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1. 发明授权

US06965847B2 Methods and computer readable medium for improved radiotherapy dosimetry planning 失效
标题翻译：用于改进放射治疗剂量测定规划的方法和计算机可读介质
公开(公告)号：US06965847B2
公开(公告)日：2005-11-15
申请号：US09814299
申请日：2001-03-21
申请人： Daniel E. Wessol , Michael W. Frandsen , Floyd J. Wheeler , David W. Nigg
发明人： Daniel E. Wessol , Michael W. Frandsen , Floyd J. Wheeler , David W. Nigg
IPC分类号： A61M36/00 , A61N5/10 , G06F19/00 , G06F9/455
CPC分类号： G06F19/3481 , A61N5/1001 , A61N5/1027 , A61N5/1031 , A61N2005/1034 , G06F19/00 , G06F19/3456 , G16H15/00 , G16H50/50
摘要： Methods and computer readable media are disclosed for ultimately developing a dosimetry plan for a treatment volume irradiated during radiation therapy with a radiation source concentrated internally within a patient or incident from an external beam. The dosimetry plan is available in near “real-time” because of the novel geometric model construction of the treatment volume which in turn allows for rapid calculations to be performed for simulated movements of particles along particle tracks therethrough. The particles are exemplary representations of alpha, beta or gamma emissions emanating from an internal radiation source during various radiotherapies, such as brachytherapy or targeted radionuclide therapy, or they are exemplary representations of high-energy photons, electrons, protons or other ionizing particles incident on the treatment volume from an external source. In a preferred embodiment, a medical image of a treatment volume irradiated during radiotherapy having a plurality of pixels of information is obtained.
摘要翻译：公开了方法和计算机可读介质，用于最终开发用于放射治疗期间照射的治疗体积的剂量测定计划，其中辐射源集中在患者内部的内部或从外部束入射。由于处理体积的新颖的几何模型构造，剂量测定计划在近处“实时”可用，这进一步允许对沿着颗粒轨道的粒子的模拟运动进行快速计算。颗粒是在各种放射治疗（例如近距离放射治疗或靶向放射性核素治疗）期间从内部辐射源发出的α，β或γ排放的示例性表示，或者它们是高能量光子，电子，质子或其他电离粒子入射的示例性表示治疗量来自外部来源。在优选实施例中，获得具有多个信息像素的放射治疗期间照射的治疗体积的医学图像。

2. 发明授权

US06845091B2 Mobile ad hoc extensions for the internet 有权
标题翻译：互联网的移动特设扩展
公开(公告)号：US06845091B2
公开(公告)日：2005-01-18
申请号：US09728211
申请日：2000-12-01
申请人： Richard G. Ogier , Carla Peccolo Woodworth , Fred Lambert Templin , Bhargav R. Bellur , James A. Arnold , D. Scott Seaton , Michael W. Frandsen , Nathan W. Williams , Christian A Gellrich
发明人： Richard G. Ogier , Carla Peccolo Woodworth , Fred Lambert Templin , Bhargav R. Bellur , James A. Arnold , D. Scott Seaton , Michael W. Frandsen , Nathan W. Williams , Christian A Gellrich
IPC分类号： H04L1/16 , H04L1/18 , H04L12/24 , H04L12/28 , H04L12/56 , H04L29/06 , H04L29/08 , H04L29/12 , H04Q7/24
CPC分类号： H04L1/1614 , H04L1/1887 , H04L29/12009 , H04L29/12358 , H04L29/12801 , H04L41/12 , H04L45/02 , H04L45/26 , H04L45/48 , H04L61/251 , H04L61/6004 , H04L67/04 , H04L69/16 , H04L69/161 , H04L69/162 , H04L69/167 , H04W24/00 , H04W24/04 , H04W28/14 , H04W40/00 , H04W40/02 , H04W40/24 , H04W40/34 , H04W76/10 , H04W80/04 , H04W80/045 , H04W84/18
摘要： Described is an internetworking system having various mobile ad hoc extensions to the Internet that are particularly suited to the dynamic environment of mobile ad hoc networks. The internetworking system includes any combination of a link-state routing protocol for disseminating topology and link-state information over a multi-hop network comprised of nodes, a neighbor discovery protocol that can detect the appearance and disappearance of new neighbor nodes, an address format that facilitates deployment of IPv6 nodes in a predominantly IPv4 network infrastructure, a queuing mechanism that can update information upon resuming interrupted communications between nodes, and dynamic network measurement techniques for adaptively using wireless bandwidth when establishing and maintaining connections between nodes and a server.
摘要翻译：描述了具有特别适合于移动自组织网络的动态环境的对互联网的各种移动自组织扩展的互联网络系统。互联网络系统包括用于传播拓扑的链路状态路由协议和由节点组成的多跳网络上的链路状态信息的任何组合，可以检测新邻居节点的出现和消失的邻居发现协议，地址格式这有助于在主要的IPv4网络基础设施中部署IPv6节点，可以在恢复节点之间的中断通信时更新信息的排队机制，以及在建立和维护节点与服务器之间的连接时自适应地使用无线带宽的动态网络测量技术。

