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1. 发明授权

US10114086B2 Hybrid PET/MR imaging systems 有权
公开(公告)号：US10114086B2
公开(公告)日：2018-10-30
申请号：US12195637
申请日：2008-08-21
申请人： Daniel Gagnon , Michael A. Morich , Douglas M. Blakeley , Robert L. Zahn , Kevin M. Nieman
发明人： Daniel Gagnon , Michael A. Morich , Douglas M. Blakeley , Robert L. Zahn , Kevin M. Nieman
IPC分类号： A61B5/05 , A61B6/00 , G01R33/28 , G01R33/3875 , G01R33/421 , G01R33/422 , G01R33/48
摘要： A hybrid imaging system includes a magnetic resonance scanner and a second modality imaging system disposed in the same radio frequency isolation space. The second modality imaging system includes radiation detectors configured to detect at least one of high energy particles and high energy photons. In some embodiments a retractable radio frequency screen is selectively extendible into a gap between the magnetic resonance scanner and the second modality imaging system. In some embodiments shim coils are disposed with the magnetic resonance scanner and are configured to compensate for distortion of the static magnetic field of the magnetic resonance scanner produced by proximity of the second modality imaging system.

2. 发明授权

US08516636B2 Patient bed for PET/MR imaging systems 有权
标题翻译： PET / MR成像系统的病床
公开(公告)号：US08516636B2
公开(公告)日：2013-08-27
申请号：US12195655
申请日：2008-08-21
申请人： Daniel Gagnon , Michael A. Morich , Douglas M. Blakeley
发明人： Daniel Gagnon , Michael A. Morich , Douglas M. Blakeley
IPC分类号： A61B6/04
CPC分类号： A61B5/0555 , A61B5/0035 , A61B6/032 , A61B6/037 , A61B6/4417 , A61B6/4429
摘要： A hybrid imaging system and a patient bed for same are disclosed. The hybrid imaging system includes a magnetic resonance scanner and a second modality imaging system spaced apart from the magnetic resonance scanner by a gap. In some embodiments, the gap is less than seven meters. The patient bed is disposed at least partially in the gap between the magnetic resonance scanner and the second modality imaging system, and includes a linearly translatable patient support pallet aligned to be selectively moved into an examination region of the magnetic resonance scanner for magnetic resonance imaging and into an examination region of the second modality imaging system for second modality imaging. In some embodiments, a linear translation range of the linearly translatable pallet is less than five times a length of the patient support pallet along the direction of linear translation.
摘要翻译：公开了一种混合成像系统和用于其的患者床。混合成像系统包括磁共振扫描器和通过间隙与磁共振扫描器隔开的第二模态成像系统。在一些实施例中，间隙小于7米。患者床至少部分地设置在磁共振扫描仪和第二模态成像系统之间的间隙中，并且包括可选择性地移动到用于磁共振成像的磁共振扫描仪的检查区域中的线性可平移的患者支撑托盘，进入用于第二模态成像的第二模态成像系统的检查区域。在一些实施例中，线性平移托盘的线性平移范围小于患者支撑托盘沿线性平移方向的长度的五倍。

