专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明申请

US20070065465A1 Conjugate vaccines for the prevention of dental caries 审中-公开
标题翻译：用于预防龋齿的共轭疫苗
公开(公告)号：US20070065465A1
公开(公告)日：2007-03-22
申请号：US11516353
申请日：2006-09-05
申请人： Andrew Lees , Daniel Smith , Martin Taubman
发明人： Andrew Lees , Daniel Smith , Martin Taubman
IPC分类号： A61K39/09
CPC分类号： C12N9/1051 , A61K39/092 , A61K2039/55566 , A61K2039/6037 , A61K2039/6068 , A61K2039/627 , C07K14/315 , C07K14/33 , Y10S424/831 , Y10S514/835 , Y10S530/806
摘要： The present invention provides glucan-based compositions and methods for stimulating an immune response against mutans streptococci components and vaccines and methods for the treatment and prevention of dental caries. In a preferred embodiment, a glucan polymer, preferably WSG, is covalently bound to one or more T cell-dependent antigens to form a conjugate vaccine. The T cell-dependent antigen preferably contains epitopes of one or more mutans streptococcal proteins, such as a glucosyltransferase. Moreover, one or more moieties, including haptens, may be conjugated to the glucan or to the glucan-T cell-dependent composition. In a preferred embodiment, these moieties are peptides which contain immunogenic epitopes corresponding to components of a mutans streptococcus.
摘要翻译：本发明提供了基于葡聚糖的组合物和刺激针对变形链球菌组分的免疫应答的方法以及用于治疗和预防龋齿的疫苗和方法。在优选的实施方案中，葡聚糖聚合物（优选WSG）与一种或多种T细胞依赖性抗原共价结合以形成缀合疫苗。 T细胞依赖性抗原优选含有一种或多种变形链球菌蛋白质的表位，例如葡糖基转移酶。此外，包括半抗原的一个或多个部分可以与葡聚糖或葡聚糖-T细胞依赖性组合物缀合。在优选的实施方案中，这些部分是含有对应于变形链球菌的组分的免疫原性表位的肽。

2. 发明申请

US20050026271A1 Glucosyltransferase immunogens 失效
标题翻译：葡萄糖转移酶免疫原
公开(公告)号：US20050026271A1
公开(公告)日：2005-02-03
申请号：US10797302
申请日：2004-03-09
申请人： Daniel Smith , Martin Taubman
发明人： Daniel Smith , Martin Taubman
IPC分类号： A61K39/00 , C07K14/315 , C07K16/12 , C07K16/40 , C12N9/10 , C12N1/20
CPC分类号： C07K16/1278 , A61K39/00 , A61K39/092 , A61K2039/645 , C07K14/315 , C07K16/1275 , C07K16/40
摘要： Vaccine compositions and immunogenic compositions are described which are glucosyltransferase subunit vaccines for dental caries and which contain at least one peptide which corresponds to a sequence of glucosyltransferase containing aspartate 413, an equivalent of aspartate 413, aspartate 451, an equivalent of aspartate 451, aspartate 562, an equivalent of aspartate 562, aspartate 567, an equivalent of aspartate 567, histidine 561, an equivalent of histidine 561, tryptophan 491, an equivalent of tryptophan 491, glutamate 489, an equivalent of glutamate 489, arginine 449, an equivalent of arginine 449, or combinations thereof. These subunit vaccines elicit antibodies which protect an immunized mammal from dental caries. Methods of provoking an immune response to intact glucosyltransferase are also described.
摘要翻译：描述了疫苗组合物和免疫原性组合物，其是用于龋齿的葡糖基转移酶亚单位疫苗，并且其含有至少一种肽，其对应于含有天冬氨酸413的葡萄糖基转移酶序列，相当于天冬氨酸413，天冬氨酸451，相当于天冬氨酸451，天冬氨酸562 ，相当于天冬氨酸562，天冬氨酸567，相当于天冬氨酸567，组氨酸561，相当于组氨酸561，色氨酸491，当量色氨酸491，谷氨酸489，当量谷氨酸489，精氨酸449，相当于精氨酸 449，或其组合。这些亚单位疫苗引发了保护免疫哺乳动物免受龋齿的抗体。还描述了引发对完整葡糖基转移酶的免疫应答的方法。

