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1. 发明申请

US20190090517A1 BEVERAGES COMPRISING STABLE GRANULES OF MILLED LUTEIN 审中-公开
公开(公告)号：US20190090517A1
公开(公告)日：2019-03-28
申请号：US16086458
申请日：2017-04-03
申请人： DSM IP Assets B.V.
发明人： Markus BECK , Antonio ESTRELLA , Elger FUNDA , Andrea HITZFELD , Christian SCHAEFER , Bernd SCHLEGEL , Kai URBAN
IPC分类号： A23L2/58 , A23L2/395 , A23L5/44 , A23L29/212
摘要： The present invention is directed towards the use of granules in beverages, wherein the granules comprise (i) a milled carotenoid selected from the group consisting of lutein and zeaxanthin and any mixture thereof having the following particle size distribution: D [3,2] in the range of from 0.6 to 1.5 μm, and D [v, 0.5] in the range of from 1.1 to 3.5 μm, and (ii) a matrix comprising at least one modified food starch, a glucose syrup and sucrose, (iii) a water-soluble antioxidant, wherein the granules have the following particle size distribution: D [3,2] in the range of from 200 to 300 μm, and D [v, 0.5] in the range of from 220 to 320 μm, all D values as measured by laser diffraction according to the Fraunhofer scattering model, whereby the milled carotenoid is encapsulated by the matrix. The present invention is also directed towards the beverages and the granules as such, as well as to a process for the manufacture of the granules. Preferably the carotenoid is lutein, zeaxanthin or any mixture thereof.

2. 发明申请

US20170008841A1 CRYSTAL FORMS OF ASTAXANTHIN 审中-公开
标题翻译：阿司匹林的晶体形式
公开(公告)号：US20170008841A1
公开(公告)日：2017-01-12
申请号：US15273555
申请日：2016-09-22
申请人： DSM IP ASSETS B.V.
发明人： Jingfei GUO , Matthew J. JONES , Christian SCHAEFER , Joachim ULRICH , Viviane VERLHAC-TRICHET
IPC分类号： C07C403/24 , A23K50/80 , A23K20/179 , A61K9/00
CPC分类号： C07C403/24 , A23K20/179 , A23K50/80 , A23L5/44 , A61K9/0056 , C07B2200/13 , Y02A40/818
摘要： The invention describes previously undisclosed crystal forms of astaxanthin designated crystal form I and II. It has been surprisingly found that the two crystal forms of astaxanthin show an improved bioavailability, a relatively high solubility in specific organic solvents and an increased long-term stability. For example the new forms are stable in solid form for at least 90 days at a temperature of 20° C.-40° C. It was further found that the two crystal forms can be prepared from each other. Therefore the invention also relates to methods for preparing said crystal forms. In addition, the invention relates to administration forms (hereinafter also called “formulations”) comprising one of the two crystal forms according to the invention or mixtures thereof dissolved or suspended in oil or organic-solvent.
摘要翻译：本发明描述了以前未公开的虾青素晶体形式，其指定为I型和II型晶体。已经令人惊讶地发现，两种虾青素的晶体形式具有改善的生物利用度，在特定的有机溶剂中的相对较高的溶解度和增加的长期稳定性。例如，新的形式在20℃-40℃的温度下以固体形式稳定至少90天。进一步发现，两种晶型可以彼此制备。因此，本发明还涉及制备所述晶形的方法。此外，本发明涉及包含根据本发明的两种晶型之一或其溶解或悬浮在油或有机溶剂中的混合物的给药形式（以下也称为“制剂”）。

