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1. 发明授权

US06914045B2 Glycopeptide antibiotics 有权
公开(公告)号：US06914045B2
公开(公告)日：2005-07-05
申请号：US10131890
申请日：2002-04-25
申请人： Darren Robert Abbanat , Valerie Sue Bernan , Russell George Dushin , Michael Greenstein , Haiyin He , Stanley Albert Lang , Howard Newman , Subas Sakya , Phaik-Eng Sum , Alan Gordon Sutherland , Ting-Zhong Wang , Jason Arnold Lotvin , Mark Edward Ruppen , Arthur Emergy Bailey , Ping Cai , Bo Shen , Fangming Kong
发明人： Darren Robert Abbanat , Valerie Sue Bernan , Russell George Dushin , Michael Greenstein , Haiyin He , Stanley Albert Lang , Howard Newman , Subas Sakya , Phaik-Eng Sum , Alan Gordon Sutherland , Ting-Zhong Wang , Jason Arnold Lotvin , Mark Edward Ruppen , Arthur Emergy Bailey , Ping Cai , Bo Shen , Fangming Kong
IPC分类号： A61K38/00 , C07H15/203 , C07H19/04 , C07K9/00
CPC分类号： C07H15/203 , A61K38/00 , C07H19/04 , C07K9/008
摘要： The invention provides compounds of formula Wherein R1, R2, R3, R4, R5, R6a, R6b, R6c, R6d, R6e and R7 are defined in the specification. These compounds are useful as antibiotic agents.

2. 发明授权

US06964860B2 Glycopeptide antibiotics 有权
标题翻译：糖肽抗生素
公开(公告)号：US06964860B2
公开(公告)日：2005-11-15
申请号：US10131847
申请日：2002-04-25
申请人： Darren Robert Abbanat , Arthur Emery Bailey , Valerie Sue Bernan , Michael Greenstein , Jason Arnold Lotvin , Mark Edward Ruppen , Alan Gordon Sutherland , Haiyin He
发明人： Darren Robert Abbanat , Arthur Emery Bailey , Valerie Sue Bernan , Michael Greenstein , Jason Arnold Lotvin , Mark Edward Ruppen , Alan Gordon Sutherland , Haiyin He
IPC分类号： C07H15/203 , C07H19/04 , C07K9/00 , C12P19/28 , C12P17/16 , A61K38/12 , A61K38/16
CPC分类号： C07H15/203 , C07H19/04 , C07K9/008 , C12P19/28
摘要： The invention provides compounds of formula Wherein R1, R2, R3, R4, R5, R6a, R6b, R6c, R6d, R6e and R7 are defined in the specification. These compounds are useful as antibiotic agents.
摘要翻译：本发明提供下式的化合物其中R 1，R 2，R 3，R 4，R 4， R 5，R 6a，R 6b，R 6c，R 6d，R SUP， > 6e和R＆lt; 7＆gt;在本说明书中定义。这些化合物可用作抗生素。

3. 发明授权

US08247211B2 Glycopeptide antibiotics 有权
标题翻译：糖肽抗生素
公开(公告)号：US08247211B2
公开(公告)日：2012-08-21
申请号：US13022764
申请日：2011-02-08
申请人： Jason Arnold Lotvin , Mark Edward Ruppen
发明人： Jason Arnold Lotvin , Mark Edward Ruppen
IPC分类号： C12N1/20
CPC分类号： C07H15/203 , C07H19/04 , C07K9/008 , C12P19/28
摘要： The invention provides compounds of formula Wherein R1, R2, R3, R4, R5, R6a, R6b, R6c, R6d, R6e and R7 are defined in the specification. These compounds are useful as antibiotic agents.
摘要翻译：本发明提供下式的化合物，其中R1，R2，R3，R4，R5，R6a，R6b，R6c，R6d，R6e和R7在本说明书中定义。这些化合物可用作抗生素。

