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1. 发明申请

US20070122891A1 Methods for the Preparation, Isolation and Purification of Epothilone B, and X-Ray Crystal Structures of Epothilone B 有权
标题翻译：埃坡霉素B的制备，分离和纯化方法以及埃坡霉素B的X射线晶体结构
公开(公告)号：US20070122891A1
公开(公告)日：2007-05-31
申请号：US11669268
申请日：2007-01-31
申请人： Daniel Benigni , Robert Stankavage , Shu-Jen Chiang , Hsing Hou , Bruce Eagan , Dennis Gu , David Hou , Les Mintzmyer , Thomas Tully , Brian Davis , Ivan Hargro , Mark Mascari , Gabriel Galvin , Gregory Stein , Cary McConlogue , Fahri Comezoglu
发明人： Daniel Benigni , Robert Stankavage , Shu-Jen Chiang , Hsing Hou , Bruce Eagan , Dennis Gu , David Hou , Les Mintzmyer , Thomas Tully , Brian Davis , Ivan Hargro , Mark Mascari , Gabriel Galvin , Gregory Stein , Cary McConlogue , Fahri Comezoglu
IPC分类号： C12P17/00 , C12N1/20 , C07D417/02
CPC分类号： C07D493/04 , C12N1/20 , C12N1/38 , C12P17/181 , C12R1/01
摘要： The present invention relates to improved methods for the production, isolation and purification of epothilone B. These methods include, for example, a fermentation process for the production of epothilone B, isolation via adsorption onto a resin, and subsequent purification.
摘要翻译：本发明涉及埃坡霉素B的生产，分离和纯化的改进方法。这些方法包括例如用于生产埃坡霉素B的发酵方法，通过吸附到树脂上进行分离和随后的纯化。

2. 发明授权

US07172884B2 Methods for the preparation, isolation and purification of epothilone B, and x-ray crystal structures of epothilone B 有权
标题翻译：埃坡霉素B的制备，分离和纯化方法以及埃坡霉素B的X射线晶体结构
公开(公告)号：US07172884B2
公开(公告)日：2007-02-06
申请号：US10668032
申请日：2003-09-22
申请人： Daniel Benigni , Robert Stankavage , Shu-Jen Chiang , Hsing Hou , Bruce Eagan , Dennis Gu , David Hou , Les Mintzmyer , Thomas P. Tully , Brian L. Davis , Ivan Hargro , Mark Mascari , Gabriel Galvin , Gregory Stein , Cary W. McConlogue , Fahri T. Comezoglu
发明人： Daniel Benigni , Robert Stankavage , Shu-Jen Chiang , Hsing Hou , Bruce Eagan , Dennis Gu , David Hou , Les Mintzmyer , Thomas P. Tully , Brian L. Davis , Ivan Hargro , Mark Mascari , Gabriel Galvin , Gregory Stein , Cary W. McConlogue , Fahri T. Comezoglu
IPC分类号： C08B30/18 , A61K31/724 , A61K31/715 , C12P17/18
CPC分类号： C07D493/04 , C12N1/20 , C12N1/38 , C12P17/181 , C12R1/01
摘要： The present invention relates to improved methods for the production, isolation and purification of epothilone B. These methods include, for example, a fermentation process for the production of epothilone B, isolation via adsorption onto a resin, and subsequent purification.
摘要翻译：本发明涉及埃坡霉素B的生产，分离和纯化的改进方法。这些方法包括例如用于生产埃坡霉素B的发酵方法，通过吸附到树脂上进行分离和随后的纯化。

