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1. 发明授权

US08158681B2 Nutraceutical and pharmaceutical compositions and use thereof for the treatment, co-treatment or prevention of inflammatory disorders 失效
标题翻译：营养品和药物组合物及其用于治疗，共同治疗或预防炎症性疾病的用途
公开(公告)号：US08158681B2
公开(公告)日：2012-04-17
申请号：US12279510
申请日：2007-02-13
申请人： Daniel Raederstorff , Joseph Schwager , Goede Schueler
发明人： Daniel Raederstorff , Joseph Schwager , Goede Schueler
IPC分类号： A61K31/20 , A61K31/085 , A61K31/192 , A61P19/02 , C07C43/23 , C07C65/28
CPC分类号： C07C43/23 , C07C65/28 , C07D311/58
摘要： The present invention relates to new methoxylated aromatic compounds. It also relates to novel compositions comprising methoxylated aromatic compounds as well as to the use of these compositions as a medicament, in particular as a medicament for the treatment, co-treatment or prevention of inflammatory disorders.
摘要翻译：本发明涉及新的甲氧基化芳族化合物。它还涉及包含甲氧基化芳族化合物的新型组合物以及这些组合物作为药物，特别是作为治疗，共同治疗或预防炎症性疾病的药物的用途。

2. 发明申请

US20100093843A1 NOVEL NUTRACEUTICAL AND PHARMACEUTICAL COMPOSITIONS AND USE THEREOF FOR THE TREATMENT, CO-TREATMENT OR PREVENTION OF CARTILAGE DEGRADATION OR CARTILAGE DAMAGE IN JOINTS 审中-公开
标题翻译：新型营养和药物组合物及其用于治疗，共同治疗或预防接合物降解或损伤的接头的药物组合物及其用途
公开(公告)号：US20100093843A1
公开(公告)日：2010-04-15
申请号：US12438405
申请日：2007-09-12
申请人： Joseph Schwager , Daniel Raederstorff , Goede Schueler
发明人： Joseph Schwager , Daniel Raederstorff , Goede Schueler
IPC分类号： A61K31/352 , C07D311/86 , A61P19/00
CPC分类号： A61K31/352
摘要： The invention relates to novel nutraceutical and pharmaceutical compositions comprising at least a compound of the general formula (I), wherein R1 and R2 are independently from each other C1-8-alk(en)yl and R3 and R4 are independently from each other hydroxy or C1-8-alkyloxy, as well as to the use of these compositions for the treatment, co-treatment or prevention of joint disorders.
摘要翻译：本发明涉及至少包含通式（I）化合物的新型营养药物和药物组合物，其中R1和R2彼此独立地为C1-8-烷（烯）基，R3和R4彼此独立为羟基或C 1-8烷氧基，以及这些组合物用于治疗，共同治疗或预防关节疾病的用途。

3. 发明申请

US20080319071A1 Novel Nutraceutical and Pharmaceutical Compositions and Use Thereof for the Treatment, Co-Treatment or Prevention of Inflammatory Disorders 失效
标题翻译：新型营养和药物组合物及其用途，用于治疗，共同治疗或预防炎性疾病
公开(公告)号：US20080319071A1
公开(公告)日：2008-12-25
申请号：US12279510
申请日：2007-02-13
申请人： Daniel Raederstorff , Joseph Schwager , Goede Schueler
发明人： Daniel Raederstorff , Joseph Schwager , Goede Schueler
IPC分类号： A61K31/20 , C07C65/28 , A61K31/085 , A61P19/02 , C07C43/23 , A61K31/192
CPC分类号： C07C43/23 , C07C65/28 , C07D311/58
摘要： The present invention relates to new methoxylated aromatic compounds. It also relates to novel compositions comprising methoxylated aromatic compounds as well as to the use of these compositions as a medicament, in particular as a medicament for the treatment, co-treatment or prevention of inflammatory disorders.
摘要翻译：本发明涉及新的甲氧基化芳族化合物。它还涉及包含甲氧基化芳族化合物的新型组合物以及这些组合物作为药物，特别是作为治疗，共同治疗或预防炎症性疾病的药物的用途。

