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1. 发明申请

US20090298665A1 Flexible centrifuge bag and methods of use 审中-公开
公开(公告)号：US20090298665A1
公开(公告)日：2009-12-03
申请号：US12454832
申请日：2009-05-21
申请人： Victor D. Dolecek , David Malcolm
发明人： Victor D. Dolecek , David Malcolm
IPC分类号： B04B1/16 , B04B9/10 , B01D21/26
CPC分类号： B04B5/0428 , A61M1/3693 , A61M1/3696 , A61M1/38 , A61M2202/0423 , B04B2005/045
摘要： A flexible, disposable centrifuge bag for receiving and holding a fluid sample, comprising one or more tubes and upper and lower flexible sheets having doughnut shaped configurations. The upper and lower sheets are superimposed and completely sealed together at their outer perimeters to define an outer perimeter of the centrifuge bag. The inner perimeter of the bag defines a central core. The tubes are sandwiched between the upper and lower sheets and extend from the central core of the centrifuge bag. The upper and lower sheets are sealed together at their inner perimeters such that the tubes are sealed between said upper and lower sheets at the inner perimeter. The bag may be used to harvest platelet rich plasma from whole blood in either a batch method or while simultaneously infusing additional aliquots of whole blood into the bag during centrifugation.

2. 发明授权

US06596181B2 Hard shell disposable reservoir having complex internal design for use in a centrifuge 有权
公开(公告)号：US06596181B2
公开(公告)日：2003-07-22
申请号：US09832741
申请日：2001-04-09
申请人： Victor D. Dolecek , David Malcolm
发明人： Victor D. Dolecek , David Malcolm
IPC分类号： B01D17038
CPC分类号： B04B5/0442 , A61M1/3693 , A61M1/3696 , A61M1/38 , A61M2202/0423 , B01D17/0217 , B01D21/262 , B01D2221/10 , B01J13/0069 , B04B5/0428 , B04B2005/045
摘要： A centrifuge rotor for separating components contained in a fluid, comprising an annular base having a first annular channel and an annular cover having a second annular channel for holding a flexible, doughnut-shaped centrifuge bag therebetween. When the base and the cover are superimposed, the first and second channels define an annular interior chamber having an off-centered figure eight configuration. The base and cover each comprise a grooved column axially centered and extending from the base top surface and the cover bottom surface, respectively. The flexible bag comprises inner and outer tubes which extend from the central core of the bag and which are seated in the column grooves to ensure that the bag is fixably rotatable with the rotor.

3. 发明授权

US07897054B2 Centrifuge container and methods of use 有权
标题翻译：离心容器及使用方法
公开(公告)号：US07897054B2
公开(公告)日：2011-03-01
申请号：US12454839
申请日：2009-05-21
申请人： Victor D. Dolecek , David Malcolm
发明人： Victor D. Dolecek , David Malcolm
IPC分类号： B01D17/038
CPC分类号： B04B5/0428 , A61M1/3693 , A61M1/3696 , A61M1/38 , A61M2202/0423 , B04B2005/045
摘要： A flexible, disposable centrifuge bag for receiving and holding a fluid sample, comprising one or more tubes and upper and lower flexible sheets having doughnut shaped configurations. The upper and lower sheets are superimposed and completely sealed together at their outer perimeters to define an outer perimeter of the centrifuge bag. The inner perimeter of the bag defines a central core. The tubes are sandwiched between the upper and lower sheets and extend from the central core of the centrifuge bag. The upper and lower sheets are sealed together at their inner perimeters such that the tubes are sealed between said upper and lower sheets at the inner perimeter. The bag may be used to harvest platelet rich plasma from whole blood in either a batch method or while simultaneously infusing additional aliquots of whole blood into the bag during centrifugation.
摘要翻译：一种用于接收和保持流体样品的柔性一次性离心机袋，包括一个或多个管和具有环形构型的上下柔性片。上片和下片在其外周叠加并完全密封在一起以限定离心机袋的外周。袋的内周界定中心芯。管夹在上下片之间并从离心机袋的中心芯延伸。上下板在其内周边密封在一起，使得管在内周边处密封在所述上板和下板之间。该袋可以用于以批量方法从全血中收集富含血小板的血浆，或者在离心过程中同时将额外的全血量等分进入袋中。

