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1. 发明授权

US07846396B2 Sample holder for surface plasmon resonance measuring instruments 有权
标题翻译：表面等离子体共振测量仪器的样品架
公开(公告)号：US07846396B2
公开(公告)日：2010-12-07
申请号：US11141167
申请日：2005-05-31
申请人： Daniel B. Roitman , Gregory D. VanWiggeren
发明人： Daniel B. Roitman , Gregory D. VanWiggeren
IPC分类号： B01L3/00
CPC分类号： G01N21/553 , B01L3/5085 , B01L3/5088 , B01L2300/0822 , B01L2300/161 , B82Y20/00 , G02B5/008 , Y10T436/24 , Y10T436/25
摘要： A droplet sample holder, especially a sample holder for use in a measuring instrument utilizing surface plasmon resonance. The sample holder reduces or minimizes the measurement distortion result of the droplet “pherpheral concentration effect” by surrounding the analysis zone with a wettable (hydrophilic) zone that captures the periphery of the droplet to keep the pheriphery of the droplet and the increased concentration of the analyte out of the analysis zone. The wettable zone is surrounded by a nonwettable (hydrophobic) zone that restricts the periphery of the droplet to analysis zone and the wettable zone.
摘要翻译：液滴样品架，特别是用于使用表面等离子体共振的测量仪器中的样品架。样品架通过用可捕获液滴的周边的可湿性（亲水性）区围绕分析区来降低或最小化液滴“pherpheral浓度效应”的测量失真结果，以保持液滴的浓度，并且增加浓度分析出分析区。可湿润区域被不可润湿（疏水）区域围绕，该区域将液滴的周边限制到分析区域和可湿性区域。

2. 发明授权

US07027676B2 Optical phase measurement of target 有权
标题翻译：目标光学相位测量
公开(公告)号：US07027676B2
公开(公告)日：2006-04-11
申请号：US10795917
申请日：2004-03-08
申请人： Gregory D. VanWiggeren , Daniel B. Roitman
发明人： Gregory D. VanWiggeren , Daniel B. Roitman
IPC分类号： G02B6/00 , G02B6/12 , G01N21/00
CPC分类号： G01J9/00 , G01N21/553
摘要： Optical phase detection includes generating a first lightwave having a first polarization and a second lightwave having a polarization that is offset from the first polarization, and imposing a relative delay between the first and second lightwaves. The relative delay causes a frequency offset between the lightwaves as wavelength is tuned over a designated wavelength range. Directing the first and second lightwaves to a target provides a third lightwave and a fourth lightwave. A polarization component of the third lightwave and a polarization component of the fourth lightwave are detected to provide a detected signal at the frequency offset. The optical phase detection then includes extracting a phase difference, induced by the target, between the polarization components of the third and the fourth lightwaves.
摘要翻译：光相位检测包括产生具有第一偏振的第一光波和具有偏离第一偏振的偏振的第二光波，并且在第一和第二光波之间施加相对延迟。当波长在指定的波长范围内调谐时，相对延迟会导致光波之间的频率偏移。将第一和第二光波导向目标提供第三光波和第四光波。检测第三光波的偏振分量和第四光波的偏振分量，以提供频偏处的检测信号。然后，光学相位检测包括在第三和第四光波的偏振分量之间提取由目标感应的相位差。

3. 发明授权

US10041941B2 Assay test strips with multiple labels and reading same 有权
公开(公告)号：US10041941B2
公开(公告)日：2018-08-07
申请号：US12410178
申请日：2009-03-24
申请人： Patrick T. Petruno , John F. Petrilla , Michael J. Brosnan , Rong Zhou , Daniel B. Roitman
发明人： Patrick T. Petruno , John F. Petrilla , Michael J. Brosnan , Rong Zhou , Daniel B. Roitman
IPC分类号： G01N33/558 , G01N33/58 , G01N21/77 , G01N35/00
摘要： In one aspect, an assay test strip includes a test label that specifically binds a target analyte and a control label that is free of any specific binding affinity for the target analyte and has a different optical characteristic than the test label. In another aspect, an assay test strip includes a test label that specifically binds a target analyte and at least one non-specific-binding label that is free of any specific binding affinity for the target analyte. Systems and methods of reading assay test strips also are described.

