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1. 发明申请

US20110270338A1 MRI OPERATION MODES FOR IMPLANTABLE MEDICAL DEVICES 有权
标题翻译：可植入医疗器械的MRI手术模式
公开(公告)号：US20110270338A1
公开(公告)日：2011-11-03
申请号：US13178571
申请日：2011-07-08
申请人： Daniel J. Cooke , Jeffrey A. Von Arx
发明人： Daniel J. Cooke , Jeffrey A. Von Arx
IPC分类号： A61N1/362 , A61N1/39 , A61N1/36
CPC分类号： A61N1/3718 , A61N1/02 , A61N1/36092 , A61N1/3688 , A61N1/3931 , A61N1/3962 , Y10S128/901
摘要： One embodiment of the present invention relates to an implantable medical device (“IMD”) that can be programmed from one operational mode to another operational mode when in the presence of electro-magnetic interference (“EMI”). In accordance with this particular embodiment, the IMD includes a communication interface for receiving communication signals from an external device, such as a command to switch the IMD from a first operation mode to a second operation mode. The IMD further includes a processor in electrical communication with the communication interface, which is operable to switch or reprogram the IMD from the first operation mode to the second operation mode upon receiving a command to do so. In addition, the IMD includes a timer operable to measure a time period from when the processor switches the IMD to the second operation mode. In accordance with this aspect of the invention, the processor is in electrical communication with the timer, and is further operable to switch the IMD from the second operation mode back to the first operation mode when the measured time period reaches a predetermined time period.
摘要翻译：本发明的一个实施例涉及当存在电磁干扰（“EMI”）时可从一个操作模式编程到另一个操作模式的可植入医疗装置（“IMD”）。根据该特定实施例，IMD包括用于从外部设备接收通信信号的通信接口，诸如将IMD从第一操作模式切换到第二操作模式的命令。 IMD还包括与通信接口电通信的处理器，其可操作以在接收到这样做的命令时将IMD从第一操作模式切换或重新编程到第二操作模式。另外，IMD包括一个定时器，可操作以测量从处理器将IMD切换到第二操作模式的时间段。根据本发明的这个方面，处理器与定时器电通信，并且当测量的时间段达到预定的时间周期时，进一步可操作地将IMD从第二操作模式切换回第一操作模式。

2. 发明授权

US08543207B2 MRI operation modes for implantable medical devices 有权
标题翻译：可植入医疗器械的MRI操作模式
公开(公告)号：US08543207B2
公开(公告)日：2013-09-24
申请号：US13178571
申请日：2011-07-08
申请人： Daniel J. Cooke , Jeffrey A. Von Arx
发明人： Daniel J. Cooke , Jeffrey A. Von Arx
IPC分类号： A61N1/37
CPC分类号： A61N1/3718 , A61N1/02 , A61N1/36092 , A61N1/3688 , A61N1/3931 , A61N1/3962 , Y10S128/901
摘要： One embodiment of the present invention relates to an implantable medical device (“IMD”) that can be programmed from one operational mode to another operational mode when in the presence of electro-magnetic interference (“EMI”). In accordance with this particular embodiment, the IMD includes a communication interface for receiving communication signals from an external device, such as a command to switch the IMD from a first operation mode to a second operation mode. The IMD further includes a processor in electrical communication with the communication interface, which is operable to switch or reprogram the IMD from the first operation mode to the second operation mode upon receiving a command to do so. In addition, the IMD includes a timer operable to measure a time period from when the processor switches the IMD to the second operation mode. In accordance with this aspect of the invention, the processor is in electrical communication with the timer, and is further operable to switch the IMD from the second operation mode back to the first operation mode when the measured time period reaches a predetermined time period.
摘要翻译：本发明的一个实施例涉及当存在电磁干扰（“EMI”）时可从一个操作模式编程到另一个操作模式的可植入医疗装置（“IMD”）。根据该特定实施例，IMD包括用于从外部设备接收通信信号的通信接口，诸如将IMD从第一操作模式切换到第二操作模式的命令。 IMD还包括与通信接口电通信的处理器，其可操作以在接收到这样做的命令时将IMD从第一操作模式切换或重新编程到第二操作模式。另外，IMD包括一个定时器，可操作以测量从处理器将IMD切换到第二操作模式的时间段。根据本发明的这个方面，处理器与定时器电通信，并且当测量的时间段达到预定的时间周期时，进一步可操作地将IMD从第二操作模式切换回第一操作模式。

