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1. 发明申请

US20100240982A1 System for the Assessment of Sleep Quality in Adults and Children 有权
标题翻译：成人和儿童睡眠质量评估系统
公开(公告)号：US20100240982A1
公开(公告)日：2010-09-23
申请号：US12726084
申请日：2010-03-17
申请人： Philip R. Westbrook , Daniel J. Levendowski , Timothy Zavora , Gene Davis , Djordje Popovic , Chris Berka , Mirko Mitrovic , Bratislav Veljkovic
发明人： Philip R. Westbrook , Daniel J. Levendowski , Timothy Zavora , Gene Davis , Djordje Popovic , Chris Berka , Mirko Mitrovic , Bratislav Veljkovic
IPC分类号： A61B5/04 , A61B5/087
CPC分类号： A61B5/4815 , A61B5/0476 , A61B5/0488 , A61B5/0496 , A61B5/087 , A61B5/4812 , A61B5/4818 , A61B5/6803 , A61B5/6814 , A61B5/6831 , A61B5/721 , A61B5/7221 , A61B5/7275
摘要： Systems and methods for assessment of sleep quality in adults and children are provided. These techniques include an apparatus worn above the forehead containing the circuitry for collecting and storing physiological signals. The apparatus integrates with a sensor strip and a nasal mask to obtain the physiological signals for the user. The form factor of this apparatus is comfortable, easy to self-apply, and results in less data artifacts than conventional techniques for capturing physiological data for analyzing sleep quality. Neuro-respiratory signals are analyzed using means to extract more accurate definitions of the frequency and severity of sleep discontinuity, sleep disordered breathing and patterns of sleep architecture. Biological biomarkers and questionnaire responses can also be compared to a database of healthy and chronically diseased patients to provide a more accurate differential diagnosis and to help determine the appropriate disease management recommendations.
摘要翻译：提供了成人和儿童睡眠质量评估系统和方法。这些技术包括佩戴在前额上方的装置，其包含用于收集和存储生理信号的电路。该装置与传感器条和鼻罩集成以获得用户的生理信号。该装置的形状因子舒适，易于自适应，并且比用于捕获用于分析睡眠质量的生理数据的常规技术导致更少的数据伪影。使用手段分析神经 - 呼吸信号，以提取睡眠不连续性，睡眠呼吸紊乱和睡眠结构模式的频率和严重程度的更准确的定义。生物标志物和问卷回答也可以与健康和长期患病患者的数据库进行比较，以提供更准确的鉴别诊断，并帮助确定适当的疾病管理建议。

2. 发明授权

US08355769B2 System for the assessment of sleep quality in adults and children 有权
标题翻译：用于评估成人和儿童睡眠质量的系统
公开(公告)号：US08355769B2
公开(公告)日：2013-01-15
申请号：US12726084
申请日：2010-03-17
申请人： Daniel J. Levendowski , Philip R. Westbrook , Chris Berka , Djordje Popovic , Timothy Zavora , Gene Davis , Mirko Mitrovic , Bratislav Veljkovic
发明人： Daniel J. Levendowski , Philip R. Westbrook , Chris Berka , Djordje Popovic , Timothy Zavora , Gene Davis , Mirko Mitrovic , Bratislav Veljkovic
IPC分类号： A61B5/0478 , A61B5/0492 , A61B5/0496 , A61B5/087
CPC分类号： A61B5/4815 , A61B5/0476 , A61B5/0488 , A61B5/0496 , A61B5/087 , A61B5/4812 , A61B5/4818 , A61B5/6803 , A61B5/6814 , A61B5/6831 , A61B5/721 , A61B5/7221 , A61B5/7275
摘要： Systems and methods for assessment of sleep quality in adults and children are provided. These techniques include an apparatus worn above the forehead containing the circuitry for collecting and storing physiological signals. The apparatus integrates with a sensor strip and a nasal mask to obtain the physiological signals for the user. The form factor of this apparatus is comfortable, easy to self-apply, and results in less data artifacts than conventional techniques for capturing physiological data for analyzing sleep quality. Neuro-respiratory signals are analyzed using means to extract more accurate definitions of the frequency and severity of sleep discontinuity, sleep disordered breathing and patterns of sleep architecture. Biological biomarkers and questionnaire responses can also be compared to a database of healthy and chronically diseased patients to provide a more accurate differential diagnosis and to help determine the appropriate disease management recommendations.
摘要翻译：提供了成人和儿童睡眠质量评估系统和方法。这些技术包括佩戴在前额上方的装置，其包含用于收集和存储生理信号的电路。该装置与传感器条和鼻罩集成以获得用户的生理信号。该装置的形状因子舒适，易于自适应，并且比用于捕获用于分析睡眠质量的生理数据的常规技术导致更少的数据伪影。使用手段分析神经 - 呼吸信号，以提取睡眠不连续性，睡眠呼吸紊乱和睡眠结构模式的频率和严重程度的更准确的定义。生物标志物和问卷回答也可以与健康和长期患病患者的数据库进行比较，以提供更准确的鉴别诊断，并帮助确定适当的疾病管理建议。

