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1. 发明申请

US20060189646A1 Glucocorticoid mimetics, methods of making them, pharmaceutical compositions, and uses thereof 有权
公开(公告)号：US20060189646A1
公开(公告)日：2006-08-24
申请号：US11305361
申请日：2005-12-16
申请人： Daniel Kuzmich , Darren DiSalvo , John Regan , David Thomson , Rajashekhar Betageri , Jennifer Kowalski
发明人： Daniel Kuzmich , Darren DiSalvo , John Regan , David Thomson , Rajashekhar Betageri , Jennifer Kowalski
IPC分类号： C07D471/02 , A61K31/4745 , A61K31/404 , C07D209/14
CPC分类号： C07D471/04 , C07D209/08 , C07D209/16 , C07D209/86 , C07D215/06 , C07D215/233 , C07D231/56 , C07D235/14 , C07D307/79 , C07D333/58 , C07D401/04 , C07D403/04 , C07D413/04
摘要： Compounds of Formula (I) wherein R1, R2, R3, R4, R5, R6, and R7 are as defined herein, or a tautomer, prodrug, solvate, or salt thereof; pharmaceutical compositions containing such compounds, and methods of modulating the glucocorticoid receptor function and methods of treating disease-states or conditions mediated by the glucocorticoid receptor function or characterized by inflammatory, allergic, or proliferative processes in a patient using these compounds.

2. 发明申请

US20060154925A1 Glucocorticoid mimetics, methods of making them, pharmaceutical compositions, and uses thereof 有权
标题翻译：糖皮质激素模拟物，其制备方法，药物组合物及其用途
公开(公告)号：US20060154925A1
公开(公告)日：2006-07-13
申请号：US11305362
申请日：2005-12-16
申请人： Daniel Kuzmich , Darren DiSalvo , John Regan , David Thomson
发明人： Daniel Kuzmich , Darren DiSalvo , John Regan , David Thomson
IPC分类号： A61K31/5377 , A61K31/498 , A61K31/4709
CPC分类号： C07D471/04 , C07D209/08 , C07D209/16 , C07D209/86 , C07D215/06 , C07D215/233 , C07D231/56 , C07D235/14 , C07D307/79 , C07D333/58 , C07D401/04 , C07D403/04 , C07D413/04
摘要： Compounds of Formula (I) wherein R1, R2, R3, R4, R5, R6, and R7 are as defined herein, or a tautomer, prodrug, solvate, or salt thereof; pharmaceutical compositions containing such compounds, and methods of modulating the glucocorticoid receptor function and methods of treating disease-states or conditions mediated by the glucocorticoid receptor function or characterized by inflammatory, allergic, or proliferative processes in a patient using these compounds.
摘要翻译：式（I）的化合物，其中R 1，R 2，R 3，R 4，R 4， R 5，R 6和R 7如本文所定义，或其互变异构体，前药，溶剂合物或其盐; 含有这些化合物的药物组合物，以及调节糖皮质激素受体功能的方法和治疗由糖皮质激素受体功能介导的疾病状态或病症的方法，或其特征在于使用这些化合物的患者的炎症，过敏或增殖过程。

3. 发明申请

US20050234091A1 Glucocorticoid mimetics, methods of making them, pharmaceutical compositions and uses thereof 审中-公开
标题翻译：糖皮质激素模拟物，其制备方法，药物组合物及其用途
公开(公告)号：US20050234091A1
公开(公告)日：2005-10-20
申请号：US11072819
申请日：2005-03-04
申请人： John Regan , Thomas Lee , David Thomson , Thomas Kirrane , Daniel Kuzmich , John Proudfoot , Younes Bekkali , Renee Zindell
发明人： John Regan , Thomas Lee , David Thomson , Thomas Kirrane , Daniel Kuzmich , John Proudfoot , Younes Bekkali , Renee Zindell
IPC分类号： A61K31/4355 , A61K31/4365 , A61K31/437 , A61K31/4375 , A61K31/4741 , A61K31/4743 , A61K31/4745 , C07D471/02 , C07D471/04 , C07D491/02 , C07D491/04 , C07D495/04 , C07D498/02 , C07D498/04 , C07D513/04
CPC分类号： C07D491/04 , C07D471/04 , C07D495/04 , C07D513/04
摘要： Compounds of Formula (I) wherein R1, R2, R3, R4, R5, R6 and X are as defined herein for Formula (IA) and Formula (IB), or a tautomer, prodrug, solvate, or salt thereof; pharmaceutical compositions containing such compounds, and methods of modulating the glucocorticoid receptor function and methods of treating disease-states or conditions mediated by the glucocorticoid receptor function or characterized by inflammatory, allergic, or proliferative processes in a patient using these compounds.
摘要翻译：式（I）的化合物，其中R 1，R 2，R 3，R 4，R 4， R 5和R 6如本文对式（IA）和式（IB）所定义，或其互变异构体，前药，溶剂合物或其盐; 含有这些化合物的药物组合物，以及调节糖皮质激素受体功能的方法和治疗由糖皮质激素受体功能介导的疾病状态或病症的方法，或其特征在于使用这些化合物的患者的炎症，过敏或增殖过程。

