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1. 发明授权

US5995864A Dose factor entry and display tool for BNCT radiotherapy 失效
标题翻译：用于BNCT放射治疗的剂量因子入门和显示工具
公开(公告)号：US5995864A
公开(公告)日：1999-11-30
申请号：US933652
申请日：1997-09-19
申请人： Daniel E. Wessol , Floyd J. Wheeler , Jeremy L. Cook
发明人： Daniel E. Wessol , Floyd J. Wheeler , Jeremy L. Cook
IPC分类号： A61N5/10 , A61B6/00
CPC分类号： A61N5/1031 , A61N2005/109 , Y10S128/922
摘要： A system for use in Boron Neutron Capture Therapy (BNCT) radiotherapy planning where a biological distribution is calculated using a combination of conversion factors and a previously calculated physical distribution. Conversion factors are presented in a graphical spreadsheet so that a planner can easily view and modify the conversion factors. For radiotherapy in multi-component modalities, such as Fast-Neutron and BNCT, it is necessary to combine each conversion factor component to form an effective dose which is used in radiotherapy planning and evaluation. The Dose Factor Entry and Display System is designed to facilitate planner entry of appropriate conversion factors in a straightforward manner for each component. The effective isodose is then immediately computed and displayed over the appropriate background (e.g. digitized image).
摘要翻译：一种用于硼中子捕获治疗（BNCT）放射治疗计划的系统，其中使用转换因子和先前计算的物理分布的组合计算生物分布。转换因子显示在图形电子表格中，以便计划人员可以轻松查看和修改转换因子。对于诸如快速中子和BNCT的多组分模式的放射治疗，有必要将每个转化因子组分组合形成用于放射治疗计划和评估的有效剂量。剂量因子输入和显示系统旨在便于每个组件以简单的方式为适当的转换因子输入适当的转换因子。然后立即计算有效等剂量并显示在合适的背景（例如数字化图像）上。

2. 发明授权

US6049729A Dose masking feature for BNCT radiotherapy planning 失效
标题翻译：用于BNCT放射治疗计划的剂量屏蔽功能
公开(公告)号：US6049729A
公开(公告)日：2000-04-11
申请号：US956811
申请日：1997-10-23
申请人： Jeremy L. Cook , Daniel E. Wessol , Floyd J. Wheeler
发明人： Jeremy L. Cook , Daniel E. Wessol , Floyd J. Wheeler
IPC分类号： A61N5/10 , G06F19/00 , A61B5/05
CPC分类号： G06F19/3437 , A61N5/1031 , A61N2005/109 , A61N5/1042
摘要： A system for displaying an accurate model of isodoses to be used in radiotherapy so that appropriate planning can be performed prior to actual treatment on a patient. The nature of the simulation of the radiotherapy planning for BNCT and Fast Neutron Therapy, etc., requires that the doses be computed in the entire volume. The "entire volume" includes the patient and beam geometries as well as the air spaces in between. Isodoses derived from the computed doses will therefore extend into the air regions between the patient and beam geometries and thus depict the unrealistic possibility that radiation deposition occurs in regions containing no physical media. This problem is solved by computing the doses for the entire geometry and then masking the physical and air regions along with the isodose contours superimposed over the patient image at the corresponding plane. The user is thus able to mask out (remove) the contour lines from the unwanted areas of the image by selecting the appropriate contour masking region from the raster image.
摘要翻译：用于显示用于放射治疗的准确的等剂量模型的系统，以便在对患者进行实际治疗之前可以进行适当的规划。 BNCT和快速中子治疗等的放射治疗计划模拟的性质要求在整个体积中计算剂量。 “整个体积”包括病人和梁的几何形状以及两者间的空气间隙。因此，从计算出的剂量得出的等同物将延伸到患者和血管几何之间的空气区域，因此描绘了在不含物理介质的区域内发生辐射沉积的不切实际的可能性。该问题通过计算整个几何形状的剂量并随后将物理和空气区域与叠加在患者图像上的等剂量轮廓相对应的平面上进行掩蔽来解决。因此，通过从光栅图像中选择合适的轮廓掩蔽区域，用户能够从图像的不需要的区域屏蔽（去除）轮廓线。

