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1. 发明申请

US20130303496A1 Method Of Treating Vascular Lesions 审中-公开
标题翻译：治疗血管病变的方法
公开(公告)号：US20130303496A1
公开(公告)日：2013-11-14
申请号：US13466504
申请日：2012-05-08
申请人： Daniel L. Cox , Stephen D. Pacetti
发明人： Daniel L. Cox , Stephen D. Pacetti
IPC分类号： A61K31/573 , A61P7/00
CPC分类号： A61L31/16 , A61L2300/222 , A61L2300/412 , A61L2300/436 , A61L2300/45 , A61L2300/602
摘要： The present invention relates to the treatment of vascular lesions using low doses of an mTOR inhibitor together with a low dose of a glucocorticoid on an implantable medical device, wherein the treatment is particularly beneficial when the patient is a diabetic or is suffering from an abnormally long or diffuse lesion.
摘要翻译：本发明涉及使用低剂量的mTOR抑制剂以及低剂量的糖皮质激素治疗可植入的医疗装置来治疗血管损伤，其中当患者是糖尿病患者或患有异常长时间时，该治疗特别有益或弥漫性病变。

2. 发明授权

US09216271B2 Local delivery with a balloon covered by a cage 有权
标题翻译：本地交付与笼子覆盖的气球
公开(公告)号：US09216271B2
公开(公告)日：2015-12-22
申请号：US13762035
申请日：2013-02-07
申请人： Daniel L. Cox
发明人： Daniel L. Cox
IPC分类号： A61M25/10 , A61M25/00 , A61M25/01 , A61M25/06
CPC分类号： A61M25/1002 , A61M25/0069 , A61M25/104 , A61M2025/0081 , A61M2025/0183 , A61M2025/0681 , A61M2025/105 , A61M2025/1052 , A61M2025/1075
摘要： A catheter configured for delivering an agent to a patient's vessel wall is described. The catheter includes an inflatable balloon substantially covered by a expandable cage such that when the inflatable balloon is inflated the expandable cage substantially surrounds an outer surface of the inflated balloon. The inflatable balloon is configured to be deployed within a lumen against a lumen wall and separated from the lumen wall by the expandable cage in an expanded state, and is adapted to provide an agent delivery to a treatment site, and the expandable cage is further collapsible and is removable from said lumen.
摘要翻译：描述了构造成将药剂递送到患者血管壁的导管。该导管包括基本上被可扩张的保持架覆盖的可膨胀气囊，使得当可充气气球膨胀时，可膨胀笼基本上围绕充气球囊的外表面。所述可充气气囊构造成相对于内腔壁部署在内腔内，并且在膨胀状态下由可膨胀保持架与管腔壁分离，并且适于提供药剂输送到治疗部位，并且可膨胀笼进一步折叠并且可从所述内腔移除。

3. 发明授权

US08556849B2 Methods and devices for eluting agents to a vessel 有权
公开(公告)号：US08556849B2
公开(公告)日：2013-10-15
申请号：US13349499
申请日：2012-01-12
申请人： Paul M. Consigny , William E. Webler , Gustavo D. Cipolla , Gordon Steward , Benny Serna , Daniel L. Cox
发明人： Paul M. Consigny , William E. Webler , Gustavo D. Cipolla , Gordon Steward , Benny Serna , Daniel L. Cox
IPC分类号： A61M31/00 , A61M37/00
CPC分类号： A61M25/104 , A61B17/22 , A61B2017/22042 , A61B2017/22051 , A61B2017/22084 , A61M25/10 , A61M2025/0057 , A61M2025/105 , A61M2025/1081
摘要： Systems, devices and methods for eluting an agent at a treatment site are disclosed. The devices include an expandable frame and at least one membrane. The membrane may carry an agent to elute at the treatment site. The membrane may allow blood flow at the treatment site during agent delivery.

