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1. 发明申请

US20070168034A1 Prosthetic intervertebral discs having stiff end plates and a compressible polymeric core 有权
标题翻译：具有刚性端板和可压缩聚合物芯的假体椎间盘
公开(公告)号：US20070168034A1
公开(公告)日：2007-07-19
申请号：US11528100
申请日：2006-09-27
申请人： Daniel Kim , Kunwoo Lee , Curtis Frank , Sung Ha
发明人： Daniel Kim , Kunwoo Lee , Curtis Frank , Sung Ha
IPC分类号： A61F2/44
CPC分类号： A61F2/4425 , A61B17/86 , A61F2/30742 , A61F2/30767 , A61F2/30965 , A61F2/442 , A61F2/4611 , A61F2002/30069 , A61F2002/30133 , A61F2002/30383 , A61F2002/30462 , A61F2002/305 , A61F2002/3052 , A61F2002/30523 , A61F2002/30563 , A61F2002/30566 , A61F2002/30578 , A61F2002/30596 , A61F2002/30604 , A61F2002/30733 , A61F2002/30841 , A61F2002/30884 , A61F2002/30904 , A61F2002/448 , A61F2002/4495 , A61F2002/4622 , A61F2002/4627 , A61F2002/4628 , A61F2220/0025 , A61F2220/0075 , A61F2230/0015 , A61F2310/00017 , A61F2310/00023 , A61F2310/00029 , A61F2310/00161 , A61F2310/00179 , A61L2430/38
摘要： A prosthetic intervertebral disc and methods for using the same are provided. The subject prosthetic discs are characterized by including top and bottom endplates separated by a fibrous compressible element that includes an annular region and a nuclear region. The two plates are held together at least one fiber wound around at least one region of the top endplate and at least one region of the bottom endplate. The subject discs may be employed with separate vertebral body fixation elements, or they may include integrated vertebral body fixation elements. Also provided are kits and systems that include the subject prosthetic discs.
摘要翻译：提供假体椎间盘及其使用方法。主体假体盘的特征在于包括由包括环形区域和核区域的纤维状可压缩元件分开的顶端和底端板。两个板保持在至少一根纤维上，该纤维缠绕在顶端板的至少一个区域和底端板的至少一个区域中。受试盘可以与独立的椎体固定元件一起使用，或者它们可以包括集成的椎体固定元件。还提供了包括主题假体盘的套件和系统。

2. 发明申请

US20050027364A1 Prosthetic intervertebral disc and methods for using the same 有权
标题翻译：假体椎间盘及其使用方法
公开(公告)号：US20050027364A1
公开(公告)日：2005-02-03
申请号：US10632538
申请日：2003-08-01
申请人： Daniel Kim , Kunwoo Lee , Curtis Frank , Sung Ha
发明人： Daniel Kim , Kunwoo Lee , Curtis Frank , Sung Ha
IPC分类号： A61B17/86 , A61F2/00 , A61F2/30 , A61F2/44 , A61F2/46
CPC分类号： A61F2/4425 , A61B17/86 , A61F2/30742 , A61F2/30767 , A61F2/30965 , A61F2/442 , A61F2/4611 , A61F2002/30069 , A61F2002/30133 , A61F2002/30383 , A61F2002/30462 , A61F2002/305 , A61F2002/3052 , A61F2002/30523 , A61F2002/30563 , A61F2002/30566 , A61F2002/30578 , A61F2002/30596 , A61F2002/30604 , A61F2002/30733 , A61F2002/30841 , A61F2002/30884 , A61F2002/30904 , A61F2002/448 , A61F2002/4495 , A61F2002/4622 , A61F2002/4627 , A61F2002/4628 , A61F2220/0025 , A61F2220/0075 , A61F2230/0015 , A61F2310/00017 , A61F2310/00023 , A61F2310/00029 , A61F2310/00161 , A61F2310/00179 , A61L2430/38
摘要： A prosthetic intervertebral disc and methods for using the same are provided. The subject prosthetic discs are characterized by including top and bottom endplates separated by a fibrous compressible element that includes an annular region and a nuclear region. The two plates are held together at least one fiber wound around at least one region of the top endplate and at least one region of the bottom endplate. The subject discs may be employed with separate vertebral body fixation elements, or they may include integrated vertebral body fixation elements. Also provided are kits and systems that include the subject prosthetic discs.
摘要翻译：提供假体椎间盘及其使用方法。主体假体盘的特征在于包括由包括环形区域和核区域的纤维状可压缩元件分开的顶端和底端板。两个板保持在至少一根纤维上，该纤维缠绕在顶端板的至少一个区域和底端板的至少一个区域中。受试盘可以与独立的椎体固定元件一起使用，或者它们可以包括集成的椎体固定元件。还提供了包括主题假体盘的套件和系统。

