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1. 发明授权

US08506500B2 Method and apparatus for morphology-based arrhythmia classification using cardiac and other physiological signals 有权
标题翻译：使用心脏和其他生理信号进行形态学心律失常分类的方法和装置
公开(公告)号：US08506500B2
公开(公告)日：2013-08-13
申请号：US13043346
申请日：2011-03-08
申请人： Dan Li , Shelley M. Cazares , Jaeho Kim , Kent Lee
发明人： Dan Li , Shelley M. Cazares , Jaeho Kim , Kent Lee
IPC分类号： A61B5/0472 , A61B5/02
CPC分类号： A61B5/0464 , A61B5/7264 , A61N1/3621 , A61N1/36521 , A61N1/36542 , A61N1/36564 , A61N1/36571 , A61N1/36578 , A61N1/36585 , A61N1/3925 , A61N1/3962
摘要： A tachyarrhythmia detection and classification system classifies tachyarrhythmias based on an analysis of morphological features of a cardiac signal enhanced by using one or more physiological parameters indicative of hemodynamic stability and/or activity level. The tachyarrhythmia detection and classification system computes a measure of similarity between an arrhythmic waveform of the cardiac signal, a template waveform for that cardiac signal, such as a correlation coefficient representative of the correlation between morphological features of the arrhythmic waveform and morphological features of the template waveform. A detected tachyarrhythmia episode is classified by comparing the measure of similarity to a threshold that is dynamically adjusted using the one or more physiological parameters.
摘要翻译：快速心律失常检测和分类系统基于通过使用指示血液动力学稳定性和/或活动水平的一个或多个生理参数来增强的心脏信号的形态学特征的分析来分类快速性心律失常。快速心律失常检测和分类系统计算心脏信号的心律失常波形与该心脏信号的模板波形之间的相似性的度量，例如表示心律失常波形的形态特征与模板的形态特征之间的相关性的相关系数波形通过将相似性测量值与使用一个或多个生理参数动态调整的阈值进行比较来分类检测到的快速性心律失常发作。

2. 发明授权

US07912545B2 Method and apparatus for morphology-based arrhythmia classification using cardiac and other physiological signals 有权
标题翻译：使用心脏和其他生理信号进行形态学心律失常分类的方法和装置
公开(公告)号：US07912545B2
公开(公告)日：2011-03-22
申请号：US12536828
申请日：2009-08-06
申请人： Dan Li , Shelley M. Cazares , Jaeho Kim , Kent Lee
发明人： Dan Li , Shelley M. Cazares , Jaeho Kim , Kent Lee
IPC分类号： A61N1/362 , A61B5/04
CPC分类号： A61B5/0464 , A61B5/7264 , A61N1/3621 , A61N1/36521 , A61N1/36542 , A61N1/36564 , A61N1/36571 , A61N1/36578 , A61N1/36585 , A61N1/3925 , A61N1/3962
摘要： A tachyarrhythmia detection and classification system classifies tachyarrhythmias based on an analysis of morphological features of a cardiac signal enhanced by using one or more physiological parameters indicative of hemodynamic stability and/or activity level. The tachyarrhythmia detection and classification system computes a measure of similarity between an arrhythmic waveform of the cardiac signal, a template waveform for that cardiac signal, such as a correlation coefficient representative of the correlation between morphological features of the arrhythmic waveform and morphological features of the template waveform. A detected tachyarrhythmia episode is classified by comparing the measure of similarity to a threshold that is dynamically adjusted using the one or more physiological parameters.
摘要翻译：快速心律失常检测和分类系统基于通过使用指示血液动力学稳定性和/或活动水平的一个或多个生理参数来增强的心脏信号的形态学特征的分析来分类快速性心律失常。快速心律失常检测和分类系统计算心脏信号的心律失常波形与该心脏信号的模板波形之间的相似性的度量，例如表示心律失常波形的形态特征与模板的形态特征之间的相关性的相关系数波形通过将相似性测量值与使用一个或多个生理参数动态调整的阈值进行比较来分类检测到的快速性心律失常发作。

