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1. 发明申请

US20090192218A1 USE OF PHTHALIDE DERIVATIVES FOR THE TREATMENT AND PREVENTION OF DIABETES MELLITUS 有权
标题翻译：用于治疗和预防糖尿病的PHTHALIDE衍生物的使用
公开(公告)号：US20090192218A1
公开(公告)日：2009-07-30
申请号：US12412577
申请日：2009-03-27
申请人： Daniel D'Orazio , Antoine De Saizieu , Goede Schueler , Daniel Raederstorff , Sandra Renata Teixeira , Ying Wang Schmidt , Peter Weber , Swen Wolfram
发明人： Daniel D'Orazio , Antoine De Saizieu , Goede Schueler , Daniel Raederstorff , Sandra Renata Teixeira , Ying Wang Schmidt , Peter Weber , Swen Wolfram
IPC分类号： A61K31/365 , A61P3/10 , C07D307/77
CPC分类号： A61K31/343
摘要： The present invention relates to the use of a compound as effective agent for the prevention or treatment of diabetes mellitus in a mammal. Said compounds being selected from the group of phthalide derivatives and exhibit excellent blood glucose lowering effects and thus are effective agents in the prevention or treatment of diabetes mellitus in mammals.
摘要翻译：本发明涉及化合物作为哺乳动物预防或治疗糖尿病的有效药物的用途。所述化合物选自苯酞衍生物，表现出优异的降血糖作用，因此是预防或治疗哺乳动物糖尿病的有效药剂。

2. 发明申请

US20090221693A1 NOVEL USE OF ORGANIC COMPOUNDS 审中-公开
标题翻译：有机化合物的新用途
公开(公告)号：US20090221693A1
公开(公告)日：2009-09-03
申请号：US12299644
申请日：2007-05-02
申请人： Daniel D'Orazio , Daniel Raederstorff , Goede Schueler , Ying Wang-Schmidt , Swen Wolfram
发明人： Daniel D'Orazio , Daniel Raederstorff , Goede Schueler , Ying Wang-Schmidt , Swen Wolfram
IPC分类号： A61K31/352 , C07D311/82 , A61P21/00
CPC分类号： A61K31/352
摘要： The present invention refers to compounds of the general formulae I as defined above, preferably α-mangostin, for use as/in a composition (especially foods and dietary supplements, cosmetic, as well as pharmaceutical compositions) for the prevention and improvement of muscular disorders and for the improvement of muscle function and endurance. Other fields of use are eating disorders such as bulimia and anorexia nervosa, use for accelerating wound healing, and/or use for the treatment/prevention of bone disorders such as osteoporosis and osteopenia. The present invention is also directed to dietary compositions such as (fortified) food, beverages, (fortified) feed, food additives, beverage additives, feed additives, clinical nutrition, dietary supplements, functional food, functional feed and nutraceuticals and to pharmaceutical compositions containing such compounds, to methods of preventing and/or treating the above mentioned disorders/diseases, as well as to methods of maintaining the healthy state and/or improving the baseline conditions in mammals including humans and to the compounds of the formula I themselves. Another object of the present invention is the use of such compounds for the manufacture of a composition for the prevention and/or treatment of such disorders/diseases as mentioned above.
摘要翻译：本发明涉及用于预防和改善肌肉疾病的组合物（特别是食品和膳食补充剂，化妆品以及药物组合物）中用作/组合物的上述通式I的化合物，优选α-谷歌蛋白并改善肌肉功能和耐力。其他使用领域是进食障碍，例如贪食症和神经性厌食症，用于加速伤口愈合，和/或用于治疗/预防骨病，如骨质疏松症和骨质减少症。本发明还涉及饮食组合物，例如（强化）食品，饮料，（强化）饲料，食品添加剂，饮料添加剂，饲料添加剂，临床营养，膳食补充剂，功能性食品，功能性饲料和营养食品，以及含有这些化合物，预防和/或治疗上述疾病/疾病的方法，以及维持健康状态和/或改善哺乳动物包括人类和式I本身化合物的基线条件的方法。本发明的另一个目的是这些化合物在制备用于预防和/或治疗上述疾病/疾病的组合物中的用途。