3. 发明授权

US4694837A Cardiac and respiratory gated magnetic resonance imaging 失效
标题翻译：心脏和呼吸门控磁共振成像
公开(公告)号：US4694837A
公开(公告)日：1987-09-22
申请号：US764440
申请日：1985-08-09
申请人： Douglas M. Blakeley , Carolyn A. Kershaw , Raymond E. Gangarosa
发明人： Douglas M. Blakeley , Carolyn A. Kershaw , Raymond E. Gangarosa
IPC分类号： A61B5/055 , A61B6/00 , A61B10/00 , G01N24/08 , G01N33/00 , G01R33/48 , G01R33/567 , A61B5/05
CPC分类号： G01R33/5673 , A61B5/7285 , A61B5/7239 , A61B6/541
摘要： A magnetic resonance imaging apparatus (A) generates a uniform main magnetic field, gradient fields transversely thereacross, excites resonance in nuclei within an image region, receives radio frequency signals from the resonating nuclei, and reconstructs images representative thereof. Electrodes (30) monitor the cardiac cycle of a patient (B) being imaged and an expansible belt (32) monitors the respiratory cycle. A carrier signal from a generator (52) is modulated with the respiratory signals. The modulated carrier signals are combined (60) with the cardiac signals and converted to a light signal by a light source (62). A fiber optic cable (36) conducts the light signals to a light receiver (70). Band pass filters (72, 100) separate the received cardiac and respiratory encoded carrier signals. A zero detector (80) provides a scan initiation signal in response to a preselected portion of the cardiac cycle. The respiratory encoded carrier signal is demodulated by demodulator (102) and a comparator (116) blocks or enables the processing of image data during a selected window of the respiratory cycle. A window adjustment means (118) adjusts the respiratory window as a function of phase encoding of the resonating nuclei.
摘要翻译：磁共振成像装置（A）产生均匀的主磁场，横向横向的梯度场激发图像区域内的核中的共振，从共振核接收射频信号，并且重建代表其的图像。电极（30）监测被成像的患者（B）的心动周期，并且可膨胀皮带（32）监测呼吸周期。来自发生器（52）的载波信号用呼吸信号进行调制。经调制的载波信号与心脏信号组合（60）并通过光源（62）转换成光信号。光纤电缆（36）将光信号传导到光接收器（70）。带通滤波器（72,100）分离所接收的心脏和呼吸编码载波信号。零检测器（80）响应于心动周期的预选部分提供扫描起始信号。呼吸编码的载波信号由解调器（102）解调，并且比较器（116）在呼吸周期的选定窗口期间阻塞或启用图像数据的处理。窗口调整装置（118）根据谐振核的相位编码调节呼吸窗口。

4. 发明授权

US06323649B1 Modular MRI gradient amplifier using unipolar PWM drive 失效
标题翻译：使用单极PWM驱动的模块化MRI梯度放大器
公开(公告)号：US06323649B1
公开(公告)日：2001-11-27
申请号：US09395652
申请日：1999-09-14
申请人： Steven D. Pace , Michael Burl , Douglas M. Blakeley
发明人： Steven D. Pace , Michael Burl , Douglas M. Blakeley
IPC分类号： G01V300
CPC分类号： G01R33/3852
摘要： A gradient amplifier (20), for driving a gradient coil (22) of an MRI scanner, includes a plurality of first modules (60). The first modules (60) provide unipolar PWM control of an input supplied thereto to generate a unipolar waveform. A high voltage DC power supply (64) electrically connected to the first modules (60) supplies the input to the first modules (60). At least one second module (140a, b) is electrically connected to the first modules (60). The second module (140a, b) selectively provides polarity switching of the unipolar waveform output from the first modules (60) to generate a bipolar waveform which drives the gradient coil (22).
摘要翻译：用于驱动MRI扫描仪的梯度线圈（22）的梯度放大器（20）包括多个第一模块（60）。第一模块（60）提供对其提供的输入的单极PWM控制以产生单极波形。电连接到第一模块（60）的高压直流电源（64）将输入端提供给第一模块（60）。至少一个第二模块（140a，b）电连接到第一模块（60）。第二模块（140a，b）选择性地提供从第一模块（60）输出的单极性波形的极性切换，以产生驱动梯形线圈（22）的双极波形。

5. 发明授权

US5170123A Magnetic resonance imager with digital transmitter/receiver 失效
标题翻译：带数字发射器/接收器的磁共振成像器
公开(公告)号：US5170123A
公开(公告)日：1992-12-08
申请号：US392649
申请日：1989-08-11
申请人： G. Neil Holland , Douglas M. Blakeley , John R. Stauber , David C. Flugan , Kenneth S. Denison
发明人： G. Neil Holland , Douglas M. Blakeley , John R. Stauber , David C. Flugan , Kenneth S. Denison
IPC分类号： A61B5/055 , G01R33/36 , G01R33/48
CPC分类号： G01R33/3607
摘要： A magnetic resonance imaging apparatus includes one or more digital transmitters (B), one or more digital receivers (C), and digital data processing circuitry (D) which are all clocked and controlled by a single clock (F). Each digital transmitter includes a numerically controlled modulated oscillator (20) which processes digital phase and frequency signals to produce an output which addresses a wave-form map stored in a PROM (22). Each wave-form output of the PROM is multiplied (24) by a digital amplitude profile signal to generate a phase, frequency, and amplitude modulated digital RF signals. A clock gate (30) controls clocking of the digital modulation to create RF pulses. A digital-to-analog converter (28) converts the digital information to an analog RF pulse which is applied to a subject in an image region. The receivers each include an analog-to-digital converter (60) which digitizes the magnetic resonance signal emanating from the subject in the image region with four fold oversampling. A pair of FIR filters (62a, 62b) multiply the digital resonance signal by digital sine and cosine filter coefficients to create in-phase and out-of-phase digital magnetic resonance signal components. After additional digital filtering (64a, 64b), the digital in-phase and quadrature components are Fourier transformed (70) and accumulated in an image memory (72) to form an image representation.

