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1. 发明授权

US10059914B2 Disposable bioreactors and methods for construction and use thereof 有权
公开(公告)号：US10059914B2
公开(公告)日：2018-08-28
申请号：US15038194
申请日：2014-11-21
申请人： Distek, Inc.
发明人： Jeff Watkins , Jeffrey Brinker
IPC分类号： C12M1/00 , C12M3/00 , C12M1/34 , C12M1/06 , C12N1/00
CPC分类号： C12M23/28 , C12M23/14 , C12M23/46 , C12M27/02 , C12M29/04 , C12M41/00 , C12M41/12 , C12M41/32 , C12N1/00
摘要： In one embodiment, a disposable bioreactor including a headplate and a stirrer. The headplate has at least one inlet port aperture and one outlet port aperture formed therein and is adapted to couple sealingly with a bag capable of receiving a culture medium. The stirrer is coupled to and extends from the headplate and is adapted to stir the culture medium when the headplate is coupled to the bag. The bioreactor is adapted to fit within the upper opening of the stand of an existing conventional glass bioreactor, so that the bag is suspended within the vessel.

2. 发明申请

US20190049344A1 Sample Probe for Dissolution Testing and the Like 审中-公开
公开(公告)号：US20190049344A1
公开(公告)日：2019-02-14
申请号：US16078120
申请日：2017-02-28
申请人： Distek, Inc.
发明人： Jeffrey Brinker , Shawn Craig , Peter K. Schutz , Timothy John Nadolski
IPC分类号： G01N1/10 , B01L3/00
摘要： In one embodiment, a sample probe has a cap and a base, wherein the cap includes a grip portion and a projection portion. The projection portion fits within a hollow portion of a filter such that the filter is disposed on the outside of the projection portion and the filter and the cap form a cap assemblage. The base comprises a base recess that receives a portion of the cap assemblage including the filter. The cap and base include corresponding media transfer regions adjacent and connected to the filter that reduces flow resistance and chances of blockage and/or contamination during dissolution-testing sampling using the sample probe.

3. 发明授权

US10164716B2 Contactless communication between rotating and stationary components 有权
公开(公告)号：US10164716B2
公开(公告)日：2018-12-25
申请号：US15557084
申请日：2016-03-07
申请人： Distek, Inc.
发明人： Jeffrey Brinker , Wenyu Wang
IPC分类号： H04B10/50 , H04B10/80 , G08C23/04 , H04B10/00 , H04Q9/00 , B23Q17/00 , H04B10/60
摘要： In one embodiment, a dissolution-testing apparatus uses a contactless communication system in place of a conventional slip ring. The communication system has a rotating infra-red (IR) communicator and a stationary IR communicator. The dissolution-testing apparatus includes a stationary base having a processor and a rotating shaft having a sensor array including at least a first sensor. The rotating communicator is part of a rotating communication module including a battery and a housing and adapted to be fixed to the shaft for rotation with the shaft. The stationary communicator is adapted to be fixed to the stationary base. The rotating communicator is adapted to (i) receive data from the first sensor while the rotating communicator rotates and (ii) transmit data corresponding to the sensor data to the stationary communicator in a contactless manner while the rotating communicator rotates with respect to the stationary communicator.

4. 发明申请

US20160290981A1 Apparatus and Methods for Disintegration Testing 审中-公开
标题翻译：仪器和方法的崩解测试
公开(公告)号：US20160290981A1
公开(公告)日：2016-10-06
申请号：US15035854
申请日：2014-11-12
申请人： DISTEK, INC.
发明人： Jeffrey Brinker , Shawn Craig , Wenyu Wang
IPC分类号： G01N33/15 , G01N21/49
CPC分类号： G01N33/15 , G01N13/00 , G01N21/49 , G01N21/8507 , G01N21/9508 , G01N2013/006
摘要： In one embodiment, a disintegration or dissolution testing apparatus (100) including at least one area for a compartment (205) to hold a dosage form during disintegration testing, and at least one light emitter (302) and at least one light detector (303) arranged around each of the areas so as to face the area. The light detector (303) is adapted to provide, when a compartment (205) is disposed within the area a signal indicative of the amount of detected light provided by the light emitter (302). In another embodiment, a bottom flange (202) for disintegration test apparatus (100) is encapsulated in a material that (i) permits the bottom flange (202) to be immersed in a liquid medium during disintegration testing without the liquid contacting any of the light emitters (302) or detectors (303), and (ii) permits light from the emitter (302) to pass through the material and be received by the light detector (303). The apparatus (100) comprises as well a drive assembly for driving the compartment (205) between a lowered position immersing the dosage form in the liquid medium and a raised postion.
摘要翻译：在一个实施方案中，一种崩解或溶解测试装置（100）包括至少一个用于在分解测试期间保持剂型的隔间（205）的区域，以及至少一个光发射器（302）和至少一个光检测器（303））布置在每个区域周围以面对该区域。光检测器（303）适于在隔室（205）设置在区域内时提供指示由光发射器（302）提供的检测光的量的信号。在另一个实施例中，用于分解测试装置（100）的底部凸缘（202）被封装在以下材料中：（i）允许底部凸缘（202）在分解测试期间浸没在液体介质中，而液体接触任何光发射器（302）或检测器（303），和（ii）允许来自发射器（302）的光通过材料并被光检测器（303）接收。装置（100）还包括用于在将剂型浸入液体介质中的降低位置和升高的位置之间驱动隔室（205）的驱动组件。

5. 发明授权

US11454570B2 Sample probe for dissolution testing and the like 有权
公开(公告)号：US11454570B2
公开(公告)日：2022-09-27
申请号：US16078120
申请日：2017-02-28
申请人： Distek, Inc.
发明人： Jeffrey Brinker , Shawn Craig , Peter K. Schultz , Timothy John Nadolski
IPC分类号： G01N1/10 , B01L3/00
摘要： In one embodiment, a sample probe has a cap and a base, wherein the cap includes a grip portion and a projection portion. The projection portion fits within a hollow portion of a filter such that the filter is disposed on the outside of the projection portion and the filter and the cap form a cap assemblage. The base comprises a base recess that receives a portion of the cap assemblage including the filter. The cap and base include corresponding media transfer regions adjacent and connected to the filter that reduces flow resistance and chances of blockage and/or contamination during dissolution-testing sampling using the sample probe.

6. 发明申请

US20180362909A1 Method for Using a Disposable Bioreactor 审中-公开
公开(公告)号：US20180362909A1
公开(公告)日：2018-12-20
申请号：US16111291
申请日：2018-08-24
申请人： Distek, Inc.
发明人： Jeff Watkins , Jeffrey Brinker
IPC分类号： C12M1/00 , C12N1/00 , C12M1/34 , C12M1/06 , C12M3/00
摘要： In one embodiment, a disposable bioreactor including a headplate and a stirrer. The headplate has at least one inlet port aperture and one outlet port aperture formed therein and is adapted to couple sealingly with a bag capable of receiving a culture medium. The stirrer is coupled to and extends from the headplate and is adapted to stir the culture medium when the headplate is coupled to the bag. The bioreactor is adapted to fit within the upper opening of the stand of an existing conventional glass bioreactor, so that the bag is suspended within the vessel.

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