3. 发明申请

US20110132378A1 Systems and Methods For Controlling Position 有权
标题翻译：控制位置的系统和方法
公开(公告)号：US20110132378A1
公开(公告)日：2011-06-09
申请号：US12794498
申请日：2010-06-04
申请人： Daniel J. Levendowski , Timothy Zavora , Philip R. Westbrook , Mirko Mitrovic , Bratislav Veljkovic , Chris Berka , Jonny Trejo
发明人： Daniel J. Levendowski , Timothy Zavora , Philip R. Westbrook , Mirko Mitrovic , Bratislav Veljkovic , Chris Berka , Jonny Trejo
IPC分类号： A61F5/56
CPC分类号： A61B5/486 , A61B5/103 , A61B5/11 , A61B5/1116 , A61B5/113 , A61B5/4806 , A61B5/4809 , A61B5/4818 , A61B5/4833 , A61B5/6819 , A61B5/6822 , A61B5/6823 , A61B5/6831 , A61B5/7282 , A61B5/7405 , A61B7/003 , A61B7/04 , A61F5/56 , A61M21/02 , A61M2021/0022 , A61M2021/0027 , A61M2021/0044 , A61M2021/0083 , A61M2205/3375 , A61M2205/3569 , A61M2205/3592 , A61M2205/502 , A61M2205/581 , A61M2205/583 , A61M2205/8206 , A61M2209/088 , A61M2230/63 , A61N1/3601 , A61N1/36014 , A61N2005/0653
摘要： Systems and methods for controlling the position of a user of a wearable positional therapy device are provided. The wearable position therapy device can be configured to monitor and store physiological signals that can be used to assess sleep quality and sleeping position of a user. The device can be configured to be worn around the head, the neck, or body of the user. The device can be configured to provide feedback to a user if the user is sleeping or is positioned in a target position to induce the user to change positions. The feedback can be provided by one or more haptic motors that can be configured to provide various levels of feedback and the level of feedback can be customized based on the user's reaction to the feedback.
摘要翻译：提供了用于控制可穿戴式位置治疗装置的使用者的位置的系统和方法。可佩戴位置治疗装置可被配置为监视和存储可用于评估使用者的睡眠质量和睡眠位置的生理信号。该装置可被配置为佩戴在使用者头部，颈部或身体周围。如果用户正在睡觉或被定位在目标位置以诱使用户改变位置，则该设备可被配置为向用户提供反馈。反馈可以由一个或多个触觉电机提供，其可以被配置为提供各种级别的反馈，并且可以基于用户对反馈的反应来定制反馈级别。