4. 发明授权

US07867159B2 Centrifuge system utilizing disposable components and automated processing of blood to collect platelet rich plasma 有权
标题翻译：离心机系统利用一次性部件和自动处理血液来收集血小板富集血浆
公开(公告)号：US07867159B2
公开(公告)日：2011-01-11
申请号：US11810071
申请日：2007-06-04
申请人： Victor D. Dolecek , Gary L. Berg , Kenneth E. Merte , David Malcolm , Kevin D. McIntosh , Vitaly G. Sitko
发明人： Victor D. Dolecek , Gary L. Berg , Kenneth E. Merte , David Malcolm , Kevin D. McIntosh , Vitaly G. Sitko
IPC分类号： B04B11/00
CPC分类号： A61M1/3693 , A61M1/1081 , A61M1/3696 , A61M2202/0415 , A61M2202/0427 , A61M2202/0429 , A61M2205/331 , B04B5/0442 , B04B7/02 , B04B13/00 , A61M2202/0092
摘要： A centrifugal method, and corresponding system, for processing blood to collect platelet rich plasma. A separation chamber is filled with blood from a fill syringe by rotating the separation chamber at a fill rotation rate and pumping the blood from the fill syringe. A soft spin is used to initially separate red blood cells from platelets by spinning the separation chamber at a soft spin rate. A percentage of the blood is drawn from the separation chamber back into the fill syringe to remove separated red blood cells. A second portion of the separated blood is drawn from the separation chamber until a red blood cell/platelet interface is detected. A hard spin is performed by spinning the separation chamber at a higher rate and connecting tubing is cleared of red blood cells by drawing a predetermined clearing volume. The platelet rich plasma is then collected in the collection syringe.
摘要翻译：一种离心法和相应的系统，用于处理血液以收集血小板富集血浆。通过以填充旋转速度旋转分离室并从填充注射器泵送血液，从填充注射器中填充分离室。软旋转用于通过以柔软的旋转速率旋转分离室来最初将红细胞与血小板分离。将血液的一部分从分离室抽出回填充注射器以除去分离的红细胞。分离出的血液的第二部分从分离室抽出直到检测到红细胞/血小板界面。通过以更高的速率旋转分离室来进行硬旋转，并且通过绘制预定的清除体积来连接管被清除红细胞。然后将富血小板血浆收集在收集注射器中。

5. 发明申请

US20080171646A1 Flexible centrifuge bag and methods of use 审中-公开
标题翻译：灵活的离心机袋及使用方法
公开(公告)号：US20080171646A1
公开(公告)日：2008-07-17
申请号：US12001257
申请日：2007-12-10
申请人： Victor D. Dolecek , David Malcolm
发明人： Victor D. Dolecek , David Malcolm
IPC分类号： B04B7/12
CPC分类号： B04B5/0428 , A61M1/3693 , A61M1/3696 , A61M1/38 , A61M2202/0423 , B04B2005/045
摘要： A flexible, disposable centrifuge bag for receiving and holding a fluid sample, comprising one or more tubes and upper and lower flexible sheets having doughnut shaped configurations. The upper and lower sheets are superimposed and completely sealed together at their outer perimeters to define an outer perimeter of the centrifuge bag. The inner perimeter of the bag defines a central core. The tubes are sandwiched between the upper and lower sheets and extend from the central core of the centrifuge bag. The upper and lower sheets are sealed together at their inner perimeters such that the tubes are sealed between said upper and lower sheets at the inner perimeter. The bag may be used to harvest platelet rich plasma from whole blood in either a batch method or while simultaneously infusing additional aliquots of whole blood into the bag during centrifugation.
摘要翻译：一种用于接收和保持流体样品的柔性一次性离心机袋，包括一个或多个管和具有环形构型的上下柔性片。上片和下片在其外周叠加并完全密封在一起以限定离心机袋的外周。袋的内周界定中心芯。管夹在上下片之间并从离心机袋的中心芯延伸。上下板在其内周边密封在一起，使得管在内周边处密封在所述上板和下板之间。该袋可以用于以批量方法从全血中收集富含血小板的血浆，或者在离心过程中同时将额外的全血量等分进入袋中。