4. 发明授权

US08178568B2 Sulfone compounds which modulate the CB2 receptor 有权
标题翻译：调节CB2受体的砜化合物
公开(公告)号：US08178568B2
公开(公告)日：2012-05-15
申请号：US13002659
申请日：2009-06-24
申请人： John Regan , Doris Riether
发明人： John Regan , Doris Riether
IPC分类号： A61K31/422 , A61K31/4015 , A61K31/4025 , C07D207/12
CPC分类号： C07D413/04 , C07D261/14 , C07D285/08 , C07D401/04 , C07D403/04 , C07D413/12 , C07D413/14 , C07D417/04
摘要： Compounds which modulate the CB2 receptor are disclosed. Compounds according to the invention bind to and are agonists of the CB2 receptor, and are useful for treating inflammation. Those compounds which are agonists are additionally useful for treating pain.
摘要翻译：公开了调节CB2受体的化合物。根据本发明的化合物与CB2受体结合并且是激动剂，并且可用于治疗炎症。作为激动剂的那些化合物另外可用于治疗疼痛。

5. 发明申请

US20050038069A1 Substituted azabicyclic compounds 失效
标题翻译：取代的氮杂双环化合物
公开(公告)号：US20050038069A1
公开(公告)日：2005-02-17
申请号：US10933077
申请日：2004-09-01
申请人： Paul Cox , Shelley Bower , David Aldous , Peter Astles , Daniel McGarry , Christopher Hulme , John Regan , Fu-Chih Huang , Stevan Djuric , Kevin Moriarty , Rose Mathew , Gregory Poli
发明人： Paul Cox , Shelley Bower , David Aldous , Peter Astles , Daniel McGarry , Christopher Hulme , John Regan , Fu-Chih Huang , Stevan Djuric , Kevin Moriarty , Rose Mathew , Gregory Poli
IPC分类号： C07D235/08 , A61K31/00 , A61K31/40 , A61K31/403 , A61K31/404 , A61K31/41 , A61K31/415 , A61K31/4164 , A61K31/4184 , A61K31/4196 , A61K31/42 , A61K31/422 , A61K31/44 , A61K31/4427 , A61K31/443 , A61K31/4433 , A61K31/4439 , A61K31/47 , A61K31/4709 , A61K31/496 , A61K31/505 , A61K31/506 , A61K31/535 , A61K31/5355 , A61K31/5375 , A61K31/5377 , A61P9/00 , A61P11/00 , A61P17/00 , A61P25/04 , A61P29/00 , A61P35/00 , A61P37/00 , A61P43/00 , C07D209/08 , C07D209/12 , C07D209/42 , C07D235/12 , C07D235/24 , C07D401/06 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/12 , C07D405/14 , C07D409/14 , C07D413/12 , C07D413/14 , C07D417/14 , C07D217/12
CPC分类号： C07D235/24 , C07D209/12 , C07D209/42 , C07D401/06 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/12 , C07D405/14 , C07D409/14 , C07D413/12 , C07D413/14 , C07D417/14
摘要： This invention is directed to physiologically active compounds of formula (I) wherein represents a bicyclic ring system, of about 10 to about 13 ring members, in which the ring is an azaheterocycle, and the ring represents an azaheteroaryl ring, or an optionally halo substituted benzene ring; R1 represents hydrogen or a straight- or branched-chain alkyl group of 1 to about 4 carbon atoms, optionally substituted by hydroxy or one or more halogen atoms, or when Z1 represents a direct bond R1 may