4. 发明授权

US07718791B2 Separation of contaminants from Streptococcus pneumoniae polysaccharide by pH manipulation 有权
标题翻译：通过pH操纵将污染物与肺炎链球菌多糖分离
公开(公告)号：US07718791B2
公开(公告)日：2010-05-18
申请号：US11396108
申请日：2006-03-31
申请人： Brian Bahler , Tsu-shun Lee , Jason Arnold Lotvin , Mark Edward Ruppen , Pamela Sue Fink Charbonneau
发明人： Brian Bahler , Tsu-shun Lee , Jason Arnold Lotvin , Mark Edward Ruppen , Pamela Sue Fink Charbonneau
IPC分类号： C07H1/06 , C07H1/00 , C12P19/04
CPC分类号： A61K39/085 , C08B37/0003 , C12N1/06 , C12N1/20 , C12P1/04 , C12P19/04
摘要： A process for reducing the protein content and preserving the capsular polysaccharide content in a complex cellular Streptococcus pneumoniae lysate broth prior to purification is described. Utilizing pH reduction after cellular lysis has resulted in a purified polysaccharide that consistently meets the protein specification, and higher recovery yields of polysaccharide during the purification process.
摘要翻译：描述了在纯化之前降低蛋白质含量并保持复合细胞肺炎链球菌裂解物肉汤中的荚膜多糖含量的方法。在细胞裂解后利用pH降低导致纯化多糖，其一致地符合蛋白质规格，并且在纯化过程中产生更高的多糖回收率。

5. 发明申请

US20110151546A1 GLYCOPEPTIDE ANTIBIOTICS 有权
标题翻译：糖蛋白抗体
公开(公告)号：US20110151546A1
公开(公告)日：2011-06-23
申请号：US13022764
申请日：2011-02-08
申请人： Jason Arnold Lotvin , Mark Edward Ruppen
发明人： Jason Arnold Lotvin , Mark Edward Ruppen
IPC分类号： C12N1/20
CPC分类号： C07H15/203 , C07H19/04 , C07K9/008 , C12P19/28
摘要： The invention provides compounds of formula Wherein R1, R2, R3, R4, R5, R6a, R6b, R6c, R6d, R6e and R7 are defined in the specification. These compounds are useful as antibiotic agents.
摘要翻译：本发明提供下式的化合物，其中R1，R2，R3，R4，R5，R6a，R6b，R6c，R6d，R6e和R7在本说明书中定义。这些化合物可用作抗生素。

6. 发明授权

US07078195B2 Antibiotics AA-896 失效
标题翻译：抗生素AA-896
公开(公告)号：US07078195B2
公开(公告)日：2006-07-18
申请号：US10713881
申请日：2003-11-14
申请人： Guy Thomas Carter , Jason Arnold Lotvin , Leonard Alexander McDonald
发明人： Guy Thomas Carter , Jason Arnold Lotvin , Leonard Alexander McDonald
IPC分类号： C12P19/44 , C12N1/00
CPC分类号： C12R1/465 , A61K38/00 , C07H19/06 , C07K9/001 , C12P17/16 , Y10S435/886
摘要： This invention relates to new antibiotics designated AA-896-A1, AA-896-A2, AA-896-A3, AA-896-A4, AA-896-A5, AA-896-A6, AA-896-Bl, AA-896-B2, AA-896-B3, AA-896-B4, AA-896-B5, AA-896-B6, AA-896-B7, AA-896-C1, AA-896-C2, AA-896-C3, AA-896-C4, AA-896-C5, AA-896-D1, AA-896-D2, AA-896-D3 and AA-896-D4 derived from the microorganism Streptomyces spp. LL-AA896 which are useful an anti-bacterial agents.
摘要翻译：本发明涉及名为AA-896-A1，AA-896-A2，AA-896-A3，AA-896-A4，AA-896-A5，AA-896-A6，AA-896-B1，AA -896-B2，AA-896-B3，AA-896-B4，AA-896-B5，AA-896-B6，AA-896-B7，AA-896-C1，AA-896-C2，AA-896 -C3，AA-896-C4，AA-896-C5，AA-896-D1，AA-896-D2，AA-896-D3和AA-896-D4。 LL-AA896是有用的抗菌剂。