3. 发明申请

US20060270012A1 Process for preparing (2R,3S)-1,2-epoxy-3-(protected)amino-4-substituted butane and intermediates thereof 有权
公开(公告)号：US20060270012A1
公开(公告)日：2006-11-30
申请号：US11365275
申请日：2006-03-01
申请人： Nigel Bowers , Paul Skonezny , Gregory Stein , Thomas Franceschini , Shu-Jen Chiang , Wendy Anderson , Li You , Zizhou Xing
发明人： Nigel Bowers , Paul Skonezny , Gregory Stein , Thomas Franceschini , Shu-Jen Chiang , Wendy Anderson , Li You , Zizhou Xing
IPC分类号： C12P7/02
CPC分类号： C12R1/01 , C12P13/001
摘要： The present invention relates to a process for preparing (2R,3S)-1-halo-2-hydroxy-3-(protected)amino-4-substituted butane comprising contacting a mutagenized Rhodococcus erythropolis having ATCC deposit no. PTA-6648 with (3S)-1-halo-2-oxo-3-(protected)amino-4-substituted butane substrate. The present invention also relates to a process comprising mixing (2R,3S)-1-halo-2-hydroxy-3-(protected)amino-4-substituted butane with at least one base in the presence of at least one solvent to produce a reaction mixture containing (2R,3S)-1,2-epoxy-3-(protected)amino-4-substituted butane. The present invention further relates to a process comprising crystallizing the (2R,3S)-1,2-epoxy-3-(protected)amino-4-substituted butane out of the reaction mixture by concurrently adding water and the reaction mixture together. The present invention is also directed to a mutagenized Rhodococcus erythropolis having ATCC deposit no. PTA-6648.

4. 发明申请

US20050020685A1 Process for recovery of 6-aminopenicillanic acid from an aqueous discharge stream 审中-公开
标题翻译：从水性排出物流中回收6-氨基青霉烷酸的方法
公开(公告)号：US20050020685A1
公开(公告)日：2005-01-27
申请号：US10865422
申请日：2004-06-10
申请人： Paul Skonezny , Robert Stankavage , Gregory Stein
发明人： Paul Skonezny , Robert Stankavage , Gregory Stein
IPC分类号： C07D499/00 , A61K31/198 , C07C323/25
CPC分类号： C07D499/00
摘要： A process for recovering residual amounts of 6-APA, on the order of 10 g/L or less, from a predominantly aqueous liquor containing phenoxyacetic acid and less than about 2% organic solvents.
摘要翻译：从含有苯氧基乙酸和小于约2％有机溶剂的主要含水液体中回收残留量为10g / L或更低的6-APA的方法。

5. 发明申请

US20070085241A1 High density performance process 审中-公开
标题翻译：高密度性能过程
公开(公告)号：US20070085241A1
公开(公告)日：2007-04-19
申请号：US11251327
申请日：2005-10-14
申请人： Christopher Husmann , Gregory Stein
发明人： Christopher Husmann , Gregory Stein
IPC分类号： H05B6/00
CPC分类号： B22F3/1055 , B29C64/153 , Y02P10/295
摘要： A manufacturing method is provided for enhancing density of a three-dimensional object defining at least one or more substantially flat surfaces. The method comprises the steps of: (a) applying a layer of powder at a target plane; (b) completely melting selected locations of the layer corresponding to a cross sectional slice of the object, the cross sectional slice defining a portion of the flat surface; and (c) repeating steps (a) and (b) to create successive layers to form the flat surface of the object in layerwise fashion, wherein at least one flat surface is oriented at an angle with respect to the target plane to mitigate against “burn through,” warping, and “swelling” of the object. The complete melting of the powder and the orientation of the flat surface tend to provide dimensional accuracy, homogenous microstructure, and enhanced strength characteristics for the object.
摘要翻译：提供一种用于增强限定至少一个或多个基本平坦表面的三维物体的密度的制造方法。该方法包括以下步骤：（a）在目标平面上施加一层粉末; （b）完全熔化对应于物体的横截面切片的层的选定位置，横截面切片限定平坦表面的一部分; 和（c）重复步骤（a）和（b）以形成连续的层以分层形式形成物体的平坦表面，其中至少一个平坦表面相对于目标平面以一定角度定向以减轻“ 燃烧通过“，翘曲，和”膨胀“的对象。粉末的完全熔化和平坦表面的取向倾向于为物体提供尺寸精度，均匀的微观结构和增强的强度特性。

6. 发明申请

US20130131028A1 METHODS FOR TREATMENT OF SLEEP-RELATED BREATHING DISORDERS 审中-公开
标题翻译：治疗与睡眠相关的呼吸障碍的方法
公开(公告)号：US20130131028A1
公开(公告)日：2013-05-23
申请号：US13640711
申请日：2011-04-11
申请人： Solomon H. Snyder , Moataz M. Gadalla , Nanduri R. Prabhakar , Gregory Stein , Gary Pace
发明人： Solomon H. Snyder , Moataz M. Gadalla , Nanduri R. Prabhakar , Gregory Stein , Gary Pace
IPC分类号： A61K31/519 , A61K31/24 , A61K31/385 , A61K45/06 , A61K31/4164 , A61K31/28 , A61K31/198 , A61K31/404 , A61K31/4178
摘要： Described herein are methods for modulation of the activity of the carotid body that afford therapeutic benefit for sleep-related breathing disorders and related conditions.
摘要翻译：本文描述了调节颈动脉体的活动的方法，其为睡眠相关呼吸障碍和相关病症提供治疗益处。