4. 发明授权

US08783264B2 Systems and methods for controlling position 有权
标题翻译：控制位置的系统和方法
公开(公告)号：US08783264B2
公开(公告)日：2014-07-22
申请号：US12794498
申请日：2010-06-04
申请人： Daniel J. Levendowski , Timothy Zavora , Philip R. Westbrook , Mirko Mitrovic , Bratislav Veljkovic , Chris Berka , Jonny Trejo
发明人： Daniel J. Levendowski , Timothy Zavora , Philip R. Westbrook , Mirko Mitrovic , Bratislav Veljkovic , Chris Berka , Jonny Trejo
IPC分类号： A61B5/11 , A61F5/56 , A61F5/37 , A61M21/02 , A61B7/00 , A61B5/00 , A61B5/113 , A61M21/00 , A61N1/36 , A61N5/06
CPC分类号： A61B5/486 , A61B5/103 , A61B5/11 , A61B5/1116 , A61B5/113 , A61B5/4806 , A61B5/4809 , A61B5/4818 , A61B5/4833 , A61B5/6819 , A61B5/6822 , A61B5/6823 , A61B5/6831 , A61B5/7282 , A61B5/7405 , A61B7/003 , A61B7/04 , A61F5/56 , A61M21/02 , A61M2021/0022 , A61M2021/0027 , A61M2021/0044 , A61M2021/0083 , A61M2205/3375 , A61M2205/3569 , A61M2205/3592 , A61M2205/502 , A61M2205/581 , A61M2205/583 , A61M2205/8206 , A61M2209/088 , A61M2230/63 , A61N1/3601 , A61N1/36014 , A61N2005/0653
摘要： Systems and methods for controlling the position of a user of a wearable positional therapy device are provided. The wearable position therapy device can be configured to monitor and store physiological signals that can be used to assess sleep quality and sleeping position of a user. The device can be configured to be worn around the head, the neck, or body of the user. The device can be configured to provide feedback to a user if the user is sleeping or is positioned in a target position to induce the user to change positions. The feedback can be provided by one or more haptic motors that can be configured to provide various levels of feedback and the level of feedback can be customized based on the user's reaction to the feedback.
摘要翻译：提供了用于控制可穿戴式位置治疗装置的使用者的位置的系统和方法。可佩戴位置治疗装置可被配置为监视和存储可用于评估使用者的睡眠质量和睡眠位置的生理信号。该装置可被配置为佩戴在使用者头部，颈部或身体周围。如果用户正在睡觉或被定位在目标位置以诱使用户改变位置，则该设备可被配置为向用户提供反馈。反馈可以由一个或多个触觉电机提供，其可以被配置为提供各种级别的反馈，并且可以基于用户对反馈的反应来定制反馈级别。

5. 发明授权

US08721555B2 Method for measuring central venous pressure or respiratory effort 有权
标题翻译：测量中枢静脉压或呼吸力的方法
公开(公告)号：US08721555B2
公开(公告)日：2014-05-13
申请号：US12708403
申请日：2010-02-18
申请人： Philip R. Westbrook , Daniel J. Levendowski , Timothy Zavora , Djordje Popovic , Milenko Cvetinovic , Chris Berka
发明人： Philip R. Westbrook , Daniel J. Levendowski , Timothy Zavora , Djordje Popovic , Milenko Cvetinovic , Chris Berka
IPC分类号： A61B5/02
CPC分类号： A61B5/14551 , A61B5/0205 , A61B5/021 , A61B5/02125 , A61B5/02416 , A61B5/037 , A61B5/0816 , A61B5/1073 , A61B5/1135 , A61B5/412 , A61B5/4818
摘要： Photoplethysmography (PPG) is obtained using one red (e.g., 660 nm) and one infrared (e.g., 880 to 940 nm) light emitting diode with a single photo diode in combination with a pressure transducer thereby allowing both CVP and SpO2 to be measured simultaneously. The system also includes sensors capable of measuring position, angle and/or movement of the sensor or patient. Once the PPG signal is acquired, high pass adaptive and/or notch filtering can be used with one element of the filter from the red and infrared signals used to measure the arterial changes needed to compute SpO2 and the other element of the signal can be used to measure CVP changes.
摘要翻译：使用一个红色（例如660nm）和一个红外（例如880至940nm）发光二极管与单个光电二极管结合压力传感器获得光电体积描记术（PPG），从而同时测量CVP和SpO2 。该系统还包括能够测量传感器或患者的位置，角度和/或运动的传感器。一旦获取了PPG信号，就可以使用来自用于测量计算SpO2所需的动脉变化的红色和红外信号的滤波器的一个元件进行高通自适应和/或陷波滤波，并且可以使用该信号的另一个元件测量CVP变化。