4. 发明申请

US20090180928A1 ASSAY TEST STRIPS WITH MULTIPLE LABELS AND READING SAME 审中-公开
标题翻译：具有多个标签和阅读的测试条
公开(公告)号：US20090180928A1
公开(公告)日：2009-07-16
申请号：US12410178
申请日：2009-03-24
申请人： Patrick T. Petruno , John F. Petrilla , Michael J. Brosnan , Rong Zhou , Daniel B. Roitman
发明人： Patrick T. Petruno , John F. Petrilla , Michael J. Brosnan , Rong Zhou , Daniel B. Roitman
IPC分类号： G01N31/22 , B82B1/00
CPC分类号： G01N33/558 , G01N33/582 , G01N2021/7786 , G01N2035/00108
摘要： In one aspect, an assay test strip includes a test label that specifically binds a target analyte and a control label that is free of any specific binding affinity for the target analyte and has a different optical characteristic than the test label. In another aspect, an assay test strip includes a test label that specifically binds a target analyte and at least one non-specific-binding label that is free of any specific binding affinity for the target analyte. Systems and methods of reading assay test strips also are described.
摘要翻译：在一个方面，分析测试条包括特异性结合目标分析物的测试标签和对目标分析物没有任何特异性结合亲和力并且具有与测试标记不同的光学特性的对照标记。在另一方面，测定试片包括特异性结合目标分析物和至少一种对目标分析物没有任何特异性结合亲和力的非特异性结合标记的测试标记。还描述了读取测定条带的系统和方法。

5. 发明授权

US07459317B2 Method for detecting an analyte in a sample 有权
标题翻译：检测样品中分析物的方法
公开(公告)号：US07459317B2
公开(公告)日：2008-12-02
申请号：US11734317
申请日：2007-04-12
申请人： Daniel B. Roitman
发明人： Daniel B. Roitman
IPC分类号： G01N33/543
CPC分类号： G01N33/54306 , G01N33/581 , G01N33/582 , G01N2458/30
摘要： Methods for detecting the presence of an analyte in a sample are provided. Aspects of the methods include mixing a sample with an indirectly-detectable labeled binding member that includes a label moiety. The mixing produces a first composition. Unbound labeled binding member is then separated from any resultant binding complexes to produce a second composition that includes the binding complexes. A second light emitted by a light wavelength converter that is excited by a first light generated by the labeled binding member of the binding complexes of the second composition is then detected to detect the presence of the analyte in the sample. Embodiments also include kits and systems that find use in practicing the subject methods.
摘要翻译：提供了用于检测样品中分析物的存在的方法。方法的方面包括将样品与包含标记部分的间接可检测的标记结合成员混合。混合产生第一组合物。然后将未结合的标记结合成员与任何所得的结合复合物分离，以产生包含结合复合物的第二组合物。然后检测由光波长转换器发射的由第二组合物的结合复合物的标记结合成员产生的第一光激发的第二光，以检测样品中分析物的存在。实施例还包括用于实践主题方法的套件和系统。

