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1. 发明申请

US20090222219A1 Method for determining average properties of molecules in solution by injection into a flowing solvent 有权
标题翻译：通过注入流动溶剂测定溶液中分子的平均性质的方法
公开(公告)号：US20090222219A1
公开(公告)日：2009-09-03
申请号：US12072986
申请日：2008-02-29
申请人： Daniel I. Some , Steven P. Trainoff
发明人： Daniel I. Some , Steven P. Trainoff
IPC分类号： G06F19/00
CPC分类号： G01N15/0205 , G01N35/085 , G01N35/1095 , G01N2021/4711 , G01N2035/1032
摘要： A new method is presented for measuring the molecular properties of an unfractionated solution of macromolecules. Sample aliquots spanning a range of concentrations are injected sequentially into a stream of solution and flow towards the detectors. Each aliquot produces, thereby, an effective “peak” whose elements correspond to different concentrations of the diluted aliquot. The weight averaged molar mass, the mean square radius, and the second virial coefficient of the macromolecules in solution are derived from an analysis of the angular and concentration dependence of the scattering signals throughout the corresponding peaks. In contrast to earlier on-line methods, better accuracy is achieved, while using a smaller quantity of sample. A similar method for determining cross virial coefficients between two distinct species of macromolecules is also presented.
摘要翻译：提出了一种用于测量大分子的未分级溶液的分子性质的新方法。将一系列浓度的样品等分试样依次注入溶液流中并流向检测器。每个等分试样产生有效的“峰”，其元素对应于稀释的等分试样的不同浓度。溶液中大分子的重量平均摩尔质量，均方半径和第二维里系数是从散射信号在整个相应峰中的角度和浓度依赖性的分析得出的。与早期的在线方法相比，在使用较少量的样品的同时，实现了更高的精度。还提出了用于确定两种不同种类的大分子之间的交叉维里系数的类似方法。

2. 发明授权

US07813882B2 Method for determining average properties of molecules in solution 有权
标题翻译：测定溶液中分子平均性质的方法
公开(公告)号：US07813882B2
公开(公告)日：2010-10-12
申请号：US12072986
申请日：2008-02-29
申请人： Daniel I. Some , Steven P. Trainoff
发明人： Daniel I. Some , Steven P. Trainoff
IPC分类号： G01N31/00
CPC分类号： G01N15/0205 , G01N35/085 , G01N35/1095 , G01N2021/4711 , G01N2035/1032
摘要： A new method is presented for measuring the molecular properties of an unfractionated solution of macromolecules. Sample aliquots spanning a range of concentrations are injected sequentially into a stream of solution and flow towards the detectors. Each aliquot produces, thereby, an effective “peak” whose elements correspond to different concentrations of the diluted aliquot. The weight averaged molar mass, the mean square radius, and the second virial coefficient of the macromolecules in solution are derived from an analysis of the angular and concentration dependence of the scattering signals throughout the corresponding peaks. In contrast to earlier on-line methods, better accuracy is achieved, while using a smaller quantity of sample. A similar method for determining cross virial coefficients between two distinct species of macromolecules is also presented.
摘要翻译：提出了一种用于测量大分子的未分级溶液的分子性质的新方法。将一系列浓度的样品等分试样依次注入溶液流中并流向检测器。每个等分试样产生有效的“峰”，其元素对应于稀释的等分试样的不同浓度。溶液中大分子的重量平均摩尔质量，均方半径和第二维里系数是从散射信号在整个相应峰中的角度和浓度依赖性的分析得出的。与早期的在线方法相比，在使用较少量的样品的同时，实现了更好的精度。还提出了用于确定两种不同种类的大分子之间的交叉维里系数的类似方法。