4. 发明授权

US07914577B2 Apparatuses and methods for heart valve repair 有权
标题翻译：心脏瓣膜修复的装置和方法
公开(公告)号：US07914577B2
公开(公告)日：2011-03-29
申请号：US11698729
申请日：2007-01-26
申请人： Daniel L. Cox
发明人： Daniel L. Cox
IPC分类号： A61F2/24
CPC分类号： A61F2/2451 , A61F2/91 , A61F2002/828 , A61F2250/001 , Y10T24/39
摘要： A medical device for treating a defective heart valve. The medical device comprises a delivery sheath and an implantable device moveably disposed within the delivery sheath. The implantable device further comprises a distal expandable basket, a proximal expandable basket, and a connecting member coupling at a first end to the distal expandable basket and at a second end to the proximal expandable basket. Each of the distal expandable basket and proximal expandable basket is in a collapsed state during delivery and an expanded state after deployment. An actuator is releasably coupled to the implantable device. When coupled to the implantable device, the actuator can move the implantable device in a way to allow for positioning of the distal and proximal expandable baskets.
摘要翻译：一种用于治疗有缺陷心脏瓣膜的医疗装置。医疗装置包括输送鞘和可移动地设置在输送鞘内的可植入装置。可植入装置还包括远端可扩张篮，近端可膨胀篮和连接构件，该连接构件在第一端处连接到远侧可膨胀篮，并且在第二端处连接到近端可膨胀篮。远端可膨胀篮和近端可膨胀篮中的每一个在分娩期间处于折叠状态，并在展开后处于膨胀状态。致动器可释放地联接到可植入装置。当联接到可植入装置时，致动器可以以允许远端和近端可扩展筐定位的方式移动可植入装置。

5. 发明申请

US20090082843A1 SELF-EXPANDING STENT WITH ENHANCED DELIVERY PRECISION AND STENT DELIVERY SYSTEM 有权
标题翻译：具有增强的交付精度和STENT交付系统的自我扩张
公开(公告)号：US20090082843A1
公开(公告)日：2009-03-26
申请号：US12238219
申请日：2008-09-25
申请人： Daniel L. Cox , Matthew J. Fitz , William James Harrison , Michael D. Schultz , Joseph A. Ventura
发明人： Daniel L. Cox , Matthew J. Fitz , William James Harrison , Michael D. Schultz , Joseph A. Ventura
IPC分类号： A61F2/06
CPC分类号： A61F2/91 , A61F2/915 , A61F2/95 , A61F2002/91516 , A61F2002/91533 , A61F2002/91575 , A61F2002/9517 , A61F2230/0013
摘要： The invention is directed to a self-expanding stent for implantation into a body lumen, such as an artery. The stent consists of a plurality of radially expandable cylindrical elements generally aligned on a common longitudinal stent axis and interconnected by a plurality of interconnecting members placed on the stent in a collinear arrangement such as to create at least one continuous spine which extends along the length of the stent. The invention is also directed to a stent delivery system for implantation of a stent in a vessel which includes an outer tubular member having a restraining sheath and an inner tubular member having a distal end which has a compressed stent mounted thereto. The proximal end of the inner tubular member is connected to a housing assembly which prevents the inner tubular member from moving when the outer tubular member is retracted to deploy the stent. The proximal end of the outer tubular member is attached to a pull-back handle which is slidably mounted on the base of the housing assembly. When the pull-back handle is retracted, the restraining sheath is retracted to deploy the sheath, while the inner tubular member remains stationary.
摘要翻译：本发明涉及用于植入体腔如动脉的自扩张支架。支架由多个可径向扩张的圆柱形元件组成，通常在共同的纵向支架轴线上对准并且通过以共线布置放置在支架上的多个互连构件相互连接，以产生至少一个连续的脊柱，其沿着支架本发明还涉及用于将支架植入容器中的支架输送系统，该支架包括具有约束护套的外管状构件和具有安装在其上的压缩支架的远端的内管状构件。内部管状构件的近端连接到壳体组件，当外部管状构件缩回以展开支架时，壳体组件防止内部管状构件移动。外管状构件的近端附接到可滑动地安装在壳体组件的基部上的拉回手柄。当拉回手柄缩回时，约束护套被缩回以展开护套，同时内部管状构件保持静止。