3. 发明申请

US20070168033A1 Prosthetic intervertebral discs having substantially rigid end plates and fibers between those end plates 审中-公开
标题翻译：假体椎间盘具有基本上刚性的端板和在这些端板之间的纤维
公开(公告)号：US20070168033A1
公开(公告)日：2007-07-19
申请号：US11527804
申请日：2006-09-26
申请人： Daniel Kim , Thomas Afzal , Michael Reo , Uriel Chee , In Cho , Kunwoo Lee , Curtis Frank , Sung Kyu Ha
发明人： Daniel Kim , Thomas Afzal , Michael Reo , Uriel Chee , In Cho , Kunwoo Lee , Curtis Frank , Sung Kyu Ha
IPC分类号： A61F2/44
CPC分类号： A61F2/4425 , A61B17/86 , A61F2/30742 , A61F2/30767 , A61F2/30965 , A61F2/442 , A61F2/4611 , A61F2002/30069 , A61F2002/30133 , A61F2002/30383 , A61F2002/30462 , A61F2002/305 , A61F2002/3052 , A61F2002/30523 , A61F2002/30563 , A61F2002/30566 , A61F2002/30578 , A61F2002/30596 , A61F2002/30604 , A61F2002/30733 , A61F2002/30841 , A61F2002/30884 , A61F2002/30904 , A61F2002/448 , A61F2002/4495 , A61F2002/4622 , A61F2002/4627 , A61F2002/4628 , A61F2220/0025 , A61F2220/0075 , A61F2230/0015 , A61F2310/00017 , A61F2310/00023 , A61F2310/00029 , A61F2310/00161 , A61F2310/00179 , A61L2430/38
摘要： Prosthetic intervertebral discs and methods for using the same are described. The subject prosthetic discs include upper and lower endplates separated by a compressible core member. The prosthetic discs described herein include one-piece, two-piece, three-piece, and four-piece structures. The subject prosthetic discs exhibit stiffness in the vertical direction, torsional stiffness, bending stiffness in the saggital plane, and bending stiffness in the front plane, where the degree of these features can be controlled independently by adjusting the components of the discs. The interface mechanism between the endplates and the core members of several embodiments of the described prosthetic discs enables a very easy surgical operation for implantation.
摘要翻译：描述了假体椎间盘及其使用方法。主体假体盘包括由可压缩的芯构件分开的上端板和下端板。本文所述的假体盘包括一件式，两件式，三件式和四件式结构。主体假体椎板在垂直方向上呈现刚度，扭转刚度，屈曲平面中的弯曲刚度和前平面中的弯曲刚度，其中可以通过调节椎间盘的部件来独立地控制这些特征的程度。所描述的假体盘的几个实施例的端板和芯构件之间的界面机构能够实现非常容易的用于植入的外科手术。