3. 发明授权

US06686602B2 Patterned wafer inspection using spatial filtering 有权
标题翻译：使用空间滤波的图案化晶圆检查
公开(公告)号：US06686602B2
公开(公告)日：2004-02-03
申请号：US10050890
申请日：2002-01-15
申请人： Daniel I. Some
发明人： Daniel I. Some
IPC分类号： G01N2188
CPC分类号： G01N21/9501 , G01N21/95623
摘要： Apparatus for spatial filtering includes a Fourier lens, adapted to collect radiation emitted from a point and to separate the collected radiation into spatial components in a Fourier plane of the lens, and a programmable spatial filter, positioned at the Fourier plane. An image sensor is optically coupled to capture an image of the spatial components of the collected radiation in the Fourier plane, while the components are incident on the filter. A filter controller is coupled to receive and analyze the image captured by the image sensor and, responsive thereto, to control the spatial filter so as to block one or more of the spatial components.
摘要翻译：用于空间滤波的装置包括傅立叶透镜，其适于收集从点发射的辐射并将收集的辐射分离成透镜的傅立叶平面中的空间分量，以及位于傅立叶平面处的可编程空间滤波器。图像传感器被光学耦合以捕获傅立叶平面中收集的辐射的空间分量的图像，同时组件入射到滤光器上。滤波器控制器被耦合以接收和分析由图像传感器捕获的图像，并且响应于此控制空间滤波器以便阻挡一个或多个空间分量。

4. 发明申请

US20130176556A1 Multiwell plate lid for improved optical measurements 有权
公开(公告)号：US20130176556A1
公开(公告)日：2013-07-11
申请号：US13492527
申请日：2012-06-08
申请人： Michael I. Larkin , Amy D. Hanlon , Daniel I. Some , Richard J. Sleiman , David N. Villalpando
发明人： Michael I. Larkin , Amy D. Hanlon , Daniel I. Some , Richard J. Sleiman , David N. Villalpando
IPC分类号： G01N21/01 , G01N21/51
CPC分类号： G01N21/01 , G01N21/0303 , G01N21/253 , G01N21/51 , G01N2201/06113
摘要： A lid for multiwell plates, allowing improved optical measurement of liquid samples within its wells, while mitigating evaporation from said samples, is disclosed. A surface element protrudes from the bottom of the lid into the fluid within a well. The protruding element may be hollow or solid such that light directed into the element may act to capture or direct the beam while preventing backscatter from reaching one or more detectors. The protruding element may direct the beam from the well without requiring the beam to pass through a fluid/air interface. The angle and shape of the lid surfaces and/or light absorbing/blocking colorization may be employed to minimize or eliminate back reflection. Evaporation is controlled by physically capping the well with the lid, either sealing against the face at the top of the well or the inside surface of the well.

5. 发明申请

US20100332146A1 Method for characterizing reversible association of macromolecules at high concentration 有权
标题翻译：表征高浓度大分子可逆缔合的方法
公开(公告)号：US20100332146A1
公开(公告)日：2010-12-30
申请号：US12459437
申请日：2009-06-30
申请人： Daniel I. Some
发明人： Daniel I. Some
IPC分类号： G06F19/00 , G01N31/00
CPC分类号： G01N21/53
摘要： A new method is presented for characterizing the associative properties of a solution of macromolecules at high concentration. Sample aliquots spanning a range of concentrations are injected sequentially into a light scattering photometer. Equilibrium association constants and association stoichiometry are derived from an analysis of the angular and concentration dependence of the scattering signals. Thermodynamic nonideality, which becomes important at high concentrations, is dealt with in the analysis in a simplified manner which is applicable to multiple associated species.
摘要翻译：提出了一种用于表征高浓度大分子溶液的缔合性质的新方法。将一系列浓度的样品等分试样顺序注入光散射光度计中。平衡缔合常数和缔合化学计量是从对散射信号的角度和浓度依赖性的分析得出的。在高浓度下变得重要的热力学非线性在分析中以简化的方式处理，该方法适用于多个相关物种。