6. 再颁专利

USRE36495E RF coil identification and testing interface for NMR systems 失效
标题翻译：核磁共振系统的射频线圈识别和测试接口
公开(公告)号：USRE36495E
公开(公告)日：2000-01-11
申请号：US146889
申请日：1998-09-02
申请人： Douglas M. Blakeley , David A. Molyneaux
发明人： Douglas M. Blakeley , David A. Molyneaux
IPC分类号： A61B5/055 , G01R33/28 , G01R33/34
CPC分类号： G01R33/28 , A61B5/0555 , G01R33/34
摘要： A movable patient supporting portion (10) of a patient couch (A) includes a socket (26) for receiving a mating plug (24) on a localized coil (B). The patient couch selectively inserts the localized coil and a supported patient into a bore (14) of a cryogenic magnet system (C). The localized coil includes a resistor (86) whose magnitude identifies the coil. A coil identification interrogator (84) interrogates the coil identification resistor and derives a corresponding binary coil identification. The coil identification addresses a look-up table (90) to retrieve diagnostic test information, an identification of a coil for a human-readable display, and, preferably, an identification of an isocenter of the coil. A diagnostic test unit (92) electrically tests the coil through the plug and socket connection with the diagnostic tests prescribed by the look-up table. A display interface (94) converts error messages from the diagnostic test unit and the coil identification from the look-up table into appropriate format for a display (40). A couch computer (18) controls a motor (20) in accordance with the isocenter of the coil from the look-up table to control positioning of the patient and the localized coil.
摘要翻译：患者躺椅（A）的可移动的患者支撑部分（10）包括用于接收局部线圈（B）上的配合插头（24）的插座（26）。患者躺椅将局部线圈和支撑的患者选择性地插入低温磁体系统（C）的孔（14）中。局部线圈包括其幅度标识线圈的电阻器（86）。线圈识别询问器（84）询问线圈识别电阻并导出对应的二进制线圈识别。线圈识别寻址用于检索诊断测试信息的查找表（90），用于人类可读显示的线圈的识别，以及优选地，线圈的等角点的识别。诊断测试单元（92）利用查找表规定的诊断测试通过插头和插座连接对线圈进行电测试。显示接口（94）将来自诊断测试单元的错误消息和线圈标识从查找表转换为用于显示器（40）的适当格式。沙发计算机（18）根据来自查找表的线圈的等角点来控制马达（20），以控制患者和局部线圈的定位。

7. 发明授权

US5551430A RF coil identification and testing interface for NMR systems 失效
公开(公告)号：US5551430A
公开(公告)日：1996-09-03
申请号：US286780
申请日：1994-08-05
申请人： Douglas M. Blakeley , David A. Molyneaux
发明人： Douglas M. Blakeley , David A. Molyneaux
IPC分类号： A61B5/055 , G01R33/28 , G01R33/34
CPC分类号： G01R33/28 , A61B5/0555 , G01R33/34
摘要： A movable patient supporting portion (10) of a patient couch (A) includes a socket (26) for receiving a mating plug (24) on a localized coil (B). The patient couch selectively inserts the localized coil and a supported patient into a bore (14) of a cryogenic magnet system (C). The localized coil includes a resistor (86) whose magnitude identifies the coil. A coil identification interrogator (84) interrogates the coil identification resistor and derives a corresponding binary coil identification. The coil identification addresses a look-up table (90) to retrieve diagnostic test information, an identification of a coil for a human-readable display, and, preferably, an identification of an isocenter of the coil. A diagnostic test unit (92) electrically tests the coil through the plug and socket connection with the diagnostic tests prescribed by the look-up table. A display interface (94) converts error messages from the diagnostic test unit and the coil identification from the look-up table into appropriate format for a display (40). A couch computer (18) controls a motor (20) in accordance with the isocenter of the coil from the look-up table to control positioning of the patient and the localized coil.

