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1. 发明授权

US07264608B2 Manual processing systems and methods for providing blood components conditioned for pathogen inactivation 有权
标题翻译：用于提供为病原体灭活而调节的血液成分的手动处理系统和方法
公开(公告)号：US07264608B2
公开(公告)日：2007-09-04
申请号：US10008361
申请日：2001-12-05
申请人： Daniel F. Bischof , Ying-Cheng Lo , Daniel Lynn , Bryan J Blickhan
发明人： Daniel F. Bischof , Ying-Cheng Lo , Daniel Lynn , Bryan J Blickhan
IPC分类号： A61M29/00 , A61M35/00
CPC分类号： A61M1/3681 , A01N1/02 , A01N1/0215 , A01N1/0263 , A61M1/0222 , A61M1/0231 , A61M1/0272 , A61M1/0281 , A61M1/3683
摘要： Systems and methods manually process blood and blood components in sterile, closed environments, which further condition the blood components for subsequent pathogen inactivation processes. The systems and methods mate the manual collection of random donor platelet units with the creation of larger therapeutic doses of platelets targeted to undergo pathogen inactivation prior to long term storage and/or transfusion.
摘要翻译：系统和方法在无菌，封闭的环境中手动处理血液和血液成分，这进一步调节血液成分以用于随后的病原体灭活过程。系统和方法将随机供体血小板单元的手动收集与在长期储存和/或输血之前进行病原体灭活的较大治疗剂量的血小板相匹配。

2. 发明授权

US06936413B1 Methods and systems for preparing blood products 有权
标题翻译：制备血液制品的方法和系统
公开(公告)号：US06936413B1
公开(公告)日：2005-08-30
申请号：US10004696
申请日：2001-12-05
申请人： Daniel F. Bischof , Ying-Cheng Lo
发明人： Daniel F. Bischof , Ying-Cheng Lo
IPC分类号： A61J3/00 , A61M1/02 , A61M1/36 , A01N1/00 , A61B19/00
CPC分类号： A61M1/3681 , A61M1/3683
摘要： Methods and systems for preparing blood products that are ready for treatment in established pathogen inactivation procedures are disclosed. The methods include providing a source of a blood component and combining the blood component with a synthetic medium in a selected ratio of the blood component to the synthetic media, whereby the resulting blood product is treatment-ready.
摘要翻译：公开了用于制备在已建立的病原体灭活程序中进行治疗的血液制品的方法和系统。所述方法包括提供血液成分来源并以所选择的血液成分与合成培养基的比例将血液成分与合成培养基结合，由此所得到的血液制品是待处理的。

3. 发明授权

US07374870B2 Systems and methods for removing viral agents from blood 有权
标题翻译：从血液中去除病毒剂的系统和方法
公开(公告)号：US07374870B2
公开(公告)日：2008-05-20
申请号：US11056347
申请日：2005-02-11
申请人： Robert E. Herman , John Chapman , Chong-Son Sun , Jean M Mathias , Daniel F. Bischof
发明人： Robert E. Herman , John Chapman , Chong-Son Sun , Jean M Mathias , Daniel F. Bischof
IPC分类号： A01N1/02 , A61B19/00
CPC分类号： A61L2/0011 , A61K35/16 , A61L2/022 , A61L2/08 , Y10S435/975
摘要： Systems and methods treat plasma carrying contaminants and cellular matter that are capable of entraining contaminants. The systems and methods separate cellular matter from the plasma by filtration, thereby removing contaminants entrained within the cellular matter. The system and methods add to the plasma a photoactive material. The systems and methods emit radiation at a selected wavelength into the plasma to activate the photoactive material and thereby eradicate the contaminant that is free of entrainment by cellular matter.
摘要翻译：系统和方法处理能够携带污染物的携带血浆的污染物和细胞物质。系统和方法通过过滤将细胞物质与血浆分离，从而去除携带在细胞内的污染物。系统和方法将等离子体添加到光敏材料中。系统和方法将所选波长的辐射发射到等离子体中以激活光活性物质，从而根除细胞物质不会夹带的污染物。

