 发明授权

US07674221B2 Apparatus for separating discrete volumes of a composite liquid with balancing elements 有权
标题翻译：用于分离离散体积的具有平衡元件的复合液体的装置
公开(公告)号：US07674221B2
公开(公告)日：2010-03-09
申请号：US11954388
申请日：2007-12-12
申请人： Darryl Hudock , Daniel A. Joseph , Victor D. Dolecek
发明人： Darryl Hudock , Daniel A. Joseph , Victor D. Dolecek
IPC分类号： B04B9/14
CPC分类号： A61M1/3693 , A61M1/0218 , A61M1/3696 , A61M1/3698 , A61M2202/0429 , A61M2202/0439 , A61M2205/3365 , B04B5/0428 , B04B9/14 , B04B2009/143 , B04B2013/006
摘要： An apparatus for separating at least two discrete volumes of a composite liquid into at least a first component and a second component comprises a centrifuge, with a rotor having a rotation axis comprising at least two separation cells, each for containing a separation bag containing a volume of composite liquid; and first balancing elements for balancing the rotor when the respective weights of the at least two separation bags in the at least two separation cells are different.
摘要翻译：一种用于将至少两个离散体积的复合液体分离成至少第一组分和第二组分的设备包括离心机，转子具有包括至少两个分离单元的旋转轴，每个分离单元用于容纳含有体积的分离袋的复合液体; 以及当所述至少两个分离单元中的所述至少两个分离袋的相应重量不同时，用于平衡所述转子的第一平衡元件。

4. 发明授权

US08366086B2 Frangible opener 有权
标题翻译：易碎的开瓶器
公开(公告)号：US08366086B2
公开(公告)日：2013-02-05
申请号：US12625095
申请日：2009-11-24
申请人： Joseph D. Bucciaglia , Victor D. Dolecek , Darryl Hudock
发明人： Joseph D. Bucciaglia , Victor D. Dolecek , Darryl Hudock
IPC分类号： B23Q3/08 , B67B7/00 , B67B7/14 , B67B7/18 , B26B15/00
CPC分类号： A61M39/221 , A61M2039/222 , A61M2209/04 , Y10T29/53
摘要： A hand held opener for opening a frangible closer comprising a handle adapted to be gripped by an operator, a motion actuator operatively connected to the handle, a first shaft connected to the motion actuator, a second shaft connected to the motion actuator, a first gripper portion on the first shaft adapted to grip the frangible closer in a first location, and a second gripper portion on the second shaft adapted to grip the frangible closer in a second location wherein the motion actuator provides reciprocal movement to the shafts to rotate the frangible closer in one direction and to rotate the frangible closer in a direction opposite the first direction.
摘要翻译：用于打开易碎的靠近器的手持式开启器，包括适于被操作者抓握的手柄，可操作地连接到手柄的运动致动器，连接到运动致动器的第一轴，连接到运动致动器的第二轴，第一夹持器第一轴上的部分适于在第一位置抓握易碎的靠近器，以及在第二轴上的第二夹持器部分，其适于在第二位置夹紧易碎的靠近器，其中运动致动器提供往复运动以使所述易碎的接近器在一个方向上并沿与第一方向相反的方向旋转易碎的近端。

5. 发明授权

US09028388B2 Multi-unit blood processor with volume prediction 有权
标题翻译：多单位血液处理器具有体积预测
公开(公告)号：US09028388B2
公开(公告)日：2015-05-12
申请号：US13102728
申请日：2011-05-06
申请人： Victor D. Dolecek , Darryl Hudock
发明人： Victor D. Dolecek , Darryl Hudock
IPC分类号： B04B5/04 , B04B11/00 , A61M1/36 , B04B13/00
CPC分类号： A61M1/0209 , A61M1/0272 , A61M1/3693 , A61M1/3696 , A61M1/3698 , A61M2205/3331 , A61M2205/3379 , B01D21/262 , B04B5/02 , B04B5/0428 , B04B5/0442 , B04B7/00 , B04B11/00 , B04B2013/006
摘要： Method and Apparatus for predicting the volume of a component separated from a composite fluid by predicting the volume of the composite fluid from sensed pressure and predicting the volume of other separated components from sensed movement of the other components to collection bags.
摘要翻译：用于通过从感测到的压力预测复合流体的体积并预测其它分离组分的体积从感测到的其它组分移动到收集袋来预测从复合流体分离的组分的体积的方法和装置。