6. 发明授权

US07691067B2 Method for measuring central venous pressure or respiratory effort 有权
标题翻译：测量中枢静脉压或呼吸力的方法
公开(公告)号：US07691067B2
公开(公告)日：2010-04-06
申请号：US11763173
申请日：2007-06-14
申请人： Philip R. Westbrook , Daniel J. Levendowski , Timothy Zavora , Djordje Popovic , Milenko Cvetinovic , Chris Berka
发明人： Philip R. Westbrook , Daniel J. Levendowski , Timothy Zavora , Djordje Popovic , Milenko Cvetinovic , Chris Berka
IPC分类号： A61B5/02
CPC分类号： A61B5/14551 , A61B5/0205 , A61B5/021 , A61B5/02125 , A61B5/02416 , A61B5/037 , A61B5/0816 , A61B5/1073 , A61B5/1135 , A61B5/412 , A61B5/4818
摘要： Photoplethysmography (PPG) is obtained using one red (e.g., 660 nm) and one infrared (e.g., 880 to 940 nm) light emitting diode with a single photo diode in combination with a pressure transducer thereby allowing both CVP and SpO2 to be measured simultaneously. The system also includes sensors capable of measuring position, angle and/or movement of the sensor or patient. Once the PPG signal is acquired, high pass adaptive and/or notch filtering can be used with one element of the filter from the red and infrared signals used to measure the arterial changes needed to compute SpO2 and the other element of the signal can be used to measure CVP changes.
摘要翻译：使用一个红色（例如660nm）和一个红外（例如880至940nm）发光二极管与单个光电二极管结合压力传感器获得光电体积描记术（PPG），从而同时测量CVP和SpO2 。该系统还包括能够测量传感器或患者的位置，角度和/或运动的传感器。一旦获取了PPG信号，就可以使用来自用于测量计算SpO2所需的动脉变化的红色和红外信号的滤波器的一个元件进行高通自适应和/或陷波滤波，并且可以使用该信号的另一个元件测量CVP变化。

7. 发明申请

US20100145201A1 METHOD FOR MEASURING CENTRAL VENOUS PRESSURE OR RESPIRATORY EFFORT 有权
标题翻译：用于测量中央静脉压或呼吸道作用的方法
公开(公告)号：US20100145201A1
公开(公告)日：2010-06-10
申请号：US12708403
申请日：2010-02-18
申请人： Philip R. Westbrook , Daniel J. Levendowski , Timothy Zavora , Djordje Popovic , Milenko Cvetinovic , Chris Berka
发明人： Philip R. Westbrook , Daniel J. Levendowski , Timothy Zavora , Djordje Popovic , Milenko Cvetinovic , Chris Berka
IPC分类号： A61B5/0205
CPC分类号： A61B5/14551 , A61B5/0205 , A61B5/021 , A61B5/02125 , A61B5/02416 , A61B5/037 , A61B5/0816 , A61B5/1073 , A61B5/1135 , A61B5/412 , A61B5/4818
摘要： Photoplethysmography (PPG) is obtained using one red (e.g., 660 nm) and one infrared (e.g., 880 to 940 nm) light emitting diode with a single photo diode in combination with a pressure transducer thereby allowing both CVP and SpO2 to be measured simultaneously. The system also includes sensors capable of measuring position, angle and/or movement of the sensor or patient. Once the PPG signal is acquired, high pass adaptive and/or notch filtering can be used with one element of the filter from the red and infrared signals used to measure the arterial changes needed to compute SpO2 and the other element of the signal can be used to measure CVP changes.
摘要翻译：使用一个红色（例如660nm）和一个红外（例如880至940nm）发光二极管与单个光电二极管结合压力传感器获得光电体积描记术（PPG），从而同时测量CVP和SpO2 。该系统还包括能够测量传感器或患者的位置，角度和/或运动的传感器。一旦获取了PPG信号，就可以使用来自用于测量计算SpO2所需的动脉变化的红色和红外信号的滤波器的一个元件进行高通自适应和/或陷波滤波，并且可以使用该信号的另一个元件测量CVP变化。

8. 发明申请

US20100292545A1 INTERACTIVE PSYCHOPHYSIOLOGICAL PROFILER METHOD AND SYSTEM 审中-公开
标题翻译：交互式心理学概况分析方法与系统
公开(公告)号：US20100292545A1
公开(公告)日：2010-11-18
申请号：US12466263
申请日：2009-05-14
申请人： Chris Berka , Daniel J. Levendowski , Philip R. Westbrook , Gene Davis , Robin Johnson , Djordje Popovic
发明人： Chris Berka , Daniel J. Levendowski , Philip R. Westbrook , Gene Davis , Robin Johnson , Djordje Popovic
IPC分类号： A61B5/0205
CPC分类号： A61B5/048 , A61B5/024 , A61B5/168
摘要： An efficient, objective, flexible and easily deployable system for conducting evaluations of mental and physiological state and recommending individualized treatment to improve said state is described. The method and system are based on commensurate measurement of mental functions, levels of stress and anxiety, and/or biologically active molecules such as neurotransmitters, immune markers including cytokines and hormones. The method and system are designed to assess an individual's cognitive function and the underlying physiology in order to delineate various disease processes, injuries, drug states, training stages, fatigue levels, stress levels, aging processes, predict susceptibility to stress and/or sleep deprivation, identify aptitude for training and/or characterize effects of any experimental conditions. The system and method may be used in recommending individualized treatment protocols, as well as to guide the treatment process by assessing the efficacy of such therapies in the clinical trials process.
摘要翻译：描述了一种用于进行心理和生理状态评估的有效，客观，灵活和易于部署的系统，并推荐个性化治疗以改善所述状态。该方法和系统基于心理功能的相应测量，应激和焦虑水平，和/或生物活性分子，例如神经递质，包括细胞因子和激素的免疫标记。该方法和系统旨在评估个体的认知功能和潜在的生理学，以描绘各种疾病过程，损伤，药物状态，训练阶段，疲劳水平，压力水平，衰老过程，预测易感性和/或睡眠剥夺确定培训的能力和/或表征任何实验条件的影响。该系统和方法可用于推荐个体化治疗方案，以及通过评估这些疗法在临床试验过程中的功效来指导治疗过程。