3. 发明申请

US20070082947A1 Use of phthalide derivatives for the treatment and prevention of diabetes mellitus 审中-公开
标题翻译：使用苯酞衍生物治疗和预防糖尿病
公开(公告)号：US20070082947A1
公开(公告)日：2007-04-12
申请号：US10556199
申请日：2004-05-05
申请人： Daniel D'Orazio , Antoine De Saizieu , Goede Schueler , Daniel Raederstorff , Sandra Teixeira , Ying Wang Schmidt , Peter Weber , Swen Wolfram
发明人： Daniel D'Orazio , Antoine De Saizieu , Goede Schueler , Daniel Raederstorff , Sandra Teixeira , Ying Wang Schmidt , Peter Weber , Swen Wolfram
IPC分类号： A61K31/365
CPC分类号： A61K31/343
摘要： The present invention relates to the use of a compound as effective agent for the prevention or treatment of diabetes mellitus in a mammal. Said compounds being selected from the group of phthalide derivatives and exhibit excellent blood glucose lowering effects and thus are effective agents in the prevention or treatment of diabetes mellitus in mammals.
摘要翻译：本发明涉及化合物作为哺乳动物预防或治疗糖尿病的有效药物的用途。所述化合物选自苯酞衍生物，表现出优异的降血糖作用，因此是预防或治疗哺乳动物糖尿病的有效药剂。

4. 发明授权

US08242168B2 Use of phthalide derivatives for the treatment of type 2 diabetes mellitus 有权
标题翻译：使用苯酞衍生物治疗2型糖尿病
公开(公告)号：US08242168B2
公开(公告)日：2012-08-14
申请号：US12412577
申请日：2009-03-27
申请人： Daniel D'Orazio , Antoine De Saizieu , Goede Schueler , Daniel Raederstorff , Sandra Renata Teixeira , Ying Wang Schmidt , Peter Weber , Swen Wolfram
发明人： Daniel D'Orazio , Antoine De Saizieu , Goede Schueler , Daniel Raederstorff , Sandra Renata Teixeira , Ying Wang Schmidt , Peter Weber , Swen Wolfram
IPC分类号： A61K31/34
CPC分类号： A61K31/343
摘要： The present invention relates to the use of a compound as effective agent for the prevention or treatment of diabetes mellitus in a mammal. Said compounds being selected from the group of phthalide derivatives and exhibit excellent blood glucose lowering effects and thus are effective agents in the prevention or treatment of diabetes mellitus in mammals.
摘要翻译：本发明涉及化合物作为哺乳动物预防或治疗糖尿病的有效药物的用途。所述化合物选自苯酞衍生物，表现出优异的降血糖作用，因此是预防或治疗哺乳动物糖尿病的有效药剂。

