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1. 发明申请

US20110136099A1 Multiplexed Analyses of Test Samples 审中-公开
标题翻译：测试样本的多路复用分析
公开(公告)号：US20110136099A1
公开(公告)日：2011-06-09
申请号：US12958620
申请日：2010-12-02
申请人： Daniel J. Schneider , Dan Nieuwlandt , Bruce Eaton , Marty Stanton , Shashi Gupta , Stephan Kraemer , Dominic Zichi , Larry Gold
发明人： Daniel J. Schneider , Dan Nieuwlandt , Bruce Eaton , Marty Stanton , Shashi Gupta , Stephan Kraemer , Dominic Zichi , Larry Gold
IPC分类号： G01N33/53 , G01N33/543 , C12Q1/68 , C12Q1/70 , G01N33/567 , G01N33/545 , G01N33/544 , G01N33/553 , G01N33/552
CPC分类号： G01N33/5308 , G01N33/54306 , G01N33/6863 , G01N33/74
摘要： The present disclosure describes methods, devices, reagents, and kits for the detection of one or more target molecules that may be present in a test sample. The described methods, devices, kits, and reagents facilitate the detection and quantification of a non-nucleic acid target (e.g., a protein target) in a test sample by detecting and quantifying a nucleic acid (i.e., an aptamer). The methods described create a nucleic acid surrogate for a non-nucleic acid target, thus allowing the wide variety of nucleic acid technologies, including amplification, to be applied to a broader range of desired targets, especially protein targets. The disclosure further describes aptamer constructs that facilitate the use of aptamers in a variety of analytical detection applications.
摘要翻译：本公开描述了用于检测可能存在于测试样品中的一种或多种靶分子的方法，装置，试剂和试剂盒。所描述的方法，装置，试剂盒和试剂通过检测和定量核酸（即，适体）促进了测试样品中非核酸靶标（例如，蛋白质靶标）的检测和定量。所描述的方法为非核酸靶产生了核酸替代物，从而允许将广泛种类的核酸技术（包括扩增）应用于更广泛的期望目标，特别是蛋白质靶标。本公开进一步描述了适于在各种分析检测应用中促进适配体使用的适体构建体。

2. 发明申请

US20090042206A1 Multiplexed Analyses of Test Samples 有权
标题翻译：测试样本的多路复用分析
公开(公告)号：US20090042206A1
公开(公告)日：2009-02-12
申请号：US12175446
申请日：2008-07-17
申请人： Daniel J. Schneider , Dan Nieuwlandt , Bruce Eaton , Marty Stanton , Shashi Gupta , Stephan Kraemer , Dominic Zichi , Larry Gold
发明人： Daniel J. Schneider , Dan Nieuwlandt , Bruce Eaton , Marty Stanton , Shashi Gupta , Stephan Kraemer , Dominic Zichi , Larry Gold
IPC分类号： C12Q1/68
CPC分类号： G01N33/5308 , C12Q1/6832 , C12Q1/6834 , C12Q2537/101 , C12Q2525/205 , C12Q2523/313 , C12Q2525/161
摘要： The present disclosure describes methods, devices, reagents, and kits for the detection of one or more target molecules that may be present in a test sample. The described methods, devices, kits, and reagents facilitate the detection and quantification of a non-nucleic acid target (e.g., a protein target) in a test sample by detecting and quantifying a nucleic acid (i.e., an aptamer). The methods described create a nucleic acid surrogate for a non-nucleic acid target, thus allowing the wide variety of nucleic acid technologies, including amplification, to be applied to a broader range of desired targets, especially protein targets. The disclosure further describes aptamer constructs that facilitate the use of aptamers in a variety of analytical detection applications.
摘要翻译：本公开描述了用于检测可能存在于测试样品中的一种或多种靶分子的方法，装置，试剂和试剂盒。所描述的方法，装置，试剂盒和试剂通过检测和定量核酸（即，适体）促进了测试样品中非核酸靶标（例如，蛋白质靶标）的检测和定量。所描述的方法为非核酸靶产生了核酸替代物，从而允许将广泛种类的核酸技术（包括扩增）应用于更广泛的期望目标，特别是蛋白质靶标。本公开进一步描述了适于在各种分析检测应用中促进适配体使用的适体构建体。