6. 发明授权

US07009695B2 Full frame thermal pump probe technique for detecting subsurface defects 有权
标题翻译：全帧热泵探头技术，用于检测地下缺陷
公开(公告)号：US07009695B2
公开(公告)日：2006-03-07
申请号：US10812817
申请日：2004-03-29
申请人： Daniel I. Some
发明人： Daniel I. Some
IPC分类号： G01N21/88
CPC分类号： G01N25/72
摘要： An area of a substrate is imaged with and without heating, to obtain a hot image and a cold image respectively. The hot and cold images are compared with one another to identify one or more locations as being defective, e.g. if the result of comparison at one location differs significantly relative to other locations. The comparison results in all locations form a differential image, and in several embodiments a number of differential images are obtained by repeatedly heating, imaging and comparing. In such embodiments, multiple differential images are averaged at each location, to improve the signal to noise ratio. Pump and probe lasers may be used for heating and for illumination respectively, or alternatively a single laser may be employed to generate both pump and probe beams.
摘要翻译：基板的面积和加热成像，分别得到热图像和冷图像。将热图像和冷图像相互比较以将一个或多个位置识别为有缺陷的图像。如果在一个位置的比较结果相对于其他位置显着不同。所有位置的比较结果形成差分图像，并且在几个实施例中，通过反复加热，成像和比较获得多个差分图像。在这样的实施例中，在每个位置对多个差分图像进行平均，以提高信噪比。泵和探针激光器可以分别用于加热和照明，或者可以使用单个激光器来产生泵浦和探针光束。

7. 发明授权

US08976353B2 Multiwell plate lid for improved optical measurements 有权
标题翻译：多孔板盖，用于改进光学测量
公开(公告)号：US08976353B2
公开(公告)日：2015-03-10
申请号：US13492527
申请日：2012-06-08
申请人： Michael I. Larkin , Amy D. Hanlon , Daniel I. Some , Richard J. Sleiman , David N. Villalpando
发明人： Michael I. Larkin , Amy D. Hanlon , Daniel I. Some , Richard J. Sleiman , David N. Villalpando
IPC分类号： G01N21/00 , G01N21/01 , G01N21/51 , G01N21/03 , G01N21/25
CPC分类号： G01N21/01 , G01N21/0303 , G01N21/253 , G01N21/51 , G01N2201/06113
摘要： A lid for multiwell plates, allowing improved optical measurement of liquid samples within its wells, while mitigating evaporation from said samples, is disclosed. A surface element protrudes from the bottom of the lid into the fluid within a well. The protruding element may be hollow or solid such that light directed into the element may act to capture or direct the beam while preventing backscatter from reaching one or more detectors. The protruding element may direct the beam from the well without requiring the beam to pass through a fluid/air interface. The angle and shape of the lid surfaces and/or light absorbing/blocking colorization may be employed to minimize or eliminate back reflection. Evaporation is controlled by physically capping the well with the lid, either sealing against the face at the top of the well or the inside surface of the well.
摘要翻译：公开了一种用于多孔板的盖，其允许改进其孔内的液体样品的光学测量，同时减轻所述样品的蒸发。表面元件从盖的底部突出到井内的流体中。突出元件可以是中空的或固体的，使得被引导到元件中的光可以用于捕获或引导光束，同时防止反向散射到达一个或多个检测器。突出元件可以将梁从井中引导，而不需要光束通过流体/空气界面。可以使用盖表面的角度和形状和/或光吸收/阻挡着色来最小化或消除背反射。蒸发是通过用盖子将油井物理地盖上来控制的，或者密封在井的顶部或者井的内表面。

8. 发明申请

US20110269635A1 SYSTEMS AND METHODS FOR HIGH-THROUGHPUT SCREENING USING LIGHT SCATTERING 审中-公开
标题翻译：使用光散射进行高通滤波的系统和方法
公开(公告)号：US20110269635A1
公开(公告)日：2011-11-03
申请号：US12770496
申请日：2010-04-29
申请人： Daniel I. Some
发明人： Daniel I. Some
IPC分类号： C40B30/04
CPC分类号： G01N33/53 , G01N15/0205 , G01N21/53 , G01N2500/02
摘要： Systems and methods for high-throughput screening can be used to determine whether binding occurs between different molecular species. Some systems compare measurements obtained from a static light scattering detector relative to a first solution that includes a target molecular species, a second solution that includes a test molecular species, and a third solution that includes a mixture of the target and test molecular species.
摘要翻译：用于高通量筛选的系统和方法可用于确定是否在不同分子物种之间发生结合。一些系统比较从静态光散射检测器获得的测量值相对于包括目标分子种类的第一溶液，包括测试分子种类的第二溶液，以及包括靶分子和测试分子物质的混合物的第三溶液。

