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1. 发明申请

US20130309222A1 AFFINITY PEPTIDES TOWARD INFLIXIMAB 有权
公开(公告)号：US20130309222A1
公开(公告)日：2013-11-21
申请号：US13474056
申请日：2012-05-17
申请人： Daphne Ann Salick Ryan , John Kehoe , John Wheeler , Chunlin Yang , Abla Creasey
发明人： Daphne Ann Salick Ryan , John Kehoe , John Wheeler , Chunlin Yang , Abla Creasey
IPC分类号： C07K7/08 , A61K39/395 , C07K7/06
CPC分类号： A61K47/42 , A61K39/3955 , A61K2039/505 , C07K7/08 , C07K14/525 , C07K16/241 , C07K2317/24 , C07K2317/76 , C07K2317/92
摘要： We have disclosed affinity peptides toward infliximab. More specifically we have disclosed an affinity biomatrix where the affinity peptide is covalently attached to a biocompatible, biodegradable polymer. The affinity biomatrix is useful in preparing controlled release devices for infliximab.
摘要翻译：我们已经向英夫利昔单抗公开了亲和肽。更具体地，我们已经公开了一种亲和力生物基质，其中亲和肽共价连接到生物相容的可生物降解的聚合物上。亲和力生物基质可用于制备英夫利昔单抗的控制释放装置。

2. 发明授权

US08822423B2 Affinity peptides toward infliximab 有权
标题翻译：针对英夫利昔单抗的亲和肽
公开(公告)号：US08822423B2
公开(公告)日：2014-09-02
申请号：US13474056
申请日：2012-05-17
申请人： Daphne Ann Salick Ryan , John Kehoe , John Wheeler , Chunlin Yang , Abla Creasey
发明人： Daphne Ann Salick Ryan , John Kehoe , John Wheeler , Chunlin Yang , Abla Creasey
IPC分类号： A61K38/10 , A61K9/00 , A61K39/395
CPC分类号： A61K47/42 , A61K39/3955 , A61K2039/505 , C07K7/08 , C07K14/525 , C07K16/241 , C07K2317/24 , C07K2317/76 , C07K2317/92
摘要： We have disclosed affinity peptides toward infliximab. More specifically we have disclosed an affinity biomatrix where the affinity peptide is covalently attached to a biocompatible, biodegradable polymer. The affinity biomatrix is useful in preparing controlled release devices for infliximab.
摘要翻译：我们已经向英夫利昔单抗公开了亲和肽。更具体地，我们已经公开了一种亲和力生物基质，其中亲和肽共价连接到生物相容的可生物降解的聚合物上。亲和力生物基质可用于制备英夫利昔单抗的控制释放装置。

3. 发明授权

US08394378B2 Antibodies binding human collagen II 有权
标题翻译：抗体结合人类胶原II
公开(公告)号：US08394378B2
公开(公告)日：2013-03-12
申请号：US13245299
申请日：2011-09-26
申请人： John Kehoe , Jennifer Lee Gardiner , Tatiana Ort , Kristen Picha , Mary Ryan , John Wheeler
发明人： John Kehoe , Jennifer Lee Gardiner , Tatiana Ort , Kristen Picha , Mary Ryan , John Wheeler
IPC分类号： A61K39/00 , C07K16/00 , C07K16/46
CPC分类号： C07K16/18 , A61K2039/505 , C07K2317/21 , C07K2317/33 , C07K2317/55 , C07K2317/92
摘要： The present invention relates to antibodies against human collagen II, polypeptides and polynucleotides encoding human collagen II antibodies or fragments thereof, and methods of making and using the foregoing.
摘要翻译：本发明涉及针对人胶原II的抗体，编码人胶原II抗体或其片段的多肽和多核苷酸，以及制备和使用上述物质的方法。

4. 发明申请

US20120108795A1 Antibodies Binding Human Collagen II 有权
标题翻译：抗体结合人胶原蛋白II
公开(公告)号：US20120108795A1
公开(公告)日：2012-05-03
申请号：US13245299
申请日：2011-09-26
申请人： John Kehoe , Jennifer Lee Gardiner , Tatiana Ort , Kristen Picha , Mary Ryan , John Wheeler
发明人： John Kehoe , Jennifer Lee Gardiner , Tatiana Ort , Kristen Picha , Mary Ryan , John Wheeler
IPC分类号： C07K16/18 , C12N15/63 , C12N1/00 , C12N1/21 , C12N5/10 , C12N15/13 , C12P21/02
CPC分类号： C07K16/18 , A61K2039/505 , C07K2317/21 , C07K2317/33 , C07K2317/55 , C07K2317/92
摘要： The present invention relates to antibodies against human collagen II, polypeptides and polynucleotides encoding human collagen II antibodies or fragments thereof, and methods of making and using the foregoing.
摘要翻译：本发明涉及针对人胶原II的抗体，编码人胶原II抗体或其片段的多肽和多核苷酸，以及制备和使用上述物质的方法。