3. 发明申请

US20190098924A1 NEW TABLETTABLE FORMULATION OF LUTEIN AND/OR ZEAXANTHIN 审中-公开
公开(公告)号：US20190098924A1
公开(公告)日：2019-04-04
申请号：US16086433
申请日：2017-04-03
申请人： DSM IP Assets B.V.
发明人： Antonio ESTRELLA , Elger FUNDA , Zdravka MISIC , Christian SCHAEFER , Markus Ivo BECK , Bernd SCHLEGEL , Kai URBAN
IPC分类号： A23L33/105 , A23L33/125 , A23L29/212 , A23P10/28
摘要： The present invention is directed towards a solid formulation comprising a milled carotenoid, at least one hydrocolloid, a glucose syrup, sucrose and at least one water-soluble antioxidant (preferably sodium ascorbate), wherein the carotenoid is selected from the group consisting of lutein and zeaxanthin and any mixture thereof, wherein the hydrocolloid is selected from the group consisting of modified food starches and any mixtures thereof, and wherein the milled carotenoid has the following particle size distribution: D [3, 2] in the range of from 0.6 to 1.5 μm and D [v, 0.5] in the range of from 1.1 to 3.5 μm, all D values as measured by laser diffraction (Malvern Instruments Ltd, Malvern, UK, Mastersizer 3000) according to the Fraunhofer scattering model. This solid formulation is in form of granules which are used for dietary supplements and pharmaceuticals, such as e.g. multi-vitamin and/or multi-mineral tablets. Surprisingly these tablets show a low compression loss.

4. 发明申请

US20160152540A1 NEW PROCESS FOR THE MAINTAINING OF A RATIO OF ISOMERS OF CAROTENOID COMPOUNDS 审中-公开
标题翻译：维持化合物化合物异构体比例的新方法
公开(公告)号：US20160152540A1
公开(公告)日：2016-06-02
申请号：US14900331
申请日：2014-06-18
申请人： DSM IP ASSETS B.V.
发明人： Basel ULRICH , Christian SCHAEFER , Franziska KREISSIG
IPC分类号： C07C45/86 , C07B63/04
CPC分类号： C07C45/86 , A23K20/105 , A23K20/179 , A23L5/44 , A23L33/10 , A23V2002/00 , C07B63/04 , C07B2200/09 , C07C7/20 , C07C403/02 , C07C403/16 , C07C403/24 , C07C2601/08 , C07C2601/16 , C07C13/28 , C07C13/20 , C07C11/21
摘要： The present invention relates to process for the maintaining of a ratio stereoisomers of carotenoid compounds by using at least one alkali and/or earth alkali metal salt of an organic acid, to specific formulations and to the use of such specific formulations.
摘要翻译：本发明涉及通过使用至少一种有机酸的碱金属和/或碱土金属盐来保持类胡萝卜素化合物的比例立体异构体的方法，以及特定制剂的使用。

5. 发明申请

US20220071237A1 BEVERAGES COMPRISING STABLE GRANULES OF MILLED LUTEIN 有权
公开(公告)号：US20220071237A1
公开(公告)日：2022-03-10
申请号：US17529121
申请日：2021-11-17
申请人： DSM IP Assets B.V.
发明人： Markus BECK , Antonio ESTRELLA , Elger FUNDA , Andrea HITZFELD , Christian SCHAEFER , Bernd SCHLEGEL , Kai URBAN
IPC分类号： A23L2/58 , A23L2/395 , A23L29/212 , A23L5/44 , A23L2/52 , A23P10/30
摘要： Beverages are provided which include a beverage liquid and granules mixed with the beverage liquid The granules include: (i) a milled carotenoid consisting of lutein and/or zeaxanthin, wherein the milled carotenoid has the following particle size distribution: D [3,2] in the range of from 0.6 to 1.5 μm, and D [v, 0.5] in the range of from 1.1 to 3.5 μm, (ii) a matrix material which encapsulates the milled carotenoid and comprises at least one modified food starch, a glucose syrup and sucrose, and (iii) a water-soluble antioxidant, wherein the granules have the following particle size distribution: D [3,2] in the range of from 200 to 300 μm, and D [v, 0.5] in the range of from 220 to 320 μm, and wherein all D values are as measured by laser diffraction according to the Fraunhofer scattering model, and wherein the granules do not include an oil or a gelatin.