also represent a lower alkenyl or lower alkynyl group, or a formyl group; R2 represents hydrogen, alkenyl, alkoxy, alkyl, alkylsulphinyl, alkylsulphonyl, alkylthio, aryl, arylalkyloxy, arylalkylsulphinyl, arylalkylsulphonyl, arylalkylthio, aryloxy, arylsulphinyl, arylsulphonyl, arylthio, cyano, cycloalkenyl, cycloalkenyloxy, cycloalkyl, cycloalkyloxy, heteroaryl, heteroarylalkyloxy, heteroaryloxy, hydroxy, —SO2NR4R5, —NR4SO2R5, —NR4R5, —C(═O)R5, —C(═O)C(═O)R5, —C(═O)NR4R5, —C(═O)OR5, —O(C═O)NR4R5, or —NR4C(═O)R5; R3 represents —C(=Z)—N(R7)R6, —C(=Z)—CHR12R6, —C(=Z)—R6, —CR8═C(R9)(CH2)p—R6, —C(R10)═C(R11)R12, —C(R13)(R10)C(R11)(R14)R12, —C(R8)(R15)CH(R9)(CH2)p—R6, —R6, —N(R16)C(=Z)R6, —C(R17)═N—OC(=0)R18, —C(═O)—N(R19)OR20, —C≡C—R6, —CH2—C(=Z)—R6, —C(=Z)—C(=Z)R6, —CH2—NHR6, —CH2-ZR6, —CH2—SOR6, —CH2—SO2R6, —CF2—OR6, —NH—CH2R6, -Z-CH2R6, —SO—CH2R6, —SO2—CH2R6, —O—CF2R6, —O—C(=Z)R6, —N═N—R6, —NH—SO2R6, —SO2—NR21R22, —CZ-CZ-NHR6, —NH—CO—OR6, —O—CO—NHR6, —NH—CO—NHR6, —R23, —CX1═CX2R6, —C(═NOR24), —(CH2)qR6, —CH2—CO—NH(CH2)qR6, —CH2—NH—CO(CH2)qR6, —CH2—CO—CH2R6, —C(═NR25)—NH(CH2)qR6, —C(X3)═N—(CH2)qR6 or —CH(X4)—CH2R6; A1 represents a direct bond, or a straight or branched C1-6 alkylene chain optionally substituted by hydroxyl, alkoxy, oxo, cycloalkyl, aryl or heteroaryl, or A1 represents a straight or branched C2-6alkenylene or C2-6alkynylene chain; Z1 represents a direct bond, an oxygen or sulphur atom or NH; n and m each represent zero or 1, provided that n is 1 when m is zero and n is zero when m is 1; and N-oxides thereof, and their prodrugs, and pharmaceutically acceptable salts and solvates of the compounds of formula (I) and N-oxides thereof, and their prodrugs. Such compounds inhibit the production or physiological effects of TNF and inhibit cyclic AMP phosphodiesterase. The invention is also directed to pharmaceutical compositions comprising compounds of formula (I), their pharmaceutical use and methods for their preparation.
摘要翻译：本发明涉及式（I）的生理活性化合物，其中代表双环体系，约10至约13个环成员，其中该环是氮杂环，并且该环代表氮杂杂芳基环，或任选地被卤素取代苯环; R 1表示氢或1至约4个碳原子的直链或支链烷基，任选被羟基或一个或多个卤素原子取代，或当Z 1表示直接键R 1时也代表低级烯基或低级炔基或甲酰基; R 2表示氢，烯基，烷氧基，烷基，烷基亚磺酰基，烷基磺酰基，烷硫基，芳基，芳基烷氧基，芳基烷基亚磺酰基，芳基烷基磺酰基，芳基烷硫基，芳氧基，芳基亚磺酰基，芳基磺酰基，芳硫基，氰基，环烯基，环烯氧基，环烷基，环烷氧基，杂芳基，，杂芳氧基，羟基，-SO 2 NR 4 R 5，-NR 4 SO 2 R 5，-NR 4 R 5，-C（= O）R 5，-C（= O）C（= O）R 5，-C（= O）NR 4 R 5，-C（= O）OR 5，-O（C = O）NR 4 R 5或-NR 4 C（= O）R 5; R 3表示-C（= Z）-N（R 7）R 6，-C（= Z）-CHR 12 R 6，-C（= Z）-R 6 ，-CR 8 = C（R 9）（CH 2）p R 6，-C（R 10）= C（R 11）R 12，-C（R 13）（R 10）C（R 11）（R 14）R 12，-C（R 8）（R 15）CH（R 9）（CH 2） pR 6，-R 6，-N（R 16）C（= Z）R 6，-C（R 17）= N-OC（= O）R 18， -C（= O）-N（R <19）