5. 发明授权

US08419722B2 Apparatus and method for injection of fibrin sealant in spinal applications 有权
标题翻译：用于脊髓应用中注射纤维蛋白封闭剂的装置和方法
公开(公告)号：US08419722B2
公开(公告)日：2013-04-16
申请号：US11650398
申请日：2007-01-05
申请人： Mark Richards , Brian D. Burkinshaw , Kevin Pauza , James B. Rogan , John Wheeler
发明人： Mark Richards , Brian D. Burkinshaw , Kevin Pauza , James B. Rogan , John Wheeler
IPC分类号： A61B18/04
CPC分类号： A61M5/19 , A61B17/00491 , A61B2017/00495 , A61M5/2425 , A61M5/31575 , A61M5/3158 , A61M5/31581 , A61M5/31585 , A61M5/31593 , A61M5/486 , A61M25/0032 , A61M2005/3152 , A61M2005/3201
摘要： An apparatus for percutaneous delivery of a sealant comprising: at least two fluid reservoirs, an introducer needle having a distal tip that is in fluid communication with at least one reservoir, a fluid delivery tube that is in fluid communication with a second reservoir, wherein the fluid delivery tube has a tip and wherein the fluid delivery tube is configured so that the tip of the fluid delivery tube does not extend past the distal tip of the introducer needle during use.
摘要翻译：一种用于经皮输送密封剂的装置，包括：至少两个流体储存器，具有与至少一个储存器流体连通的远侧末端的导引器针，与第二储存器流体连通的流体输送管，其中流体输送管具有尖端，并且其中流体输送管构造成使得流体输送管的尖端在使用期间不延伸超过导引针的远端。

6. 发明申请

US20110318353A1 Humanized IL-25 Antibodies 有权
标题翻译：人源化IL-25抗体
公开(公告)号：US20110318353A1
公开(公告)日：2011-12-29
申请号：US13075241
申请日：2011-03-30
申请人： Juan Carlos Almagro , Patrick Branigan , Colleen Kane , William Strohl , Susann Taudte , Mark Tornetta , John Wheeler
发明人： Juan Carlos Almagro , Patrick Branigan , Colleen Kane , William Strohl , Susann Taudte , Mark Tornetta , John Wheeler
IPC分类号： A61K39/395 , C12N15/13 , C12N15/63 , A61P29/00 , C12N1/21 , C12P21/00 , C12P21/02 , A61P11/06 , C07K16/24 , C12N5/10
CPC分类号： C07K16/244 , C07K2317/24 , C07K2317/33 , C07K2317/34 , C07K2317/55 , C07K2317/565 , C07K2317/76 , C07K2317/92
摘要： The present invention relates to target binding members (e.g., antibodies) that bind a specified epitope of human IL-25. The invention also relates to target binding members (e.g., antibodies) that comprise one or more humanized antibody VL domain sequences and bind IL-25. The invention further relates to compositions comprising target binding members (e.g., antibodies) that bind IL-25, methods of producing such target binding members, and uses of such target binding members for the treatment or prevention of diseases and conditions (e.g., asthma, inflammatory bowel disease).
摘要翻译：本发明涉及结合人IL-25的指定表位的靶结合成员（例如抗体）。本发明还涉及包含一个或多个人源化抗体VL结构域序列并结合IL-25的靶结合成员（例如，抗体）。本发明还涉及包含结合IL-25的靶结合成员（例如，抗体），产生此类靶结合成员的方法，以及这些靶结合成员用于治疗或预防疾病和病症（例如，哮喘，炎性肠病）。