8. 发明授权

US5323776A MRI compatible pulse oximetry system 失效
标题翻译： MRI兼容脉搏血氧饱和度测定系统
公开(公告)号：US5323776A
公开(公告)日：1994-06-28
申请号：US961150
申请日：1992-10-15
申请人： Douglas M. Blakeley , Robert C. Gauss , David C. Flugan
发明人： Douglas M. Blakeley , Robert C. Gauss , David C. Flugan
IPC分类号： A61B5/024 , G01R33/465 , A61B5/0245 , A61B5/055
CPC分类号： G01R33/465 , A61B5/02416 , Y10S128/901
摘要： Magnetic resonance imaging hardware (A) defines a patient receiving region (20) that is surrounded by a bore liner (22). A socket (50) is mounted in the bore liner with an appropriate receptacle for receiving a standard plug (52) of a conventional pulse oximetry system. Conventional pulse oximetry systems include a sensor unit (54) connected with a cable (56) having the plug (52) at one end thereof. A notch filter (62) attenuates currents near the resonance frequency of the imager. A preamplifier (60) amplifies signals from the sensor unit. Within the shielding (66) of the preamplifier, a low pass filter (68) is provided to remove induced radio frequency components from the preamplified sensor unit signal. A radio frequency filter (70) mounted at the shield of the shielded room (B) prevents radio frequency signals from reaching an exterior processing and display unit (E) and prevents radio frequency signals from a clock (72) of the processing and display unit from being conveyed into the shielded room (B). The processing and display unit processes the signal received from the preamplifier to generate a pulse rate display (78) and a blood oxygen concentration display (80).
摘要翻译：磁共振成像硬件（A）限定由孔衬套（22）包围的患者接收区域（20）。插座（50）用适当的插座安装在孔衬里中，用于接收常规脉搏血氧仪系统的标准插头（52）。传统的脉搏血氧饱和度测量系统包括与其一端具有插头（52）的电缆（56）连接的传感器单元（54）。陷波滤波器（62）衰减成像器谐振频率附近的电流。前置放大器（60）放大来自传感器单元的信号。在前置放大器的屏蔽（66）内，提供了一个低通滤波器（68），以从前置放大的传感器单元信号中去除感应射频分量。安装在屏蔽室（B）的屏蔽处的射频滤波器（70）防止射频信号到达外部处理和显示单元（E），并防止来自处理和显示单元的时钟（72）的射频信号从被传送到屏蔽室（B）。处理和显示单元处理从前置放大器接收的信号以产生脉搏率显示（78）和血氧浓度显示（80）。

9. 发明授权

US06566879B1 Apparatus for effecting heat transfer from power semiconductors 失效
标题翻译：用于实现功率半导体传热的装置
公开(公告)号：US06566879B1
公开(公告)日：2003-05-20
申请号：US09516003
申请日：2000-02-29
申请人： Denis W. Vanek , Douglas M. Blakeley
发明人： Denis W. Vanek , Douglas M. Blakeley
IPC分类号： G01V300
CPC分类号： G01R33/3852
摘要： A magnetic resonance imaging system includes a main magnetic field generator (10, 12) which produces a temporally constant magnetic field through an examination region (14). A gradient coil assembly (18) powered by a gradient field amplifier (20) produces gradient fields orthogonal to the main magnetic field. The gradient field amplifier (20) includes a heat sink (40) for dissipating the thermal energy of at least one power semiconductor device (44) having a first surface opposite a thermally conductive surface (42). The thermally conductive surface (42) is in contact with the heat sink (40) for transferring the thermal energy. A rigid plate clamp assembly (50) is affixed to the heat sink (40) and the semiconductor device (44) is disposed therebetween. A resiliently deformable spring (60) is positioned between a first surface of the semiconductor package (44) and the plate clamp (50) maintaining positive pressure between the thermally conductive surface (42) and the heat sink (40). The resilient deformable spring (60) has an inner ring (62) in contact with the rigid plate assembly (50) and an outer ring (64) angled from the inner ring in contact with the first surface of the semiconductor package (44). Preferably, a plurality of semiconductor devices are provided each utilizing a deformable spring to ensure thermal contact between each semiconductor power device and the heat sink.
摘要翻译：磁共振成像系统包括通过检查区域（14）产生时间上恒定的磁场的主磁场发生器（10,12）。由梯度场放大器（20）供电的梯度线圈组件（18）产生与主磁场正交的梯度场。梯度场放大器（20）包括用于耗散至少一个功率半导体器件（44）的热能的散热器（40），其具有与导热表面（42）相对的第一表面。导热表面（42）与用于传递热能的散热器（40）接触。刚性板夹组件（50）固定在散热器（40）上，半导体器件（44）位于它们之间。可弹性变形的弹簧（60）位于半导体封装（44）的第一表面和板夹（50）之间，保持导热表面（42）和散热片（40）之间的正压。弹性变形弹簧（60）具有与刚性板组件（50）接触的内环（62）和与内环成角度的与所述半导体封装（44）的第一表面接触的外环（64）。优选地，提供多个半导体器件，每个半导体器件利用可变形弹簧来确保每个半导体功率器件与散热器之间的热接触。