3. 发明申请

US20090138058A1 MRI OPERATION MODES FOR IMPLANTABLE MEDICAL DEVICES 有权
标题翻译：可植入医疗器械的MRI手术模式
公开(公告)号：US20090138058A1
公开(公告)日：2009-05-28
申请号：US11015807
申请日：2004-12-17
申请人： Daniel J. Cooke , Jeffrey A. Von Arx
发明人： Daniel J. Cooke , Jeffrey A. Von Arx
IPC分类号： A61N1/08 , A61N1/362 , A61N1/39
CPC分类号： A61N1/3718 , A61N1/02 , A61N1/36092 , A61N1/3688 , A61N1/3931 , A61N1/3962 , Y10S128/901
摘要： One embodiment of the present invention relates to an implantable medical device (“IMD”) that can be programmed from one operational mode to another operational mode when in the presence of electro-magnetic interference (“EMI”). In accordance with this particular embodiment, the IMD includes a communication interface for receiving communication signals from an external device, such as a command to switch the IMD from a first operation mode to a second operation mode. The IMD further includes a processor in electrical communication with the communication interface, which is operable to switch or reprogram the IMD from the first operation mode to the second operation mode upon receiving a command to do so. In addition, the IMD includes a timer operable to measure a time period from when the processor switches the IMD to the second operation mode. In accordance with this aspect of the invention, the processor is in electrical communication with the timer, and is further operable to switch the IMD from the second operation mode back to the first operation mode when the measured time period reaches a predetermined time period.
摘要翻译：本发明的一个实施例涉及当存在电磁干扰（“EMI”）时可从一个操作模式编程到另一个操作模式的可植入医疗装置（“IMD”）。根据该特定实施例，IMD包括用于从外部设备接收通信信号的通信接口，诸如将IMD从第一操作模式切换到第二操作模式的命令。 IMD还包括与通信接口电通信的处理器，其可操作以在接收到这样做的命令时将IMD从第一操作模式切换或重新编程到第二操作模式。另外，IMD包括一个定时器，可操作以测量从处理器将IMD切换到第二操作模式的时间段。根据本发明的这个方面，处理器与定时器电通信，并且当测量的时间段达到预定的时间周期时，进一步可操作地将IMD从第二操作模式切换回第一操作模式。

4. 发明授权

US08014867B2 MRI operation modes for implantable medical devices 有权
标题翻译：可植入医疗器械的MRI操作模式
公开(公告)号：US08014867B2
公开(公告)日：2011-09-06
申请号：US11015807
申请日：2004-12-17
申请人： Daniel J. Cooke , Jeffrey A. Von Arx
发明人： Daniel J. Cooke , Jeffrey A. Von Arx
IPC分类号： A61N1/37
CPC分类号： A61N1/3718 , A61N1/02 , A61N1/36092 , A61N1/3688 , A61N1/3931 , A61N1/3962 , Y10S128/901
摘要： One embodiment of the present invention relates to an implantable medical device (“IMD”) that can be programmed from one operational mode to another operational mode when in the presence of electro-magnetic interference (“EMI”). In accordance with this particular embodiment, the IMD includes a communication interface for receiving communication signals from an external device, such as a command to switch the IMD from a first operation mode to a second operation mode. The IMD further includes a processor in electrical communication with the communication interface, which is operable to switch or reprogram the IMD from the first operation mode to the second operation mode upon receiving a command to do so. In addition, the IMD includes a timer operable to measure a time period from when the processor switches the IMD to the second operation mode. In accordance with this aspect of the invention, the processor is in electrical communication with the timer, and is further operable to switch the IMD from the second operation mode back to the first operation mode when the measured time period reaches a predetermined time period.
摘要翻译：本发明的一个实施例涉及当存在电磁干扰（“EMI”）时可从一个操作模式编程到另一个操作模式的可植入医疗装置（“IMD”）。根据该特定实施例，IMD包括用于从外部设备接收通信信号的通信接口，诸如将IMD从第一操作模式切换到第二操作模式的命令。 IMD还包括与通信接口电通信的处理器，其可操作以在接收到这样做的命令时将IMD从第一操作模式切换或重新编程到第二操作模式。另外，IMD包括一个定时器，可操作以测量从处理器将IMD切换到第二操作模式的时间段。根据本发明的这个方面，处理器与定时器电通信，并且当测量的时间段达到预定的时间周期时，进一步可操作地将IMD从第二操作模式切换回第一操作模式。