4. 发明申请

US20080103599A1 Prosthetic Intervertebral Discs Having Substantially Rigid End Plates and Fibers Between Those End Plates 有权
标题翻译：在这些端板之间具有基本刚性端板和纤维的假体椎间盘
公开(公告)号：US20080103599A1
公开(公告)日：2008-05-01
申请号：US11968183
申请日：2008-01-01
申请人： Daniel Kim , Thomas Afzal , Michael Reo , Uriel Chee , In Cho , Kunwoo Lee , Curtis Frank , Sung Kyu Ha
发明人： Daniel Kim , Thomas Afzal , Michael Reo , Uriel Chee , In Cho , Kunwoo Lee , Curtis Frank , Sung Kyu Ha
IPC分类号： A61F2/44
CPC分类号： A61F2/4425 , A61B17/86 , A61F2/30742 , A61F2/30767 , A61F2/30965 , A61F2/442 , A61F2/4611 , A61F2002/30069 , A61F2002/30133 , A61F2002/30383 , A61F2002/30462 , A61F2002/305 , A61F2002/3052 , A61F2002/30523 , A61F2002/30563 , A61F2002/30566 , A61F2002/30578 , A61F2002/30596 , A61F2002/30604 , A61F2002/30733 , A61F2002/30841 , A61F2002/30884 , A61F2002/30904 , A61F2002/448 , A61F2002/4495 , A61F2002/4622 , A61F2002/4627 , A61F2002/4628 , A61F2220/0025 , A61F2220/0075 , A61F2230/0015 , A61F2310/00017 , A61F2310/00023 , A61F2310/00029 , A61F2310/00161 , A61F2310/00179 , A61L2430/38
摘要： Prosthetic intervertebral discs and methods for using the same are described. The subject prosthetic discs include upper and lower endplates separated by a compressible core member. The prosthetic discs described herein include one-piece, two-piece, three-piece, and four-piece structures. The subject prosthetic discs exhibit stiffness in the vertical direction, torsional stiffness, bending stiffness in the sagittal plane, and bending stiffness in the front plane, where the degree of these features can be controlled independently by adjusting the components of the discs. The interface mechanism between the endplates and the core members of several embodiments of the described prosthetic discs enables a very easy surgical operation for implantation.
摘要翻译：描述了假体椎间盘及其使用方法。主体假体盘包括由可压缩的芯构件分开的上端板和下端板。本文所述的假体盘包括一件式，两件式，三件式和四件式结构。主体假体椎板在垂直方向上呈现刚度，扭转刚度，矢状平面中的弯曲刚度和前平面中的弯曲刚度，其中可以通过调节椎间盘的部件来独立地控制这些特征的程度。所描述的假体盘的几个实施例的端板和芯构件之间的界面机构能够实现非常容易的用于植入的外科手术。

5. 发明申请

US20050228500A1 Prosthetic intervertebral disc and methods for using same 有权
标题翻译：假体椎间盘及其使用方法
公开(公告)号：US20050228500A1
公开(公告)日：2005-10-13
申请号：US10903276
申请日：2004-07-30
申请人： Daniel Kim , Thomas Afzal , Michael Reo , Uriel Chee , In Cho , Kunwoo Lee , Curtis Frank , Sung Kyu Ha
发明人： Daniel Kim , Thomas Afzal , Michael Reo , Uriel Chee , In Cho , Kunwoo Lee , Curtis Frank , Sung Kyu Ha
IPC分类号： A61B17/86 , A61F2/00 , A61F2/30 , A61F2/44 , A61F2/46 , A61B17/88 , A61B17/16
CPC分类号： A61F2/4425 , A61B17/86 , A61F2/30742 , A61F2/30767 , A61F2/30965 , A61F2/442 , A61F2/4611 , A61F2002/30069 , A61F2002/30133 , A61F2002/30383 , A61F2002/30462 , A61F2002/305 , A61F2002/3052 , A61F2002/30523 , A61F2002/30563 , A61F2002/30566 , A61F2002/30578 , A61F2002/30596 , A61F2002/30604 , A61F2002/30733 , A61F2002/30841 , A61F2002/30884 , A61F2002/30904 , A61F2002/448 , A61F2002/4495 , A61F2002/4622 , A61F2002/4627 , A61F2002/4628 , A61F2220/0025 , A61F2220/0075 , A61F2230/0015 , A61F2310/00017 , A61F2310/00023 , A61F2310/00029 , A61F2310/00161 , A61F2310/00179 , A61L2430/38
摘要： Prosthetic intervertebral discs and methods for using the same are described. The subject prosthetic discs include upper and lower endplates separated by a compressible core member. The prosthetic discs described herein include one-piece, two-piece, three-piece, and four-piece structures. The subject prosthetic discs exhibit stiffness in the vertical direction, torsional stiffness, bending stiffness in the saggital plane, and bending stiffness in the front plane, where the degree of these features can be controlled independently by adjusting the components of the discs. The interface mechanism between the endplates and the core members of several embodiments of the described prosthetic discs enables a very easy surgical operation for implantation.
摘要翻译：描述了假体椎间盘及其使用方法。主体假体盘包括由可压缩的芯构件分开的上端板和下端板。本文所述的假体盘包括一件式，两件式，三件式和四件式结构。主体假体椎板在垂直方向上呈现刚度，扭转刚度，屈曲平面中的弯曲刚度和前平面中的弯曲刚度，其中可以通过调节椎间盘的部件来独立地控制这些特征的程度。所描述的假体盘的几个实施例的端板和芯构件之间的界面机构能够实现非常容易的用于植入的外科手术。