3. 发明授权

US06175761B1 Methods and computer executable instructions for rapidly calculating simulated particle transport through geometrically modeled treatment volumes having uniform volume elements for use in radiotherapy 失效
公开(公告)号：US06175761B1
公开(公告)日：2001-01-16
申请号：US09063736
申请日：1998-04-21
申请人： Michael W. Frandsen , Daniel E. Wessol , Floyd J. Wheeler
发明人： Michael W. Frandsen , Daniel E. Wessol , Floyd J. Wheeler
IPC分类号： A61B600
CPC分类号： A61N5/1031 , A61N2005/1034 , A61N2005/109 , Y10S128/92
摘要： Methods and computer executable instructions are disclosed for ultimately developing a dosimetry plan for a treatment volume targeted for irradiation during cancer therapy. The dosimetry plan is available in “real-time” which especially enhances clinical use for in vivo applications. The real-time is achieved because of the novel geometric model constructed for the planned treatment volume which, in turn, allows for rapid calculations to be performed for simulated movements of particles along particle tracks there through. The particles are exemplary representations of neutrons emanating from a neutron source during BNCT. In a preferred embodiment, a medical image having a plurality of pixels of information representative of a treatment volume is obtained. The pixels are: (i) converted into a plurality of substantially uniform volume elements having substantially the same shape and volume of the pixels; and (ii) arranged into a geometric model of the treatment volume. An anatomical material associated with each uniform volume element is defined and stored. Thereafter, a movement of a particle along a particle track is defined through the geometric model along a primary direction of movement that begins in a starting element of the uniform volume elements and traverses to a next element of the uniform volume elements. The particle movement along the particle track is effectuated in integer based increments along the primary direction of movement until a position of intersection occurs that represents a condition where the anatomical material of the next element is substantially different from the anatomical material of the starting element. This position of intersection is then useful for indicating whether a neutron has been captured, scattered or exited from the geometric model. From this intersection, a distribution of radiation doses can be computed for use in the cancer therapy. The foregoing represents an advance in computational times by multiple factors of time magnitudes.

4. 发明授权

US07533020B2 Method and apparatus for performing relational speech recognition 有权
标题翻译：执行关系语音识别的方法和装置
公开(公告)号：US07533020B2
公开(公告)日：2009-05-12
申请号：US11063357
申请日：2005-02-23
申请人： James F. Arnold , Michael W. Frandsen , Anand Venkataraman , Douglas A. Bercow , Gregory K. Myers , David J. Israel , Venkata Ramana Rao Gadde , Horacio Franco , Harry Bratt
发明人： James F. Arnold , Michael W. Frandsen , Anand Venkataraman , Douglas A. Bercow , Gregory K. Myers , David J. Israel , Venkata Ramana Rao Gadde , Horacio Franco , Harry Bratt
IPC分类号： G10L15/18
CPC分类号： G10L15/183 , G10L15/065
摘要： A method and apparatus are provided for performing speech recognition using observable and meaningful relationships between words within a single utterance and using a structured data source as a source of constraints on the recognition process. Results from a first constrained speech recognition pass can be combined with information about the observable and meaningful word relationships to constrain or simplify subsequent recognition passes. This iterative process greatly reduces the search space required for each recognition pass, making the speech recognition process more efficient, faster and accurate.
摘要翻译：提供了一种方法和装置，用于使用单个话语中的单词之间的可观察和有意义的关系来执行语音识别，并且使用结构化数据源作为识别过程的约束来源。来自第一约束语音识别通行证的结果可以与关于可观察和有意义的词关系的信息组合以约束或简化后续的识别通行证。这种迭代过程大大减少了每个识别通过所需的搜索空间，使得语音识别过程更加高效，更快速和准确。

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