5. 发明授权

US07561915B1 MRI system having implantable device safety features 有权
标题翻译： MRI系统具有植入式装置的安全特征
公开(公告)号：US07561915B1
公开(公告)日：2009-07-14
申请号：US11016191
申请日：2004-12-17
申请人： Daniel J. Cooke , Jeffrey A. Von Arx
发明人： Daniel J. Cooke , Jeffrey A. Von Arx
IPC分类号： A61N1/37
CPC分类号： A61N1/3718 , A61B5/055 , A61N1/37264
摘要： One embodiment of the present invention relates to a telemetry device which is in communication with an MRI system, and which is operable to communicate with an implantable medical device (IMD). The telemetry device includes a controller and telemetry circuitry. In one embodiment, the telemetry device is operable to automatically detect the presence of an IMD, and determine if the IMD is in an MRI-safe mode. If the IMD is not in an MRI-safe mode, the telemetry device can initiate processing to prevent the MRI system from conducting an MRI scan while the IMD in not in an MRI-safe mode.
摘要翻译：本发明的一个实施例涉及一种与MRI系统通信并且可操作以与可植入医疗装置（IMD）进行通信的遥测装置。遥测装置包括控制器和遥测电路。在一个实施例中，遥测装置可操作以自动检测IMD的存在，并确定IMD是否处于MRI安全模式。如果IMD不在MRI安全模式，则遥测装置可以启动处理以防止MRI系统在IMD不在MRI安全模式下进行MRI扫描。

6. 发明申请

US20120052184A1 DRUG ELUTING COATINGS FOR A MEDICAL LEAD AND METHOD 审中-公开
标题翻译：用于医疗铅和药物的药物涂覆涂料
公开(公告)号：US20120052184A1
公开(公告)日：2012-03-01
申请号：US13288487
申请日：2011-11-03
申请人： Harshad M. Borgaonkar , Ronald W. Heil, JR. , Arienne P. Simon , Jeannette C. Polkinghorne , Daniel J. Cooke
发明人： Harshad M. Borgaonkar , Ronald W. Heil, JR. , Arienne P. Simon , Jeannette C. Polkinghorne , Daniel J. Cooke
IPC分类号： B05D5/00 , B05D3/00 , B05D7/00
CPC分类号： A61N1/056 , A61N1/0568
摘要： A medical electrical lead includes a drug eluting coating provided over at least a portion of the lead body. The drug eluting coating can be provided over at least a portion of the lead body and adjacent to at least one electrode located on the lead body. The drug eluting coating can include at least one matrix polymer layer including a polymer admixed with a therapeutic agent. The therapeutic agent, for example, can be an anti-proliferative agent or an anti-inflammatory agent. The matrix polymer can include a medical adhesive. The rate of elution of the drug from the matrix polymer layer is affected by the drug to polymer ratio of the drug in the matrix polymer layer.
摘要翻译：医用电引线包括提供在引线主体的至少一部分上的药物洗脱涂层。药物洗脱涂层可以提供在引线主体的至少一部分上并与位于引线主体上的至少一个电极相邻。药物洗脱涂层可以包括至少一种包含与治疗剂混合的聚合物的基质聚合物层。治疗剂例如可以是抗增殖剂或抗炎剂。基质聚合物可以包括医用粘合剂。药物从基质聚合物层的洗脱速率受基质聚合物层中药物与聚合物的比例的影响。

