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1. 发明申请

US20120207771A1 FOLATE RECEPTOR ALPHA AS A DIAGNOSTIC AND PROGNOSTIC MARKER FOR FOLATE RECEPTOR ALPHA-EXPRESSING CANCERS 审中-公开
标题翻译：将受体ALPHA作为诊断和预防标记作为脂肪细胞受体表达癌症
公开(公告)号：US20120207771A1
公开(公告)日：2012-08-16
申请号：US13289892
申请日：2011-11-04
申请人： Daniel J. O'Shannessy , Luigi Grasso , Shanhong Wan , Qimin Chao , Elizabeth Brooke Somers
发明人： Daniel J. O'Shannessy , Luigi Grasso , Shanhong Wan , Qimin Chao , Elizabeth Brooke Somers
IPC分类号： A61K39/395 , G01N21/64 , A61P35/00 , G01N33/574
CPC分类号： G01N33/57423 , A61K39/395 , G01N33/57449 , G01N33/57484 , G01N33/82 , G01N2800/52 , G01N2800/56
摘要： The present invention provides methods and kits for assessing whether a subject is afflicted with an FRα-expressing cancer, methods and kits for predicting the progression of ovarian cancer in a subject afflicted with an FRα-expressing cancer, methods and kits for assessing the level of risk that a subject will develop an FRα-expressing cancer, and methods of stratifying a subject with an FRα-expressing cancer into cancer therapy groups. The methods involve determining the level of folate receptor alpha (FRα) which is not bound to a cell in a sample derived from the subject and comparing this level with the level of FRα in a control sample.
摘要翻译：本发明提供用于评估受试者是否患有表达FRα的癌症的方法和试剂盒，用于预测患有FRα表达的癌症的受试者的卵巢癌进展的方法和试剂盒，用于评估受试者将发展出表达FRα的癌症的风险，以及将具有表达FRα的癌症的受试者分层为癌症治疗组的方法。该方法涉及确定不受来自受试者的样品中细胞的叶酸受体α（FRα）的水平，并将该水平与对照样品中FRα的水平进行比较。

2. 发明授权

US5395587A Surface plasmon resonance detector having collector for eluted ligate 失效
标题翻译：表面等离子体共振检测器具有用于洗脱连接的收集器
公开(公告)号：US5395587A
公开(公告)日：1995-03-07
申请号：US088006
申请日：1993-07-06
申请人： Michael Brigham-Burke , Daniel J. O'Shannessy
发明人： Michael Brigham-Burke , Daniel J. O'Shannessy
IPC分类号： G01N33/543 , G01N1/00 , G01N21/21 , G01N21/27 , G01N21/41 , G01N21/55 , G01N35/10 , G01N21/43 , B01L3/00
CPC分类号： G01N35/1095 , G01N21/553 , Y10S435/808 , Y10S436/805
摘要： An improved surface plasmon resonance detector, capable of recovering a desired eluted ligate allows for the collection and subsequent analysis of ligate solutions following interaction of the ligate with an immobilized ligand on a surface of a sensor chip of the surface plasmon resonance detector, permits the isolation and characterization of novel ligates and ligands.
摘要翻译：改进的表面等离子体共振检测器能够回收所需的洗脱连接物允许在连接物与表面等离子体共振检测器的传感器芯片的表面上的固定配体相互作用之后收集和随后分析连接液，允许隔离和新型连接子和配体的表征。

3. 发明授权

US5561069A Surface plasmon resonance detector having collector for eluted ligate 失效
标题翻译：表面等离子体共振检测器具有用于洗脱连接的收集器
公开(公告)号：US5561069A
公开(公告)日：1996-10-01
申请号：US342511
申请日：1994-11-21
申请人： Michael Brigham-Burke , Daniel J. O'Shannessy
发明人： Michael Brigham-Burke , Daniel J. O'Shannessy
IPC分类号： G01N33/543 , G01N1/00 , G01N21/21 , G01N21/27 , G01N21/41 , G01N21/55 , G01N35/10
CPC分类号： G01N35/1095 , G01N21/553 , Y10S435/808 , Y10S436/805
摘要： An improved surface plasmon resonance detector, capable of recovering a desired eluted ligate, permits the isolation and characterization of novel ligates and ligands.
摘要翻译：能够回收所需洗脱的连接物的改进的表面等离子体共振检测器允许分离和表征新的连接物和配体。

4. 发明授权

US4874813A Proteins bound to a marker or solid phase support matrix using a hydrazone linkage 失效
标题翻译：使用腙键与蛋白质结合至标记或固相支持基质
公开(公告)号：US4874813A
公开(公告)日：1989-10-17
申请号：US12456
申请日：1987-02-09
申请人： Daniel J. O'Shannessy
发明人： Daniel J. O'Shannessy
IPC分类号： C07K17/06
CPC分类号： C07K17/06 , Y10S530/81 , Y10S530/811 , Y10S530/812 , Y10S530/813 , Y10S530/814 , Y10S530/815 , Y10S530/816
摘要： A biological composition comprises a solid phase support matrix or marker molecule bound to protein, typically a glycoprotein such as an immunoglobulin through a linking group, spacer arm, and hydrazone group. The linking group is conveniently an ether linkage, while the spacer arm is a linear chain including six atoms, where at least one of the atoms is a tertiary amine which is protonated at a pH below about 8. The hydrazone is formed by reacting the solid phase or marker molecule having the linking arm and the spacer arm including a terminal hydrazide group with a glycoprotein oxidized to include a terminal aldehyde group. Immunological reagents prepared by linking an immunoglobulin (IgG) through a carbohydrate on the Fc or hinge regions have been found to provide very high binding capacity approaching the theoretical bivalent limit of two moles of bound antigen for every mole of bound immunoglobulin.
摘要翻译：生物组合物包含与蛋白质结合的固相支持基质或标记分子，通常通过连接基团，间隔臂和腙基团等糖蛋白例如免疫球蛋白。连接基团方便地是醚键，而间隔臂是包含六个原子的直链，其中至少一个原子是在低于约8的pH下被质子化的叔胺。腙通过使固体具有连接臂和间隔臂的相或标记分子包括具有被氧化以包括末端醛基的糖蛋白的末端酰肼基团。已经发现通过在Fc或铰链区上通过碳水化合物连接免疫球蛋白（IgG）而制备的免疫试剂提供非常高的结合能力，接近每摩尔结合的免疫球蛋白的两摩尔结合抗原的理论二价极限。

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