4. 发明授权

US08680147B2 Compositions 失效
标题翻译：组合
公开(公告)号：US08680147B2
公开(公告)日：2014-03-25
申请号：US12515332
申请日：2007-11-21
申请人： Daniel Raederstorff , Goede Schueler , Joseph Schwager , Christof Wehrli
发明人： Daniel Raederstorff , Goede Schueler , Joseph Schwager , Christof Wehrli
IPC分类号： A61K31/192 , C07C63/33 , A61P19/02
CPC分类号： A61K31/192 , A23K20/105 , A23K50/40 , A23L33/105 , A23V2002/00 , A61K8/347 , A61K8/35 , A61K8/365 , A61K8/37 , A61K8/4973 , A61Q17/04 , A61Q19/005 , A61Q19/08 , A23V2200/324 , A23V2250/21
摘要： The present invention relates to novel composition for the treatment, co-treatment or prevention of inflammatory disorders comprising an effective amount of carnosic acid 12-methylether.
摘要翻译：本发明涉及用于治疗，共同治疗或预防炎性疾病的新型组合物，其包含有效量的鼠尾草酸12-甲基醚。

5. 发明申请

US20100056634A1 NOVEL COMPOSITIONS 失效
标题翻译：新组合
公开(公告)号：US20100056634A1
公开(公告)日：2010-03-04
申请号：US12515332
申请日：2007-11-21
申请人： Daniel Raederstorff , Goede Schueler , Joseph Schwager , Chirstof Wehrli
发明人： Daniel Raederstorff , Goede Schueler , Joseph Schwager , Chirstof Wehrli
IPC分类号： A61K31/192 , C07C63/33 , A61P19/02
CPC分类号： A61K31/192 , A23K20/105 , A23K50/40 , A23L33/105 , A23V2002/00 , A61K8/347 , A61K8/35 , A61K8/365 , A61K8/37 , A61K8/4973 , A61Q17/04 , A61Q19/005 , A61Q19/08 , A23V2200/324 , A23V2250/21
摘要： The present invention relates to novel composition for the treatment, co-treatment or prevention of inflammatory disorders comprising an effective amount of carnosic acid 12-methylether.
摘要翻译：本发明涉及用于治疗，共同治疗或预防炎性疾病的新型组合物，其包含有效量的鼠尾草酸12-甲基醚。

6. 发明申请

US20100056615A1 USE OF TRICYCLIC DITERPENES AND THEIR DERIVATIVES FOR THE TREATMENT, CO-TREATMENT OR PREVENTION OF INFLAMMATORY DISORDERS AND/OR JOINT DISORDERS 审中-公开
标题翻译：治疗，治疗或预防感染性疾病和/或联合疾病的三环磷酸酯及其衍生物的使用
公开(公告)号：US20100056615A1
公开(公告)日：2010-03-04
申请号：US12515329
申请日：2007-11-21
申请人： Daniel Raederstorff , Goede Schueler , Joseph Schwager , Christof Wehrli
发明人： Daniel Raederstorff , Goede Schueler , Joseph Schwager , Christof Wehrli
IPC分类号： A61K31/335 , C07C59/00 , C07C35/42 , C07C69/76 , C07C49/403 , A61K31/192 , A61K31/045 , A61K31/215 , A61K31/122 , A61P29/00 , A61P17/00 , A61P19/02
CPC分类号： A61K31/192 , A23K20/105 , A23K50/40 , A23L33/105 , A23V2002/00 , A61K8/347 , A61K8/35 , A61K8/365 , A61K8/37 , A61K8/4973 , A61Q17/04 , A61Q19/005 , A61Q19/08 , A23V2200/324 , A23V2250/21
摘要： The present invention refers to the use of at least one tricyclic diterpenes for the manufacture of a nutraceutical or pharmaceutical for the treatment, co-treatment or prevention of inflammatory disorders and/or joint disorders.
摘要翻译：本发明涉及至少一种三环二萜用于制备用于治疗，共同治疗或预防炎症性疾病和/或关节病症的营养药物或药物的用途。

