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1. 发明授权

US08530178B2 Hydrolase detection system with caged substrates 失效
标题翻译：水解酶检测系统与笼式底物
公开(公告)号：US08530178B2
公开(公告)日：2013-09-10
申请号：US12445378
申请日：2007-10-17
申请人： Daniel Sobek , Jianghong Rao
发明人： Daniel Sobek , Jianghong Rao
IPC分类号： C12Q1/42
CPC分类号： C12Q1/34
摘要： An enzyme detection method includes forming a caged substrate; releasing an uncaged substrate by cleaving a caging molecule from the caged substrate; and emitting a light emission from a Bioluminescence Resonance Energy Transfer luminescent nanocrystal conjugate reacting with the uncaged substrate.
摘要翻译：酶检测方法包括形成笼状基材; 通过从笼形基底切割笼状分子释放未起皮的底物; 并且从与未起始的底物反应的生物发光共振能量转移发光纳米晶体共轭物发射发光。

2. 发明申请

US20100068741A1 ASSAY SYSTEM FOR ADENOSINE TRIPHOSPHATE AND CREATINE KINASE 审中-公开
标题翻译：腺苷三磷酸和发酵激酶的测定系统
公开(公告)号：US20100068741A1
公开(公告)日：2010-03-18
申请号：US12445384
申请日：2007-10-17
申请人： Daniel Sobek , Jianghong Rao
发明人： Daniel Sobek , Jianghong Rao
IPC分类号： C12Q1/48
CPC分类号： G01N33/587 , G01N33/542 , G01N33/5735 , G01N2333/9123
摘要： An assay method includes providing a luminescent nanocrystal; combining a solution having an adenosine triphosphate molecule; and displaying a light emission by the luminescent nanocrystal and the solution combined.
摘要翻译：测定方法包括提供发光纳米晶体; 组合具有三磷酸腺苷分子的溶液; 并且通过发光纳米晶体显示发光并且将所述溶液组合。

3. 发明申请

US20100055725A1 SYSTEM FOR ASSAYS OF AMINOTRANSFERASE 审中-公开
标题翻译：氨基转移酶测定系统
公开(公告)号：US20100055725A1
公开(公告)日：2010-03-04
申请号：US12440677
申请日：2007-10-17
申请人： Jianghong Rao , Daniel Sobek
发明人： Jianghong Rao , Daniel Sobek
IPC分类号： C12Q1/48
CPC分类号： C12Q1/48 , G01N2333/91188
摘要： An assay system (300) comprising providing a platform (102) having a contact surface (104); immobilizing an amino acid group (108), having an amine side group (109), on the contact surface (104); transforming the amine side group (109), in the amino acid group (108) to a ketone group (120); and reacting an indicator (122) with the ketone group (120) for displaying a light emission (128) from the indicator (122).
摘要翻译：一种分析系统（300），包括提供具有接触表面（104）的平台（102）; 将具有胺侧基（109）的氨基酸（108）固定在接触表面（104）上; 将氨基酸组（108）中的胺侧基（109）转化为酮基（120）; 并使指示剂（122）与酮基（120）反应，用于从指示剂（122）显示发光（128）。

4. 发明申请

US20100035290A1 ENZYME DETECTION SYSTEM WITH CAGED SUBSTRATES 失效
标题翻译：带有基底的酶检测系统
公开(公告)号：US20100035290A1
公开(公告)日：2010-02-11
申请号：US12445378
申请日：2007-10-17
申请人： Daniel Sobek , Jianghong Rao
发明人： Daniel Sobek , Jianghong Rao
IPC分类号： C12Q1/34
CPC分类号： C12Q1/34
摘要： An enzyme detection method includes forming a caged substrate; releasing an uncaged substrate by cleaving a caging molecules from the caged substrate; and emitting a light emission from a Bioluminescence Resonance Energy Transfer luminescent nanocrystal conjugate reacting with the uncaged substrate.
摘要翻译：酶检测方法包括形成笼状基材; 通过从笼形基底切割笼状分子来释放未起皮的底物; 并且从与未起始的底物反应的生物发光共振能量转移发光纳米晶体共轭物发射发光。

5. 发明申请

US20080251383A1 Microfluidic Liquid Stream Configuration System 有权
标题翻译：微流体液流配置系统
公开(公告)号：US20080251383A1
公开(公告)日：2008-10-16
申请号：US12064630
申请日：2006-08-23
申请人： Daniel Sobek , Jun Zeng
发明人： Daniel Sobek , Jun Zeng
IPC分类号： G01N27/00
CPC分类号： B01L3/502792 , B01L3/50273 , B01L3/502738 , B01L2300/0645 , B01L2300/069 , B01L2300/089 , B01L2400/0415 , B01L2400/0448 , B01L2400/06 , F04B19/006 , G01N33/4905
摘要： A microfluidic liquid stream configuration system is provided including providing a substrate; forming a first co-planar electrode and a second co-planar electrode on the substrate; applying a dielectric layer, with a controlled surface energy, on the first co-planar electrode and the second co-planar electrode; forming an input reservoir on the first co-planar electrode and a second co-planar electrode; supplying a liquid in the input reservoir for analysis; and imposing an electric field, an electric field gradient, or a combination thereof on the liquid for respectively driving surface charge or dipole moments in the liquid for configuring a liquid stream.
摘要翻译：提供了一种微流体液流配置系统，包括提供基板; 在所述基板上形成第一共面电极和第二共面电极; 在所述第一共平面电极和所述第二共面电极上施加具有受控表面能的电介质层; 在所述第一共平面电极和第二共面电极上形成输入容器; 在输入容器中供应液体进行分析; 并在液体上施加电场，电场梯度或其组合，以分别驱动用于构成液体流的液体中的表面电荷或偶极矩。