4. 发明申请

US20080108954A1 Flow Controllers 审中-公开
标题翻译：流量控制器
公开(公告)号：US20080108954A1
公开(公告)日：2008-05-08
申请号：US11555797
申请日：2006-11-02
申请人： Jean-Marie Mathias , Richard L. West , Georges Rondeau , Joseph H. Bowman , Benjamin S. Grant , Daniel F. Bischof
发明人： Jean-Marie Mathias , Richard L. West , Georges Rondeau , Joseph H. Bowman , Benjamin S. Grant , Daniel F. Bischof
IPC分类号： A61M39/22
CPC分类号： A61M39/223 , A61M1/0209 , A61M1/0236 , A61M5/16804 , F16K11/0853 , F16K11/0856
摘要： Flow controllers are provided for interconnecting a fluid source to two separate collection zones. The flow controllers include a body having a fluid inlet communicating with the source and two fluid outlets, each communicating with one of the collection zones. An actuator member received within a cavity of the body includes first and second flow paths. In a first position, the first flow path is aligned with the fluid inlet of the body to allow fluid communication with one of the fluid outlets and the associated collection zone. The actuator member is non-rotationally moved to a second position within the cavity to align the second flow path with the fluid inlet of the body, thereby halting flow through the first flow path and allowing fluid communication with the other collection zone. An optional safety feature prevents movement of the actuator member from the second position to the first position.
摘要翻译：提供流量控制器用于将流体源互连到两个单独的收集区。流量控制器包括具有与源连通的流体入口和两个流体出口的主体，每个流体出口与一个收集区域连通。容纳在主体的空腔内的致动器构件包括第一和第二流动路径。在第一位置，第一流动路径与主体的流体入口对准以允许与流体出口和相关联的收集区域中的一个流体连通。致动器构件非旋转地移动到空腔内的第二位置，以将第二流动路径与主体的流体入口对准，从而停止流过第一流动路径并允许与另一个收集区域的流体连通。可选的安全特征防止致动器构件从第二位置移动到第一位置。

5. 发明授权

US06872307B2 Systems and methods for on line finishing of cellular blood products like platelets harvested for therapeutic purposes 失效
标题翻译：用于治疗目的收获的血小板的细胞血液制品的在线整理的系统和方法
公开(公告)号：US06872307B2
公开(公告)日：2005-03-29
申请号：US10430785
申请日：2003-05-06
申请人： Daniel F. Bischof
发明人： Daniel F. Bischof
IPC分类号： A61K35/14 , A61M1/36 , B01D21/26 , B01D36/00
CPC分类号： A61M1/3693 , A61M1/3696 , A61M2202/0427 , A61M2202/0439 , A61M2202/0071 , A61M2202/0057
摘要： Blood processing systems and methods establish on line communication between a container and a source of blood containing leukocytes and platelets, such as a human donor. The systems and methods create a centrifugal field between the source of blood and the container that separates from the blood an unfinished suspension of platelets having a first physiologic characteristic different than the desired physiologic characteristic. The systems and methods pump the unfinished platelet suspension outside the centrifugal field through a finishing device. The finishing device changes the first physiologic characteristic to the desired physiological characteristic, thereby creating the finished platelet suspension. The systems and methods convey the finished platelet suspension from the finishing device directly into the container. The systems and methods function without interrupting the on line communication between the container and the source of blood.
摘要翻译：血液处理系统和方法建立容器和含有白细胞和血小板的血液来源（例如人供体）之间的在线通信。该系统和方法在血液源和从血液分离出具有不同于所需生理特征的第一生理特征的血小板的未完成悬浮液之间产生离心场。系统和方法通过精整装置将未完成的血小板悬浮液泵送到离心场外部。整理装置将第一生理特征改变到所需的生理特征，从而产生完成的血小板悬浮液。系统和方法将完成的血小板悬浮液从精加工装置直接输送到容器中。系统和方法的功能不会中断容器和血源之间的在线通信。

