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1. 发明授权

US07112552B2 Compositions for separating molecules 失效
标题翻译：用于分离分子的组合物
公开(公告)号：US07112552B2
公开(公告)日：2006-09-26
申请号：US10689176
申请日：2003-10-20
申请人： Daniel J. Simpson , Tonny Johnson , Roderick G. Flemming
发明人： Daniel J. Simpson , Tonny Johnson , Roderick G. Flemming
IPC分类号： B01J20/22 , B01J20/10 , B01J20/283 , B01J29/04 , C12N11/00
CPC分类号： B01D15/3828 , B01J20/103 , B01J20/28009 , B01J20/286 , B01J20/3204 , B01J20/3217 , B01J20/3219 , B01J20/3234 , B01J20/3242 , B01J20/3251 , B01J20/3259 , B01J20/3265 , B01J20/3289 , B01J20/3293 , B01J45/00 , B01J2220/58 , B01J2220/66 , C02F1/285 , C02F2101/20 , C07K1/20 , G01N2030/042
摘要： The present invention provides compositions for the separation of metals or biomolecules such as polypeptides, nucleic acids, or endotoxins using modified solid supports.
摘要翻译：本发明提供了使用改性固体支持物分离金属或生物分子例如多肽，核酸或内毒素的组合物。

2. 发明授权

US07354750B2 Methods for separating molecules 失效
标题翻译：分离分子的方法
公开(公告)号：US07354750B2
公开(公告)日：2008-04-08
申请号：US10689368
申请日：2003-10-20
申请人： Daniel J. Simpson , Tonny Johnson , John Shultz , Roderick G. Flemming , Rebecca Godat , Sanchayita Kar , Robin Hurst
发明人： Daniel J. Simpson , Tonny Johnson , John Shultz , Roderick G. Flemming , Rebecca Godat , Sanchayita Kar , Robin Hurst
IPC分类号： C12N11/00 , B01J20/22 , B01J20/10 , B01J20/283 , B01J29/04
CPC分类号： B01D15/3828 , B01J20/103 , B01J20/28009 , B01J20/286 , B01J20/3204 , B01J20/3217 , B01J20/3219 , B01J20/3234 , B01J20/3242 , B01J20/3251 , B01J20/3259 , B01J20/3265 , B01J20/3289 , B01J20/3293 , B01J45/00 , B01J2220/58 , B01J2220/66 , C02F1/285 , C02F2101/20 , C07K1/20 , G01N2030/042
摘要： The present invention provides compositions and methods for the separation of metals or molecules such as polypeptides, nucleic acids, or endotoxins using a metal-modified solid support. The metals or molecules are isolated from a starting material using the modified solid supports of the invention. Also provided by the invention are kits that can be used in connection with the inventive methods.
摘要翻译：本发明提供使用金属改性固体支持物分离金属或分子例如多肽，核酸或内毒素的组合物和方法。使用本发明的改性固体载体，从原料中分离金属或分子。本发明还提供了可以结合本发明方法使用的试剂盒。

3. 发明授权

US07304015B2 Compositions for separating molecules 失效
标题翻译：用于分离分子的组合物
公开(公告)号：US07304015B2
公开(公告)日：2007-12-04
申请号：US11201714
申请日：2005-08-11
申请人： Daniel J. Simpson , Tonny Johnson , Roderick G. Flemming
发明人： Daniel J. Simpson , Tonny Johnson , Roderick G. Flemming
IPC分类号： B01J20/22 , B01J20/10 , B01J20/283 , B01J29/04 , C12N11/00
CPC分类号： B01D15/3828 , B01J20/103 , B01J20/28009 , B01J20/286 , B01J20/3204 , B01J20/3217 , B01J20/3219 , B01J20/3234 , B01J20/3242 , B01J20/3251 , B01J20/3259 , B01J20/3265 , B01J20/3289 , B01J20/3293 , B01J45/00 , B01J2220/58 , B01J2220/66 , C02F1/285 , C02F2101/20 , C07K1/20 , G01N2030/042
摘要： The present invention provides compositions for the separation of metals or biomolecules such as polypeptides, nucleic acids, or endotoxins using modified solid supports.
摘要翻译：本发明提供了使用改性固体支持物分离金属或生物分子例如多肽，核酸或内毒素的组合物。

4. 发明授权

US06787307B1 Lysate clearance and nucleic acid isolation using silanized silica matrices 有权
标题翻译：裂解液清除和使用硅烷化二氧化硅基质的核酸分离
公开(公告)号：US06787307B1
公开(公告)日：2004-09-07
申请号：US09711782
申请日：2000-11-13
申请人： Rex M. Bitner , Daniel J. Simpson , Roderick G. Flemming , Susan C. Koller
发明人： Rex M. Bitner , Daniel J. Simpson , Roderick G. Flemming , Susan C. Koller
IPC分类号： C12Q168
CPC分类号： C12N15/1006 , C12N1/02 , C12N15/1013 , C12Q1/6806 , Y10T436/143333
摘要： A method is provided for using a silanized silica matrix to isolate a target nucleic acids, such as plasmid DNA, fragments of DNA, chromosomal DNA, or RNA from contaminants, including proteins, lipids, cellular debris, or non-target nucleic acids. The silanized silica matrix comprises a silica based solid phase and a plurality of silane ligands covalently attached to the surface of the solid phase. Non-target material adsorbs to the silanized silica matrix in the presence of a sufficient concentration of chaotropic salt, while target nucleic acids adsorb to the matrix under other solution conditions. The method of using the silanized silica matrix of the present invention can be used to clear solutions of disrupted biological material, and to isolate nucleic acids therefrom or from other solutions containing nucleic acids and at least one contaminant.
摘要翻译：提供了一种使用硅烷化二氧化硅基质从污染物（包括蛋白质，脂质，细胞碎片或非目标核酸）分离靶核酸（如质粒DNA），DNA片段，染色体DNA或RNA的方法。硅烷化二氧化硅基质包含二氧化硅基固相和共价连接到固相表面的多个硅烷配体。非目标物质在足够浓度的离液盐存在下吸附到硅烷化二氧化硅基质上，而靶核酸在其它溶液条件下吸附到基质上。使用本发明的硅烷化二氧化硅基质的方法可用于清除破坏的生物材料的溶液，并从其中分离核酸或从其它含有核酸和至少一种污染物的溶液中分离出核酸。

5. 发明授权

US07304016B2 Compositions for separating molecules 失效
公开(公告)号：US07304016B2
公开(公告)日：2007-12-04
申请号：US11419230
申请日：2006-05-19
申请人： Daniel J. Simpson , Tonny M. Johnson , Roderick G. Flemming
发明人： Daniel J. Simpson , Tonny M. Johnson , Roderick G. Flemming
IPC分类号： B01J20/22 , B01J20/10 , B01J20/283 , B01J29/04 , C12N11/00
CPC分类号： B01D15/3828 , B01J20/103 , B01J20/28009 , B01J20/286 , B01J20/3204 , B01J20/3217 , B01J20/3219 , B01J20/3234 , B01J20/3242 , B01J20/3251 , B01J20/3259 , B01J20/3265 , B01J20/3289 , B01J20/3293 , B01J45/00 , B01J2220/58 , B01J2220/66 , C02F1/285 , C02F2101/20 , C07K1/20 , G01N2030/042
摘要： The present invention provides compositions for the separation of metals or biomolecules such as polypeptides, nucleic acids, or endotoxins using modified solid supports.

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