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1. 再颁专利

USRE43122E1 Apparatus and method for trapping bead based reagents within microfluidic analysis systems 有权
标题翻译：在微流体分析系统中捕获珠基试剂的装置和方法
公开(公告)号：USRE43122E1
公开(公告)日：2012-01-24
申请号：US12820390
申请日：2010-06-22
申请人： D. Jed Harrison , Richard Oleschuk , Loranelle L. Lockyear , Cameron Skinner , Paul Li
发明人： D. Jed Harrison , Richard Oleschuk , Loranelle L. Lockyear , Cameron Skinner , Paul Li
IPC分类号： G01N27/26 , G01N33/00
CPC分类号： G01N30/56 , B01L3/0241 , B01L3/5027 , B01L3/502753 , B01L2200/0668 , B01L2300/0816 , B01L2300/087 , B01L2400/0415 , B01L2400/0487 , G01N27/44704 , G01N27/44791 , G01N30/6095 , G01N2030/009 , G01N2030/285 , G01N2030/565
摘要： The present invention provides an on-chip packed reactor bed design that allows for an effective exchange of packing materials such as beads at a miniaturized level. The present invention extends the function of microfluidic analysis systems to new applications including on-chip solid phase extraction (SPE) and on-chip capillary electrochromatography (CEC). The design can be further extended to include integrated packed bed immuno- or enzyme reactors.
摘要翻译：本发明提供一种片上填充反应器床设计，其允许以小型化水平有效地交换诸如珠粒的包装材料。本发明将微流控分析系统的功能扩展到包括片上固相萃取（SPE）和片上毛细管电色谱（CEC）的新应用。该设计可以进一步扩展到包括集成的填充床免疫或酶反应器。

2. 发明申请

US20080237146A1 APPARATUS AND METHOD FOR TRAPPING BEAD BASED REAGENTS WITHIN MICROFLUIDIC ANALYSIS SYSTEMS 审中-公开
标题翻译：在微流感分析系统中捕获基于珠粒的试剂的装置和方法
公开(公告)号：US20080237146A1
公开(公告)日：2008-10-02
申请号：US11955902
申请日：2007-12-13
申请人： D. Jed Harrison , Richard Oleschuk , Loranelle Shultz-Lockyear , Cameron Skinner , Paul Li
发明人： D. Jed Harrison , Richard Oleschuk , Loranelle Shultz-Lockyear , Cameron Skinner , Paul Li
IPC分类号： B01J8/00
CPC分类号： B01L3/502707 , B01L3/502761 , B01L2200/0668 , B01L2300/0816 , B01L2300/0877 , B01L2400/0415 , B01L2400/043 , B01L2400/0487 , G01N1/40 , G01N1/405 , G01N30/56 , G01N30/6095 , G01N2030/285 , G01N2030/565 , Y10T436/25 , Y10T436/25375 , Y10T436/255 , Y10T436/2575
摘要： An on-chip packed reactor bed design is disclosed that allows for an effective exchange of packing materials such as beads at a miniaturized level. Also disclosed is a method of treating a sample within a microfluidic analysis system, comprising: providing a main channel having a trapping zone; providing a slurry of a reagent treated packing material; inducing a flow of said packing material into said trapping zone through a flow channel connected to said trapping zone to load said trapping zone and form a packed bed of said packing material; and flowing a sample containing analytes through said packed bed, said reagent treating the sample. The present invention extends the function of microfluidic analysis systems to new applications including on-chip solid phase extraction (SPE) and on-chip capillary electrochromatography (CEC). The design can be further extended to include integrated packed bed immuno- or enzyme reactors.
摘要翻译：公开了片上堆叠反应器床设计，其允许在小型化水平上有效地交换包装材料，例如珠粒。还公开了一种处理微流体分析系统内的样品的方法，包括：提供具有捕获区的主通道; 提供试剂处理的包装材料的浆料; 通过连接到所述捕集区的流动通道将所述包装材料流入所述捕集区，以加载所述捕集区并形成所述包装材料的填充床; 并将含有分析物的样品流经所述填充床，所述试剂处理样品。本发明将微流控分析系统的功能扩展到包括片上固相萃取（SPE）和片上毛细管电色谱（CEC）的新应用。该设计可以进一步扩展到包括集成的填充床免疫或酶反应器。