6. 发明授权

US07897054B2 Centrifuge container and methods of use 有权
标题翻译：离心容器及使用方法
公开(公告)号：US07897054B2
公开(公告)日：2011-03-01
申请号：US12454839
申请日：2009-05-21
申请人： Victor D. Dolecek , David Malcolm
发明人： Victor D. Dolecek , David Malcolm
IPC分类号： B01D17/038
CPC分类号： B04B5/0428 , A61M1/3693 , A61M1/3696 , A61M1/38 , A61M2202/0423 , B04B2005/045
摘要： A flexible, disposable centrifuge bag for receiving and holding a fluid sample, comprising one or more tubes and upper and lower flexible sheets having doughnut shaped configurations. The upper and lower sheets are superimposed and completely sealed together at their outer perimeters to define an outer perimeter of the centrifuge bag. The inner perimeter of the bag defines a central core. The tubes are sandwiched between the upper and lower sheets and extend from the central core of the centrifuge bag. The upper and lower sheets are sealed together at their inner perimeters such that the tubes are sealed between said upper and lower sheets at the inner perimeter. The bag may be used to harvest platelet rich plasma from whole blood in either a batch method or while simultaneously infusing additional aliquots of whole blood into the bag during centrifugation.
摘要翻译：一种用于接收和保持流体样品的柔性一次性离心机袋，包括一个或多个管和具有环形构型的上下柔性片。上片和下片在其外周叠加并完全密封在一起以限定离心机袋的外周。袋的内周界定中心芯。管夹在上下片之间并从离心机袋的中心芯延伸。上下板在其内周边密封在一起，使得管在内周边处密封在所述上板和下板之间。该袋可以用于以批量方法从全血中收集富含血小板的血浆，或者在离心过程中同时将额外的全血量等分进入袋中。

7. 发明授权

US07867159B2 Centrifuge system utilizing disposable components and automated processing of blood to collect platelet rich plasma 有权
标题翻译：离心机系统利用一次性部件和自动处理血液来收集血小板富集血浆
公开(公告)号：US07867159B2
公开(公告)日：2011-01-11
申请号：US11810071
申请日：2007-06-04
申请人： Victor D. Dolecek , Gary L. Berg , Kenneth E. Merte , David Malcolm , Kevin D. McIntosh , Vitaly G. Sitko
发明人： Victor D. Dolecek , Gary L. Berg , Kenneth E. Merte , David Malcolm , Kevin D. McIntosh , Vitaly G. Sitko
IPC分类号： B04B11/00
CPC分类号： A61M1/3693 , A61M1/1081 , A61M1/3696 , A61M2202/0415 , A61M2202/0427 , A61M2202/0429 , A61M2205/331 , B04B5/0442 , B04B7/02 , B04B13/00 , A61M2202/0092
摘要： A centrifugal method, and corresponding system, for processing blood to collect platelet rich plasma. A separation chamber is filled with blood from a fill syringe by rotating the separation chamber at a fill rotation rate and pumping the blood from the fill syringe. A soft spin is used to initially separate red blood cells from platelets by spinning the separation chamber at a soft spin rate. A percentage of the blood is drawn from the separation chamber back into the fill syringe to remove separated red blood cells. A second portion of the separated blood is drawn from the separation chamber until a red blood cell/platelet interface is detected. A hard spin is performed by spinning the separation chamber at a higher rate and connecting tubing is cleared of red blood cells by drawing a predetermined clearing volume. The platelet rich plasma is then collected in the collection syringe.
摘要翻译：一种离心法和相应的系统，用于处理血液以收集血小板富集血浆。通过以填充旋转速度旋转分离室并从填充注射器泵送血液，从填充注射器中填充分离室。软旋转用于通过以柔软的旋转速率旋转分离室来最初将红细胞与血小板分离。将血液的一部分从分离室抽出回填充注射器以除去分离的红细胞。分离出的血液的第二部分从分离室抽出直到检测到红细胞/血小板界面。通过以更高的速率旋转分离室来进行硬旋转，并且通过绘制预定的清除体积来连接管被清除红细胞。然后将富血小板血浆收集在收集注射器中。