10. 发明授权

US5209233A Temperature sensing and control system for cardiac monitoring electrodes 失效
标题翻译：心脏监测电极温度感应和控制系统
公开(公告)号：US5209233A
公开(公告)日：1993-05-11
申请号：US653628
申请日：1991-02-11
申请人： G. Neil Holland , Douglas M. Blakeley , Theodore J. Reisker , David A. Molyneaux
发明人： G. Neil Holland , Douglas M. Blakeley , Theodore J. Reisker , David A. Molyneaux
IPC分类号： A61B5/0456 , A61B5/055 , A61B5/113 , A61B6/00 , G01N33/00 , G01R33/28 , G01R33/56 , G01R33/567
CPC分类号： G01R33/5673 , A61B5/0456 , A61B5/055 , A61B5/1135 , A61B5/411 , G01R33/28 , A61B5/7285 , A61B6/541 , Y10S128/901
摘要： A cardiac electrode (40) has a plug (48) which is frictionally received in a socket (50) of an electrical lead (56). An impedance (54) is connected in series between the electrical lead and the socket to pass ECG signals substantially unattenuated and for blocking radio frequency signals induced in the lead from reaching the socket and the electrode and heating the electrode to a sufficient temperature to burn the patient. The impedance includes an LC circuit (66, 68) which freely passes low frequency signals, such as cardiac signals, but which is tuned to resonance at radio frequencies, particularly at the frequency of resonance excitation and manipulation pulses of a magnetic resonance imager (A). Alternately, the impedance may include a resistive element for blocking the induced currents. A temperature sensor (60) is mounted in intimate contact with an electrically and thermally conductive socket portion (52) to sense the temperature of the electrode, indirectly. A temperature sensor lead (62), the cardiac lead (56), and a respiratory or other anatomical condition sensor are connected with a multiplexing means (140) which cyclically connects the output signals thereof with an analog to digital converter (142). The digital signals are converted to digital optical signals (102) to be conveyed along a light path (104) out of the examination region. The bits of the received digital signal are sorted (144) between an R-wave detector (120), a temperature limit check (122) which checks whether the temperature of the electrode exceeds preselected limits, and a respiratory detector (132).
摘要翻译：心电极（40）具有摩擦地容纳在电引线（56）的插座（50）中的插头（48）。阻抗（54）串联连接在电引线和插座之间以使ECG信号基本上不衰减，并阻止在引线中感应的射频信号到达插座和电极，并将电极加热到足够的温度以烧毁患者。该阻抗包括一个LC电路（66,68），它可以自由地通过诸如心脏信号的低频信号，但被调谐到无线电频率的共振，特别是在磁共振成像器（A）的共振激励和操纵脉冲的频率）。或者，阻抗可以包括用于阻挡感应电流的电阻元件。温度传感器（60）安装成与导电和导热插座部分（52）紧密接触以间接地感测电极的温度。温度传感器引线（62），心脏引线（56）以及呼吸或其他解剖条件传感器与将其输出信号与模数转换器（142）循环连接的多路复用装置（140）连接。数字信号被转换成数字光信号（102），沿着光路（104）输送出检查区域。所接收的数字信号的比特在R波检测器（120），检查电极的温度是否超过预定极限的温度极限检查（122）和呼吸检测器（132）之间进行排序（144）。

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