6. 发明申请

US20070005140A1 Fabrication and use of biocompatible materials for treating and repairing herniated spinal discs 审中-公开
标题翻译：生物相容性材料的制造和使用，用于治疗和修复脊髓狭窄
公开(公告)号：US20070005140A1
公开(公告)日：2007-01-04
申请号：US11359754
申请日：2006-02-21
申请人： Daniel Kim , Curtis Frank
发明人： Daniel Kim , Curtis Frank
IPC分类号： A61F2/44
CPC分类号： A61F2/442 , A61B17/7095 , A61B17/8836 , A61F2/441 , A61F2/4611 , A61F2002/0086 , A61F2002/009 , A61F2002/30032 , A61F2002/30062 , A61F2002/30075 , A61F2002/30224 , A61F2002/30235 , A61F2002/30583 , A61F2002/30588 , A61F2002/30601 , A61F2002/30677 , A61F2002/3092 , A61F2002/3093 , A61F2002/30932 , A61F2002/30971 , A61F2002/4435 , A61F2002/444 , A61F2002/4627 , A61F2002/4685 , A61F2210/0004 , A61F2210/0061 , A61F2210/0085 , A61F2230/0069 , A61F2250/003 , A61L27/18 , A61L27/56 , A61L2400/06 , A61L2430/38 , C08L75/04
摘要： The present invention involves the fabrication and use of biocompatible polymers that are injected percutaneously into the inner portion of a defective region of a spinal disc and swell or expand or subsequently cure in situ to form a disc nucleus prosthesis. The polymers may be synthetic or natural (e.g., collagen), and may be provided in forms including, but not limited to hydrogels, compressible foams, cords, balloons, etc. Subsequent to injection into a target space or void within the disc, one or more cell binding agents, growth factors, and/or drugs on or within the cured polymer then interact with the remaining portion of the disc to support tissue ingrowth and to achieve a higher probability of biological mimicking.
摘要翻译：本发明涉及生物相容性聚合物的制造和使用，所述生物相容性聚合物经皮注射到脊椎盘的缺陷区域的内部并膨胀或膨胀或随后在原位固化以形成椎间盘假体。聚合物可以是合成的或天然的（例如胶原），并且可以以包括但不限于水凝胶，可压缩泡沫，帘线，气球等的形式提供。在注入到盘中的目标空间或空隙之后，一个或更多的细胞粘附剂，生长因子和/或固化的聚合物上或之内的药物然后与盘的剩余部分相互作用以支持组织向内生长并且实现更高的生物模拟可能性。