6. 发明授权

US06361692B1 On line blood processing system for obtaining for storage a blood suspension having a reduced residual leukocyte population 有权
标题翻译：在线血液处理系统，用于获得具有减少的残留白细胞群体的血液悬浮液
公开(公告)号：US06361692B1
公开(公告)日：2002-03-26
申请号：US09548190
申请日：2000-04-13
申请人： Daniel F. Bischof
发明人： Daniel F. Bischof
IPC分类号： B01D3600
CPC分类号： A61M1/3693 , A61M1/3696 , A61M2202/0427 , A61M2202/0439 , A61M2202/0071 , A61M2202/0057
摘要： Blood processing systems and methods establish on line communication between a container and a source of blood containing leukocytes and platelets, such as a human donor. The systems and methods create a centrifugal field between the source of blood and the container that separates from the blood an unfinished suspension of platelets having a first physiologic characteristic different than the desired physiologic characteristic. The systems and methods pump the unfinished platelet suspension outside the centrifugal field through a finishing device. The finishing device changes the first physiologic characteristic to the desired physiological characteristic, thereby creating the finished platelet suspension. The systems and methods convey the finished platelet suspension from the finishing device directly into the container. The systems and methods function without interrupting the on line communication between the container and the source of blood.
摘要翻译：血液处理系统和方法建立容器和含有白细胞和血小板的血液来源（例如人供体）之间的在线通信。该系统和方法在血液源和从血液分离出具有不同于所需生理特征的第一生理特征的血小板的未完成悬浮液之间产生离心场。系统和方法通过精整装置将未完成的血小板悬浮液泵送到离心场外部。整理装置将第一生理特征改变到所需的生理特征，从而产生完成的血小板悬浮液。系统和方法将完成的血小板悬浮液从精加工装置直接输送到容器中。系统和方法的功能不会中断容器和血源之间的在线通信。

7. 发明授权

US6126618A Apparatus for obtaining liquid samples 有权
标题翻译：用于获得液体样品的装置
公开(公告)号：US6126618A
公开(公告)日：2000-10-03
申请号：US231682
申请日：1999-01-14
申请人： Daniel F. Bischof
发明人： Daniel F. Bischof
IPC分类号： A61B5/154 , A61B5/15 , A61M1/02 , A61M39/02 , A61M39/04 , A61B5/00 , A61B19/00
CPC分类号： A61B5/154 , A61B5/15003 , A61B5/150366 , A61B5/150389 , A61B5/150473 , A61B5/150572 , A61B5/150732 , A61B5/150992 , A61M39/04 , A61M2039/0202
摘要： An apparatus for obtaining liquid samples from a fluid flow path is disclosed. The apparatus includes a housing having an access site communicating with the flow path and carrying a piercing member at a location spaced from the access site. The housing allows for translational movement of the piercing member toward the access site and into the flow path from where the sample is removed.
摘要翻译：公开了一种用于从流体流路获得液体样品的装置。该装置包括壳体，该壳体具有与流动路径连通的进入位置，并且在与进入位置间隔开的位置处承载穿孔构件。外壳允许刺穿构件朝向进入位置的平移运动并进入从其中取出样品的流动路径。

8. 发明申请

US20090014395A1 Systems and Methods for On Line Finishing of Cellular Blood Products Like Platelets Harvested for Therapeutic Purposes 审中-公开
标题翻译：细胞血液制品在线整理的系统和方法，如用于治疗目的的血小板
公开(公告)号：US20090014395A1
公开(公告)日：2009-01-15
申请号：US12179658
申请日：2008-07-25
申请人： Daniel F. Bischof
发明人： Daniel F. Bischof
IPC分类号： A61M1/36 , B01D21/26 , B01D36/02
CPC分类号： A61M1/3693 , A61M1/3696 , A61M2202/0427 , A61M2202/0439 , A61M2202/0071 , A61M2202/0057
摘要： Blood processing systems and methods establish on line communication between a container and a source of blood containing leukocytes and platelets, such as a human donor. The systems and methods create a centrifugal field between the source of blood and the container that separates from the blood an unfinished suspension of platelets having a first physiologic characteristic different than the desired physiologic characteristic. The systems and methods pump the unfinished platelet suspension outside the centrifugal field through a finishing device. The finishing device changes the first physiologic characteristic to the desired physiological characteristic, thereby creating the finished platelet suspension. The systems and methods convey the finished platelet suspension from the finishing device directly into the container. The systems and methods function without interrupting the on line communication between the container and the source of blood.
摘要翻译：血液处理系统和方法建立容器和含有白细胞和血小板的血液来源（例如人供体）之间的在线通信。该系统和方法在血液源和从血液分离出具有不同于所需生理特征的第一生理特征的血小板的未完成悬浮液之间产生离心场。系统和方法通过精整装置将未完成的血小板悬浮液泵送到离心场外部。整理装置将第一生理特征改变到所需的生理特征，从而产生完成的血小板悬浮液。系统和方法将完成的血小板悬浮液从精加工装置直接输送到容器中。系统和方法的功能不会中断容器和血源之间的在线通信。