7. 发明申请

US20090221885A1 Optical Window Assembly for Implantable Medical Device 审中-公开
标题翻译：用于植入式医疗设备的光学窗组件
公开(公告)号：US20090221885A1
公开(公告)日：2009-09-03
申请号：US12391761
申请日：2009-02-24
申请人： Peter Hall , Daniel J. Cooke , Michael John Kane
发明人： Peter Hall , Daniel J. Cooke , Michael John Kane
IPC分类号： A61B5/1473 , B23K31/02
CPC分类号： A61B5/14542 , A61B5/1473
摘要： Embodiments of the invention are related to optical window assemblies for implantable medical devices, amongst other things. In an embodiment, the invention includes an optical window assembly for a medical device. The assembly can include a ferrule defining an aperture and a spacer ring disposed within the aperture. The assembly can also include an optical window coupled to the metal ferrule and the spacer ring. In an embodiment, the invention includes an implantable medical device including a housing and an optical window assembly coupled to the housing. In an embodiment, the invention can include a method of manufacturing a medical device. The method can include brazing a spacer ring to a metal ferrule, coupling an optical window to the spacer ring and the metal ferrule with a bonding glass material, depositing a chemical sensing element over the optical window, and coupling a porous cover layer to the spacer ring and the ferrule with an adhesive. Other embodiments are also included herein.
摘要翻译：本发明的实施例涉及用于可植入医疗装置的光学窗组件，其中包括。在一个实施例中，本发明包括用于医疗装置的光学窗组件。组件可以包括限定孔的套圈和设置在孔内的间隔环。组件还可以包括耦合到金属套圈和间隔环的光学窗口。在一个实施例中，本发明包括可植入医疗装置，其包括壳体和耦合到壳体的光学窗组件。在一个实施例中，本发明可以包括制造医疗装置的方法。该方法可以包括将间隔环钎焊到金属套箍上，用光学玻璃材料将光学窗口耦合到间隔环和金属套圈，在光学窗口上沉积化学感测元件，以及将多孔覆盖层耦合到间隔物环和带有粘合剂的套圈。本文还包括其它实施例。

8. 发明授权

US08324290B2 Polyisobutylene urethane, urea and urethane/urea copolymers and medical devices containing the same 有权
标题翻译：聚异丁烯聚氨酯，尿素和氨基甲酸酯/尿素共聚物以及含有它们的医疗装置
公开(公告)号：US08324290B2
公开(公告)日：2012-12-04
申请号：US12492483
申请日：2009-06-26
申请人： Shrojalkumar Desai , Marlene C. Schwarz , Mark Boden , Mohan Krishnan , Michael C. Smith , Frederick H. Strickler , Daniel J. Cooke
发明人： Shrojalkumar Desai , Marlene C. Schwarz , Mark Boden , Mohan Krishnan , Michael C. Smith , Frederick H. Strickler , Daniel J. Cooke
IPC分类号： A61N1/05
CPC分类号： C08G18/6204 , A61L27/18 , A61L31/06 , C08G18/10 , C08G18/12 , C08G18/4063 , C08G18/4854 , C08G18/4858 , C08G18/6511 , C08G18/7657 , C08L75/00 , C08G18/3206
摘要： The present invention pertains to polyisobutylene urethane, urea and urethane/urea copolymers, to methods of making such copolymers and to medical devices that contain such polymers. According to certain aspects of the invention, polyisobutylene urethane, urea and urethane/urea copolymers are provided, which comprise a polyisobutylene segment, an additional polymeric segment that is not a polyisobutylene segment, and a segment comprising a residue of a diisocyanate. According to other aspects of the invention, polyisobutylene urethane, urea and urethane/urea copolymers are provided, which comprise a polyisobutylene segment and end groups that comprise alkyl-, alkenyl- or alkynyl-chain-containing end groups.
摘要翻译：本发明涉及聚异丁烯氨基甲酸酯，脲和氨基甲酸酯/尿素共聚物，涉及制备这种共聚物的方法和含有这种聚合物的医疗装置。根据本发明的某些方面，提供聚异丁烯氨基甲酸酯，脲和氨基甲酸酯/脲共聚物，其包含聚异丁烯链段，不是聚异丁烯链段的另外的聚合链段和包含二异氰酸酯残基的链段。根据本发明的其它方面，提供聚异丁烯氨基甲酸酯，脲和氨基甲酸酯/脲共聚物，其包含聚异丁烯链段和包含含有烷基，链烯基或炔基链的端基的端基。