6. 发明申请

US20120245986A1 MOBILE PAYMENT AND POINT SYSTEM AND METHOD 审中-公开
标题翻译：移动支付和点系统和方法
公开(公告)号：US20120245986A1
公开(公告)日：2012-09-27
申请号：US13410527
申请日：2012-03-02
申请人： John Regan , Michael Irvine , Keith Saunders , Craig Henkels
发明人： John Regan , Michael Irvine , Keith Saunders , Craig Henkels
IPC分类号： G06Q30/06 , G06Q30/02
CPC分类号： G06Q20/322 , G06Q20/20 , G06Q20/32 , G06Q20/325 , G06Q20/387 , G06Q20/42 , G06Q30/02 , G06Q30/0222 , G06Q30/0226 , G06Q30/0228 , G06Q30/0253 , G06Q30/0267 , G06Q30/06
摘要： A system and method allows a consumer to purchase goods and services from merchants and redeem offers made by a merchant with a digital transaction on a smart phone. The merchant receives and enters the consumer's telephone number into an application. The consumer's telephone number is sent to a server, which checks for electronic coupons and loyalty points. Accounting for the value of any coupon/accumulated loyalty points, the merchant enters the payment amount into the application. which. in turn sends it back to the server. The server then sends the payment amount, any coupon details and the merchant's name to the consumer's phone. The consumer can choose to accept or decline the sale with or without using the coupon/loyalty points. A PIN number confirms the sale, which transmits to the server and then to the merchant. A digital sales receipt is sent to the merchant and consumer.
摘要翻译：系统和方法允许消费者从商家购买商品和服务，并且在智能电话上用数字交易兑换由商家提供的优惠。商家接收并将消费者的电话号码输入应用程序。消费者的电话号码被发送到服务器，该服务器检查电子优惠券和忠诚度点。考虑到任何优惠券/累积积分的价值，商家将付款金额纳入申请。哪一个。反过来又将其发送回服务器。服务器然后将支付金额，任何优惠券细节和商家名称发送给消费者的电话。消费者可以选择接受或拒绝有或没有使用优惠券/忠诚点的销售。 PIN码确认销售，将其发送到服务器，然后发送给商家。将数字销售收据发送给商家和消费者。

7. 发明授权

US4345735A Blowout preventer 失效
标题翻译：防喷器
公开(公告)号：US4345735A
公开(公告)日：1982-08-24
申请号：US288711
申请日：1981-07-31
申请人： John Regan
发明人： John Regan
IPC分类号： E21B33/06
CPC分类号： F16J15/46 , E21B33/06 , F16J15/168
摘要： An oil well blowout preventer includes a radially compressible annular packing having radially-sectored end portions in a housing having axially aligned upper and lower bores communicating with the inner bore of the packing and with the sectored ends, and also includes hydraulic means for radially constricting the packing, thereby causing it to axially expand. A plurality of circumferentially-arranged rigid wedge members carried by the sectored end portions are individually movable radially into the bores to control the axial expansion whereby radial sectors of the packing may move sequentially inward to effect a seal between the upper and lower bores in response to progressive axial expansion of the packing as the packing undergoes nonuniform sector-wise radial compression. The inward radial movement of the rigid members are limited by stops to a common radial position independent of the uniformity of the radial compression. The blowout preventer effects a seal between the inner bore and the upper and lower bores regardless of the presence of an oil well tool therein.
摘要翻译：油井防喷器包括可径向压缩的环形密封件，其具有在壳体中具有径向切除的端部，该壳体具有与衬垫的内孔连通并具有截面的轴向对准的上孔和下孔，并且还包括用于径向收缩填充，从而使其轴向膨胀。多个沿圆周布置的刚性楔形构件由圆柱形布置的刚性楔形构件可以径向分别地移动到孔中以控制轴向膨胀，由此密封件的径向扇形部可以顺序向内移动，以响应于上部孔和下孔而形成密封当包装经历不均匀的扇形径向压缩时，填料的逐渐轴向膨胀。刚性构件的向内径向运动被限制到与径向压缩的均匀性无关的公共径向位置。防喷器在内孔和上下孔之间产生密封，而不管其中是否有油井工具。