6. 发明授权

US06793828B2 Method of separating and collecting components from a fluid 有权
标题翻译：从流体中分离和收集组分的方法
公开(公告)号：US06793828B2
公开(公告)日：2004-09-21
申请号：US10431894
申请日：2003-05-08
申请人： Victor D. Dolecek , David Malcolm , Kevin D. McIntosh
发明人： Victor D. Dolecek , David Malcolm , Kevin D. McIntosh
IPC分类号： B01D1738
CPC分类号： B04B5/0428 , B04B5/0442 , B04B2005/045
摘要： A centrifugal method of separating and collecting components from a fluid is provided, comprising providing a centrifuge operable at a plurality of rotation speeds and having a mounting assembly for positioning and retaining a disposable collection assembly relative to the centrifuge at the rotation speeds; mounting a separation assembly comprising a number of collection chambers in the mounting assembly, wherein each of the collection chambers include an outer, conical-shaped collection portion with a port for providing a fluid pathway for the fluid into and out of the collection chambers and wherein the mounting includes fluidically connecting the ports with a fluid tube; connecting a fluid source to the fluid tube; rotating the centrifuge at a fill speed; and operating the fluid source to supply the fluid to the fluid tube, whereby the fluid is concurrently supplied in substantially equal volumetric and component density quantities to each of the collection chambers.
摘要翻译：提供了一种从流体分离和收集部件的离心方法，包括提供可以多个旋转速度操作的离心机，并具有安装组件，用于以一定速度相对于离心机定位和保持一次性收集组件; 将包括多个收集室的分离组件安装在所述安装组件中，其中每个所述收集室包括具有端口的外部圆锥形收集部分，所述端口用于提供流体进入和离开所述收集室的流体路径，并且其中安装件包括使端口与流体管流体连接; 将流体源连接到流体管; 以填充速度旋转离心机; 并且操作所述流体源以将流体供应到所述流体管，由此所述流体同时以基本相等的体积和组分密度数量供应到每个所述收集室。

7. 发明申请

US20090294383A1 Flexible centrifuge bag and methods of use 有权
标题翻译：灵活的离心机袋及使用方法
公开(公告)号：US20090294383A1
公开(公告)日：2009-12-03
申请号：US12454839
申请日：2009-05-21
申请人： Victor D. Dolecek , David Malcolm
发明人： Victor D. Dolecek , David Malcolm
IPC分类号： B01D21/26
CPC分类号： B04B5/0428 , A61M1/3693 , A61M1/3696 , A61M1/38 , A61M2202/0423 , B04B2005/045
摘要： A flexible, disposable centrifuge bag for receiving and holding a fluid sample, comprising one or more tubes and upper and lower flexible sheets having doughnut shaped configurations. The upper and lower sheets are superimposed and completely sealed together at their outer perimeters to define an outer perimeter of the centrifuge bag. The inner perimeter of the bag defines a central core. The tubes are sandwiched between the upper and lower sheets and extend from the central core of the centrifuge bag. The upper and lower sheets are sealed together at their inner perimeters such that the tubes are sealed between said upper and lower sheets at the inner perimeter. The bag may be used to harvest platelet rich plasma from whole blood in either a batch method or while simultaneously infusing additional aliquots of whole blood into the bag during centrifugation.
摘要翻译：一种用于接收和保持流体样品的柔性一次性离心机袋，包括一个或多个管和具有环形构型的上下柔性片。上片和下片在其外周叠加并完全密封在一起以限定离心机袋的外周。袋的内周界定中心芯。管夹在上下片之间并从离心机袋的中心芯延伸。上下板在其内周边密封在一起，使得管在内周边处密封在所述上板和下板之间。该袋可以用于以批量方法从全血中收集富含血小板的血浆，或者在离心过程中同时将额外的全血量等分进入袋中。

8. 发明授权

US07252758B2 Centrifuge system utilizing disposable components and automated processing of blood to collect platelet rich plasma 有权
公开(公告)号：US07252758B2
公开(公告)日：2007-08-07
申请号：US11271434
申请日：2005-11-10
申请人： Victor D. Dolecek , Gary L. Berg , Kenneth E. Merte , David Malcolm , Kevin D. McIntosh , Vitaly G. Sitko
发明人： Victor D. Dolecek , Gary L. Berg , Kenneth E. Merte , David Malcolm , Kevin D. McIntosh , Vitaly G. Sitko
IPC分类号： C02F1/38
CPC分类号： A61M1/3693 , A61M1/1081 , A61M1/3696 , A61M2202/0415 , A61M2202/0427 , A61M2202/0429 , A61M2205/331 , B04B5/0442 , B04B7/02 , B04B13/00 , A61M2202/0092
摘要： A centrifugal method, and corresponding system, for processing blood to collect platelet rich plasma. A separation chamber is filled with blood from a fill syringe by rotating the separation chamber at a fill rotation rate and pumping the blood from the fill syringe. A soft spin is used to initially separate red blood cells from platelets by spinning the separation chamber at a soft spin rate. A percentage of the blood is drawn from the separation chamber back into the fill syringe to remove separated red blood cells. A second portion of the separated blood is drawn from the separation chamber until a red blood cell/platelet interface is detected. A hard spin is performed by spinning the separation chamber at a higher rate and connecting tubing is cleared of red blood cells by drawing a predetermined clearing volume. The platelet rich plasma is then collected in the collection syringe.