3. 发明授权

US07312611B1 Apparatus and method for trapping bead based reagents within microfluidic analysis systems 有权
标题翻译：在微流体分析系统中捕获珠基试剂的装置和方法
公开(公告)号：US07312611B1
公开(公告)日：2007-12-25
申请号：US10148425
申请日：2000-11-27
申请人： D. Jed Harrison , Richard Oleschuk , Loranelle Shultz-Lockyear , Cameron Skinner , Paul Li
发明人： D. Jed Harrison , Richard Oleschuk , Loranelle Shultz-Lockyear , Cameron Skinner , Paul Li
IPC分类号： G01N27/60 , G01N27/12 , G01N27/26
CPC分类号： B01L3/502707 , B01L3/502761 , B01L2200/0668 , B01L2300/0816 , B01L2300/0877 , B01L2400/0415 , B01L2400/043 , B01L2400/0487 , G01N1/40 , G01N1/405 , G01N30/56 , G01N30/6095 , G01N2030/285 , G01N2030/565 , Y10T436/25 , Y10T436/25375 , Y10T436/255 , Y10T436/2575
摘要： The present invention provides an on-chip packed reactor bed design that allows for an effective exchange of packing materials such as beads at a miniaturized level. In accordance with the present invention, there is provided a method of concentrating an analyte within a microfluidic analysis system, comprising the steps of: a) providing a main channel having a trapping zone suitable for trapping packing material; b) providing a slurry of a reagent treated packing material prepared in a solution having a predetermined composition of a solvent; c) inducing a flow of said packing material into said trapping zone through a flow channel connected to said trapping zone so as to load said trapping zone and form a packed bed of said packing material; d) and flowing a sample containing analytes through said packed bed, said reagent acting to concentrate at least some of said analytes within said trapping zone. The present invention extends the function of microfluidic analysis systems to new applications including on-chip solid phase extraction (SPE) and on-chip capillary electrochromatography (CEC). The design can be further extended to include integrated packed bed immuno- or enzyme reactors.
摘要翻译：本发明提供一种片上填充反应器床设计，其允许以小型化水平有效地交换诸如珠粒的包装材料。根据本发明，提供了一种将分析物浓缩在微流体分析系统内的方法，包括以下步骤：a）提供具有适于捕获包装材料的捕集区的主通道; b）提供在具有预定组成的溶剂的溶液中制备的试剂处理的填充材料的浆料; c）通过连接到所述捕集区的流动通道引导所述包装材料流入所述捕集区域，以便装载所述捕集区并形成所述包装材料的填充床; d）并使含有分析物的样品流过所述填充床，所述试剂用于将所述分析物中的至少一些浓缩至所述捕集区内。本发明将微流控分析系统的功能扩展到包括片上固相萃取（SPE）和片上毛细管电色谱（CEC）的新应用。该设计可以进一步扩展到包括集成的填充床免疫或酶反应器。

4. 发明授权

US08034628B2 Apparatus and method for trapping bead based reagents within microfluidic analysis systems 有权
标题翻译：在微流体分析系统中捕获珠基试剂的装置和方法
公开(公告)号：US08034628B2
公开(公告)日：2011-10-11
申请号：US12831949
申请日：2010-07-07
申请人： D. Jed Harrison , Richard Oleschuk , Loranelle Shultz-Lockyear , Cameron Skinner , Paul Li
发明人： D. Jed Harrison , Richard Oleschuk , Loranelle Shultz-Lockyear , Cameron Skinner , Paul Li
IPC分类号： G01N1/18 , G01N31/20
CPC分类号： B01L3/502707 , B01L3/502761 , B01L2200/0668 , B01L2300/0816 , B01L2300/0877 , B01L2400/0415 , B01L2400/043 , B01L2400/0487 , G01N1/40 , G01N1/405 , G01N30/56 , G01N30/6095 , G01N2030/285 , G01N2030/565 , Y10T436/25 , Y10T436/25375 , Y10T436/255 , Y10T436/2575
摘要： An on-chip packed reactor bed design is disclosed that allows for an effective exchange of packing materials such as beads at a miniaturized level. Also disclosed is a method of treating a sample within a microfluidic analysis system, comprising; providing a main channel having a trapping zone; providing a slurry of a reagent treated packing material; inducing a flow of said packing material into said trapping zone through a flow channel connected to said trapping zone to load said trapping zone and form a packed bed of said packing material; and flowing a sample containing analytes through said packed bed, said reagent treating the sample. The present invention extends the function of microfluidic analysis systems to new applications including on-chip solid phase extraction (SPE) and on-chip capillary electrochromatography (CEC). The design can be further extended to include integrated packed bed immuno- or enzyme reactors.
摘要翻译：公开了片上堆叠反应器床设计，其允许在小型化水平上有效地交换包装材料，例如珠粒。还公开了一种处理微流体分析系统内的样品的方法，包括：提供具有捕获区的主通道; 提供试剂处理的包装材料的浆料; 通过连接到所述捕集区的流动通道将所述包装材料流入所述捕集区，以加载所述捕集区并形成所述包装材料的填充床; 并将含有分析物的样品流经所述填充床，所述试剂处理样品。本发明将微流控分析系统的功能扩展到包括片上固相萃取（SPE）和片上毛细管电色谱（CEC）的新应用。该设计可以进一步扩展到包括集成的填充床免疫或酶反应器。

