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1. 发明申请

US20050038069A1 Substituted azabicyclic compounds 失效
标题翻译：取代的氮杂双环化合物
公开(公告)号：US20050038069A1
公开(公告)日：2005-02-17
申请号：US10933077
申请日：2004-09-01
申请人： Paul Cox , Shelley Bower , David Aldous , Peter Astles , Daniel McGarry , Christopher Hulme , John Regan , Fu-Chih Huang , Stevan Djuric , Kevin Moriarty , Rose Mathew , Gregory Poli
发明人： Paul Cox , Shelley Bower , David Aldous , Peter Astles , Daniel McGarry , Christopher Hulme , John Regan , Fu-Chih Huang , Stevan Djuric , Kevin Moriarty , Rose Mathew , Gregory Poli
IPC分类号： C07D235/08 , A61K31/00 , A61K31/40 , A61K31/403 , A61K31/404 , A61K31/41 , A61K31/415 , A61K31/4164 , A61K31/4184 , A61K31/4196 , A61K31/42 , A61K31/422 , A61K31/44 , A61K31/4427 , A61K31/443 , A61K31/4433 , A61K31/4439 , A61K31/47 , A61K31/4709 , A61K31/496 , A61K31/505 , A61K31/506 , A61K31/535 , A61K31/5355 , A61K31/5375 , A61K31/5377 , A61P9/00 , A61P11/00 , A61P17/00 , A61P25/04 , A61P29/00 , A61P35/00 , A61P37/00 , A61P43/00 , C07D209/08 , C07D209/12 , C07D209/42 , C07D235/12 , C07D235/24 , C07D401/06 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/12 , C07D405/14 , C07D409/14 , C07D413/12 , C07D413/14 , C07D417/14 , C07D217/12
CPC分类号： C07D235/24 , C07D209/12 , C07D209/42 , C07D401/06 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/12 , C07D405/14 , C07D409/14 , C07D413/12 , C07D413/14 , C07D417/14
摘要： This invention is directed to physiologically active compounds of formula (I) wherein represents a bicyclic ring system, of about 10 to about 13 ring members, in which the ring is an azaheterocycle, and the ring represents an azaheteroaryl ring, or an optionally halo substituted benzene ring; R1 represents hydrogen or a straight- or branched-chain alkyl group of 1 to about 4 carbon atoms, optionally substituted by hydroxy or one or more halogen atoms, or when Z1 represents a direct bond R1 may also represent a lower alkenyl or lower alkynyl group, or a formyl group; R2 represents hydrogen, alkenyl, alkoxy, alkyl, alkylsulphinyl, alkylsulphonyl, alkylthio, aryl, arylalkyloxy, arylalkylsulphinyl, arylalkylsulphonyl, arylalkylthio, aryloxy, arylsulphinyl, arylsulphonyl, arylthio, cyano, cycloalkenyl, cycloalkenyloxy, cycloalkyl, cycloalkyloxy, heteroaryl, heteroarylalkyloxy, heteroaryloxy, hydroxy, —SO2NR4R5, —NR4SO2R5, —NR4R5, —C(═O)R5, —C(═O)C(═O)R5, —C(═O)NR4R5, —C(═O)OR5, —O(C═O)NR4R5, or —NR4C(═O)R5; R3 represents —C(=Z)—N(R7)R6, —C(=Z)—CHR12R6, —C(=Z)—R6, —CR8═C(R9)(CH2)p—R6, —C(R10)═C(R11)R12, —C(R13)(R10)C(R11)(R14)R12, —C(R8)(R15)CH(R9)(CH2)p—R6, —R6, —N(R16)C(=Z)R6, —C(R17)═N—OC(=0)R18, —C(═O)—N(R19)OR20, —C≡C—R6, —CH2—C(=Z)—R6, —C(=Z)—C(=Z)R6, —CH2—NHR6, —CH2-ZR6, —CH2—SOR6, —CH2—SO2R6, —CF2—OR6, —NH—CH2R6, -Z-CH2R6, —SO—CH2R6, —SO2—CH2R6, —O—CF2R6, —O—C(=Z)R6, —N═N—R6, —NH—SO2R6, —SO2—NR21R22, —CZ-CZ-NHR6, —NH—CO—OR6, —O—CO—NHR6, —NH—CO—NHR6, —R23, —CX1═CX2R6, —C(═NOR24), —(CH2)qR6, —CH2—CO—NH(CH2)qR6, —CH2—NH—CO(CH2)qR6, —CH2—CO—CH2R6, —C(═NR25)—NH(CH2)qR6, —C(X3)═N—(CH2)qR6 or —CH(X4)—CH2R6; A1 represents a direct bond, or a straight or branched C1-6 alkylene chain optionally substituted by hydroxyl, alkoxy, oxo, cycloalkyl, aryl or heteroaryl, or A1 represents a straight or branched C2-6alkenylene or C2-6alkynylene chain; Z1 represents a direct bond, an oxygen or sulphur atom or NH; n and m each represent zero or 1, provided that n is 1 when m is zero and n is zero when m is 1; and N-oxides thereof, and their prodrugs, and pharmaceutically acceptable salts and solvates of the compounds of formula (I) and N-oxides thereof, and their prodrugs. Such compounds inhibit the production or physiological effects of TNF and inhibit cyclic AMP phosphodiesterase. The invention is also directed to pharmaceutical compositions comprising compounds of formula (I), their pharmaceutical use and methods for their preparation.
摘要翻译：本发明涉及式（I）的生理活性化合物，其中代表双环体系，约10至约13个环成员，其中该环是氮杂环，并且该环代表氮杂杂芳基环，或任选地被卤素取代苯环; R 1表示氢或1至约4个碳原子的直链或支链烷基，任选被羟基或一个或多个卤素原子取代，或当Z 1表示直接键R 1时也代表低级烯基或低级炔基或甲酰基; R 2表示氢，烯基，烷氧基，烷基，烷基亚磺酰基，烷基磺酰基，烷硫基，芳基，芳基烷氧基，芳基烷基亚磺酰基，芳基烷基磺酰基，芳基烷硫基，芳氧基，芳基亚磺酰基，芳基磺酰基，芳硫基，氰基，环烯基，环烯氧基，环烷基，环烷氧基，杂芳基，，杂芳氧基，羟基，-SO 2 NR 4 R 5，-NR 4 SO 2 R 5，-NR 4 R 5，-C（= O）R 5，-C（= O）C（= O）R 5，-C（= O）NR 4 R 5，-C（= O）OR 5，-O（C = O）NR 4 R 5或-NR 4 C（= O）R 5; R 3表示-C（= Z）-N（R 7）R 6，-C（= Z）-CHR 12 R 6，-C（= Z）-R 6 ，-CR 8 = C（R 9）（CH 2）p R 6，-C（R 10）= C（R 11）R 12，-C（R 13）（R 10）C（R 11）（R 14）R 12，-C（R 8）（R 15）CH（R 9）（CH 2） pR 6，-R 6，-N（R 16）C（= Z）R 6，-C（R 17）= N-OC（= O）R 18， -C（= O）-N（R <19）