3. 发明授权

US08700138B2 Methods and devices for determination of arrhythmia rate zone thresholds 有权
标题翻译：用于确定心律失常率区域阈值的方法和装置
公开(公告)号：US08700138B2
公开(公告)日：2014-04-15
申请号：US12545364
申请日：2009-08-21
申请人： Shelley M. Cazares , Carlos A. Ricci , Jaeho Kim
发明人： Shelley M. Cazares , Carlos A. Ricci , Jaeho Kim
IPC分类号： A61B5/04
CPC分类号： A61B5/0464 , A61N1/3925 , A61N1/3962
摘要： Approaches for determining threshold values for one or more arrhythmia rate zones and/or the number of rate zones are described. A probability function for heart rate is determined using collected and measured heart rate values. One or more heart rate probability values are selected. Thresholds for arrhythmia rate zones are determined from the probability function based on the selected probability values. Determining the rate zone thresholds may involve determining a threshold for a lower rate limit and/or determining one or more tachyarrhythmia rate zone thresholds. The number of rate zones may also be determined based on the probability function.
摘要翻译：描述了用于确定一个或多个心律失常率区域的阈值和/或速率区域的数量的方法。使用收集和测量的心率值来确定心率的概率函数。选择一个或多个心率概率值。基于所选择的概率值，从概率函数确定心律失常率区域的阈值。确定速率区阈值可以包括确定较低速率限制的阈值和/或确定一个或多个快速性心律失常率区域阈值。速率区域的数量也可以基于概率函数来确定。

4. 发明申请

US20090292332A1 METHOD AND APPARATUS FOR MORPHOLOGY-BASED ARRHYTHMIA CLASSIFICATION USING CARDIAC AND OTHER PHYSIOLOGICAL SIGNALS 有权
标题翻译：使用心脏和其他生理信号进行形态学基于ARRHYTHMIA分类的方法和装置
公开(公告)号：US20090292332A1
公开(公告)日：2009-11-26
申请号：US12536828
申请日：2009-08-06
申请人： Dan Li , Shelley Cazares , Jaeho Kim , Kent Lee
发明人： Dan Li , Shelley Cazares , Jaeho Kim , Kent Lee
IPC分类号： A61N1/39 , A61B5/02 , A61B5/0205
CPC分类号： A61B5/0464 , A61B5/7264 , A61N1/3621 , A61N1/36521 , A61N1/36542 , A61N1/36564 , A61N1/36571 , A61N1/36578 , A61N1/36585 , A61N1/3925 , A61N1/3962
摘要： A tachyarrhythmia detection and classification system classifies tachyarrhythmias based on an analysis of morphological features of a cardiac signal enhanced by using one or more physiological parameters indicative of hemodynamic stability and/or activity level. The tachyarrhythmia detection and classification system computes a measure of similarity between an arrhythmic waveform of the cardiac signal a template waveform for that cardiac signal, such as a correlation coefficient representative of the correlation between morphological features of the arrhythmic waveform and morphological features of the template waveform. A detected tachyarrhythmia episode is classified by comparing the measure of similarity to a threshold that is dynamically adjusted using the one or more physiological parameters.
摘要翻译：快速心律失常检测和分类系统基于通过使用指示血液动力学稳定性和/或活动水平的一个或多个生理参数来增强的心脏信号的形态学特征的分析来分类快速性心律失常。快速心律失常检测和分类系统计算心脏信号的心律失常波形与该心脏信号的模板波形之间的相似性的度量，例如表示心律失常波形的形态特征与模板波形的形态特征之间的相关性的相关系数。通过将相似性测量值与使用一个或多个生理参数动态调整的阈值进行比较来分类检测到的快速性心律失常发作。