7. 发明申请

US20080060970A1 Apparatus and method for delivery of biologic sealant 有权
标题翻译：用于输送生物密封剂的装置和方法
公开(公告)号：US20080060970A1
公开(公告)日：2008-03-13
申请号：US11977441
申请日：2007-10-24
申请人： John Wheeler , Gary Whipple , A. Boccuti , Thomas Washburn , Andrew Gentile , J. Ratz , John Spiridigliozzi
发明人： John Wheeler , Gary Whipple , A. Boccuti , Thomas Washburn , Andrew Gentile , J. Ratz , John Spiridigliozzi
IPC分类号： A61M5/00 , A61M37/00 , B65D69/00
CPC分类号： A61B17/00491 , A61B17/0057 , A61B2017/00495 , A61K38/363 , A61K38/482 , A61K45/06 , A61L24/106 , A61L27/225 , A61L27/50 , A61L27/54 , A61L2300/00 , A61L2400/06 , A61L2430/38 , B05C17/00553 , B05C17/0116 , Y10T29/49826 , A61K2300/00
摘要： A device for delivery of biologic materials, comprising: a cartridge having at least two cylinder bores for fluids to be delivered, wherein each cylinder includes an exit port for a fluid, a plunger within each cylinder for pushing the fluids out of the cylinder, a housing adapted to receive the cartridge, wherein the housing or cartridge includes an adaptor to receive and lock a manifold that operably connects to the exit ports of the cartridge, at least two toothed rams, wherein each toothed ram is at least partially within a cylinder bore, a trigger connected to the housing, wherein the trigger includes a toothed drive rack, a toothed wheel assembly that cooperates with the toothed drive rack and with the toothed rams, as well as methods of making the device, methods of using the device to treat discs, kits including the device.
摘要翻译：一种用于输送生物材料的装置，包括：具有用于待输送流体的至少两个气缸孔的筒，其中每个气缸包括用于流体的出口，用于将流体推出气缸的每个气缸内的柱塞，壳体，其适于接收所述盒，其中所述壳体或盒包括用于容纳和锁定歧管的适配器，所述歧管可操作地连接到所述药筒的出口，至少两个齿状的公柱，其中每个齿状的压头至少部分地在汽缸孔内触发器，其连接到所述壳体，其中所述触发器包括齿形驱动齿条，与所述齿形驱动齿条和所述齿状凸起协作的齿轮组件，以及制造所述装置的方法，使用所述装置的方法来治疗光盘，套件，包括设备。

8. 发明申请

US20050003346A1 Apparatus and method for detecting microscopic living organisms using bacteriophage 审中-公开
标题翻译：使用噬菌体检测微生物生物的仪器和方法
公开(公告)号：US20050003346A1
公开(公告)日：2005-01-06
申请号：US10823294
申请日：2004-04-12
申请人： Kent Voorhees , John Rees , John Wheeler , Angelo Madonna
发明人： Kent Voorhees , John Rees , John Wheeler , Angelo Madonna
IPC分类号： C12Q1/04 , G01N33/543 , G01N33/569 , C12Q1/70
CPC分类号： C12Q1/04 , G01N33/54326 , G01N33/56911
摘要： A method for detecting one or more target bacteria in a raw sample where: 1) bacteriophage(s) specific to each target bacterium are added to the raw sample, 2) the test sample is incubated, and 3) the test sample is tested for the presence of each phage in sufficient numbers to indicate the presence of the associated target bacteria in the raw sample. In one embodiment, each phage is initially added to the raw sample in concentrations below the detection limit of the final phage detection process. In another embodiment, the parent phages are tagged in such a way that they can be separated from the progeny phage prior to the detection process. Preferred phage detection processes are immunoassay methods utilizing antibodies that bind specifically to each phage. Antibodies can be used that bind to the protein capsid of the phage. Alternatively, the phage can by dissociated after the incubation process and the sample tested for the presence of individual capsid proteins or phage nucleic acids. The invention can be used to test target bacteria for antibiotic resistance.
摘要翻译：一种用于检测原料样品中的一种或多种目标细菌的方法，其中：1）将每种靶细菌特异性的噬菌体加入到原始样品中，2）将测试样品孵育，并且3）测试样品每个噬菌体的存在足够数量以指示原始样品中相关靶细菌的存在。在一个实施方案中，每个噬菌体最初以低于最终噬菌体检测过程的检测限的浓度加入到原始样品中。在另一个实施方案中，母体噬菌体的标记方式使得它们可以在检测过程之前与后代噬菌体分离。优选的噬菌体检测方法是利用与每个噬菌体特异性结合的抗体的免疫测定方法。可以使用结合噬菌体的蛋白质衣壳的抗体。或者，噬菌体可以通过在孵育过程之后解离并且样品测试个体衣壳蛋白或噬菌体核酸的存在。本发明可用于测试目标细菌的抗生素耐药性。