3. 发明申请

US20050031633A1 Glucan binding protein and glucosyltransferase immunogens 有权
标题翻译：葡聚糖结合蛋白和葡糖基转移酶免疫原
公开(公告)号：US20050031633A1
公开(公告)日：2005-02-10
申请号：US10797821
申请日：2004-03-09
申请人： Daniel Smith , Martin Taubman
发明人： Daniel Smith , Martin Taubman
IPC分类号： A61K39/00 , C07K14/315 , C07K16/12 , C07K16/40 , C12N9/10
CPC分类号： C07K14/315 , A61K39/00 , A61K39/092 , A61K2039/645 , C07K16/1275 , C07K16/1278 , C07K16/40
摘要： Immunogenic compositions and subunit vaccines for dental caries are described which comprise peptide subunits of glucan binding protein-B and peptide subunits of glucan binding protein-B in combination with peptide subunits of glucosyltransferase. Methods of provoking an immune response to S. mutans glucan binding protein-B or glucosyltransferase. Methods of immunizing a mammal against dental caries are also described, along with antibodies which bind particular epitopes of glucan binding protein-B or glucosyltransferase.
摘要翻译：描述了用于龋齿的免疫原性组合物和亚单位疫苗，其包含葡聚糖结合蛋白B的肽亚基和葡聚糖结合蛋白B的肽亚基与葡糖基转移酶的肽亚基的组合。引发对变形链球菌葡聚糖结合蛋白B或葡糖基转移酶的免疫应答的方法。还描述了免疫哺乳动物抵抗龋齿的方法，以及结合葡聚糖结合蛋白B或葡糖基转移酶的特定表位的抗体。

4. 外观设计

USD849666S1 Truck rack for carrying multiple ATVS 有权
公开(公告)号：USD849666S1
公开(公告)日：2019-05-28
申请号：US29642136
申请日：2018-03-28
申请人： Daniel Smith
设计人： Daniel Smith
摘要： FIG. 1 is a perspective view of a truck rack for carrying multiple ATVS, showing my new design.
FIG. 2 is a right side view of the truck rack
FIG. 3 is a left side view of the truck rack of FIG. 2.
FIG. 4 is a bottom plan view thereof.
FIG. 5 is a top plan view thereof.
FIG. 6 is a rear elevational view thereof; and,
FIG. 7 is a front elevational view of thereof.
The broken lines in the Figures of the pick-up truck and ATVS form no part of the claimed design.

5. 发明申请

US20180195202A1 Epitaxial Quartz Homeotypes Crystal Growth On Beta Quartz For Pressure Sensors and Accelerometers 审中-公开
公开(公告)号：US20180195202A1
公开(公告)日：2018-07-12
申请号：US15530412
申请日：2017-01-10
申请人： Daniel Smith
发明人： Daniel Smith
IPC分类号： C30B19/12 , C30B19/08 , C30B7/10 , C30B19/02 , C30B25/18 , C30B29/18 , C30B29/14 , C30B29/22 , H01L41/113
CPC分类号： C30B19/12 , C30B7/10 , C30B19/02 , C30B19/08 , C30B23/02 , C30B25/18 , C30B29/14 , C30B29/18 , C30B29/22 , H01L41/187 , H01L41/1875 , H01L41/316 , H01L41/317
摘要： The purpose of quartz homeotypes grown epitaxially on beta quartz for use in pressure sensors or accelerometers is to be able to drastically cut down production costs on otherwise expensive or time-consuming to grow crystals that are necessary in various industrial applications. This is done via epitaxial growth of quartz homeotypes across the whole surface of a sample of beta quartz, an easily accessible and high temperature capable crystal. This invention also applies to the epitaxial application of piezoelectric material atop a piezoelectric crystal for the purpose of altering its piezoelectric coefficient and the epitaxial application of a piezoelectric crystal atop a host crystal for the purpose of increasing its insulation resistance.