3. 发明授权

US07855054B2 Multiplexed analyses of test samples 有权
标题翻译：测试样品的多重分析
公开(公告)号：US07855054B2
公开(公告)日：2010-12-21
申请号：US12175446
申请日：2008-07-17
申请人： Daniel J. Schneider , Dan Nieuwlandt , Bruce Eaton , Marty Stanton , Shashi Gupta , Stephan Kraemer , Dominic Zichi , Larry Gold
发明人： Daniel J. Schneider , Dan Nieuwlandt , Bruce Eaton , Marty Stanton , Shashi Gupta , Stephan Kraemer , Dominic Zichi , Larry Gold
IPC分类号： C12Q1/68 , C07H21/02 , C07H21/04 , C12P19/34
CPC分类号： G01N33/5308 , C12Q1/6832 , C12Q1/6834 , C12Q2537/101 , C12Q2525/205 , C12Q2523/313 , C12Q2525/161
摘要： The present disclosure describes methods, devices, reagents, and kits for the detection of one or more target molecules that may be present in a test sample. The described methods, devices, kits, and reagents facilitate the detection and quantification of a non-nucleic acid target (e.g., a protein target) in a test sample by detecting and quantifying a nucleic acid (i.e., an aptamer). The methods described create a nucleic acid surrogate for a non nucleic acid target, thus allowing the wide variety of nucleic acid technologies, including amplification, to be applied to a broader range of desired targets, especially protein targets. The disclosure further describes aptamer constructs that facilitate the use of aptamers in a variety of analytical detection applications.
摘要翻译：本公开描述了用于检测可能存在于测试样品中的一种或多种靶分子的方法，装置，试剂和试剂盒。所描述的方法，装置，试剂盒和试剂通过检测和定量核酸（即，适体）促进了测试样品中非核酸靶标（例如，蛋白质靶标）的检测和定量。所描述的方法为非核酸靶产生了核酸替代物，从而允许将广泛种类的核酸技术（包括扩增）应用于更广泛的期望目标，特别是蛋白质靶标。本公开进一步描述了适于在各种分析检测应用中促进适配体使用的适体构建体。

4. 发明申请

US20100147484A1 METHOD AND DEVICE FOR MANUFACTURING A METAL STRIP BY MEANS OF CONTINUOUS CASTING AND ROLLING 失效
标题翻译：通过连续铸造和轧制制造金属条的方法和装置
公开(公告)号：US20100147484A1
公开(公告)日：2010-06-17
申请号：US12733271
申请日：2008-08-21
申请人： Dieter Rosenthal , Stephan Kraemer , Christoph Klein , Juergen Seidel , Wolfgang-Dietmar Hackenberg
发明人： Dieter Rosenthal , Stephan Kraemer , Christoph Klein , Juergen Seidel , Wolfgang-Dietmar Hackenberg
IPC分类号： B22D11/00 , B22D11/128 , B22D11/126
CPC分类号： B22D11/1206 , B21B1/46 , B21B39/004 , C21D8/0226 , C21D8/0426 , C21D9/48 , Y10T29/49991
摘要： The invention pertains to a method for manufacturing a metal strip (1) by means of continuous casting and rolling, wherein a thin slab (3) is initially cast in a casting machine (2) and this thin slab is subsequently rolled in at least one rolling train (4, 5) by utilizing the primary heat of the casting process, wherein a continuous manufacture of the metal strip (1) (continuous rolling) can be realized in a first operating mode by directly coupling the casting machine (2) to the at least one rolling train (4, 5), and wherein a discontinuous manufacture of the metal strip (1) (batch rolling) can be realized in a second operating mode by decoupling the casting machine (2) from the at least one rolling train (4, 5). In order to increase the flexibility of the system, the invention proposes that cast slabs (3) or preliminary strips (3′) are removed from the main transport line (6) downstream of the casting machine (2) referred to the strip transport direction (F) in the discontinuous manufacture of the metal strip (1), stored and subsequently transported back into the main transport line (6), wherein the removed slabs (3) or preliminary strips (3′) are heated to a desired temperature or maintained at a desired temperature prior to the transport back into the main transport line (6). The invention furthermore pertains to a device for manufacturing a metal strip (1) by means of continuous casting and rolling.
摘要翻译：本发明涉及通过连续铸造和轧制制造金属带（1）的方法，其中薄板坯（3）最初在铸造机（2）中铸造，并且该薄板坯随后在至少一个通过利用铸造工艺的一次热量，可以在第一操作模式中实现金属带（1）的连续制造（连续轧制），直接将铸造机（2）连接到所述至少一个轧制系（4,5），并且其中通过使所述铸造机（2）与所述至少一个轧制（2）脱模，可以在第二操作模式中实现所述金属带（1）（批轧）的不连续制造火车（4,5）。为了增加系统的灵活性，本发明提出，铸造板坯（3）或初步条带（3'）从铸造机器（2）下游的主输送线（6）被移除（F）在金属带（1）的不连续制造中，储存并随后被运送回主输送线（6），其中将移除的板坯（3）或初步条带（3'）加热到所需温度或在运送回主输送线（6）之前保持在所需温度。本发明还涉及通过连续铸造和轧制制造金属带（1）的装置。