6. 发明申请

US20080171397A1 Multiple analyte detection systems and methods of detecting multiple analytes 有权
标题翻译：多种分析物检测系统和检测多种分析物的方法
公开(公告)号：US20080171397A1
公开(公告)日：2008-07-17
申请号：US11653568
申请日：2007-01-16
申请人： Ian Hardcastle , Carol T. Schembri , John Francis Petrilla , Rene B. Helbing , Daniel B. Roitman
发明人： Ian Hardcastle , Carol T. Schembri , John Francis Petrilla , Rene B. Helbing , Daniel B. Roitman
IPC分类号： G01N21/76
CPC分类号： G01N21/78 , G01N21/253 , G01N21/8483
摘要： A multiple analyte detection system includes a carrier having reagents disposed thereat, with each of the reagents capable of optically changing in response to exposure to a respective analyte. The system further includes a photodetector positioned to collectively detect light interacted with each of the reagents, a processor to determine a presence or an absence of each of the analytes in response to the light collectively-detected, and an indicator to provide an indication of the presence or the absence of each of the analytes. A method of detecting multiple analytes includes exposing reagents capable of optically changing in response to exposure to a respective analyte to a sample. The method further includes collectively detecting light interacted with each of the reagents, determining a presence or an absence of each of the analytes in response to the light collectively detected, and indicating the presence or the absence of each of the analytes determined.
摘要翻译：多分析物检测系统包括具有在其上设置的试剂的载体，其中每种试剂能够响应于暴露于相应分析物而光学变化。该系统还包括光电检测器，其被定位成共同检测与每个试剂相互作用的光;处理器，用于响应于总体检测的光来确定每个分析物的存在或不存在;以及指示器，存在或不存在每种分析物。检测多种分析物的方法包括将暴露于相应分析物的样品响应于能够进行光学变化的试剂露出。该方法还包括共同检测与每种试剂相互作用的光，响应于共同检测的光，确定每种分析物的存在或不存在，并指示所确定的每种分析物的存在或不存在。

7. 发明授权

US07152758B2 Scented material dispense system for a hand-held device 失效
标题翻译：用于手持设备的气味物料分配系统
公开(公告)号：US07152758B2
公开(公告)日：2006-12-26
申请号：US10919669
申请日：2004-08-17
申请人： Ronald Shane Fazzio , Richard Ruby , Kevin Patrick Killeen , Daniel B. Roitman , Jeremy Alfred Theil
发明人： Ronald Shane Fazzio , Richard Ruby , Kevin Patrick Killeen , Daniel B. Roitman , Jeremy Alfred Theil
IPC分类号： B67D5/60
CPC分类号： H04M1/21 , A45D34/02 , A61L9/035 , A61L9/14 , B05B5/1691 , B05B7/1686 , B05B7/2464 , B05B7/2472 , B05B9/0861 , B05B12/00 , H04M1/72519
摘要： A dispense system stores a scented material or materials and is provided with an electrical interface that is compatible with a hand-held device. The dispense system can be connected to the hand-held device and driven with the help of the hand-held device to dispense the scented material. The dispense system can be configured to store different scented materials that can be mixed to create different scents. Logic within the hand-held device supports the mixing and dispensing of the scented materials.
摘要翻译：分配系统存储有香味的材料或材料，并且设置有与手持装置兼容的电接口。分配系统可以连接到手持式装置并借助手持装置驱动以分配香味材料。分配系统可以被配置为存储可以混合以产生不同气味的不同香味材料。手持装置内的逻辑支持混合和分配香味材料。

8. 发明授权

US07052618B2 Nanostructures and methods of making the same 失效
标题翻译：纳米结构和制作方法
公开(公告)号：US07052618B2
公开(公告)日：2006-05-30
申请号：US10766639
申请日：2004-01-28
申请人： Nicolas J. Moll , Daniel B. Roitman , Jennifer Q. Lu
发明人： Nicolas J. Moll , Daniel B. Roitman , Jennifer Q. Lu
IPC分类号： B44C1/22
CPC分类号： H01L51/0048 , B82Y10/00 , B82Y30/00 , B82Y40/00 , C01B32/162 , C01B2202/02 , Y10S977/70 , Y10S977/773
摘要： Nanostructures and methods of making the same are described. In one aspect, a film including a vector polymer comprising a payload moiety is formed on a substrate. The film is patterned. Organic components of the patterned film are removed to form a payload-comprising nanoparticle.
摘要翻译：描述了纳米结构及其制备方法。一方面，在基材上形成包含载体聚合物的膜，该载体聚合物包含有效载荷部分。电影是图案的。去除图案化膜的有机组分以形成含有载体的纳米颗粒。