9. 发明授权

US6144464A Method and system for modification of fax data rate over wireless channels 失效
标题翻译：通过无线信道修改传真数据速率的方法和系统
公开(公告)号：US6144464A
公开(公告)日：2000-11-07
申请号：US927693
申请日：1997-09-11
申请人： Scott W. Rupp , John Wheeler , Brady Brown
发明人： Scott W. Rupp , John Wheeler , Brady Brown
IPC分类号： H04B7/26 , H04L1/00 , H04L1/18 , H04N1/00 , H04N1/333 , H04Q7/32 , H04N1/32
CPC分类号： H04N1/33361 , H04B7/2659 , H04L1/0002 , H04N1/00281 , H04N1/3333 , H04L1/18 , H04N2201/3335
摘要： A method and apparatus for improving the successful transmission of facsimile data over a wireless communication channel is provided comprising a facsimile machine, a wireless transceiver and a connector interfacing therebetween. The facsimile machine detects an interface with the wireless transceiver and notifies the facsimile machine of a wireless communication channel through which facsimile data will traverse. The facsimile machine, in conjunction with the wireless transceiver, establishes a wireless communication channel according to an initial data transfer rate corresponding with the capability of the wireless transceiver or known communication channel conditions. The facsimile machine then exchanges facsimile data over the wireless communication channel and a receiving facsimile machine evaluates the facsimile data to detect errors injected through the wireless communication channel. When such errors are detected, the facsimile machine may institute retransmission of the previous facsimile data relying upon an anticipated improved condition of the wireless communication channel. When the conditions of this wireless communication channel have not improved, the facsimile machine renegotiates a data transfer rate more conducive with the present capability of the wireless communication channel. A facsimile machine further determines when the wireless transceiver is removed and reverts back to traditional wired communication channel data rates.
摘要翻译：提供了一种用于通过无线通信信道改善传真数据的成功传输的方法和装置，其包括传真机，无线收发机以及在它们之间的连接器。传真机检测与无线收发器的接口，并向传真机通知传真数据将穿过的无线通信信道。传真机与无线收发器结合，根据与无线收发机的能力对应的初始数据传输速率或已知的通信信道条件建立无线通信信道。然后，传真机通过无线通信信道交换传真数据，接收传真机对传真数据进行评估，以检测通过无线通信信道注入的错误。当检测到这样的错误时，传真机可以依赖于无线通信信道的预期改进状况来重传先前的传真数据。当该无线通信信道的条件没有改善时，传真机重新协商更有利于无线通信信道当前能力的数据传输速率。传真机进一步确定无线收发器何时被去除并且回复到传统的有线通信信道数据速率。

10. 发明授权

US08785605B2 Humanized IL-25 antibodies 有权
标题翻译：人源化IL-25抗体
公开(公告)号：US08785605B2
公开(公告)日：2014-07-22
申请号：US13075241
申请日：2011-03-30
申请人： Juan Carlos Almagro , Patrick Branigan , Colleen Kane , William Strohl , Susann Taudte , Mark Tornetta , John Wheeler
发明人： Juan Carlos Almagro , Patrick Branigan , Colleen Kane , William Strohl , Susann Taudte , Mark Tornetta , John Wheeler
IPC分类号： C07K16/24 , A61K9/19 , A61K39/395
CPC分类号： C07K16/244 , C07K2317/24 , C07K2317/33 , C07K2317/34 , C07K2317/55 , C07K2317/565 , C07K2317/76 , C07K2317/92
摘要： The present invention relates to target binding members (e.g., antibodies) that bind a specified epitope of human IL-25. The invention also relates to target binding members (e.g., antibodies) that comprise one or more humanized antibody VL domain sequences and bind IL-25. The invention further relates to compositions comprising target binding members (e.g., antibodies) that bind IL-25, methods of producing such target binding members, and uses of such target binding members for the treatment or prevention of diseases and conditions (e.g., asthma, inflammatory bowel disease).
摘要翻译：本发明涉及结合人IL-25的指定表位的靶结合成员（例如抗体）。本发明还涉及包含一个或多个人源化抗体VL结构域序列并结合IL-25的靶结合成员（例如抗体）。本发明还涉及包含结合IL-25的靶结合成员（例如，抗体），产生此类靶结合成员的方法，以及这些靶结合成员用于治疗或预防疾病和病症（例如，哮喘，炎性肠病）。

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