5. 发明授权

US06432290B1 Apparatus and method for trapping bead based reagents within microfluidic analysis systems 有权
标题翻译：在微流体分析系统中捕获珠基试剂的装置和方法
公开(公告)号：US06432290B1
公开(公告)日：2002-08-13
申请号：US09450272
申请日：1999-11-26
申请人： D. Jed Harrison , Richard Oleschuk , Loranelle Shultz-Lockyear , Cameron Skinner , Paul Li
发明人： D. Jed Harrison , Richard Oleschuk , Loranelle Shultz-Lockyear , Cameron Skinner , Paul Li
IPC分类号： G01N2726
CPC分类号： G01N30/56 , B01L3/0241 , B01L3/5027 , B01L3/502753 , B01L2200/0668 , B01L2300/0816 , B01L2300/087 , B01L2400/0415 , B01L2400/0487 , G01N27/44704 , G01N27/44791 , G01N30/6095 , G01N2030/009 , G01N2030/285 , G01N2030/565
摘要： The present invention provides an on-chip packed reactor bed design that allows for an effective exchange of packing materials such as beads at a miniaturized level. The present invention extends the function of microfluidic analysis systems to new applications including on-chip solid phase extraction (SPE) and on-chip capillary electrochromatography (CEC). The design can be further extended to include integrated packed bed immuno- or enzyme reactors.
摘要翻译：本发明提供一种片上填充反应器床设计，其允许以小型化水平有效地交换诸如珠粒的包装材料。本发明将微流控分析系统的功能扩展到包括片上固相萃取（SPE）和片上毛细管电色谱（CEC）的新应用。该设计可以进一步扩展到包括集成的填充床免疫或酶反应器。

6. 发明申请

US20110048945A1 APPARATUS AND METHOD FOR TRAPPING BEAD BASED REAGENTS WITHIN MICROFLUIDIC ANALYSIS SYSTEMS 审中-公开
标题翻译：在微流感分析系统中捕获基于珠粒的试剂的装置和方法
公开(公告)号：US20110048945A1
公开(公告)日：2011-03-03
申请号：US12852370
申请日：2010-08-06
申请人： D. Jed Harrison , Richard Oleschuk , Loranelle Shultz-Lockyear , Cameron Skinner , Paul Li
发明人： D. Jed Harrison , Richard Oleschuk , Loranelle Shultz-Lockyear , Cameron Skinner , Paul Li
IPC分类号： G01N27/447
CPC分类号： B01L3/502707 , B01L3/502761 , B01L2200/0668 , B01L2300/0816 , B01L2300/0877 , B01L2400/0415 , B01L2400/043 , B01L2400/0487 , G01N1/40 , G01N1/405 , G01N30/56 , G01N30/6095 , G01N2030/285 , G01N2030/565 , Y10T436/25 , Y10T436/25375 , Y10T436/255 , Y10T436/2575
摘要： An on-chip packed reactor bed design is disclosed that allows for an effective exchange of packing materials such as beads at a miniaturized level. Also disclosed is a method of treating a sample within a microfluidic analysis system, comprising; providing a main channel having a trapping zone; providing a slurry of a reagent treated packing material; inducing a flow of said packing material into said trapping zone through a flow channel connected to said trapping zone to load said trapping zone and form a packed bed of said packing material; and flowing a sample containing analytes through said packed bed, said reagent treating the sample. The present invention extends the function of microfluidic analysis systems to new applications including on-chip solid phase extraction (SPE) and on-chip capillary electrochromatography (CEC). The design can be further extended to include integrated packed bed immuno- or enzyme reactors.
摘要翻译：公开了片上堆叠反应器床设计，其允许在小型化水平上有效地交换包装材料，例如珠粒。还公开了一种处理微流体分析系统内的样品的方法，包括：提供具有捕获区的主通道; 提供试剂处理的包装材料的浆料; 通过连接到所述捕集区的流动通道将所述包装材料流入所述捕集区，以加载所述捕集区并形成所述包装材料的填充床; 并将含有分析物的样品流经所述填充床，所述试剂处理样品。本发明将微流控分析系统的功能扩展到包括片上固相萃取（SPE）和片上毛细管电色谱（CEC）的新应用。该设计可以进一步扩展到包括集成的填充床免疫或酶反应器。