7. 发明申请

US20090202961A1 Ultrasonic Dental Tool Having a Light Source 审中-公开
标题翻译：具有光源的超声牙科工具
公开(公告)号：US20090202961A1
公开(公告)日：2009-08-13
申请号：US11840914
申请日：2007-08-17
申请人： Pejman Fani , Travis Pham , Gregory Stein , Brian Zargari , Eric P. Rose , Steven Ziemba
发明人： Pejman Fani , Travis Pham , Gregory Stein , Brian Zargari , Eric P. Rose , Steven Ziemba
IPC分类号： A61C3/03
CPC分类号： A61C1/088 , A61C3/03 , A61C17/20
摘要： An ultrasonic dental insert having at least one light source. A first transducer generates ultrasonic vibrations. A connecting body has a proximal end and a distal end having a tip attached thereto. The proximal end is attached to the first transducer so as to receive the ultrasonic vibrations therefrom and to transmit the ultrasonic vibrations toward the tip attached to the distal end. A second transducer is disposed substantially proximate to the connecting body for generating a voltage signal in response to movement of a portion of the connecting body according to the ultrasonic vibrations. A magnetic material including a source of a magnetic field is present in close proximity to the insert. At least one light source substantially proximate or distal to the tip is connected to and receives the voltage signal from the second transducer to generate light. The ultrasonic dental insert may be inserted into a handpiece for providing electromagnetic energy to the first transducer to generate the ultrasonic vibrations.
摘要翻译：一种具有至少一个光源的超声牙科插入物。第一传感器产生超声波振动。连接体具有近端和具有附接到其上的尖端的远端。近端附接到第一换能器以便从其接收超声波振动，并将超声波振动传递到附接到远端的尖端。第二传感器基本上靠近连接体设置，用于响应于根据超声波振动的连接体的一部分的移动而产生电压信号。包括磁场源的磁性材料靠近插入件存在。基本上靠近或远离尖端的至少一个光源连接到并接收来自第二换能器的电压信号以产生光。超声波牙插入件可以插入到手持件中，以向第一换能器提供电磁能以产生超声波振动。

8. 发明申请

US20080064006A1 Ultrasonic Dental Tool 审中-公开
标题翻译：超声牙科工具
公开(公告)号：US20080064006A1
公开(公告)日：2008-03-13
申请号：US11840929
申请日：2007-08-17
申请人： Christopher Quan , Pejman Fani , Gregory Stein , Travis Pham , Brian Zargari
发明人： Christopher Quan , Pejman Fani , Gregory Stein , Travis Pham , Brian Zargari
IPC分类号： A61C1/07
CPC分类号： A61C17/20 , A61C1/0015
摘要： The present invention relates to ultrasonic dental tools having an integral sheath and at least one light source adapted to utilize the electromagnetic energy already available in the existing ultrasonic dental unit. The handpiece includes a substantially hollow housing having a primary power source that may include a coil. In one aspect, the ultrasonic dental insert includes a sheath. The sheath may be formed such that it may cover at least part of the handpiece housing. In general, the sheath may serve as a barrier such that it may reduce cross-contamination to and from the patient's mouth. During operation, the primary coil of the handpiece may be inductively coupled to an illumination energy coil such that the illumination energy coil may draw energy from the electromagnetic field of the primary coil to power at least one light emitting element.
摘要翻译：本发明涉及具有整体护套的超声牙科工具和适于利用现有超声牙科单元中已经可获得的电磁能的至少一个光源。手持件包括具有可以包括线圈的主电源的基本上中空的壳体。一方面，超声牙科插入物包括护套。护套可以形成为可以覆盖手机壳体的至少一部分。通常，护套可以用作屏障，使得其可以减少与患者口部的交叉污染。在操作期间，手持件的初级线圈可以感应地耦合到照明能量线圈，使得照明能量线圈可以从初级线圈的电磁场吸取能量以对至少一个发光元件供电。