9. 发明授权

US06853446B1 Variable angle illumination wafer inspection system 有权
标题翻译：可变角度照明晶圆检查系统
公开(公告)号：US06853446B1
公开(公告)日：2005-02-08
申请号：US09641137
申请日：2000-08-16
申请人： Gilad Almogy , Hadar Mazaki , Zvi Howard Phillip , Silviu Reinhorn , Boris Goldberg , Daniel I. Some
发明人： Gilad Almogy , Hadar Mazaki , Zvi Howard Phillip , Silviu Reinhorn , Boris Goldberg , Daniel I. Some
IPC分类号： G01N21/21 , G01N21/95 , G02B21/08 , G02B26/10 , G01N21/00
CPC分类号： G02B26/10 , G01N21/21 , G01N21/9501 , G02B21/082
摘要： A variable illumination angle inspection system is provided, including a light source providing a light beam and a scanner imparting scanning deflection to the light beam to provide a scanning beam approaching a substrate at a first angle. A deflection element is selectively insertable into an optical path of the scanning beam to deflect the scanning beam so as to cause the scanning beam to approach the substrate at a second angle.
摘要翻译：提供了可变照明角度检查系统，包括提供光束的光源和向光束施加扫描偏转的扫描器，以提供以第一角度接近基板的扫描光束。偏转元件可选择性地插入到扫描光束的光路中以偏转扫描光束，以使扫描光束以第二角度接近基板。

10. 发明授权

US06791099B2 Laser scanning wafer inspection using nonlinear optical phenomena 失效
标题翻译：激光扫描晶圆检查采用非线性光学现象
公开(公告)号：US06791099B2
公开(公告)日：2004-09-14
申请号：US09784626
申请日：2001-02-14
申请人： Daniel I. Some , Silviu Reinhorn , Gilad Almogy
发明人： Daniel I. Some , Silviu Reinhorn , Gilad Almogy
IPC分类号： G01V800
CPC分类号： G01N21/9501 , G01N21/4788 , G01N21/64 , G01N21/65 , G01N21/658
摘要： An optical inspection apparatus and method is provided that utilizes both linear and nonlinear optical phenomena to detect defects. Embodiments include irradiating a portion of the surface of an article, such as a semiconductor device, with a light beam, such as a scanning laser at an incident wavelength. The light emanating from the irradiated surface portion is then separated into light at the incident wavelength and light at one or more predetermined non-incident wavelengths, as by a diffraction grating, prism or filters. The light at the incident and nonincident wavelengths is sent to separate detectors, such as photomultipliers (PMT), which respectively convert the detected linear optical phenomena (representing, e.g., surface topography) into an electrical signal, and the detected nonlinear optical phenomena, such as fluorescence, Raman scattering and/or second harmonic generation, into electrical signals representing, e.g., chemical composition and material interfaces. The signal from each detector is sent to a processor, which generates a defect map based on the information gleaned from both the linear and nonlinear optical phenomena.
摘要翻译：提供一种利用线性和非线性光学现象来检测缺陷的光学检查装置和方法。实施例包括用入射波长的诸如扫描激光束的光束照射诸如半导体器件的物品的表面的一部分。然后将从照射的表面部分发出的光分离成入射波长的光和一个或多个预定非入射波长的光，如通过衍射光栅，棱镜或滤光器。将入射波长和非相干波长的光发送到分离的检测器，例如光电倍增管（PMT），其分别将检测到的线性光学现象（例如，表面形貌）转换为电信号，以及检测到的非线性光学现象作为荧光，拉曼散射和/或二次谐波产生，代表例如化学成分和材料界面的电信号。来自每个检测器的信号被发送到处理器，其基于从线性和非线性光学现象收集的信息产生缺陷图。

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