2. 发明授权

US06473657B1 Adaptive motion controller 失效
标题翻译：自适应运动控制器
公开(公告)号：US06473657B1
公开(公告)日：2002-10-29
申请号：US09558021
申请日：2000-04-25
申请人： Kevin Moriarty
发明人： Kevin Moriarty
IPC分类号： G05B1302
CPC分类号： G05B19/19 , G05B13/024 , G05B2219/41002 , G05B2219/41028 , G05B2219/42177 , H02P23/0077 , Y10S388/911
摘要： An adaptive motion controller for driving a servo motor. The adaptive motion controller has an amplifier including a voltage command which can be set at a voltage at which the amplifier will be operated, a frequency selector which can be set at a frequency at which the amplifier will be operated, a power supply having a current feedback, and a control for driving the servo motor in a test mode wherein the voltage command is set at a selected voltage, and the frequency selector is sequentially set with a series of different frequencies. The servo motor is operated at each frequency, and the frequency of the series of frequencies that has the lowest current feedback is determined and the frequency selector is set at that frequency when the amplifier is operated to drive the servo motor.
摘要翻译：一种用于驱动伺服电机的自适应运动控制器。自适应运动控制器具有放大器，该放大器包括可以设置在放大器将被操作的电压的电压指令，可以设置在放大器将被操作的频率的频率选择器，具有电流的电源反馈，以及在电压指令被设定为选定电压的测试模式下驱动伺服电动机的控制，并且频率选择器依次设置有一系列不同的频率。伺服电机在每个频率下工作，确定具有最低电流反馈的一系列频率的频率，并且当驱动放大器驱动伺服电机时，频率选择器被设置为该频率。

3. 发明申请

US20050203158A1 Substituted benzimidazole compounds 有权
标题翻译：取代的苯并咪唑化合物
公开(公告)号：US20050203158A1
公开(公告)日：2005-09-15
申请号：US10632888
申请日：2003-08-01
申请人： Joerg Bentzien , Brian Cook , Charles Cywin , Roman Fleck , Ho Lo , Peter Nemoto , Steven Pullen , Gregory Roth , Roger Snow , Hidenori Takahashi , Ji Wang , Kevin Moriarty , Lei Qiao , Michael Winters
发明人： Joerg Bentzien , Brian Cook , Charles Cywin , Roman Fleck , Ho Lo , Peter Nemoto , Steven Pullen , Gregory Roth , Roger Snow , Hidenori Takahashi , Ji Wang , Kevin Moriarty , Lei Qiao , Michael Winters
IPC分类号： A61K31/4184 , A61K39/00 , A61P1/04 , A61P3/10 , A61P11/00 , A61P11/06 , A61P11/08 , A61P17/00 , A61P17/06 , A61P25/00 , A61P27/02 , A61P27/16 , A61P29/00 , A61P35/00 , A61P37/02 , A61P37/08 , A61P43/00 , C07D235/28 , C07D235/30 , C07D409/12 , C07D43/02
CPC分类号： C07D409/12 , C07D235/30
摘要： Disclosed are substituted benzimidazole compounds of formula (I): wherein R1, R2, R3, R4 and Xa are defined herein. The compounds of the invention inhibit Itk kinase and are therefore useful for treating diseases and pathological conditions involving inflammation, immunological disorders and allergic disorders. Also disclosed are processes for preparing these compounds and to pharmaceutical compositions comprising these compounds.
摘要翻译：公开了式（I）的取代的苯并咪唑化合物：其中R 1，R 2，R 3，R 4， >和X > 。本发明的化合物抑制Itk激酶，因此可用于治疗涉及炎症，免疫学障碍和过敏性疾病的疾病和病理状况。还公开了制备这些化合物的方法和包含这些化合物的药物组合物。

4. 发明申请

US20050251178A1 Hooked rod delivery system for use in minimally invasive surgery 审中-公开
标题翻译：用于微创手术的钩杆输送系统
公开(公告)号：US20050251178A1
公开(公告)日：2005-11-10
申请号：US11119649
申请日：2005-05-02
申请人： Michael Tirabassi , Kevin Moriarty , Richard Wait
发明人： Michael Tirabassi , Kevin Moriarty , Richard Wait
IPC分类号： A61B17/04 , A61B17/06 , A61B17/064 , A61B17/08 , A61B17/11 , A61B17/12
CPC分类号： A61B17/11 , A61B17/0469 , A61B17/06 , A61B17/062 , A61B17/064 , A61B17/0644 , A61B2017/1107 , A61B2017/1135
摘要： A delivery system for use in minimally invasive surgery that is made up of a substantially cylindrical hollow sleeve and a hooked deployment rod adapted to slide within the hollow sleeve is provided. The inventive delivery system serves to protect and pass anastomotic devices such as self-closing surgical devices (e.g., self-closing surgical clip assemblies) through laparoscopic and thoracoscopic parts. The subject invention also provides a method for protecting and passing such anastomotic devices through laparoscopic and thoracoscopic parts and for precisely delivering these devices to operating or surgical sites.
摘要翻译：提供了一种用于微创手术的输送系统，其由基本上圆柱形的中空套筒和适于在中空套筒内滑动的钩状展开杆组成。本发明的递送系统用于通过腹腔镜和胸腔镜部分保护和传递诸如自闭合手术装置（例如，自闭合手术夹子组件）的吻合装置。本发明还提供了一种用于通过腹腔镜和胸腔镜部件保护和传递这样的吻合装置并且将这些装置精确地递送到手术或手术部位的方法。