6. 发明授权

US07128757B2 Radiopaque and MRI compatible nitinol alloys for medical devices 有权
标题翻译：用于医疗器械的不透射线和MRI兼容镍钛诺合金
公开(公告)号：US07128757B2
公开(公告)日：2006-10-31
申请号：US10814326
申请日：2004-03-30
申请人： John F. Boylan , Daniel L. Cox , Pamela A. Kramer-Brown
发明人： John F. Boylan , Daniel L. Cox , Pamela A. Kramer-Brown
IPC分类号： A61F2/90
CPC分类号： A61L31/022 , A61F2/915 , A61F2002/91516 , A61F2002/91525 , A61F2002/91533 , A61F2002/91575 , A61F2230/0013 , A61F2250/0098 , A61L31/18 , A61L2400/16 , C22C19/00
摘要： A radiopaque nitinol medical device such as a stent for use with or implantation in a body lumen is disclosed. The stent is made from a superelastic alloy such as nickel-titanium or nitinol, and includes a ternary element selected from the group of chemical elements consisting of iridium, platinum, gold, rhenium, tungsten, palladium, rhodium, tantalum, silver, ruthenium, or hafnium. The nitinol stent has improved radiopacity yet retains its superelastic and shape memory behavior and further maintains a thin strut/wall thickness for high flexibility. Another embodiment includes a balloon expandable stent made from a radiopaque and MRI compatible alloy such as nitinol and includes a ternary element selected from the group of chemical elements consisting of iridium, platinum, gold, rhenium, tungsten, palladium, rhodium, tantalum, silver, ruthenium, hafnium, osmium, zirconium, niobium, or molybdenum.
摘要翻译：公开了一种不透射线的镍钛诺医疗装置，例如用于或植入体腔内的支架。支架由镍 - 钛或镍钛诺等超弹性合金制成，并且包括选自由铱，铂，金，铼，钨，钯，铑，钽，银，钌等组成的化学元素组的三元元素，或铪。镍钛诺支架具有改善的射线不透性，但仍然保持其超弹性和形状记忆行为，并进一步保持薄的支柱/壁厚以获得高度的灵活性。另一个实施方案包括由不透射线和MRI相容合金如镍钛诺制成的球囊可扩张支架，并且包括选自由铱，铂，金，铼，钨，钯，铑，钽，银等组成的化学元素组的三元元素，钌，铪，锇，锆，铌或钼。

7. 发明授权

US06855161B2 Radiopaque nitinol alloys for medical devices 失效
标题翻译：用于医疗器械的不透射线的镍钛诺合金
公开(公告)号：US06855161B2
公开(公告)日：2005-02-15
申请号：US09752212
申请日：2000-12-27
申请人： John F. Boylan , Daniel L. Cox
发明人： John F. Boylan , Daniel L. Cox
IPC分类号： A61L29/00 , A61F2/00 , A61F2/06 , A61F2/84 , A61F2/90 , A61F9/00
CPC分类号： A61F2/915 , A61F2002/91516 , A61F2002/91525 , A61F2002/91533 , A61F2002/91575 , A61F2230/0013 , A61F2250/0098 , A61L31/022 , A61L31/18 , A61L2400/16 , C22C19/00 , Y10S623/901 , Y10T29/49995
摘要： A radiopaque nitinol medical device such as a stent for use with or implantation in a body lumen is disclosed. The stent is made from a superelastic alloy such as nickel-titanium or nitinol, and includes a ternary element selected from the group of chemical elements consisting of iridium, platinum, gold, rhenium, tungsten, palladium, rhodium, tantalum, silver, ruthenium, or hafnium. The added ternary element improves the radiopacity of the nitinol stent comparable to that of a stainless steel stent of the same size and strut pattern coated with a thin layer of gold. The nitinol stent has improved radiopacity yet retains its superelastic and shape memory behavior and further maintains a thin strut/wall thickness for high flexibility.
摘要翻译：公开了一种不透射线的镍钛诺医疗装置，例如用于或植入体腔内的支架。支架由镍 - 钛或镍钛诺等超弹性合金制成，并且包括选自由铱，铂，金，铼，钨，钯，铑，钽，银，钌等组成的化学元素组的三元元素，或铪。添加的三元元素提高了镍钛诺支架的不透射线能力，与具有相同尺寸的不锈钢支架和涂有薄层金的支柱图案相比。镍钛诺支架具有改善的射线不透性，但仍然保持其超弹性和形状记忆行为，并进一步保持薄的支柱/壁厚以获得高度的灵活性。