6. 发明授权

US07173240B2 Electrospray devices for mass spectrometry 有权
标题翻译：用于质谱的电喷雾装置
公开(公告)号：US07173240B2
公开(公告)日：2007-02-06
申请号：US11001268
申请日：2004-11-30
申请人： Karen L. Seaward , Hongfeng Yin , Kevin P. Killeen , Daniel Sobek , Daniel Roitman
发明人： Karen L. Seaward , Hongfeng Yin , Kevin P. Killeen , Daniel Sobek , Daniel Roitman
IPC分类号： H01J49/10
CPC分类号： H01J49/167 , G01N30/7266
摘要： An electrospray device for a mass spectrometry system is described. The electrospray device comprises a body portion and a tip portion extending from the body portion. The tip portion comprises a polymeric material. The electrospray device also comprises a hydrophobic coating substantially selectively covering the tip portion.
摘要翻译：描述了用于质谱系统的电喷雾装置。电喷雾装置包括主体部分和从主体部分延伸的尖端部分。尖端部分包括聚合材料。电喷雾装置还包括基本上选择性地覆盖尖端部分的疏水涂层。

7. 发明申请

US20060102862A1 Electrostatic sealing device and method of use thereof 审中-公开
标题翻译：静电密封装置及其使用方法
公开(公告)号：US20060102862A1
公开(公告)日：2006-05-18
申请号：US11318994
申请日：2005-12-27
申请人： Daniel Sobek
发明人： Daniel Sobek
IPC分类号： F16K31/02
CPC分类号： F04B43/12 , B01L3/502707 , B01L3/50273 , B01L3/502738 , B01L2200/0689 , B01L2300/0887 , B01L2300/123 , B01L2400/0481 , B01L2400/0655 , B29C65/008 , B29C65/76 , B29C66/1122 , B29C66/12443 , B29C66/53461 , B29C66/54 , B29C66/5412 , B29C66/71 , B29L2031/756 , B81B2201/058 , B81C3/001 , F04B43/043 , F16K99/0001 , B29K2083/00 , B29K2081/06 , B29K2077/00 , B29K2075/00 , B29K2069/00 , B29K2033/12 , B29K2033/08 , B29K2027/18 , B29K2027/12 , B29K2027/06 , B29K2023/38 , B29K2023/12 , B29K2021/00
摘要： A microfluidic structure having an electrostatic sealing device is disclosed. The electrostatic sealing device includes a first electrode and a second electrode opposite the first electrode. At least one of the electrodes has an elastic layer facing the other electrode. The second electrode is capable of moving toward the first electrode and forming a seal with the first electrode in response to a voltage difference between the two electrodes. The electrostatic sealing device eliminates the need for mechanical components that are traditionally used for generating a mechanical force between two components of a microfluidic structure and thus reduces complexity of the microfluidic structure and possible interference with optical interrogation of the microfluidic structure. Moreover, the seal can be established or removed simply by turning the voltage on or off. The electrostatic sealing device can also be used as a valve, a pump, or a combination thereof, to control fluid flow in the microchannels of a microfluidic structure.
摘要翻译：公开了一种具有静电密封装置的微流体结构。静电密封装置包括与第一电极相对的第一电极和第二电极。至少一个电极具有面向另一个电极的弹性层。第二电极能够朝着第一电极移动并且响应于两个电极之间的电压差而与第一电极形成密封。静电密封装置消除了对传统上用于在微流体结构的两个部件之间产生机械力的机械部件的需要，并且因此降低了微流体结构的复杂性以及对微流体结构的光询问的可能干扰。此外，通过打开或关闭电压，可以简单地建立或移除密封。静电密封装置也可以用作阀，泵或其组合，以控制微流体结构的微通道中的流体流动。