7. 发明授权

US06689763B2 Antibiotics AA-896 失效
标题翻译：抗生素AA-896
公开(公告)号：US06689763B2
公开(公告)日：2004-02-10
申请号：US10132005
申请日：2002-04-25
申请人： Guy Thomas Carter , Jason Arnold Lotvin , Leonard Alexander McDonald
发明人： Guy Thomas Carter , Jason Arnold Lotvin , Leonard Alexander McDonald
IPC分类号： A61K3170
CPC分类号： C12R1/465 , A61K38/00 , C07H19/06 , C07K9/001 , C12P17/16 , Y10S435/886
摘要： This invention relates to new antibiotics designated AA-896-A1, AA-896-A2, AA-896-A3, AA-896-A4, AA-896-A5, AA-896-A6, AA-896-B1, AA-896-B2, AA-896-B3, AA-896-B4, AA-896-B5, AA-896-B6, AA-896-B7, AA-896-C1, AA-896-C2, AA-896-C3, AA-896-C4, AA-896-C5, AA-896-D1, AA-896-D2, AA-896-D3 and AA-896-D4 derived from the microorganism Streptomyces spp. LL-AA896 which are useful an anti-bacterial agents.
摘要翻译：本发明涉及名为AA-896-A1，AA-896-A2，AA-896-A3，AA-896-A4，AA-896-A5，AA-896-A6，AA-896-B1，AA -896-B2，AA-896-B3，AA-896-B4，AA-896-B5，AA-896-B6，AA-896-B7，AA-896-C1，AA-896-C2，AA-896 -C3，AA-896-C4，AA-896-C5，AA-896-D1，AA-896-D2，AA-896-D3和AA-896-D4。 LL-AA896是有用的抗菌剂。

8. 发明授权

US5888798A Chondroitinase I and chondroitinase II producing mutants of P. vulgaris 失效
标题翻译：软骨素酶I和软骨素酶II产生普通寻常型突变体
公开(公告)号：US5888798A
公开(公告)日：1999-03-30
申请号：US476261
申请日：1995-06-07
申请人： Jason Arnold Lotvin , Kiran M. Khandke , Mark E. Ruppen
发明人： Jason Arnold Lotvin , Kiran M. Khandke , Mark E. Ruppen
IPC分类号： C12N15/09 , C12N1/21 , C12N9/88 , C12Q1/527 , C12R1/19 , C12R1/37 , C12N1/20
CPC分类号： C12R1/37 , C12N9/88 , Y10S435/873
摘要： Mutant Proteus vulgaris strains are provided that, when grown in the absence of an exogenous chondroitinase I and II inducer, produce P. vulgans chondroitinase I and chondroitinase II proteins. The mutants typically produce chondroitinase I and II proteins in the absence of exogenous inducers and in amounts in excess of those produced by wild-type P. vulgaris strains induced with such inducers. Two classes of such mutants, Classes 1 and 2, are disclosed. Class 1 and class 2 mutants differ in the relative amounts of chondroitinases I and II produced when cells are grown in casamino acids--supplemented minimal medium. Additional phenotypic variants that release chondroitinase I protein into the culture medium are provided as well. Also contemplated is a method for producing P. vulgaris chondroitinase I and II proteins. The mutant cells described above are cultured in the absence of a conventional exogenous chondroitinase I and II inducer, after which the cells are harvested and chondroitinase I and II are recovered from the harvested cells. A method for in situ detection of chondroitinase I and II production by bacterial colonies is also provided.
摘要翻译：提供突变型普通变形杆菌，当在不存在外源性软骨素酶I和II诱导物的情况下生长时，产生P. vulgans软骨素酶I和软骨素II蛋白。突变体通常在没有外源性诱导物的情况下产生软骨素酶I和II蛋白，并且其量超过由这种诱导物诱导的野生型寻常型菌株产生的那些。披露了两类这类突变体，1类和2类。 1类和2类突变体在细胞生长在补充有酪氨酸氨酸的基本培养基中时产生的软骨素酶I和II的相对量不同。还提供将软骨素酶蛋白质释放到培养基中的其他表型变体。还考虑了用于产生寻常性软骨素酶I和II蛋白质的方法。在不存在常规外源性软骨素酶I和II诱导剂的情况下培养上述突变细胞，之后收获细胞，从收获的细胞中回收软骨素酶I和II。还提供了通过细菌菌落原位检测软骨素酶I和II产生的方法。

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