8. 发明授权

US06569193B1 Tapered self-expanding stent 有权
标题翻译：锥形自扩张支架
公开(公告)号：US06569193B1
公开(公告)日：2003-05-27
申请号：US09359550
申请日：1999-07-22
申请人： Daniel L. Cox , Kent C. B. Stalker , Joe Ventura, II
发明人： Daniel L. Cox , Kent C. B. Stalker , Joe Ventura, II
IPC分类号： A61F206
CPC分类号： A61F2/915 , A61F2/91 , A61F2002/91516 , A61F2002/91525 , A61F2002/91533 , A61F2002/91575 , A61F2230/0013 , A61F2250/0039
摘要： A self-expanding, tapered profile stent for implantation in a body lumen, such as an artery, is disclosed. The stent is constructed of a plurality of radially expandable cylindrical elements generally aligned on a common longitudinal stent axis and interconnected by one or more interconnecting members placed so that the stent is flexible in the longitudinal direction. The lengths of the cylindrical elements increase from one end of the stent to the opposite end by increasing the lengths of the struts and the lengths of the interconnecting members. Each cylindrical element is formed from repeating patterns of upright V's and inverted V's connected by straight strut arms with shoulders to create an overall serpentine wave pattern around the circumference. A step, continuous, parabolic, or curved taper in the stent can be imparted by using an expansion mandrel and applying deforming forces to the stent. The stent is made from pseudoelastic and shape memory alloys.
摘要翻译：公开了一种用于植入体腔（例如动脉）中的自扩张锥形轮廓支架。所述支架由多个可径向扩张的圆柱形元件构成，所述多个可径向扩张的圆柱形元件通常在公共纵向支架轴线上对准并且通过一个或多个相互连接的构件相互连接，以使支架在纵向方向上具有柔性。通过增加支柱的长度和互连构件的长度，圆柱形元件的长度从支架的一端增加到相对端。每个圆柱形元件由具有肩部的直的支撑臂连接的直立V和倒V的重复图案形成，以围绕圆周产生整体蛇形波形图案。可以通过使用扩张心轴并向支架施加变形力来赋予支架中的台阶，连续，抛物线或弯曲的锥度。支架由假弹性和形状记忆合金制成。

9. 发明授权

US06375676B1 Self-expanding stent with enhanced delivery precision and stent delivery system 有权
公开(公告)号：US06375676B1
公开(公告)日：2002-04-23
申请号：US09313780
申请日：1999-05-17
申请人： Daniel L. Cox
发明人： Daniel L. Cox
IPC分类号： A61F206
CPC分类号： A61F2/91 , A61F2/915 , A61F2/95 , A61F2002/91516 , A61F2002/91533 , A61F2002/91575 , A61F2002/9517 , A61F2230/0013
摘要： The invention is directed to a self-expanding stent for implantation into a body lumen, such as an artery. The stent consists of a plurality of radially expandable cylindrical elements generally aligned on a common longitudinal stent axis and interconnected by a plurality of interconnecting members placed on the stent in a collinear arrangement such as to create at least one continuous spine which extends along the length of the stent. The invention is also directed to a stent delivery system for implantation of a stent in a vessel which includes an outer tubular member having a restraining sheath and an inner tubular member having a distal end which has a compressed stent mounted thereto. The proximal end of the inner tubular member is connected to a housing assembly which prevents the inner tubular member from moving when the outer tubular member is retracted to deploy the stent. The proximal end of the outer tubular member is attached to a pull-back handle which is slidably mounted on the base of the housing assembly. When the pull-back handle is retracted, the restraining sheath is retracted to deploy the sheath, while the inner tubular member remains stationary.

10. 发明授权

US6083232A Vibrating stent for opening calcified lesions 失效
标题翻译：振动支架用于开放钙化病变
公开(公告)号：US6083232A
公开(公告)日：2000-07-04
申请号：US720098
申请日：1996-09-27
申请人： Daniel L. Cox
发明人： Daniel L. Cox
IPC分类号： A61M25/00 , A61B17/22 , A61F2/06 , A61F2/82 , A61F2/84 , A61M29/02
CPC分类号： A61B17/22012 , A61F2/958 , A61M25/104
摘要： An intraluminal catheter and stent delivery system using vibratory energy to open calcified lesions. The catheter having an expandable stent mounted on a balloon portion thereof, is adapted to convey vibratory energy through the stent to a calcified lesion to facilitate crossing and dilating the lesion during a PTCA procedure. A vibratory energy source is transmitted through a flexible wire to provide vibratory energy to the stent, which in turn provides vibratory energy to a calcified lesion to thereby at least partially pulverize the lesion and assist in crossing and dilating the body lumen.
摘要翻译：使用振动能打开钙化病变的管腔内导管和支架输送系统。具有安装在其球囊部分上的可扩张支架的导管适于将振动能量通过支架传送至钙化损伤，以便于在PTCA手术期间穿过和扩张病变。振动能量源通过柔性线传递以向支架提供振动能量，其又向钙化的损伤提供振动能，从而至少部分地粉碎病变并且有助于穿过和扩张体腔。

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