3. 发明授权

US06175761B1 Methods and computer executable instructions for rapidly calculating simulated particle transport through geometrically modeled treatment volumes having uniform volume elements for use in radiotherapy 失效
公开(公告)号：US06175761B1
公开(公告)日：2001-01-16
申请号：US09063736
申请日：1998-04-21
申请人： Michael W. Frandsen , Daniel E. Wessol , Floyd J. Wheeler
发明人： Michael W. Frandsen , Daniel E. Wessol , Floyd J. Wheeler
IPC分类号： A61B600
CPC分类号： A61N5/1031 , A61N2005/1034 , A61N2005/109 , Y10S128/92
摘要： Methods and computer executable instructions are disclosed for ultimately developing a dosimetry plan for a treatment volume targeted for irradiation during cancer therapy. The dosimetry plan is available in “real-time” which especially enhances clinical use for in vivo applications. The real-time is achieved because of the novel geometric model constructed for the planned treatment volume which, in turn, allows for rapid calculations to be performed for simulated movements of particles along particle tracks there through. The particles are exemplary representations of neutrons emanating from a neutron source during BNCT. In a preferred embodiment, a medical image having a plurality of pixels of information representative of a treatment volume is obtained. The pixels are: (i) converted into a plurality of substantially uniform volume elements having substantially the same shape and volume of the pixels; and (ii) arranged into a geometric model of the treatment volume. An anatomical material associated with each uniform volume element is defined and stored. Thereafter, a movement of a particle along a particle track is defined through the geometric model along a primary direction of movement that begins in a starting element of the uniform volume elements and traverses to a next element of the uniform volume elements. The particle movement along the particle track is effectuated in integer based increments along the primary direction of movement until a position of intersection occurs that represents a condition where the anatomical material of the next element is substantially different from the anatomical material of the starting element. This position of intersection is then useful for indicating whether a neutron has been captured, scattered or exited from the geometric model. From this intersection, a distribution of radiation doses can be computed for use in the cancer therapy. The foregoing represents an advance in computational times by multiple factors of time magnitudes.

4. 发明授权

US06965847B2 Methods and computer readable medium for improved radiotherapy dosimetry planning 失效
标题翻译：用于改进放射治疗剂量测定规划的方法和计算机可读介质
公开(公告)号：US06965847B2
公开(公告)日：2005-11-15
申请号：US09814299
申请日：2001-03-21
申请人： Daniel E. Wessol , Michael W. Frandsen , Floyd J. Wheeler , David W. Nigg
发明人： Daniel E. Wessol , Michael W. Frandsen , Floyd J. Wheeler , David W. Nigg
IPC分类号： A61M36/00 , A61N5/10 , G06F19/00 , G06F9/455
CPC分类号： G06F19/3481 , A61N5/1001 , A61N5/1027 , A61N5/1031 , A61N2005/1034 , G06F19/00 , G06F19/3456 , G16H15/00 , G16H50/50
摘要： Methods and computer readable media are disclosed for ultimately developing a dosimetry plan for a treatment volume irradiated during radiation therapy with a radiation source concentrated internally within a patient or incident from an external beam. The dosimetry plan is available in near “real-time” because of the novel geometric model construction of the treatment volume which in turn allows for rapid calculations to be performed for simulated movements of particles along particle tracks therethrough. The particles are exemplary representations of alpha, beta or gamma emissions emanating from an internal radiation source during various radiotherapies, such as brachytherapy or targeted radionuclide therapy, or they are exemplary representations of high-energy photons, electrons, protons or other ionizing particles incident on the treatment volume from an external source. In a preferred embodiment, a medical image of a treatment volume irradiated during radiotherapy having a plurality of pixels of information is obtained.
摘要翻译：公开了方法和计算机可读介质，用于最终开发用于放射治疗期间照射的治疗体积的剂量测定计划，其中辐射源集中在患者内部的内部或从外部束入射。由于处理体积的新颖的几何模型构造，剂量测定计划在近处“实时”可用，这进一步允许对沿着颗粒轨道的粒子的模拟运动进行快速计算。颗粒是在各种放射治疗（例如近距离放射治疗或靶向放射性核素治疗）期间从内部辐射源发出的α，β或γ排放的示例性表示，或者它们是高能量光子，电子，质子或其他电离粒子入射的示例性表示治疗量来自外部来源。在优选实施例中，获得具有多个信息像素的放射治疗期间照射的治疗体积的医学图像。

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