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    • 10. 发明授权
    • Therapeutic agents for regulating serum phosphorus
    • 用于调节血清磷的治疗剂
    • US08969299B2
    • 2015-03-03
    • US13492778
    • 2012-06-08
    • Felix KarimGregory Bell
    • Felix KarimGregory Bell
    • C07K7/06A61K38/08A61K45/06
    • C07K7/06A61K38/08A61K45/06
    • Methods for modulating serum phosphorus levels are described, wherein calcimimetic agents are administered to a subject in need thereof. In one embodiment, the compound is cinacalcet, and in other embodiments the compound is comprised of a contiguous sequence of subunits, X1—X2—X3—X4—X5—X6—X7, wherein the X1 subunit comprises a thiol-containing moiety and the distribution of charge on the X2-X7 subunits. The compound, when administered at selected times to a patient undergoing dialysis, lowers serum phosphorus levels, relative to pre-dosing levels, and achieves a sustained reduced level for a period of time after administration.
    • 描述了调节血清磷水平的方法,其中向有需要的受试者施用拟拟剂。 在一个实施方案中,化合物是西那卡塞,在其它实施方案中,该化合物由亚单位X1-X2-X3-X4-X5-X6-X7的连续序列组成,其中X1亚基包含含硫醇的部分, X2-X7亚基上的电荷分布。 该化合物在选定的时间对经历透析的患者施用时,相对于给药前水平降低血清磷水平,并且在施用后达到持续降低水平一段时间。