5. 发明申请

US20110160551A1 METHOD AND APPARATUS FOR MORPHOLOGY-BASED ARRHYTHMIA CLASSIFICATION USING CARDIAC AND OTHER PHYSIOLOGICAL SIGNALS 有权
标题翻译：使用心脏和其他生理信号进行形态学基于ARRHYTHMIA分类的方法和装置
公开(公告)号：US20110160551A1
公开(公告)日：2011-06-30
申请号：US13043346
申请日：2011-03-08
申请人： Dan Li , Shelley Cazares , Jaeho Kim , Kent Lee
发明人： Dan Li , Shelley Cazares , Jaeho Kim , Kent Lee
IPC分类号： A61B5/02
CPC分类号： A61B5/0464 , A61B5/7264 , A61N1/3621 , A61N1/36521 , A61N1/36542 , A61N1/36564 , A61N1/36571 , A61N1/36578 , A61N1/36585 , A61N1/3925 , A61N1/3962
摘要： A tachyarrhythmia detection and classification system classifies tachyarrhythmias based on an analysis of morphological features of a cardiac signal enhanced by using one or more physiological parameters indicative of hemodynamic stability and/or activity level. The tachyarrhythmia detection and classification system computes a measure of similarity between an arrhythmic waveform of the cardiac signal, a template waveform for that cardiac signal, such as a correlation coefficient representative of the correlation between morphological features of the arrhythmic waveform and morphological features of the template waveform. A detected tachyarrhythmia episode is classified by comparing the measure of similarity to a threshold that is dynamically adjusted using the one or more physiological parameters.
摘要翻译：快速心律失常检测和分类系统基于通过使用指示血液动力学稳定性和/或活动水平的一个或多个生理参数来增强的心脏信号的形态学特征的分析来分类快速性心律失常。快速心律失常检测和分类系统计算心脏信号的心律失常波形与该心脏信号的模板波形之间的相似性的度量，例如表示心律失常波形的形态特征与模板的形态特征之间的相关性的相关系数波形通过将相似性测量值与使用一个或多个生理参数动态调整的阈值进行比较来分类检测到的快速性心律失常发作。

6. 发明申请

US20070149890A1 Method and apparatus for morphology-based arrhythmia classification using cardiac and other physiological signals 有权
标题翻译：使用心脏和其他生理信号进行形态学心律失常分类的方法和装置
公开(公告)号：US20070149890A1
公开(公告)日：2007-06-28
申请号：US11316332
申请日：2005-12-22
申请人： Dan Li , Shelley Cazares , Jaeho Kim , Kent Lee
发明人： Dan Li , Shelley Cazares , Jaeho Kim , Kent Lee
IPC分类号： A61B5/04
CPC分类号： A61B5/0464 , A61B5/7264 , A61N1/3621 , A61N1/36521 , A61N1/36542 , A61N1/36564 , A61N1/36571 , A61N1/36578 , A61N1/36585 , A61N1/3925 , A61N1/3962
摘要： A tachyarrhythmia detection and classification system classifies tachyarrhythmias based on an analysis of morphological features of a cardiac signal enhanced by using one or more physiological parameters indicative of hemodynamic stability and/or activity level. The tachyarrhythmia detection and classification system computes a measure of similarity between an arrhythmic waveform of the cardiac signal a template waveform for that cardiac signal, such as a correlation coefficient representative of the correlation between morphological features of the arrhythmic waveform and morphological features of the template waveform. A detected tachyarrhythmia episode is classified by comparing the measure of similarity to a threshold that is dynamically adjusted using the one or more physiological parameters.
摘要翻译：快速心律失常检测和分类系统基于通过使用指示血液动力学稳定性和/或活动水平的一个或多个生理参数来增强的心脏信号的形态学特征的分析来分类快速性心律失常。快速心律失常检测和分类系统计算心脏信号的心律失常波形与该心脏信号的模板波形之间的相似性的度量，例如表示心律失常波形的形态特征与模板波形的形态特征之间的相关性的相关系数。通过将相似性测量值与使用一个或多个生理参数动态调整的阈值进行比较来分类检测到的快速性心律失常发作。