8. 发明授权

US07635343B2 Fluid dispenser 失效
标题翻译：流体分配器
公开(公告)号：US07635343B2
公开(公告)日：2009-12-22
申请号：US11341153
申请日：2006-01-27
申请人： Kevin D. McIntosh , Victor D. Dolecek
发明人： Kevin D. McIntosh , Victor D. Dolecek
IPC分类号： A61M37/00
CPC分类号： A61M5/19 , A61B17/00491 , A61B2017/00495 , A61M2205/6081 , B01F5/0256 , B05C17/00553
摘要： Dispensing assemblies, methods, and kits of parts for dispensing two separate fluids to an treatment site, including entraining non-atomized flow of a first fluid in an atomized flow of a second fluid, delivering a first fluid upstream from a second fluid, delivering a first fluid and a second fluid with re-shapeable malleable tubes, delivering first and second fluids with releasable connectors maintained by a handle assembly, and kits of parts with angularly offset pockets.
摘要翻译：用于将两个分离的流体分配到处理部位的分配组件，方法和套件，包括夹带第二流体的雾化流中的第一流体的非雾化流，从第二流体上游输送第一流体，第一流体和具有可重塑的可延展管的第二流体，通过由手柄组件保持的具有可释放连接器的第一和第二流体以及具有角度偏移的袋的部件套件递送。

9. 发明申请

US20080171646A1 Flexible centrifuge bag and methods of use 审中-公开
标题翻译：灵活的离心机袋及使用方法
公开(公告)号：US20080171646A1
公开(公告)日：2008-07-17
申请号：US12001257
申请日：2007-12-10
申请人： Victor D. Dolecek , David Malcolm
发明人： Victor D. Dolecek , David Malcolm
IPC分类号： B04B7/12
CPC分类号： B04B5/0428 , A61M1/3693 , A61M1/3696 , A61M1/38 , A61M2202/0423 , B04B2005/045
摘要： A flexible, disposable centrifuge bag for receiving and holding a fluid sample, comprising one or more tubes and upper and lower flexible sheets having doughnut shaped configurations. The upper and lower sheets are superimposed and completely sealed together at their outer perimeters to define an outer perimeter of the centrifuge bag. The inner perimeter of the bag defines a central core. The tubes are sandwiched between the upper and lower sheets and extend from the central core of the centrifuge bag. The upper and lower sheets are sealed together at their inner perimeters such that the tubes are sealed between said upper and lower sheets at the inner perimeter. The bag may be used to harvest platelet rich plasma from whole blood in either a batch method or while simultaneously infusing additional aliquots of whole blood into the bag during centrifugation.
摘要翻译：一种用于接收和保持流体样品的柔性一次性离心机袋，包括一个或多个管和具有环形构型的上下柔性片。上片和下片在其外周叠加并完全密封在一起以限定离心机袋的外周。袋的内周界定中心芯。管夹在上下片之间并从离心机袋的中心芯延伸。上下板在其内周边密封在一起，使得管在内周边处密封在所述上板和下板之间。该袋可以用于以批量方法从全血中收集富含血小板的血浆，或者在离心过程中同时将额外的全血量等分进入袋中。

10. 发明授权

US06951612B2 Blood centrifuge having overhanging disposable blood container 有权
标题翻译：血液离心机具有突出的一次性血液容器
公开(公告)号：US06951612B2
公开(公告)日：2005-10-04
申请号：US10408406
申请日：2003-04-07
申请人： Victor D. Dolecek
发明人： Victor D. Dolecek
IPC分类号： A61M1/36 , B01D17/038 , B04B5/04 , B04B9/08 , B04B15/00
CPC分类号： B04B9/08 , A61M1/3693 , A61M1/3696 , A61M2202/0427 , A61M2205/331 , B04B5/0442
摘要： A centrifuge system with an externally positioned sensor assembly for detecting the separation of components in a fluid sample, such as platelets in a blood sample. The system includes a centrifuge with a drive portion and a rotor portion with a sample reservoir or centrifuge bag for receiving and containing a fluid sample during rotation of the rotor portion. An external sensor assembly is positioned relative to the centrifuge to direct a radiation beam from a radiation source through the rotor portion and the centrifuge bag and to allow a detector to receive the lower-intensity radiation beams at a location external to the rotor portion. In one embodiment, the rotor portion is fabricated from a transparent material and extends radially outward from the sides of the drive portion to allow the radiation source and detector to be positioned externally on opposing sides of the extending rotor portion.
摘要翻译：一种具有外部定位的传感器组件的离心机系统，用于检测流体样品（例如血液样品中的血小板）中的组分的分离。该系统包括具有驱动部分的离心机和具有用于在转子部分旋转期间接收和容纳流体样品的样品容器或离心机袋的转子部分。外部传感器组件相对于离心机定位以将来自辐射源的辐射束引导通过转子部分和离心机袋，并允许检测器在转子部分外部的位置处接收较低强度的辐射束。在一个实施例中，转子部分由透明材料制成并且从驱动部分的侧面径向向外延伸，以允许辐射源和检测器在外部位于延伸转子部分的相对侧上。

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