5. 发明申请

US20050239770A1 N-heterocyclic inhibitors of TNF-alpha expression 有权
标题翻译： TNF-α表达的N-杂环抑制剂
公开(公告)号：US20050239770A1
公开(公告)日：2005-10-27
申请号：US11143430
申请日：2005-06-02
申请人： Kevin Moriarty , Yvonne Shimshock , Gulzar Ahmed , Junjun Wu , James Wen , Wei Li , Shawn Erickson , Jeffrey Letourneau , Edward McDonald , Katerina Leftheris , Stephen Wrobleski , Zahid Hussain , Ian Henderson , Axel Metzger , John Baldwin , Alaric Dyckman
发明人： Kevin Moriarty , Yvonne Shimshock , Gulzar Ahmed , Junjun Wu , James Wen , Wei Li , Shawn Erickson , Jeffrey Letourneau , Edward McDonald , Katerina Leftheris , Stephen Wrobleski , Zahid Hussain , Ian Henderson , Axel Metzger , John Baldwin , Alaric Dyckman
IPC分类号： A61K31/40 , A61K31/551 , C07D251/52 , C07D251/54 , C07D401/04 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/12 , C07D403/14 , C07D405/14 , C07D521/00
CPC分类号： C07D251/52 , C07D231/12 , C07D233/56 , C07D249/08 , C07D251/48 , C07D251/54 , C07D401/04 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/12 , C07D403/14 , C07D405/14 , C07D409/14 , C07D413/14 , C07D417/14
摘要： N-heterocyclic compounds that block cytokine production via inhibition of p38 kinase are disclosed. In one embodiment, compounds of the present invention are represented by Formula I: Methods of production, pharmaceutical compositions and methods of treating conditions associated with inappropriate p38 kinase activity or TNF-α expression utilizing compounds of the present invention are also disclosed.
摘要翻译：公开了通过抑制p38激酶阻断细胞因子产生的N-杂环化合物。在一个实施方案中，本发明的化合物由式I表示：还公开了使用本发明化合物的生产方法，药物组合物和治疗与不适当的p38激酶活性或TNF-α表达相关的病症的方法。

6. 发明申请

US20050176792A1 Ketone substituted benzimidazole compounds 审中-公开
标题翻译：酮取代的苯并咪唑化合物
公开(公告)号：US20050176792A1
公开(公告)日：2005-08-11
申请号：US11035876
申请日：2005-01-07
申请人： Kevin Moriarty , Lei Qiao , Gregory Roth
发明人： Kevin Moriarty , Lei Qiao , Gregory Roth
IPC分类号： A61K31/4184 , A61K31/42 , C07D235/30 , C07D413/02 , C07D45/02
CPC分类号： C07D235/30
摘要： Disclosed are ketone substituted benzimidazole compounds of formula(I): wherein R1, R2, R3, R4 and Xa are defined herein. The compounds of the invention inhibit Itk kinase and are therefore useful for treating diseases and pathological conditions involving inflammation, immunological disorders and allergic disorders. Also disclosed are processes for preparing these compounds and to pharmaceutical compositions comprising these compounds.
摘要翻译：公开了式（I）的酮取代的苯并咪唑化合物：其中R 1，R 2，R 3，R 4， SUB＆gt;和X＆lt; a＆gt;在本文中定义。本发明的化合物抑制Itk激酶，因此可用于治疗涉及炎症，免疫学障碍和过敏性疾病的疾病和病理状况。还公开了制备这些化合物的方法和包含这些化合物的药物组合物。