7. 发明申请

US20100326826A1 APPARATUS AND METHOD FOR TRAPPING BEAD BASED REAGENTS WITHIN MICROFLUIDIC ANALYSIS SYSTEMS 有权
标题翻译：在微流感分析系统中捕获基于珠粒的试剂的装置和方法
公开(公告)号：US20100326826A1
公开(公告)日：2010-12-30
申请号：US12831949
申请日：2010-07-07
申请人： D. Jed Harrison , Richard Oleschuk , Loranelle Shultz-Lockyear , Cameron Skinner , Paul Li
发明人： D. Jed Harrison , Richard Oleschuk , Loranelle Shultz-Lockyear , Cameron Skinner , Paul Li
IPC分类号： G01N27/26 , B01L3/00
CPC分类号： B01L3/502707 , B01L3/502761 , B01L2200/0668 , B01L2300/0816 , B01L2300/0877 , B01L2400/0415 , B01L2400/043 , B01L2400/0487 , G01N1/40 , G01N1/405 , G01N30/56 , G01N30/6095 , G01N2030/285 , G01N2030/565 , Y10T436/25 , Y10T436/25375 , Y10T436/255 , Y10T436/2575
摘要： An on-chip packed reactor bed design is disclosed that allows for an effective exchange of packing materials such as beads at a miniaturized level. Also disclosed is a method of treating a sample within a microfluidic analysis system, comprising; providing a main channel having a trapping zone; providing a slurry of a reagent treated packing material; inducing a flow of said packing material into said trapping zone through a flow channel connected to said trapping zone to load said trapping zone and form a packed bed of said packing material; and flowing a sample containing analytes through said packed bed, said reagent treating the sample. The present invention extends the function of microfluidic analysis systems to new applications including on-chip solid phase extraction (SPE) and on-chip capillary electrochromatography (CEC). The design can be further extended to include integrated packed bed immuno- or enzyme reactors.
摘要翻译：公开了片上堆叠反应器床设计，其允许在小型化水平上有效地交换包装材料，例如珠粒。还公开了一种处理微流体分析系统内的样品的方法，包括：提供具有捕获区的主通道; 提供试剂处理的包装材料的浆料; 通过连接到所述捕集区的流动通道将所述包装材料流入所述捕集区，以加载所述捕集区并形成所述包装材料的填充床; 并将含有分析物的样品流经所述填充床，所述试剂处理样品。本发明将微流控分析系统的功能扩展到包括片上固相萃取（SPE）和片上毛细管电色谱（CEC）的新应用。该设计可以进一步扩展到包括集成的填充床免疫或酶反应器。