7. 发明授权

US07582061B2 Method and apparatus for morphology-based arrhythmia classification using cardiac and other physiological signals 有权
标题翻译：使用心脏和其他生理信号进行形态学心律失常分类的方法和装置
公开(公告)号：US07582061B2
公开(公告)日：2009-09-01
申请号：US11316332
申请日：2005-12-22
申请人： Dan Li , Shelley Cazares , Jaeho Kim , Kent Lee
发明人： Dan Li , Shelley Cazares , Jaeho Kim , Kent Lee
IPC分类号： A61B5/02
CPC分类号： A61B5/0464 , A61B5/7264 , A61N1/3621 , A61N1/36521 , A61N1/36542 , A61N1/36564 , A61N1/36571 , A61N1/36578 , A61N1/36585 , A61N1/3925 , A61N1/3962
摘要： A tachyarrhythmia detection and classification system classifies tachyarrhythmias based on an analysis of morphological features of a cardiac signal enhanced by using one or more physiological parameters indicative of hemodynamic stability and/or activity level. The tachyarrhythmia detection and classification system computes a measure of similarity between an arrhythmic waveform of the cardiac signal a template waveform for that cardiac signal, such as a correlation coefficient representative of the correlation between morphological features of the arrhythmic waveform and morphological features of the template waveform. A detected tachyarrhythmia episode is classified by comparing the measure of similarity to a threshold that is dynamically adjusted using the one or more physiological parameters.
摘要翻译：快速心律失常检测和分类系统基于通过使用指示血液动力学稳定性和/或活动水平的一个或多个生理参数来增强的心脏信号的形态学特征的分析来分类快速性心律失常。快速心律失常检测和分类系统计算心脏信号的心律失常波形与该心脏信号的模板波形之间的相似性的度量，例如表示心律失常波形的形态特征与模板波形的形态特征之间的相关性的相关系数。通过将相似性测量值与使用一个或多个生理参数动态调整的阈值进行比较来分类检测到的快速性心律失常发作。

8. 发明申请

US20090306486A1 SENSING VECTOR CONFIGURATION IN ICD TO ASSIST ARRHYTHMIA DETECTION AND ANNOTATION 有权
标题翻译： ICD中的感应矢量配置，以帮助ARRHYTHMIA检测和报告
公开(公告)号：US20090306486A1
公开(公告)日：2009-12-10
申请号：US12478476
申请日：2009-06-04
申请人： Dan Li , Allan C. Shuros , Quan Ni , Aaron R. McCabe , Yunlong Zhang , Jaeho Kim
发明人： Dan Li , Allan C. Shuros , Quan Ni , Aaron R. McCabe , Yunlong Zhang , Jaeho Kim
IPC分类号： A61B5/046 , A61B5/02 , A61B5/0464
CPC分类号： A61B5/0464 , A61B5/0215 , A61B5/0422 , A61B5/046 , A61N1/3622 , A61N1/3702
摘要： An apparatus comprises an implantable cardiac signal sensing circuit, configured to provide a sensed near-field depolarization signal from a ventricle and to provide a sensed a far-field intrinsic atrial signal using a far-field atrial sensing channel, and a controller circuit communicatively coupled to the cardiac signal sensing circuit. The controller circuit includes a P-wave detection module configured to detect an atrial depolarization in the sensed far-field intrinsic atrial signal and a tachyarrhythmia detection module configured to detect an episode of tachyarrhythmia using the sensed near-field depolarization signal and to determine whether the tachyarrhythmia episode is indicative of supraventricular tachycardia (SVT) using the detected atrial depolarization and the sensed near-field depolarization signal.
摘要翻译：一种装置包括可植入心脏信号感测电路，其被配置为提供来自心室的感测的近场去极化信号，并且使用远场心房感测通道提供感测到的远场固有心房信号，以及控制器电路，到心脏信号感测电路。所述控制器电路包括P波检测模块，所述P波检测模块被配置为检测所感测的远场固有心房信号中的心房去极化，以及快速性心律失常检测模块，其被配置为使用所感测的近场去极化信号来检测快速性心律失常发作，并且确定是否快速性心律失常发作指示使用检测到的心房去极化和感测的近场去极化信号的室上性心动过速（SVT）。