7. 发明授权

US5818190A Programmable electronic clutch for I.S. machine 失效
标题翻译：可编程电子离合器机
公开(公告)号：US5818190A
公开(公告)日：1998-10-06
申请号：US857840
申请日：1997-05-16
申请人： Timothy J. Liska , Kevin Moriarty , Joseph F. Ferrigno , George Jay Collins
发明人： Timothy J. Liska , Kevin Moriarty , Joseph F. Ferrigno , George Jay Collins
IPC分类号： C03B35/10 , B23Q7/06 , C03B9/41 , C03B9/453 , G05B19/416 , G05B11/01
CPC分类号： G05B19/416 , B23Q7/06 , C03B9/41 , C03B9/453 , G05B2219/34189 , G05B2219/37103 , G05B2219/41259
摘要： A pusher mechanism comprising a finger assembly, an upper cylinder including a shaft secured to the finger assembly for displacing the finger assembly between retracted and extended positions, housing means supporting the upper cylinder for pivotal displacement, means for pivotally displacing the upper cylinder from a start location to an end location when the finger assembly is extended including a servomotor, a control including profile generating means for generating a profile having a plurality of constant acceleration segments beginning at selected locations and an amplifier for receiving the profile and for driving the servomotor in response thereto, dynamic electronic clutch means for stopping the servomotor to prevent damage to the pusher mechanism when the pivotal displacement of the upper cylinder to the end location is prevented including the amplifier including means for generating a motor current signal, limit logic means including a corresponding plurality of selected constant current limits corresponding to the plurality of constant acceleration segments and logic means for outputting the constant current limit corresponding to a constant acceleration segment when the finger assembly is located at the start location of the segment, means for supplying the logic means with location data for the finger assembly as the extended finger assembly is displaced from the start location to the end location, comparator means for comparing the current limit signal and the motor current signal and for generating a servomotor stop signal in the event that the motor current signal exceeds the current limit signal, and the amplifier further comprising means for receiving the servomotor stop signal and for stopping the servomotor.
摘要翻译：一种推动器机构，包括指状物组件，上部圆柱体，其包括固定到指状组件的轴，用于在缩回位置和伸出位置之间移动指状物组件;支撑上部气缸以枢转位移的壳体装置，用于将上部气缸从起始点当手指组件被延伸的位置到包括伺服电动机的端部位置的控制器，包括轮廓生成装置的控制器，用于产生具有从选定位置开始的多个恒定加速度段的轮廓，以及用于接收轮廓并用于响应于驱动伺服电动机的放大器动力电子离合器装置，用于当上述汽缸与端部位置的转动位移被阻止时，停止伺服电动机以防止损坏推进机构，该放大器包括用于产生电动机电流信号的装置，包括对应的多个的选择对应于多个恒定加速段的稳定电流极限和用于当手指组件位于段的开始位置时输出对应于恒定加速度段的恒定电流极限的逻辑装置，用于向逻辑装置提供位置数据的装置作为伸出的手指组件的手指组件从起始位置移动到结束位置，比较器装置用于比较电流限制信号和电动机电流信号，并且在电动机电流信号超过电流的情况下产生伺服电动机停止信号并且所述放大器还包括用于接收所述伺服电机停止信号并停止所述伺服电动机的装置。