5. 发明申请

US20100041746A1 NOVEL USE OF ORGANIC COMPOUNDS 审中-公开
标题翻译：有机化合物的新用途
公开(公告)号：US20100041746A1
公开(公告)日：2010-02-18
申请号：US12301505
申请日：2007-05-24
申请人： Daniel D'Orazio , Daniel Raederstorff , Goede Schueler , Ying Wang-Schmidt , Karin Wertz , Swen Wolfram
发明人： Daniel D'Orazio , Daniel Raederstorff , Goede Schueler , Ying Wang-Schmidt , Karin Wertz , Swen Wolfram
IPC分类号： A61K31/352 , A61K31/12 , A61K31/36 , C07C49/255 , C07D317/46 , C07D311/02 , A61P21/00
CPC分类号： A23K20/111 , A23L2/52 , A23L33/10 , A23V2002/00 , A61K31/12 , A61K31/166 , A61K31/352 , A23V2200/316 , A23V2200/328 , A23V2200/326 , A23V2200/318 , A23V2200/32
摘要： The present invention refers to compounds of the general formulae Ia to Ie as defined above for use as/in a composition (especially foods and dietary supplements, cosmetic, as well as pharmaceutical compositions) for the prevention and improvement of muscular disorders and for the improvement of muscle function. Other fields of use are disorders connected to impaired lipid metabolism, impaired glucose metabolism and impaired insulin action, obesity, overweight conditions, eating disorders such as bulimia and anorexia nervosa, cardiovascular diseases, atherosclerosis, vascular diseases, heart failure, inflammatory disorders such as arthritis, rheumatoid arthritis, osteoarthritis, gout, gastrointestinal disorders such as inflammatory bowel syndrome, Crohn's disease, gastritis, irritable bowel syndrome and ulcerative colitis, skin related conditions such as psoriasis, eczema, burns, dermatitis, and allergy, respiratory disorders such as asthma, chronic obstructive pulmonary disease (COPD), allergic diseases, and/or bone disorders such as osteoporosis and osteopenia. The compounds may also be used for bodyshaping, for improving the muscle:fat ratio or for accelerating skin wound healing. The present invention is also directed to dietary compositions such as (fortified) food, beverages, (fortified) feed, food additives, beverage additives, feed additives, clinical nutrition, dietary supplements, functional food, functional feed and nutraceuticals and to pharmaceutical compositions containing such compounds, to methods of treating the above mentioned disorders/diseases in mammals including humans and to the compounds of the formula I themselves. Another object of the present invention is the use of such compounds for the manufacture of a composition for the treatment of such disorders/diseases as mentioned above.
摘要翻译：本发明涉及如上定义的用于预防和改善肌肉疾病和改善的组合物（特别是食品和膳食补充剂，化妆品以及药物组合物）中的上述通式Ia至Ie的化合物的肌肉功能。其他使用领域是与脂质代谢受损，葡萄糖代谢受损和胰岛素作用受损，肥胖症，超重症状，进食障碍如贪食症和神经性厌食症，心血管疾病，动脉粥样硬化，血管疾病，心力衰竭，炎症性疾病如关节炎相关的疾病类风湿性关节炎，骨关节炎，痛风，胃肠道疾病如炎性肠综合征，克罗恩病，胃炎，肠易激综合征和溃疡性结肠炎，皮肤相关病症如牛皮癣，湿疹，烧伤，皮炎和过敏，呼吸系统疾病如哮喘，慢性阻塞性肺疾病（COPD），过敏性疾病和/或骨骼疾病如骨质疏松症和骨质减少。这些化合物也可用于体脂整形，用于改善肌肉：脂肪比例或用于加速皮肤伤口愈合。本发明还涉及饮食组合物，例如（强化）食品，饮料，（强化）饲料，食品添加剂，饮料添加剂，饲料添加剂，临床营养，膳食补充剂，功能性食品，功能性饲料和营养食品，以及含有这些化合物，涉及治疗哺乳动物（包括人）和式I本身化合物的上述疾病/疾病的方法。本发明的另一个目的是使用这些化合物来制备用于治疗如上所述的这种疾病/疾病的组合物。

6. 发明申请

US20090203773A1 Compounds for the Treatment of Non-Autoimmune Type 2 Diabetes Mellitus and/or Syndrome X 审中-公开
标题翻译：用于治疗非自身免疫性2型糖尿病和/或综合征X的化合物
公开(公告)号：US20090203773A1
公开(公告)日：2009-08-13
申请号：US11922604
申请日：2006-06-23
申请人： Daniel D'Orazio , Antoine De Saizieu , Goede Schuler , Ying Wang-Schmidt , Christof Wehrli , Swen Wolfram , Karin Wertz , Daniel Raederstorff
发明人： Daniel D'Orazio , Antoine De Saizieu , Goede Schuler , Ying Wang-Schmidt , Christof Wehrli , Swen Wolfram , Karin Wertz , Daniel Raederstorff
IPC分类号： A61K31/357 , C07D317/44 , C07C69/76 , A61K31/235 , A61P3/10
CPC分类号： C07H15/04 , C07C49/796 , C07C49/835 , C07C49/84 , C07C69/618 , C07C69/78 , C07C233/33 , C07D317/64
摘要： The present invention relates to compounds of the formula (I); wherein R1 is H, CH3 or OCH3; R3=H, OH, CH3, OCH3, O-glucose or benzoyloxy; R4=H; R5=H or OH; R6=H or OCH3; R7=H, CH3, OCH3, cinnamoyloxy or (3,4,5-trimethoxy)-benzoyloxy; R8=H, OH, CH3 or OCH3; or R7 and R8 form together a group 0-CH2—O; R9=H or OCH3; R10=H or N-acetyl, N-methyl-2-aminoethyl; to their use as medicament for the treatment of non-autoimmune type 2 diabetes mellitus and/or syndrome X, to dietary and pharmaceutical compositions containing them and to a method for the treatment of non-autoimmune type 2 diabetes mellitus and/or syndrome X in animals including humans, said method comprising the step of administering an effective dose of a compound of the formula (I) to animals including humans which are in need thereof.
摘要翻译：本发明涉及式（I）的化合物; 其中R1是H，CH3或OCH3; R3 = H，OH，CH3，OCH3，O-葡萄糖或苯甲酰氧基; R4 = H; R5 = H或OH; R6 = H或OCH3; R7 = H，CH3，OCH3，肉桂酰氧基或（3,4,5-三甲氧基） - 苯甲酰氧基; R8 = H，OH，CH3或OCH3; 或者R 7和R 8一起形成O-CH 2 -O基团; R9 = H或OCH3; R 10 = H或N-乙酰基，N-甲基-2-氨基乙基; 用于治疗非自身免疫性2型糖尿病和/或综合征X的药物用于含有它们的膳食和药物组合物以及用于治疗非自身免疫性2型糖尿病和/或症状X的综合征的方法包括人的动物，所述方法包括向有需要的动物（包括人）施用有效剂量的式（I）化合物的步骤。