5. 发明授权

US08925175B2 Device and method to accurately and easily assemble glass slides 有权
标题翻译：准确，轻松地组装玻片的装置和方法
公开(公告)号：US08925175B2
公开(公告)日：2015-01-06
申请号：US14238695
申请日：2012-08-17
申请人： Jeff Aldred , Tracy R Keeney , Jonathan Vaught , Chris Bock , Stephan Kraemer , Alexis Stuart Foreman
发明人： Jeff Aldred , Tracy R Keeney , Jonathan Vaught , Chris Bock , Stephan Kraemer , Alexis Stuart Foreman
IPC分类号： B25B11/02 , B23P19/04 , B23P19/10 , B01L9/00 , G02B21/34 , B25B11/00
CPC分类号： B01L9/52 , B01L9/02 , B01L99/00 , B01L2200/025 , B01L2300/043 , B01L2300/0636 , B01L2300/0822 , B23P19/04 , B23P19/10 , B25B11/005 , B25B11/007 , B25B11/02 , G02B21/34 , Y10T29/4978 , Y10T29/4984 , Y10T29/49902 , Y10T29/49998 , Y10T29/53 , Y10T29/53191 , Y10T29/53961
摘要： Embodiments provide a slide assembly device having a static tooling base which is statically and solidly affixed to a base such as a table and a moveable tooling arm that is rotatable about a hinge connected to the static tooling base, so that moveable tooling arm rotates about the hinge in a manner similar to a book cover opening and closing. The embodiments further provide an upper slide chuck that is removably attachable to the moveable tooling arm and a lower slide receiver that is removably attachable to the static tooling base. The upper slide chuck is configured to hold an experimental slide via a vacuum mechanism to engagedly hold the experimental slide to the upper slide chuck while the moveable tooling arm is rotated about the hinge from an open-book position to a closed-book position.
摘要翻译：实施例提供了一种滑动组合装置，其具有静态和牢固地固定到诸如桌子的基座和可移动的工具臂的静态工具基座，该工具臂可围绕连接到静态工具基座的铰链旋转，使得可移动的工具臂围绕铰链的方式类似于书盖打开和关闭。这些实施例还提供了可滑动地附接到可移动工具臂的上部滑动卡盘和可移除地附接到静态工具基座的下部滑动接收器。上滑动卡盘构造成通过真空机构保持实验滑块，以将实验滑块接合地保持在上滑动卡盘上，同时可移动的工具臂围绕铰链从打开书位置旋转到封闭位置。

6. 发明授权

US06314940B1 Fuel feed system for a spark-ignition internal combustion engine and a method of operating such an internal combustion engine 失效
标题翻译：用于火花点火内燃机的燃料供给系统和操作这种内燃机的方法
公开(公告)号：US06314940B1
公开(公告)日：2001-11-13
申请号：US09523245
申请日：2000-03-10
申请人： Juergen Frey , Guenter Karl , Stephan Kraemer
发明人： Juergen Frey , Guenter Karl , Stephan Kraemer
IPC分类号： F02B700
CPC分类号： F02M69/046 , F02B23/101 , F02B2023/102 , F02B2075/125 , F02D41/3094 , F02F1/38 , F02F2001/245 , F02M67/00 , F02M67/02 , F02M69/044 , F02M69/045 , F02M69/08 , Y02T10/123 , Y02T10/125
摘要： In a fuel feed system for a spark-ignition internal combustion engine, which system has at least a first injection valve, which is arranged in or on a cylinder head and to which fuel is fed under pressure for discharging directly into a combustion chamber of the internal combustion engine, at least one further injection valve is provided in an engine intake passage to discharge, in certain operating ranges of the internal combustion engine, fuel into the intake passage of the internal combustion engine in addition to the discharge of the fuel of the first injection valve into the cylinder, and the first injection valve is designed for fuel injection volume lower than that required for full power operation of the engine.
摘要翻译：在用于火花点火式内燃机的燃料供给系统中，该系统具有至少第一喷射阀，其布置在气缸盖中或其上，并且在压力下供给燃料直接排放到燃烧室的燃烧室中内燃机，至少一个进一步的喷射阀设置在发动机进气通道中，以在内燃机的某些工作范围内将燃料排放到内燃机的进气通道中，除了排出燃料第一喷射阀进入气缸，并且第一喷射阀被设计为比发动机全功率运行所需的燃料喷射量低的燃料喷射量。