8. 发明申请

US20090078004A1 Control for I. S. machine 审中-公开
标题翻译：控制机器
公开(公告)号：US20090078004A1
公开(公告)日：2009-03-26
申请号：US11903248
申请日：2007-09-20
申请人： John P. Moriarty , Kevin Moriarty
发明人： John P. Moriarty , Kevin Moriarty
IPC分类号： C03B9/41
CPC分类号： C03B9/41
摘要： An I. S. Machine has a plurality of sections each of which has a controller located with the blank side operator interface which receives a sync signal from a machine control and data from a machine data server. The controller operates the section in accordance with a number of cycles commanded by an operator via blank and blow side interfaces.
摘要翻译：机器具有多个部分，每个部分具有位于空白侧操作者界面的控制器，其接收来自机器控制的同步信号和来自机器数据服务器的数据。控制器根据操作员通过空白和吹风侧接口指令的循环次数操作该部分。

9. 发明申请

US20070054909A1 VLA-4 inhibitor compounds 审中-公开
公开(公告)号：US20070054909A1
公开(公告)日：2007-03-08
申请号：US11594432
申请日：2006-11-08
申请人： John Baldwin , Edward McDonald , Kevin Moriarty , Christopher Sarko , Nobuo Machinaga , Atsushi Nakayama , Jun Chiba , Shin Iimura , Yoshiyuki Yoneda
发明人： John Baldwin , Edward McDonald , Kevin Moriarty , Christopher Sarko , Nobuo Machinaga , Atsushi Nakayama , Jun Chiba , Shin Iimura , Yoshiyuki Yoneda
IPC分类号： A61K31/5375 , A61K31/496 , A61K31/4439 , A61K31/426 , A61K31/401 , A61K31/405 , C07D403/02
CPC分类号： C07D207/08 , C07C275/42 , C07C2601/02 , C07D207/09 , C07D207/12 , C07D207/14 , C07D207/16 , C07D207/22 , C07D207/24 , C07D209/12 , C07D211/26 , C07D211/34 , C07D211/38 , C07D213/55 , C07D217/02 , C07D277/04 , C07D277/28 , C07D277/48 , C07D295/13 , C07D295/185 , C07D307/33 , C07D311/20 , C07D401/06 , C07D401/12 , C07D401/14 , C07D403/02 , C07D413/06 , C07D491/04
摘要： Compounds that selectively inhibit the binding of ligands to α4β1 integrin (VLA-4) and methods for their preparation are disclosed. In one embodiment, compounds of the invention are represented by Formula I: As selective inhibitors of VLA-4 mediated cell adhesion, compounds of the present invention are useful in the treatment of conditions associated with such adhesion, including, but not limited to, such conditions as inflammatory and autoimmune responses, diabetes, asthma, psoriasis, inflammatory bowel disease, transplantation rejection, and tumor metastasis. Also disclosed are methods of inhibiting VLA-4 mediated cell adhesion and methods of treating conditions associated with LA-4 mediated cell adhesion.

10. 发明授权

US5798626A Servo motor control 失效
标题翻译：伺服电机控制
公开(公告)号：US5798626A
公开(公告)日：1998-08-25
申请号：US694883
申请日：1996-08-09
申请人： Timothy J. Liska , Kevin Moriarty , Joseph T. Ferrigno
发明人： Timothy J. Liska , Kevin Moriarty , Joseph T. Ferrigno
IPC分类号： G05B19/18 , G05B19/07 , G05B19/4155 , G05B19/416 , H02P8/00 , H02P29/00 , G05B11/32
CPC分类号： G05B19/416 , G05B19/075 , G05B2219/36513 , G05B2219/43162
摘要： An amplifier circuit which communicates over a two way bus with a CPU having a profile generating computer for defining at least one profile and which supplies a control signal to a motor. The amplifier circuit has a profile generating computer for generating at least one profile which has been downloaded from the CPU and a motor controller for receiving the profile and for issuing a control signal for the motor.
摘要翻译：一种放大器电路，其通过双向总线与具有配置文件生成计算机的CPU通信，用于定义至少一个配置文件，并向电动机提供控制信号。放大器电路具有用于生成从CPU下载的至少一个配置文件和用于接收配置文件的电动机控制器以及用于发出用于电动机的控制信号的配置文件生成计算机。

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