7. 发明申请

US20090186942A1 NOVEL NUTRACEUTICAL AND PHARMACEUTICAL COMPOSITIONS AND USE THEREOF FOR THE TREATMENT, CO-TREATMENT OR PREVENTION OF INFLAMMATORY DISORDERS 审中-公开
标题翻译：新型营养和药物组合物及其用于治疗，并发治疗或预防炎症性疾病的组合物
公开(公告)号：US20090186942A1
公开(公告)日：2009-07-23
申请号：US12279516
申请日：2007-02-13
申请人： Daniel Raederstorff , Joseph Schwager , Goede Schueler
发明人： Daniel Raederstorff , Joseph Schwager , Goede Schueler
IPC分类号： A61K31/192 , C07C65/03 , A61P29/00
CPC分类号： A61K31/05 , A61K31/60
摘要： The invention relates to novel compositions comprising a phenolic compound as well as to the use of these compositions as a medicament, in particular for the manufacture of a nutraceutical or pharmaceutical composition for the treatment, co-treatment or prevention of inflammatory disorders, such as arthritis, asthma, inflammatory bowel diseases, inflammatory diseases of the skin (e.g., psoriasis, eczema, atopic dermatitis, sunburn) and chronic inflammatory disorders, such as atherosclerosis, heart diseases, metabolic syndrome X, cancer, Alzheimer's disease and pre-stages thereof such as mild cognitive impairment. Also, the invention relates to the use of a cosmetic composition comprising a phenolic compound for the cosmetic treatment, co-treatment or prevention of inflammation of the skin, in particular for the cosmetic treatment, co-treatment or prevention of sunburn or of impure skin.
摘要翻译：本发明涉及包含酚类化合物的新型组合物以及这些组合物作为药物的用途，特别是用于制备用于治疗，共同治疗或预防炎症性疾病如关节炎的营养药物或药物组合物，哮喘，炎症性肠病，皮肤炎性疾病（例如牛皮癣，湿疹，特应性皮炎，晒伤）和慢性炎症性疾病如动脉粥样硬化，心脏病，代谢综合征X，癌症，阿尔茨海默氏病及其前期阶段作为轻度认知障碍。此外，本发明涉及包含酚类化合物的化妆品组合物在美容治疗，共同治疗或预防皮肤炎症中的用途，特别是用于美容治疗，共同治疗或预防晒伤或不纯的皮肤。

8. 发明申请

US20090192218A1 USE OF PHTHALIDE DERIVATIVES FOR THE TREATMENT AND PREVENTION OF DIABETES MELLITUS 有权
标题翻译：用于治疗和预防糖尿病的PHTHALIDE衍生物的使用
公开(公告)号：US20090192218A1
公开(公告)日：2009-07-30
申请号：US12412577
申请日：2009-03-27
申请人： Daniel D'Orazio , Antoine De Saizieu , Goede Schueler , Daniel Raederstorff , Sandra Renata Teixeira , Ying Wang Schmidt , Peter Weber , Swen Wolfram
发明人： Daniel D'Orazio , Antoine De Saizieu , Goede Schueler , Daniel Raederstorff , Sandra Renata Teixeira , Ying Wang Schmidt , Peter Weber , Swen Wolfram
IPC分类号： A61K31/365 , A61P3/10 , C07D307/77
CPC分类号： A61K31/343
摘要： The present invention relates to the use of a compound as effective agent for the prevention or treatment of diabetes mellitus in a mammal. Said compounds being selected from the group of phthalide derivatives and exhibit excellent blood glucose lowering effects and thus are effective agents in the prevention or treatment of diabetes mellitus in mammals.
摘要翻译：本发明涉及化合物作为哺乳动物预防或治疗糖尿病的有效药物的用途。所述化合物选自苯酞衍生物，表现出优异的降血糖作用，因此是预防或治疗哺乳动物糖尿病的有效药剂。