9. 发明申请

US20100042195A1 IMPLANTABLE LEAD WITH FLEXIBLE TIP FEATURES 有权
标题翻译：具有灵活提示功能的可伸缩引线
公开(公告)号：US20100042195A1
公开(公告)日：2010-02-18
申请号：US12508322
申请日：2009-07-23
申请人： Daniel J. Cooke , Leslie L. Carion , Shrojalkumar Desai , Brendan E. Koop , Ronald W. Heil, JR. , Harshad M. Borgaonkar , Matthew S. Finlay
发明人： Daniel J. Cooke , Leslie L. Carion , Shrojalkumar Desai , Brendan E. Koop , Ronald W. Heil, JR. , Harshad M. Borgaonkar , Matthew S. Finlay
IPC分类号： A61N1/05
CPC分类号： A61N1/057 , A61N1/0568
摘要： A medical electrical lead comprises a flexible, elongate lead body extending along a longitudinal axis and having a proximal end and a distal end. A protective distal tip structure is disposed on the distal end of the lead body. The tip structure includes a plurality of compliant projections each extending distally from the distal end of the body in the direction of the longitudinal axis. The projections are configured to contact and bear against cardiac tissue when the lead is implanted, and are deformable under the action of an axially or radially directed force. The projections optionally include a coating over a substrate. The coating can include a hydrogel material and/or a pharmaceutical agent such as a steroid for reducing inflammation at the implantation site.
摘要翻译：医疗电引线包括沿着纵向轴线延伸并且具有近端和远端的柔性细长引线体。保护性的顶端结构设置在引线体的远端。尖端结构包括多个顺从突起，每个突起从纵向轴线的方向远离主体的远端延伸。突起被配置为当铅被植入时与心脏组织接触并承受，并且在轴向或径向力的作用下可变形。突起任选地包括在基底上的涂层。涂层可以包括水凝胶材料和/或药剂，例如类固醇，用于在植入部位减少炎症。

10. 发明申请

US20080046059A1 LEAD INCLUDING A HEAT FUSED OR FORMED LEAD BODY 审中-公开
标题翻译：引导包括热熔或形成的铅体
公开(公告)号：US20080046059A1
公开(公告)日：2008-02-21
申请号：US11462479
申请日：2006-08-04
申请人： Paul E. Zarembo , Mohan Krishnan , David Durand , Donna Osterkamp , Daniel J. Cooke
发明人： Paul E. Zarembo , Mohan Krishnan , David Durand , Donna Osterkamp , Daniel J. Cooke
IPC分类号： A61N1/00
CPC分类号： A61N1/056 , A61N1/057
摘要： An implantable lead comprises a lead body extending from a lead proximal end portion to a lead distal end portion. In one example, the lead body may comprise a heat-formed bias portion. In another example, an outer insulator is fused to the lead body. In such an example, a lead body fusable plug may be disposed distal to at least one conductor. In another example, the lead comprises an inner boot and an outer boot fused to one another. In another example, the lead includes an atraumatic tip fused to the lead distal end portion. In another example, the lead body is reducable in size using heat shrink tubing. In yet another example, two or more lead sections may be interconnected using an outer insulator fused to the respective lead bodies. In a further example, a stiffener member is fused to the lead body adjacent a lead component.
摘要翻译：可植入引线包括从引线近端部分延伸到引线远端部分的引线体。在一个示例中，引线体可以包括加热成形的偏压部分。在另一示例中，外绝缘体熔合到引线体。在这种示例中，引线本体可熔插塞可以设置在至少一个导体的远侧。在另一个示例中，引线包括彼此融合的内靴和外靴。在另一示例中，引线包括熔合到引线远端部分的无创尖端。在另一个例子中，使用热缩管可以使引线体尺寸减小。在又一示例中，两个或更多个引线部分可以使用融合到相应引线体的外绝缘体互连。在另一个例子中，加强件与引线部件相邻地被引导体熔合。

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