8. 发明申请

US20070022051A1 System and method for multi-application payment processing 审中-公开
标题翻译：多应用程序支付处理的系统和方法
公开(公告)号：US20070022051A1
公开(公告)日：2007-01-25
申请号：US11436406
申请日：2006-05-18
申请人： John Regan , Michael Irvine , Mark Connolly , Gerard Kiley
发明人： John Regan , Michael Irvine , Mark Connolly , Gerard Kiley
IPC分类号： G06Q40/00 , G06Q99/00 , H04L9/00 , H04K1/00
CPC分类号： G06Q20/3574 , G06Q20/102 , G06Q20/20 , G06Q20/26 , G06Q20/382 , G06Q20/4033
摘要： A multi-application payment system and method operates in a hybrid closed/open manner. The multi-application payment system and method features a smart card wherein funds are added to the card at point of sale (POS) locations. The card keeps track of the available balance and is used to purchase goods/services at any POS location. During a transaction, the POS location verifies the amount of funds available and then debits the funds available on the card. Transactions between the card and the POS location are preformed in a substantially closed manner. The POS location then transfers data about the transaction (preferably in a batch manner) to a central processing system. The central processing system processes the data in a generally open manner to move funds to the appropriate account, preferably using the Federal ACH interface.
摘要翻译：多应用支付系统和方法以混合封闭/开放方式操作。多应用支付系统和方法具有智能卡，其中在销售点（POS）位置将资金添加到卡中。该卡跟踪可用余额，用于在任何POS位置购买商品/服务。在交易期间，POS位置验证可用资金的数量，然后借记卡上可用的资金。卡和POS位置之间的交易以基本上封闭的方式进行。然后，POS位置将关于交易的数据（优选以批次方式）传送到中央处理系统。中央处理系统以一般开放的方式处理数据，以将资金转移到适当的帐户，优选使用联邦ACH界面。

9. 发明申请

US20050222947A1 Lender and insurer transaction processing system and method 审中-公开
标题翻译：贷款人和保险人交易处理系统和方法
公开(公告)号：US20050222947A1
公开(公告)日：2005-10-06
申请号：US11129480
申请日：2005-05-16
申请人： John Regan
发明人： John Regan
IPC分类号： G06Q40/00 , G06F17/60
CPC分类号： G06Q40/02 , G06Q20/10 , G06Q40/00 , G06Q40/025
摘要： A system and method for transaction processing includes a central repository of transaction information which can be accessed by a variety of participants who may be located over a wide geographic area in the recovery process of a property unit such as a vehicle or other collateral. Interfacing with a variety of computer systems over a communication network, such as the Internet, allows interchange of data relating to the recovery process and centralized coordination of the recovery process.
摘要翻译：用于交易处理的系统和方法包括交易信息的中央存储库，其可以由可能位于诸如车辆或其他抵押品的财产单元的恢复过程中的广泛地理区域的各种参与者访问。通过诸如因特网的通信网络与各种计算机系统进行接口，允许与恢复过程相关的数据和恢复过程的集中协调的交换。

10. 发明授权

US4358085A Keying means for segmented end ring blowout preventer 失效
标题翻译：用于分段端环防喷器的键控手段
公开(公告)号：US4358085A
公开(公告)日：1982-11-09
申请号：US285677
申请日：1981-07-20
申请人： John Regan , Bruce J. Watkins
发明人： John Regan , Bruce J. Watkins
IPC分类号： E21B33/06 , F16J15/46
CPC分类号： F16J15/46 , E21B33/06
摘要： An improvement in blowout preventer apparatus of the type having a radially compressible annular packing mounted within a housing chamber, the housing having axially aligned upper and lower conical bores communicating with an inner bore of the annular packing, the packing axially expanding towards said upper and lower bores upon said radial compression, a plurality of rigid end ring segments attached to sectored webs of the ends of the packing and thereby individually movable axially outwardly and radially inwardly relative to the upper and lower conical bores to control the packing axial expansion during radial compression of the packing has keying means cooperating with the rigid end ring segments of the packing and the conical bores for guiding a sector-wise movement of the segments in individually separate and predetermined paths along the conical bores to a common radial position independent of the uniformity of the packing radial compression and/or axial expansion. Exemplary keying means include a key member provided in a slot in the packing end ring segment and a mating keyway in the conical bore.
摘要翻译：具有安装在容纳室内的可径向压缩的环形填料的类型的防喷器装置的改进，所述壳体具有与环形填料的内孔连通的轴向对准的上和下锥形孔，所述填料沿着所述上部和下部轴向膨胀在所述径向压缩时开孔，多个刚性端环段连接到衬垫的端部的分段腹板，从而相对于上和下锥形孔单独地轴向向外和径向向内移动，以在径向压缩期间控制衬垫轴向膨胀密封件具有与密封件的刚性端环段和锥形孔配合的键合装置，用于沿着锥形孔沿独立且预定的路径将段的扇形运动引导到公共径向位置，而与包装径向压缩和/或轴向膨胀。示例性的键控装置包括设置在包装端环段中的槽中的键构件和锥形孔中的配合键槽。

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