9. 发明授权

US06827863B2 Flexible centrifuge bag and methods of use 失效
标题翻译：灵活的离心机袋及使用方法
公开(公告)号：US06827863B2
公开(公告)日：2004-12-07
申请号：US10462426
申请日：2003-06-16
申请人： Victor D. Dolecek , David Malcolm
发明人： Victor D. Dolecek , David Malcolm
IPC分类号： B01D17038
CPC分类号： B04B5/0428 , A61M1/3693 , A61M1/3696 , A61M1/38 , A61M2202/0423 , B04B2005/045
摘要： A flexible, disposable centrifuge bag for receiving and holding a fluid sample, comprising one or more tubes and upper and lower flexible sheets having doughnut shaped configurations. The upper and lower sheets are superimposed and completely sealed together at their outer perimeters to define an outer perimeter of the centrifuge bag. The inner perimeter of the bag defines a central core. The tubes are sandwiched between the upper and lower sheets and extend from the central core of the centrifuge bag. The upper and lower sheets are sealed together at their inner perimeters such that the tubes are sealed between said upper and lower sheets at the inner perimeter. The bag may be used to harvest platelet rich plasma from whole blood in either a batch method or while simultaneously infusing additional aliquots of whole blood into the bag during centrifugation.
摘要翻译：一种用于接收和保持流体样品的柔性一次性离心机袋，包括一个或多个管和具有环形构型的上下柔性片。上片和下片在其外周叠加并完全密封在一起以限定离心机袋的外周。袋的内周界定中心芯。管夹在上下片之间并从离心机袋的中心芯延伸。上下板在其内周边密封在一起，使得管在内周边处密封在所述上板和下板之间。该袋可以用于以批量方法从全血中收集富含血小板的血浆，或者在离心过程中同时将额外的全血量等分进入袋中。

10. 发明申请

US20090008307A1 Blood centrifuge having clamshell blood reservoir holder with index line 有权
标题翻译：血液离心机具有折叠线的蛤壳血液储存器
公开(公告)号：US20090008307A1
公开(公告)日：2009-01-08
申请号：US12079238
申请日：2008-03-24
申请人： Victor D. Dolecek , David Malcolm
发明人： Victor D. Dolecek , David Malcolm
IPC分类号： B01D21/26
CPC分类号： A61M1/3693 , A61M1/3696 , A61M1/38 , A61M2202/0423 , B04B5/0428 , B04B2005/045
摘要： A rotatable rotor for separating components contained in a fluid, comprising an annular base having a first annular channel and an annular cover having a second annular channel for holding a flexible doughnut-shaped centrifuge bag therebetween. The cover has one or more radially spaced apart concentric indicator lines for monitoring the separation of the components. When the base and cover are superimposed, the first and second channels define an annular interior chamber having an off-centered figure eight configuration. The base and cover each comprise a grooved column axially centered and extending from the base top surface and the cover bottom surface, respectively. The flexible bag comprises inner and outer tubes extending from the core of the bag and which are seated in the column grooves to ensure that the bag is fixably rotatable with the rotor.
摘要翻译：一种用于分离流体中包含的组分的可旋转转子，包括具有第一环形通道的环形基座和具有第二环形通道的环形盖，所述第二环形通道用于在其间保持柔性的环形离心机袋。盖具有一个或多个径向间隔开的同心指示线，用于监测部件的分离。当底座和盖子叠加时，第一和第二通道限定具有偏心图形八配置的环形内部腔室。基座和盖板分别包括一个轴向对中并从底部顶表面和盖底表面延伸的开槽的柱。柔性袋包括从袋的芯延伸并且位于柱槽中的内管和外管，以确保袋与转子可固定地旋转。

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