7. 发明申请

US20100119646A1 Dihydroeugenol as Additive for feed 审中-公开
标题翻译：二氢丁子香酚作为饲料添加剂
公开(公告)号：US20100119646A1
公开(公告)日：2010-05-13
申请号：US12525614
申请日：2008-01-31
申请人： Daniel D'Orazio , Antoine Saizieu-De , Goede Schueler , Aurelia Seon , Carlos Simoes-Nunes
发明人： Daniel D'Orazio , Antoine Saizieu-De , Goede Schueler , Aurelia Seon , Carlos Simoes-Nunes
IPC分类号： A23K1/18 , C07C41/00 , A23D9/013 , A23L1/30
CPC分类号： A23K50/30 , A23K20/111 , A23K50/75 , A23V2002/00 , A23V2200/3202 , A23V2250/2132
摘要： The present invention relates to the use of a selected group of phenol derivatives as components of animal feed or feed additives for the improvement of animal performance as well as to the corresponding animal feed or feed additives containing them.
摘要翻译：本发明涉及所选择的一组苯酚衍生物作为动物饲料或饲料添加剂的组分用于改善动物性能以及相应的含有它们的动物饲料或饲料添加剂的用途。

8. 发明授权

US07711711B1 Networked storage system employing information lifecycle management in conjunction with a distributed global file system 有权
标题翻译：网络存储系统采用信息生命周期管理与分布式全局文件系统结合使用
公开(公告)号：US07711711B1
公开(公告)日：2010-05-04
申请号：US11393185
申请日：2006-03-29
申请人： J. Andrew Linnell , Daniel D'Orazio
发明人： J. Andrew Linnell , Daniel D'Orazio
IPC分类号： G06F12/00
CPC分类号： G06F3/0643 , G06F3/0604 , G06F3/0649 , G06F3/067 , G06F17/30194 , H04L67/1097
摘要： A networked storage system includes network-attached file system (FS) nodes implementing a distributed global file system. Each FS node includes a file system server and at least one storage system including storage resources (such as disk drives) representing portions of a global file system storage space. The FS nodes are organized according to respective cost-performance characteristics of the storage systems, generally ranging from a high-cost, high-performance characteristic to a low-cost, low-performance characteristic. A storage management system performs information lifecycle management (ILM) which includes allocating the FS nodes for storing data according to a mapping between an ILM-based data classification scheme and the cost-performance characteristics of the storage devices, as well as dynamically managing the placement of data among the storage devices according to the ILM-based classification of the data. The storage management system also performs global file system management including allocating a set of identifiers (e.g. segment identifiers) of the distributed global file system among the FS nodes, and dynamically adjusting the allocation of the identifiers among the FS nodes in response to the addition and removal of whole storage systems and/or storage resources within each of the storage systems.
摘要翻译：网络存储系统包括实现分布式全局文件系统的网络连接文件系统（FS）节点。每个FS节点包括文件系统服务器和包括表示全局文件系统存储空间的部分的存储资源（例如磁盘驱动器）的至少一个存储系统。 FS节点根据存储系统的成本性能特征进行组织，通常从高成本，高性能特性到低成本，低性能特性。存储管理系统执行信息生命周期管理（ILM），其包括根据基于ILM的数据分类方案与存储设备的成本性能特征之间的映射来分配用于存储数据的FS节点，以及动态地管理放置的存储设备之间的数据根据基于ILM的数据分类。存储管理系统还执行全局文件系统管理，包括在FS节点之间分配一组分布式全局文件系统的标识符（例如分段标识符），以及响应于添加而动态调整FS节点之间的标识符分配，以及在每个存储系统内移除整个存储系统和/或存储资源。

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