6. 发明申请

US20170306525A1 Diffusion assisted crystal hydrothermal and flux growth 审中-公开
公开(公告)号：US20170306525A1
公开(公告)日：2017-10-26
申请号：US14999312
申请日：2016-04-22
申请人： Daniel Smith
发明人： Daniel Smith
IPC分类号： C30B30/06 , C30B29/18 , C30B7/10 , C30B9/00 , C30B29/22 , C30B29/20
CPC分类号： C30B29/18 , C30B7/10 , C30B9/10 , C30B29/22
摘要： The purpose of diffusion assisted crystal hydrothermal growth is to facilitate a greatly increased crystal growth rate that would save time that is precious in such a material and manpower costly process. The assisted crystal growth itself requires the utilization of a piezoelectric shaker connected to the autoclave in which most industrial hydrothermal crystals are grown. The waveform can be modulated to induce transport of nutrient in a singular direction, customized to the topology of the apparatus. As it stands currently, the growth of most crystals that require autoclaves for their production can take anywhere from 3 months to up to 2 years, and accordingly carries many costs, particularly electricity and supervision of the autoclave(s), and other issues that may arise during the growth. While the product of this labor results in high-quality crystals, in reality, these are not at all what is needed outside of the laboratory environment. Using the assisted crystal hydrothermal growth process, average crystal growth can be cut in half, with the resulting crystals consequently being of a slightly lower quality, though still sufficient for most engineering purposes. Another advantage of using a piezoelectric shaker is that an additional sensor can be added to the autoclave to monitor the health of the autoclave using trending data obtained during the growth.

7. 发明授权

US09675837B2 Therapeutic stick and method of use 有权
公开(公告)号：US09675837B2
公开(公告)日：2017-06-13
申请号：US15335509
申请日：2016-10-27
申请人： Daniel Smith
发明人： Daniel Smith
IPC分类号： A63B21/02 , A63B21/00 , A63B23/02 , A63B23/025 , A63B23/04 , A63B23/16 , A63B69/00 , A63B69/36 , A63B23/00
CPC分类号： A63B21/4035 , A61H1/02 , A61H2201/0161 , A61H2201/1253 , A61H2201/1261 , A61H2201/1635 , A61H2201/164 , A61H2201/5048 , A63B15/00 , A63B21/02 , A63B21/026 , A63B21/1618 , A63B21/169 , A63B21/4039 , A63B23/0205 , A63B23/0233 , A63B23/025 , A63B23/03525 , A63B23/04 , A63B23/12 , A63B23/16 , A63B69/0002 , A63B69/002 , A63B69/36 , A63B2023/006 , A63B2069/0006 , A63B2071/0625 , A63B2071/0694 , A63B2209/02 , A63B2209/10 , A63B2210/50 , A63B2225/05 , A63B2225/685
摘要： An apparatus for improving flexibility and its method of use are provided. The apparatus features a flexible member, which can have varying degrees of stiffness and flexibility, based on user preference. Further, the apparatus features a first and second auxiliary grip, as well as a first and second primary grip. In conjunction, these grips provide a vast multitude of ways to grip the apparatus, enabling it to be used in a wide variety of stretches and exercises, promoting strength as well as joint mobility and flexibility.