9. 发明申请

US20070236018A1 Method for joining parts fabricated via selective laser sintering while maintaining proper alignment 审中-公开
标题翻译：用于连接通过选择性激光烧结制造的部件，同时保持适当对准的方法
公开(公告)号：US20070236018A1
公开(公告)日：2007-10-11
申请号：US11220097
申请日：2005-09-06
申请人： Christopher Husmann , Gregory Stein
发明人： Christopher Husmann , Gregory Stein
IPC分类号： F16L21/00
CPC分类号： F16L37/2445 , B33Y70/00 , B33Y80/00 , F16L37/252 , F24F13/0245
摘要： Mating air ducts may be joined to each other via an integrally formed protrusion on male air duct and an integrally formed groove on a female air duct for effecting linear and angular alignment of the mating air ducts. The integrally formed protrusion and groove may be formed on the air ducts via a process known as selective laser sintering or stereo lithography. Further, more than one groove and protrusion may be formed on the air ducts in an uneven manner such that the protrusions fit within the grooves in only one angular orientation. The protrusion may be a nub or a thread. Also, the groove may be a channel aligned to a central axis of the female air duct or a helical groove. The male air duct is linearly aligned and/or angularly aligned to the female air duct when the protrusion engages a distal portion of the groove or an abrupt change of the groove.
摘要翻译：接合空气管道可以通过阳空气管道上的整体形成的突起和阴空气管道上的整体形成的凹槽彼此接合，以实现配合空气管道的线性和角度对准。整体形成的突起和凹槽可以通过称为选择性激光烧结或立体光刻的工艺形成在空气管道上。此外，可以以不均匀的方式在空气管道上形成多于一个的凹槽和凸起，使得凸起仅以一个角度取向装配在凹槽内。突出部可以是凸起或螺纹。此外，槽可以是与阴空气管道的中心轴线或螺旋槽对准的通道。当突出部接合凹槽的远端部分或槽的突然变化时，阳空气管道与阴空气管道线性对准和/或成角度地对准。

10. 发明申请

US20120185408A1 CREATING AND MAINTAINING A PAYOUT-READY PORTFOLIO WITHIN AN INVESTMENT PLAN TO GENERATE A SUSTAINABLE INCOME STREAM 失效
标题翻译：在投资计划中创建和维护一个付费准备工具，以产生可持续收入流
公开(公告)号：US20120185408A1
公开(公告)日：2012-07-19
申请号：US13245807
申请日：2011-09-26
申请人： Jason S. Scott , Shinichiro Inoue , Jeffrey N. Maggioncalda , David Ramirez , Wei-Yin Hu , John G. Watson , David Boudreau , Gregory Stein , James W. Shearer
发明人： Jason S. Scott , Shinichiro Inoue , Jeffrey N. Maggioncalda , David Ramirez , Wei-Yin Hu , John G. Watson , David Boudreau , Gregory Stein , James W. Shearer
IPC分类号： G06Q40/06
CPC分类号： G06Q40/04 , G06Q20/10 , G06Q40/06
摘要： Financial advisory methods and systems for creating a steady lifetime income stream within an investment plan is provided. According to one embodiment, based on an investor's current holdings in the investment plan, a pattern of periodic cash payouts is identified that can be made to the investor from an in-plan payout program implemented with the limited universe of financial products available within the investment plan. The assets of the investment plan are rebalanced to form a payout portfolio and an equity exposure portfolio. The payout portfolio is constructed to create an annuity-like stream of income to support the pattern of periodic cash payouts and includes multiple bond funds. The equity exposure portfolio is constructed to address inflation risk by providing an ability to rise with equities markets. Finally, a periodic cash payout of the pattern of periodic cash payouts is caused to be paid to the investor from the investment plan.
摘要翻译：提供了在投资计划中创造稳定的终身收入流的财务咨询方法和系统。根据一个实施例，基于投资者目前持有的投资计划，确定了可以通过在投资范围内可用的有限金融产品实施的计划内支付计划向投资者提供定期现金支出的模式计划。投资计划的资产重新平衡，形成支付组合和股权投资组合。支付组合的建立是为了创建年金般的收入流，以支持定期现金支付的模式，并包括多个债券基金。股权投资组合的构建旨在通过提供股票市场上涨的能力来解决通货膨胀风险。最后，通过投资计划向投资者支付定期现金支付方式的定期现金支付。

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