9. 发明授权

US06168718A Method for purifying blood plasma and apparatus suitable therefor 有权
标题翻译：血浆纯化方法及其适用的装置
公开(公告)号：US06168718A
公开(公告)日：2001-01-02
申请号：US09500794
申请日：2000-02-10
申请人： Mark Alexander Sutter , Noel Tod Borton , Daniel F. Bischof , John Chapman , Robert E. Herman , Chong-Son Sun
发明人： Mark Alexander Sutter , Noel Tod Borton , Daniel F. Bischof , John Chapman , Robert E. Herman , Chong-Son Sun
IPC分类号： B01D3700
CPC分类号： A61M1/3633 , A61M2202/0415 , A61M2202/0439 , B01D61/18 , B01D63/08 , B01D63/081 , B01D69/12 , A61M2202/0042 , A61M2202/005
摘要： A method for purifying conventionally treated blood plasma to remove substantially all residual leukocytes while maintaining useful flow rates for medically useful amounts of plasma utilizes a disposable, heat-sterilizable filter employing one or more depth-type prefilters and at least one intermediate hydrophilic microporous membrane followed by at least one final hydrophilic microporous membrane having a smaller pore size than the intermediate membrane within a common housing. The purified plasma is preferably subjected to chemical treatment to destroy infectious agents such as hepatitis and HIV.
摘要翻译：用于纯化常规处理的血浆以除去基本上所有残留的白细胞同时保持医学上有用量的血浆的有效流速的方法利用一次性热灭菌过滤器，其使用一种或多种深度型预过滤器和至少一种中间亲水微孔膜通过至少一个具有比共同外壳中的中间膜更小的孔径的最终亲水微孔膜。纯化的血浆优选进行化学处理以破坏感染因子如肝炎和HIV。

10. 发明授权

US5641622A Continuous centrifugation process for the separation of biological components from heterogeneous cell populations 失效
标题翻译：用于从异质细胞群分离生物成分的连续离心过程
公开(公告)号：US5641622A
公开(公告)日：1997-06-24
申请号：US255107
申请日：1994-06-07
申请人： William C. Lake , Richard Giesler , Dennis Van Epps , John R. Chapman , Jeffrey A. Martinson , Dale R. Ellis , Frederick Aono , Daniel F. Bischof
发明人： William C. Lake , Richard Giesler , Dennis Van Epps , John R. Chapman , Jeffrey A. Martinson , Dale R. Ellis , Frederick Aono , Daniel F. Bischof
IPC分类号： A61M1/36 , C12N5/00 , C12N5/02 , C12N5/06 , C12Q1/24 , G01N33/50 , G01N33/569 , A01N1/02 , C12N1/02 , C12Q1/68
CPC分类号： G01N33/56972 , A61M1/362 , A61M1/3696 , C12Q1/24 , G01N33/5002 , G01N33/5005 , G01N33/569 , Y10T436/111666 , Y10T436/25375 , Y10T436/2575
摘要： A method combining the techniques of immunoaffinity separation and continuous flow centrifugal separation is provided for selective separation of a nucleated heterogeneous cell population from a heterogeneous cell mixture. The heterogeneous cell mixture is intimately contacted to promote binding thereto by particles having attached a substance that actively binds to a specific desired type of cell out of the cell mixture. The particles are selected so that the sedimentation velocity of the particle/cell conjugate differs sufficiently from those of other cells in the cell mixture to allow its separation by means of a continuous flow cell separator. The method rapidly processes large volumes of cell mixture with the high accuracy expected of immunoaffinity separation and can be used to separate, for example, various types of leukocytes from whole blood, bone marrow concentrate, or a peripheral blood stem cell concentrate; or precursors of lymphokine activated killer cells, tumor infiltrating lymphocyte cells, or activated killer monocytes from lymphocyte or monocyte cell concentrates or from a tissue cell preparation.
摘要翻译：提供了结合免疫亲和分离和连续流离心分离技术的方法，用于从异质细胞混合物中选择性分离成核的异质细胞群。非均相细胞混合物紧密接触以促进与附着有活性结合特定所需类型的细胞的细胞混合物的颗粒结合。选择颗粒使得颗粒/细胞共轭体的沉降速度与细胞混合物中的其它细胞的沉降速度充分不同，以允许其通过连续流动细胞分离器分离。该方法以预期的免疫亲和力分离的高精度快速处理大量的细胞混合物，并且可用于分离例如来自全血，骨髓浓缩物或外周血干细胞浓缩物的各种类型的白细胞; 或淋巴因子活化的杀伤细胞的前体，肿瘤浸润性淋巴细胞细胞或来自淋巴细胞或单核细胞浓缩物或来自组织细胞制剂的活化的杀伤单核细胞。

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