9. 发明授权

US08227508B2 Dietary and pharmaceutical compositions containing carnosol and/or rosmanol and their uses 有权
标题翻译：含有鼠尾草酚和/或罗斯曼醇的饮食和药物组合物及其用途
公开(公告)号：US08227508B2
公开(公告)日：2012-07-24
申请号：US12514881
申请日：2007-11-22
申请人： Ann Fowler , Regina Goralczyk , Claus Kilpert , Hasan Mohajeri , Daniel Raederstorff , Antoine De Saizieu , Goede Schueler , Ying Wang-Schmidt , Christof Wehrli
发明人： Ann Fowler , Regina Goralczyk , Claus Kilpert , Hasan Mohajeri , Daniel Raederstorff , Antoine De Saizieu , Goede Schueler , Ying Wang-Schmidt , Christof Wehrli
IPC分类号： A61K31/352 , C07D311/78
CPC分类号： A61K31/365 , A23K20/10 , A23K20/111 , A23L33/105 , A61K2300/00
摘要： The present invention refers to carnosol and rosmanol for use (as medicament) in the treatment of a disorder connected to reduced neurotransmission, cognitive dysfunction and/or symptoms caused by headache and/or migraine, as well as to dietary and pharmaceutical compositions and their uses.
摘要翻译：本发明涉及用于治疗与减少的神经传递，认知功能障碍和/或由头痛和/或偏头痛引起的症状相关的病症的鼠属溶胶和rosmanol，以及饮食和药物组合物及其用途。

10. 发明申请

US20090221693A1 NOVEL USE OF ORGANIC COMPOUNDS 审中-公开
标题翻译：有机化合物的新用途
公开(公告)号：US20090221693A1
公开(公告)日：2009-09-03
申请号：US12299644
申请日：2007-05-02
申请人： Daniel D'Orazio , Daniel Raederstorff , Goede Schueler , Ying Wang-Schmidt , Swen Wolfram
发明人： Daniel D'Orazio , Daniel Raederstorff , Goede Schueler , Ying Wang-Schmidt , Swen Wolfram
IPC分类号： A61K31/352 , C07D311/82 , A61P21/00
CPC分类号： A61K31/352
摘要： The present invention refers to compounds of the general formulae I as defined above, preferably α-mangostin, for use as/in a composition (especially foods and dietary supplements, cosmetic, as well as pharmaceutical compositions) for the prevention and improvement of muscular disorders and for the improvement of muscle function and endurance. Other fields of use are eating disorders such as bulimia and anorexia nervosa, use for accelerating wound healing, and/or use for the treatment/prevention of bone disorders such as osteoporosis and osteopenia. The present invention is also directed to dietary compositions such as (fortified) food, beverages, (fortified) feed, food additives, beverage additives, feed additives, clinical nutrition, dietary supplements, functional food, functional feed and nutraceuticals and to pharmaceutical compositions containing such compounds, to methods of preventing and/or treating the above mentioned disorders/diseases, as well as to methods of maintaining the healthy state and/or improving the baseline conditions in mammals including humans and to the compounds of the formula I themselves. Another object of the present invention is the use of such compounds for the manufacture of a composition for the prevention and/or treatment of such disorders/diseases as mentioned above.
摘要翻译：本发明涉及用于预防和改善肌肉疾病的组合物（特别是食品和膳食补充剂，化妆品以及药物组合物）中用作/组合物的上述通式I的化合物，优选α-谷歌蛋白并改善肌肉功能和耐力。其他使用领域是进食障碍，例如贪食症和神经性厌食症，用于加速伤口愈合，和/或用于治疗/预防骨病，如骨质疏松症和骨质减少症。本发明还涉及饮食组合物，例如（强化）食品，饮料，（强化）饲料，食品添加剂，饮料添加剂，饲料添加剂，临床营养，膳食补充剂，功能性食品，功能性饲料和营养食品，以及含有这些化合物，预防和/或治疗上述疾病/疾病的方法，以及维持健康状态和/或改善哺乳动物包括人类和式I本身化合物的基线条件的方法。本发明的另一个目的是这些化合物在制备用于预防和/或治疗上述疾病/疾病的组合物中的用途。

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