9. 发明申请

US20120215273A1 METHOD AND APPARATUS FOR CONCURRENT ATRIO-VENTRICULAR ANTI-TACHYCARDIA PACING 有权
标题翻译：相关性ATRIO-VENTRICULAR ANTI-TACHYCARDIA PACING的方法和装置
公开(公告)号：US20120215273A1
公开(公告)日：2012-08-23
申请号：US13457630
申请日：2012-04-27
申请人： Dan Li , Jaeho Kim , Joseph M. Bocek
发明人： Dan Li , Jaeho Kim , Joseph M. Bocek
IPC分类号： A61N1/365
CPC分类号： A61N1/3621 , A61N1/368 , A61N1/3688
摘要： An implantable medical device delivers anti-tachyarrhythmia therapies including anti-tachycardia pacing (ATP). If a detected tachyarrhythmia is classified as a type suitable for treatment using ATP, the implantable medical device selects one of an atrial ATP (A-ATP) mode, a ventricular ATP (V-ATP) mode, and a concurrent atrio-ventricular ATP (concurrent AV-ATP) mode according to the characteristics of the detected tachyarrhythmia. The concurrent ATP mode is an ATP mode during which the atrial pacing pulses and the ventricular pacing pulses are delivered concurrently. In one embodiment, the concurrent AV-ATP mode includes a synchronized atrio-ventricular ATP (synchronized AV-ATP) mode during which atrial and ventricular pacing pulses are delivered synchronously and an independent atrio-ventricular ATP (independent AV-ATP) mode during which atrial and ventricular pacing pulses are delivered concurrently but timed independently.
摘要翻译：植入式医疗装置提供抗心律失常疗法，包括抗心动过速起搏（ATP）。如果检测到的快速性心律失常被分类为适合于使用ATP治疗的类型，则可植入医疗装置选择心房ATP（A-ATP）模式，心室ATP（V-ATP）模式和并发心室ATP 并发AV-ATP）模式，根据检测到的快速性心律失常的特点。并发ATP模式是ATP模式，其中心房起搏脉冲和心室起搏脉冲同时传递。在一个实施方案中，并发的AV-ATP模式包括同步的心房ATP（同步的AV-ATP）模式，其中同步递送心房和心室起搏脉冲以及独立的心房ATP（独立的AV-ATP）模式，在此期间心房和心室起搏脉冲同时传递，但可以独立计时。

10. 发明授权

US08170669B2 Method and apparatus for concurrent atrio-ventricular anti-tachycardia pacing 有权
标题翻译：并发房室性心动过速起搏方法及装置
公开(公告)号：US08170669B2
公开(公告)日：2012-05-01
申请号：US12234840
申请日：2008-09-22
申请人： Dan Li , Jaeho Kim , Joseph M. Bocek
发明人： Dan Li , Jaeho Kim , Joseph M. Bocek
IPC分类号： A61N1/365
CPC分类号： A61N1/3621 , A61N1/368 , A61N1/3688
摘要： An implantable medical device delivers anti-tachyarrhythmia therapies including anti-tachycardia pacing (ATP). If a detected tachyarrhythmia is classified as a type suitable for treatment using ATP, the implantable medical device selects one of an atrial ATP (A-ATP) mode, a ventricular ATP (V-ATP) mode, and a concurrent atrio-ventricular ATP (concurrent AV-ATP) mode according to the characteristics of the detected tachyarrhythmia. The concurrent ATP mode is an ATP mode during which the atrial pacing pulses and the ventricular pacing pulses are delivered concurrently. In one embodiment, the concurrent AV-ATP mode includes a synchronized atrio-ventricular ATP (synchronized AV-ATP) mode during which atrial and ventricular pacing pulses are delivered synchronously and an independent atrio-ventricular ATP (independent AV-ATP) mode during which atrial and ventricular pacing pulses are delivered concurrently but timed independently.
摘要翻译：植入式医疗装置提供抗心律失常疗法，包括抗心动过速起搏（ATP）。如果检测到的快速性心律失常被分类为适合于使用ATP治疗的类型，则可植入医疗装置选择心房ATP（A-ATP）模式，心室ATP（V-ATP）模式和并发心室ATP 并发AV-ATP）模式，根据检测到的快速性心律失常的特点。并发ATP模式是ATP模式，其中心房起搏脉冲和心室起搏脉冲同时传递。在一个实施方案中，并发的AV-ATP模式包括同步的心房ATP（同步的AV-ATP）模式，其中同步递送心房和心室起搏脉冲以及独立的心房ATP（独立的AV-ATP）模式，在此期间心房和心室起搏脉冲同时传递，但可以独立计时。

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