9. 发明授权

US08277385B2 Method and apparatus for non-invasive assessment of hemodynamic and functional state of the brain 有权
标题翻译：用于非侵入性评估脑血流动力学和功能状态的方法和装置
公开(公告)号：US08277385B2
公开(公告)日：2012-10-02
申请号：US12700619
申请日：2010-02-04
申请人： Chris Berka , Daniel J. Levendowski , Djordje Popovic , Philip R. Westbrook
发明人： Chris Berka , Daniel J. Levendowski , Djordje Popovic , Philip R. Westbrook
IPC分类号： A61B5/02 , A61B5/04 , A61B5/00
CPC分类号： A61B5/031 , A61B5/02433 , A61B5/048 , A61B5/4094
摘要： A method and apparatus for assessment of hemodynamic and functional state of the brain is disclosed. In one embodiment, the method and apparatus includes non-invasive measurement of intracranial pressure, assessment of the brain's electrical activity, and measurement of cerebral blood flow. In some embodiments, the method and apparatus include measuring the volume change in the intracranial vessels with a near-infrared spectroscopy or other optical method, measuring the volume change in the intracranial vessels with rheoencephalography or other electrical method, and measuring the brain's electrical activity using electroencephalography.
摘要翻译：公开了一种用于评估大脑血液动力学和功能状态的方法和装置。在一个实施例中，该方法和装置包括颅内压的非侵入性测量，脑电活动的评估和脑血流量的测量。在一些实施方案中，所述方法和装置包括用近红外光谱法或其他光学方法测量颅内血管的体积变化，通过脑电图或其他电气方法测量颅内血管的体积变化，并使用脑电图

10. 发明申请

US20100268096A1 Method and Apparatus For Non-Invasive Assessment of Hemodynamic and Functional State of the Brain 有权
标题翻译：用于非侵入性评估脑血流动力学和功能状态的方法和装置
公开(公告)号：US20100268096A1
公开(公告)日：2010-10-21
申请号：US12700619
申请日：2010-02-04
申请人： Chris Berka , Daniel J. Levendowski , Djordje Popovic , Philip R. Westbrook
发明人： Chris Berka , Daniel J. Levendowski , Djordje Popovic , Philip R. Westbrook
IPC分类号： A61B5/02 , A61B5/026 , A61B5/0476
CPC分类号： A61B5/031 , A61B5/02433 , A61B5/048 , A61B5/4094
摘要： A method and apparatus for assessment of hemodynamic and functional state of the brain is disclosed. In one embodiment, the method and apparatus includes non-invasive measurement of intracranial pressure, assessment of the brain's electrical activity, and measurement of cerebral blood flow. In some embodiments, the method and apparatus include measuring the volume change in the intracranial vessels with a near-infrared spectroscopy or other optical method, measuring the volume change in the intracranial vessels with rheoencephalography or other electrical method, and measuring the brain's electrical activity using electroencephalography.
摘要翻译：公开了一种用于评估大脑血液动力学和功能状态的方法和装置。在一个实施例中，该方法和装置包括颅内压的非侵入性测量，脑电活动的评估和脑血流量的测量。在一些实施方案中，所述方法和装置包括用近红外光谱法或其他光学方法测量颅内血管的体积变化，通过脑电图或其他电气方法测量颅内血管的体积变化，并使用脑电图

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