9. 发明授权

US06552488B1 Organic electroluminescent device 有权
标题翻译：有机电致发光器件
公开(公告)号：US06552488B1
公开(公告)日：2003-04-22
申请号：US09382025
申请日：1999-08-24
申请人： Daniel B. Roitman , John S. Hargreaves , Homer Antoniadis , Karen L. Seaward
发明人： Daniel B. Roitman , John S. Hargreaves , Homer Antoniadis , Karen L. Seaward
IPC分类号： H05B3306
CPC分类号： H01J37/32082 , H01L27/322 , H01L27/3244 , H01L51/5253 , H01L51/529 , H01L2251/5315
摘要： A color organic electroluminescent device includes color filters, light emitting layers and substrate integrated into a single assembly, with the light emitting layers lying between the substrate and the color filters. Unlike color electroluminescent devices where an image must be viewed through a transparent substrate, or where color filters are deposited upon another device and later combined with the assembly, the present disclosure calls for a transparent protective layer of silicon nitride or a similar material to be deposited over the light emitting layers to protect the light emitting layers from oxygen and moisture, and to serve as a platform for color filters. In order to achieve sufficient density in the protective layer and avoid defects, a cold plasma deposition or similar process is used for deposition of the protective layer. By viewing light through this protective layer instead of a substrate, nearly any substrate can be used.
摘要翻译：彩色有机电致发光器件包括滤色器，发光层和集成到单个组件中的衬底，其中发光层位于衬底和滤色器之间。不同于彩色电致发光器件，其中必须通过透明衬底观察图像，或者滤色器沉积在另一器件上并且随后与组件结合在一起，本公开要求具有氮化硅的透明保护层或要沉积的类似材料在发光层上，以保护发光层免受氧气和水分的影响，并且用作滤色器的平台。为了在保护层中获得足够的密度并避免缺陷，使用冷等离子体沉积或类似的工艺来沉积保护层。通过观察通过该保护层的光而不是基板，可以使用几乎任何基板。

10. 发明授权

US06191433B1 OLED display device and method for patterning cathodes of the device 有权
标题翻译： OLED显示装置和用于图案化装置的阴极的方法
公开(公告)号：US06191433B1
公开(公告)日：2001-02-20
申请号：US09528413
申请日：2000-03-17
申请人： Daniel B. Roitman , Homer Antoniadis
发明人： Daniel B. Roitman , Homer Antoniadis
IPC分类号： H01L3524
CPC分类号： H01L27/3281 , H01L51/5221 , H01L2251/5315
摘要： An OLED display device and a method of fabricating the device utilize a patterned layer of conductive pads formed over a substrate to fabricate a cathode layer without the need to subsequently pattern the cathode layer to create individually addressable cathodes. The design of the OLED display device is such that the cathode layer is positioned below the anode layer. The OLED display device may be configured to emit light through the substrate or through the top layer, i.e., the anode layer. In a first embodiment, the conductive pads have sharp edges that effectively pattern the cathode layer when it is formed over the pads. In a second embodiment, the conductive pads do not include sharp edges. In this embodiment, the cathode layer is made of a composite material, which includes cathode components and non-conducting components. The composite material allows the resulting cathode layer to have the desired characteristics to effectively inject electrons vertically into the EL region of the device, while limiting lateral conduction between the conductive pads.
摘要翻译： OLED显示装置和制造该器件的方法利用形成在衬底上的图形化的导电焊盘层以制造阴极层，而不需要随后对阴极层进行图案以产生可单独寻址的阴极。 OLED显示装置的设计使得阴极层位于阳极层下方。 OLED显示装置可以被配置为通过衬底或通过顶层即阳极层发光。在第一实施例中，导电焊盘具有尖锐边缘，当阴极层形成在焊盘上时，其有效地图案化阴极层。在第二实施例中，导电焊盘不包括锋利的边缘。在该实施例中，阴极层由包括阴极部件和非导电部件的复合材料制成。复合材料允许所得到的阴极层具有所需的特性，以有效地将电子垂直注入器件的EL区域，同时限制导电焊盘之间的横向传导。

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