7. 发明申请

US20060134672A1 Macromolecular arrays on polymeric brushes & methods for preparing the same 审中-公开
标题翻译：聚合物刷上的大分子阵列及其制备方法
公开(公告)号：US20060134672A1
公开(公告)日：2006-06-22
申请号：US11289897
申请日：2005-11-30
申请人： Ying Chang , Curtis Frank , Glenn McGall
发明人： Ying Chang , Curtis Frank , Glenn McGall
IPC分类号： C12Q1/68 , C08G63/91 , C12M1/34
CPC分类号： C07H21/00 , C07B2200/11 , C08F4/02 , C08F289/00 , C08F290/06 , C08L51/08 , C08L51/10 , C40B40/00 , G01N33/544
摘要： Polymeric brush substrates and methods for their preparation are provided. Methods are also provided for preparing macromolecular arrays on such polymeric brush substrates. Using polymeric brush substrates allows control over functional site density as well as wettability and porosity of the substrate. These polymeric brushes are useful in solid-phase synthesis of arrays of peptides, polynucleotides or small organic molecules.
摘要翻译：提供聚合物刷底物及其制备方法。还提供了用于在这种聚合物刷基底上制备高分子阵列的方法。使用聚合物刷基质可以控制基质的功能位点密度以及润湿性和孔隙率。这些聚合物刷可用于肽，多核苷酸或小有机分子阵列的固相合成。

8. 发明申请

US20070233240A1 Intraocular lens implant 审中-公开
标题翻译：人工晶状体植入物
公开(公告)号：US20070233240A1
公开(公告)日：2007-10-04
申请号：US11725190
申请日：2007-03-16
申请人： Curtis Frank , Christopher Ta , David Myung , Jaan Noolandi , Michael Carrasco , Won-Gun Koh
发明人： Curtis Frank , Christopher Ta , David Myung , Jaan Noolandi , Michael Carrasco , Won-Gun Koh
IPC分类号： A61F2/16
CPC分类号： A61K35/44 , A61F2/142 , A61F2/145 , A61L27/26 , A61L27/3804 , A61L27/3813 , A61L27/3839 , A61L27/52 , A61L27/54 , A61L2300/25 , A61L2300/252 , A61L2300/602 , A61L2430/16 , C12N5/0621 , C12N2533/30 , C08L33/08 , C08L71/02
摘要： The present invention provides a hydrogel-based intraocular lens (IOL) implant that can covalently attach to a lens capsule on implantation into an eye. The inventive IOL has a high refractive index, high elasticity, and is of a similar size to a naturally occurring lens. In addition, the IOL can be implanted in a smaller, dehydrated state, allowing the IOL to be placed in the lens capsule with a small incision (up to about 1/10 the volume of the IOL). Exposure to fluid can then initiate rapid swelling of the dried polymer to the shape and dimensions of a natural lens, with full occupation of the lens capsule. Upon equilibrium swelling, the IOL can then make contact with the inner aspect of the lens capsule and covalently bind to it. By this attachment process, the IOL may accommodate in a manner identical to that of the natural lens.
摘要翻译：本发明提供一种水凝胶型眼内透镜（IOL）植入物，其可以植入眼睛中共价连接到晶状体囊。本发明的IOL具有高折射率，高弹性，并且具有与天然存在的透镜相似的尺寸。此外，IOL可以植入较小的脱水状态，允许IOL以小切口（高达IOL体积的约1/10）放置在晶状体囊中。然后暴露于流体可以引发干燥的聚合物快速膨胀到天然晶状体的形状和尺寸，完全占据晶状体囊。在平衡肿胀时，IOL然后可以与镜片胶囊的内部部分接触并共价结合。通过该附接过程，IOL可以以与天然镜片相同的方式容纳。