6. 发明申请

US20140057999A1 PROTECTIVE, HYDROCOLLOID FOR ACTIVE INGREDIENTS 审中-公开
标题翻译：保护性，主动成分的水解胶
公开(公告)号：US20140057999A1
公开(公告)日：2014-02-27
申请号：US13762640
申请日：2013-02-08
申请人： DSM IP ASSETS B.V.
发明人： Markus BECK , Navagnana S. HETTIARACHCHY , Bruno H. F. LEUENBERGER , Ilankovan PARAMAN , Christian SCHAEFER , Gerhard WAGNER
IPC分类号： C07K14/415 , C12P21/06 , A61K47/42
CPC分类号： C07K14/415 , A23J1/12 , A23J3/14 , A23J3/34 , A23K20/174 , A23K20/179 , A23K40/00 , A23L5/44 , A23L7/115 , A23L7/198 , A23L33/155 , A23P10/40 , A61K47/42 , C12P21/06 , C12Y304/00
摘要： (Modified) rice endosperm protein is used as novel protective hydrocolloid for active ingredients, especially fat-soluble active ingredients and/or colorants. Included are compositions comprising (modified) rice endosperm protein and at least one active ingredient and to their manufacture, as well as to the (modified) rice endosperm protein itself and its manufacture. These compositions are used for the enrichment, fortification and/or coloration of food, beverages, animal feed, personal care or pharmaceutical compositions, and to food, beverages, animal feed, personal care and pharmaceutical compositions containing such a (modified) rice endosperm protein and such a composition, respectively.
摘要翻译：（改良型）水稻胚乳蛋白用作活性成分，特别是脂溶性活性成分和/或着色剂的新型保护性水胶体。包括包含（修饰的）水稻胚乳蛋白质和至少一种活性成分及其制备的组合物以及（修饰的）水稻胚乳蛋白质本身及其制造的组合物。这些组合物用于食品，饮料，动物饲料，个人护理或药物组合物的富集，强化和/或着色，以及含有这种（修饰的）水稻胚乳蛋白质的食品，饮料，动物饲料，个人护理和药物组合物和这样的组合物。

7. 发明申请

US20160038436A1 LUTEIN COMPOSITION SUITABLE FOR INFANT FOOD FORMULATIONS 审中-公开
标题翻译：罗素组合物适用于婴儿食品配方
公开(公告)号：US20160038436A1
公开(公告)日：2016-02-11
申请号：US14780244
申请日：2014-03-27
申请人： DSM IP ASSETS B.V.
发明人： Markus BECK , Andrea HITZFELD , Bernd SCHLEGEL , Christian SCHAEFER
IPC分类号： A61K31/047 , A61K9/00 , A23L1/00 , A61K9/16 , A23L1/29 , A23L1/30
摘要： The present invention is related to a powderous composition which comprises lutein and which is used in infant food formulations or premixes for infant food formulations.
摘要翻译：本发明涉及含有叶黄素的粉末组合物，其用于婴儿食品制剂或婴儿食品配方的预混物。

8. 发明申请

US20140221694A1 CRYSTAL FORMS OF ASTAXANTHIN 审中-公开
标题翻译：阿司匹林的晶体形式
公开(公告)号：US20140221694A1
公开(公告)日：2014-08-07
申请号：US14245930
申请日：2014-04-04
申请人： DSM IP ASSETS B.V.
发明人： Jingfei GUO , Matthew J. JONES , Christian SCHAEFER , Joachim ULRICH , Viviane VERLHAC-TRICHET
IPC分类号： A23K1/16 , A23K1/18
CPC分类号： C07C403/24 , A23K20/179 , A23K50/80 , A23L5/44 , A61K9/0056 , C07B2200/13 , Y02A40/818
摘要： The invention describes previously undisclosed crystal forms of astaxanthin designated crystal form I and II. It has been surprisingly found that the two crystal forms of astaxanthin show an improved bioavailability, a relatively high solubility in specific organic solvents and an increased long-term stability. For example the new forms are stable in solid form for at least 90 days at a temperature of 20° C.-40° C. It was further found that the two crystal forms can be prepared from each other. Therefore the invention also relates to methods for preparing said crystal forms. In addition, the invention relates to administration forms (hereinafter also called “formulations”) comprising one of the two crystal forms according to the invention or mixtures thereof dissolved or suspended in oil or organic-solvent.
摘要翻译：本发明描述了以前未公开的虾青素晶体形式，其指定为I型和II型晶体。已经令人惊讶地发现，两种虾青素的晶体形式具有改善的生物利用度，在特定的有机溶剂中的相对较高的溶解度和增加的长期稳定性。例如，新的形式在20℃-40℃的温度下以固体形式稳定至少90天。进一步发现，两种晶型可以彼此制备。因此，本发明还涉及制备所述晶形的方法。此外，本发明涉及包含根据本发明的两种晶型之一或其溶解或悬浮在油或有机溶剂中的混合物的给药形式（以下也称为“制剂”）。

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