8. 发明授权

US07022982B2 Ion source frequency feedback device and method 失效
标题翻译：离子源频率反馈装置及方法
公开(公告)号：US07022982B2
公开(公告)日：2006-04-04
申请号：US10896981
申请日：2004-07-23
申请人： Daniel Sobek , Jing Cai , Kevin Killeen , Hongfeng Yin
发明人： Daniel Sobek , Jing Cai , Kevin Killeen , Hongfeng Yin
IPC分类号： H01J49/10
CPC分类号： H01J49/165
摘要： An ion source for an analytical instrument is described. The ion source comprises a capillary tip and counter-electrode interface and a feedback loop control device connected to the capillary tip and counter-electrode interface. The feedback loop control device comprises a transimpedance amplifier, a DC de-coupler, a frequency to voltage converter, a controller, and a voltage-controlled high-voltage power supply that provides a tip to counter-electrode voltage to the capillary tip and counter-electrode interface. The feedback loop control device measures the modulation frequency of ionization currents and provides a feedback adjustment of the tip-to-counter-electrode voltage to maintain ionization efficiency.
摘要翻译：描述了用于分析仪器的离子源。离子源包括毛细管尖端和对电极界面以及连接到毛细管尖端和对电极界面的反馈回路控制装置。反馈回路控制装置包括跨阻抗放大器，直流去耦合器，频率 - 电压转换器，控制器和电压控制的高压电源，其提供针对毛细管尖端和计数器的对电极电压的尖端电极接口。反馈回路控制装置测量电离电流的调制频率，并提供端对电极电压的反馈调整，以维持电离效率。

9. 发明申请

US20060011548A1 Mobile phase gradient generation microfluidic device 有权
公开(公告)号：US20060011548A1
公开(公告)日：2006-01-19
申请号：US11224904
申请日：2005-09-12
申请人： Hongfeng Yin , Kevin Killeen , Daniel Sobek
发明人： Hongfeng Yin , Kevin Killeen , Daniel Sobek
IPC分类号： B01D15/08
CPC分类号： G01N30/34 , G01N30/6095 , G01N2030/201 , G01N2030/202 , G01N2030/285
摘要： The present invention relates to a microfluidic device for separating the components of a fluid sample. A cover plate is arranged over the first surface of a substrate, which, in combination with a microchannel formed in the first surface, defines a separation conduit for separating the components of the fluid sample. An inlet port in fluid communication with the separation conduit allows a mobile phase containing a gradient of a selected mobile-phase component to be introduced from an integrated gradient-generation means to the separation conduit. A method is also provided for separating the components of a fluid sample using a mobile phase containing a gradient of a selected mobile-phase component, wherein the gradient is generated within a small volume of mobile phase.

10. 发明申请

US20050098750A1 Electrostatic sealing device and method of use thereof 审中-公开
标题翻译：静电密封装置及其使用方法
公开(公告)号：US20050098750A1
公开(公告)日：2005-05-12
申请号：US10701502
申请日：2003-11-06
申请人： Daniel Sobek
发明人： Daniel Sobek
IPC分类号： B01L3/00 , B81B1/00 , B81C3/00 , F04B19/00 , F04B43/04 , F04B43/12 , F15C5/00 , F16K31/02
CPC分类号： F04B43/12 , B01L3/502707 , B01L3/50273 , B01L3/502738 , B01L2200/0689 , B01L2300/0887 , B01L2300/123 , B01L2400/0481 , B01L2400/0655 , B29C65/008 , B29C65/76 , B29C66/1122 , B29C66/12443 , B29C66/53461 , B29C66/54 , B29C66/5412 , B29C66/71 , B29L2031/756 , B81B2201/058 , B81C3/001 , F04B43/043 , F16K99/0001 , B29K2083/00 , B29K2081/06 , B29K2077/00 , B29K2075/00 , B29K2069/00 , B29K2033/12 , B29K2033/08 , B29K2027/18 , B29K2027/12 , B29K2027/06 , B29K2023/38 , B29K2023/12 , B29K2021/00
摘要： A microfluidic structure having an electrostatic sealing device is disclosed. The electrostatic sealing device includes a first electrode and a second electrode opposite the first electrode. At least one of the electrodes has an elastic layer facing the other electrode. The second electrode is capable of moving toward the first electrode and forming a seal with the first electrode in response to a voltage difference between the two electrodes. The electrostatic sealing device eliminates the need for mechanical components that are traditionally used for generating a mechanical force between two components of a microfluidic structure and thus reduces complexity of the microfluidic structure and possible interference with optical interrogation of the microfluidic structure. Moreover, the seal can be established or removed simply by turning the voltage on or off. The electrostatic sealing device can also be used as a valve, a pump, or a combination thereof, to control fluid flow in the microchannels of a microfluidic structure.
摘要翻译：公开了一种具有静电密封装置的微流体结构。静电密封装置包括与第一电极相对的第一电极和第二电极。至少一个电极具有面向另一个电极的弹性层。第二电极能够朝着第一电极移动并且响应于两个电极之间的电压差而与第一电极形成密封。静电密封装置消除了对传统上用于在微流体结构的两个部件之间产生机械力的机械部件的需要，并且因此降低了微流体结构的复杂性以及对微流体结构的光询问的可能干扰。此外，通过打开或关闭电压，可以简单地建立或移除密封。静电密封装置也可以用作阀，泵或其组合，以控制微流体结构的微通道中的流体流动。

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