7. 发明申请

US20140201965A1 Device and Method to Accurately and Easily Assemble Glass Slides 有权
标题翻译：准确，轻松地组装玻璃滑块的装置和方法
公开(公告)号：US20140201965A1
公开(公告)日：2014-07-24
申请号：US14238695
申请日：2012-08-17
申请人： Jeff Aldred , Alexis Stuart Foreman , Tracy R. Keeney , Jonathan Vaught , Chris Bock , Stephan Kraemer
发明人： Jeff Aldred , Alexis Stuart Foreman , Tracy R. Keeney , Jonathan Vaught , Chris Bock , Stephan Kraemer
IPC分类号： B23P19/04
CPC分类号： B01L9/52 , B01L9/02 , B01L99/00 , B01L2200/025 , B01L2300/043 , B01L2300/0636 , B01L2300/0822 , B23P19/04 , B23P19/10 , B25B11/005 , B25B11/007 , B25B11/02 , G02B21/34 , Y10T29/4978 , Y10T29/4984 , Y10T29/49902 , Y10T29/49998 , Y10T29/53 , Y10T29/53191 , Y10T29/53961
摘要： Embodiments provide a slide assembly device having a static tooling base which is statically and solidly affixed to a base such as a table and a moveable tooling arm that is rotatable about a hinge connected to the static tooling base, so that moveable tooling arm rotates about the hinge in a manner similar to a book cover opening and closing. The embodiments further provide an upper slide chuck that is removably attachable to the moveable tooling arm and a lower slide receiver that is removably attachable to the static tooling base. The upper slide chuck is configured to hold an experimental slide via a vacuum mechanism to engagedly hold the experimental slide to the upper slide chuck while the moveable tooling arm is rotated about the hinge from an open-book position to a closed-book position.
摘要翻译：实施例提供了一种滑动组合装置，其具有静态和牢固地固定到诸如桌子的基座和可移动的工具臂的静态工具基座，该工具臂可围绕连接到静态工具基座的铰链旋转，使得可移动的工具臂围绕铰链的方式类似于书盖打开和关闭。这些实施例还提供了可滑动地附接到可移动工具臂的上部滑动卡盘和可移除地附接到静态工具基座的下部滑动接收器。上滑动卡盘构造成通过真空机构保持实验滑块，以将实验滑块接合地保持在上滑动卡盘上，同时可移动的工具臂围绕铰链从打开书位置旋转到封闭位置。

8. 发明授权

US5983853A Method of providing an ignitable fuel/air mixture in an internal combustion engine with direct fuel injection 失效
标题翻译：在具有直接燃料喷射的内燃机中提供可点燃的燃料/空气混合物的方法
公开(公告)号：US5983853A
公开(公告)日：1999-11-16
申请号：US950958
申请日：1997-10-15
申请人： Klaus Roessler , Stephan Kraemer , Guenter Karl , Christian Enderle
发明人： Klaus Roessler , Stephan Kraemer , Guenter Karl , Christian Enderle
IPC分类号： F02B17/00 , F02B23/10 , F02B75/12 , F02D33/00 , F02D41/40 , F02F3/26 , F02M51/06 , F02M61/08 , F02M61/16 , F02B3/04
CPC分类号： F02M61/08 , F02B17/005 , F02B23/101 , F02D33/00 , F02F3/26 , F02M51/0603 , F02M61/161 , F02B2023/102 , F02B2075/125 , F02D2041/389 , F02D41/402 , Y02T10/123 , Y02T10/125
摘要： In a method of providing an ignitable fuel/air mixture in the combustion chambers of the various cylinders of an internal combustion engine with direct fuel injection wherein fuel is injected into the combustion chambers by way of injectors including injection nozzles with valve members for controllably opening and closing the injection nozzles, the valve member opening strokes and the valve member opening times are variably adjusted depending on specific engine operating conditions.
摘要翻译：在具有直接燃料喷射的内燃机的各种气缸的燃烧室中提供可燃燃料/空气混合物的方法中，其中燃料通过喷射器喷射到燃烧室中，所述喷射器包括具有用于可控地打开的阀构件的喷嘴，关闭喷嘴，根据具体的发动机工作条件可变地调节阀构件打开行程和阀构件打开时间。

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