9. 发明申请

US20070126982A1 Interpenetrating polymer network hydrogel contact lenses 有权
标题翻译：互穿聚合物网络水凝胶隐形眼镜
公开(公告)号：US20070126982A1
公开(公告)日：2007-06-07
申请号：US11636114
申请日：2006-12-07
申请人： David Myung , Jaan Noolandi , Christopher Ta , Curtis Frank
发明人： David Myung , Jaan Noolandi , Christopher Ta , Curtis Frank
IPC分类号： G02C7/04
CPC分类号： G02B1/043 , C08L51/08
摘要： The present invention provides interpenetrating polymer network hydrogels that have high oxygen permeability, strength, water content, and resistance to protein adsorption. The hydrogels include two interpenetrating polymer networks. The first polymer network is based on a hydrophilic telechelic macromonomer. The second polymer network is based on a hydrophilic monomer. The hydrophilic monomer is polymerized and cross-linked to form the second polymer network in the presence of the first polymer network. The telechelic macromonomer preferably has a molecular weight of between about 575 Da and about 20,000 Da. Mixtures of molecular weights may also be used. In a preferred embodiment, the hydrophilic telechelic macromonomer is PEG-diacrylate or PEG-dimethacrylate and the hydrophilic monomer is an acrylic-based monomer. The material is designed to serve as a contact lens.
摘要翻译：本发明提供了具有高透氧性，强度，含水量和耐蛋白质吸附性的互穿聚合物网状水凝胶。水凝胶包括两个互穿聚合物网络。第一个聚合物网络是基于亲水的遥爪大分子单体。第二聚合物网络基于亲水性单体。在第一聚合物网络的存在下，亲水单体聚合并交联以形成第二聚合物网络。遥爪大分子单体的分子量优选为约575Da至约20,000Da。也可以使用分子量的混合物。在优选的实施方案中，亲水遥爪大分子单体是PEG-二丙烯酸酯或PEG-二甲基丙烯酸酯，亲水性单体是丙烯酸类单体。该材料被设计成用作隐形眼镜。

10. 发明申请

US20060287721A1 Artificial cornea 审中-公开
标题翻译：人造角膜
公开(公告)号：US20060287721A1
公开(公告)日：2006-12-21
申请号：US11409218
申请日：2006-04-20
申请人： David Myung , Christopher Ta , Nabeel Farooqui , Curtis Frank , Won-Gun Koh , Jungmin Ko , Jaan Noolandi , Michael Carrasco
发明人： David Myung , Christopher Ta , Nabeel Farooqui , Curtis Frank , Won-Gun Koh , Jungmin Ko , Jaan Noolandi , Michael Carrasco
IPC分类号： A61F2/14
CPC分类号： A61F2/142 , A61F2/15 , A61K35/12
摘要： The present invention provides an artificial corneal implant having an optically clear central core and a porous, hydrophilic, biocompatible skirt peripheral to the central core. In one embodiment, the central core is made of an interpenetrating double network hydrogel and the skirt is made of poly(2-hydroxyethyl acrylate) (PHEA). In another embodiment, both the central core and the skirt are made of interpenetrating double network hydrogels. The artificial corneal implant may also have an interdiffusion zone in which the skirt component is interpenetrated with the core component, or vice versa. In a preferred embodiment, biomolecules are linked to the skirt, central core or both. These biomolecules may be any type of biomolecule, but are preferably biomolecules that support epithelial and/or fibroblast cell survival and growth. Preferably, the biomolecules are linked in a spatially selective manner. The present invention also provides a method of making an artificial corneal implant using photolithography.
摘要翻译：本发明提供了一种人造角膜植入物，其具有光学透明的中心纤芯和围绕中心纤芯的多孔，亲水的，生物相容的裙部。在一个实施方案中，中心芯由互穿双网络水凝胶制成，裙部由聚（丙烯酸2-羟乙酯）（PHEA）制成。在另一个实施例中，中心芯和裙部均由互穿双网络水凝胶制成。人造角膜植入物也可以具有相互扩散区域，其中裙部组件与芯部件互穿，反之亦然。在优选的实施方案中，生物分子连接到裙部，中心芯或两者。这些生物分子可以是任何类型的生物分子，但优选支持上皮和/或成纤维细胞存活和生长的生物分子。优选地，生物分子以空间选择性方式连接。本发明还提供了使用光刻法制造人造角膜植入物的方法。

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