8. 发明申请

US20150363525A1 SYSTEM AND METHOD FOR CREATING REUSABLE GEOMETRY SEQUENCES FOR MULTIPHYSICS MODELING 有权
标题翻译：用于创建用于多元建模的可重复几何序列的系统和方法
公开(公告)号：US20150363525A1
公开(公告)日：2015-12-17
申请号：US14652747
申请日：2013-12-20
申请人： Daniel BERTILSSON , Erik DANIELSSON , Lars LANGEMYR , Victor LITTMARCK , Svante LITTMARCK , Nils MALM , Daniel SMITH , Tomas NORMARK , COMSOL AB
发明人： Daniel Bertilsson , Erik Danielsson , Eduardo Fontes , Lars Langemyr , Victor Littmarck , Svante Littmarck , Nils Malm , Björn Sjödin , Daniel Smith , Tomas Normark
IPC分类号： G06F17/50
CPC分类号： G06F17/5018 , G06F8/00 , G06F8/20
摘要： A system generates a customized application data structure for modeling physical systems. The system includes a processor, an input device, optionally a display device, and a memory device. The processor is adapted to embed a multiphysics model data structure in the application data structure. The multiphysics model data structure comprises a representation of models of physical systems. Geometry data representing geometry subroutines and call data representing geometry subroutine calls are added to the embedded multiphysics model data structure. Data representing application features are added to the application data structure. Each application feature comprises one or more of (i) first data representing a form feature, or (ii) second data representing an action feature. A customized application data structure is generated providing a customized modeling of the physical systems using a modeling operation, a geometry of the one or more models of physical systems, an application feature, and a geometry subroutine.
摘要翻译：系统生成用于建模物理系统的定制应用程序数据结构。该系统包括处理器，输入设备，可选地显示设备和存储设备。处理器适于在应用数据结构中嵌入多物理场模型数据结构。多物理场模型数据结构包括物理系统模型的表示。代表几何子例程的几何数据和表示几何子程序调用的调用数据被添加到嵌入式多物理场模型数据结构中。表示应用程序功能的数据被添加到应用程序数据结构中。每个应用特征包括（i）表示表单特征的第一数据或（ii）表示动作特征的第二数据中的一个或多个。生成定制的应用数据结构，其使用建模操作，物理系统的一个或多个模型的几何，应用特征和几何子例程来提供物理系统的定制建模。

9. 发明授权

US08221129B2 Wearable wound simulant 有权
标题翻译：穿戴伤口模拟器
公开(公告)号：US08221129B2
公开(公告)日：2012-07-17
申请号：US12131980
申请日：2008-06-03
申请人： David Parry , Daniel Parry , Daniel Pipito , Brian Letizia , Morris Ravich , Daniel Smith
发明人： David Parry , Daniel Parry , Daniel Pipito , Brian Letizia , Morris Ravich , Daniel Smith
IPC分类号： G09B23/28
CPC分类号： G09B23/30 , G09B9/003
摘要： A wearable wound simulant including a skin replica having the appearance of a particular region of the human body, examples including but not limited to a leg, arm, torso, or stomach, and a wound disposed along the skin replica is described. The skin replica includes a plurality of bendable layers arranged to replicate the visual and tactile properties of human tissues and at least one tear resistant layer comprised of a fabric material disposed between two bendable layers. The tear resistant layers are less stretchable than the bendable layers so as to prevent the bendable layers from stretching beyond their failure threshold. Design elements of the present invention facilitate the visual, tactile, and functional aspects of a battlefield wound so as to allow for the diagnosis of injuries associated therewith. Furthermore, the present invention allows for the insertion of a needle or the like, the probing and/or packing of wounds, the compression of vascular simulants to stop or limit blood loss, and the replacement of dislodged organs.
摘要翻译：描述了包括具有人体特定区域的外观的皮肤复制品的可穿戴伤口模拟物，包括但不限于腿，臂，躯干或胃的实例以及沿着皮肤复制品布置的伤口。皮肤复制品包括多个可弯曲的层，其布置成复制人体组织的视觉和触觉特性以及由布置在两个可弯曲层之间的织物材料构成的至少一个抗撕裂层。抗撕裂层比可弯曲层具有更小的拉伸性，从而防止可弯曲层伸展超过它们的破坏阈值。本发明的设计元件有助于战场伤口的视觉，触觉和功能方面，从而允许诊断与之相关的伤害。此外，本发明允许插入针或类似物，伤口的探测和/或包装，血管模拟物的压缩以停止或限制失血，以及更换移位的器官。

10. 外观设计

USD613140S1 Bottle opener 有权
公开(公告)号：USD613140S1
公开(公告)日：2010-04-06
申请号：US29337951
申请日：2009-06-02
申请人： Daniel Smith
设计人： Daniel Smith

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式