8. 发明授权

US06605472B1 Microfluidic devices connected to glass capillaries with minimal dead volume 失效
标题翻译：微流体装置连接到具有最小死体积的玻璃毛细管
公开(公告)号：US06605472B1
公开(公告)日：2003-08-12
申请号：US09169146
申请日：1998-10-09
申请人： Cameron Skinner , Thompson Tang , D. Jed Harrison , Nicolas Bings , Can Wang , Gregor Ocvirk , Jianjun Li , Pierre Thibault
发明人： Cameron Skinner , Thompson Tang , D. Jed Harrison , Nicolas Bings , Can Wang , Gregor Ocvirk , Jianjun Li , Pierre Thibault
IPC分类号： G01N3300
CPC分类号： B01L3/502707 , B01L3/502715 , B01L2200/027 , B01L2200/12 , B01L2300/0816 , B01L2300/0838 , B01L2400/0421 , G01N27/44791 , G01N30/6034 , G01N30/6095 , G01N30/7266 , Y10T436/14 , Y10T436/142222 , Y10T436/143333 , Y10T436/24 , Y10T436/25 , Y10T436/25375 , Y10T436/255 , Y10T436/2575
摘要： A method is provided for joining a microchip device to a capillary tube. The microchip device has a capillary channel opening onto an edge surface of the device. A short hole is drilled into the edge surface, aligned with the capillary channel. The drilling is done with a flat bottom, preferably by a two-step drilling process. Then, the end of the capillary can be inserted into the hole so that its end is substantially flush with the flat bottom of the hole, thereby eliminating dead volume. Testing has shown that this connection provides very little band broadening of samples transported through the capillary channel into the capillary tube. The tip of the capillary tube can be tapered, so that it is suitable for use as an electrospray source for a mass spectrometer.
摘要翻译：提供了一种将微芯片器件连接到毛细管上的方法。微芯片装置具有在装置的边缘表面上开口的毛细通道。在边缘表面钻出一个短孔，与毛细管通道对齐。钻孔采用平坦的底部，优选通过两步钻孔工艺进行。然后，毛细管的端部可以插入孔中，使得其端部与孔的平坦底部基本齐平，从而消除死体积。测试表明，这种连接提供了通过毛细管通道进入毛细管的样品的极小带宽扩大。毛细管的尖端可以是锥形的，使得其适合用作质谱仪的电喷雾源。

9. 发明授权

US06706164B2 Method for controlling sample introduction in microcolumn separation techniques and sampling device 失效
标题翻译：微柱分离技术和取样装置中样品引入的控制方法
公开(公告)号：US06706164B2
公开(公告)日：2004-03-16
申请号：US09737120
申请日：2000-12-13
申请人： Andreas Manz , D. Jed Harrison , Carlo S. Effenhauser
发明人： Andreas Manz , D. Jed Harrison , Carlo S. Effenhauser
IPC分类号： G01N27447
CPC分类号： C07K1/26 , G01N27/44743 , G01N27/44791
摘要： In a method for controlling sample introduction in microcolumn separation techniques, more particularly in capillary electrophoresis (CE), where a sample is injected as a sample plug into a sampling device which comprises at least a channel for the electrolyte buffer and a supply and drain channel for the sample. The supply and drain channels discharge into the electrolyte channel at respective supply and drain ports. The distance between the supply port and the drain port geometrically defines a sample volume. The injection of the sample plug into the electrolyte channel is accomplished electrokinetically by applying an electric field across the supply and drain channels for a time at least long enough that the sample component having the lowest electrophoretic mobility is contained within the geometrically defined volume. The supply and drain channels each are inclined to the electrolyte channel. Means are provided for electrokinetically injecting the sample into the sample volume. The resistance to flow of the supply and drain channels with respect to the electrolyte buffer is at least about 5% lower than the respective resistance to flow of the electrolyte channel.
摘要翻译：在用于控制微柱分离技术中的样品引入的方法中，更具体地在毛细管电泳（CE）中，其中将样品作为样品塞注入采样装置中，所述采样装置至少包括用于电解质缓冲液的通道和供排水通道为样品。供应和排出通道在相应的供排水口排放到电解液通道中。供应端口和排水口之间的距离几何定义了样品体积。通过在供电和漏极通道上施加电场至少足够长的时间使得具有最低电泳迁移率的样品组分包含在几何限定的体积内，电动地将样品塞注入电解质通道。供应和排出通道各自倾斜于电解质通道。提供了用于将样品电动注入样品体积的装置。供电和排出通道相对于电解质缓冲液的流动阻力比电解液通道的相应阻力低至少约5％。

10. 发明授权

US06586253B1 Microchip based enzymatic analysis 失效
标题翻译：基于Microchip的酶分析
公开(公告)号：US06586253B1
公开(公告)日：2003-07-01
申请号：US09058702
申请日：1998-04-10
申请人： D. Jed Harrison , Per E. Andersson , Edgar Arriaga , Gregor Ocvirk
发明人： D. Jed Harrison , Per E. Andersson , Edgar Arriaga , Gregor Ocvirk
IPC分类号： G01N33543
CPC分类号： C12Q1/48 , B01L3/5027 , C12Q1/34 , C12Q1/66 , G01N1/31 , G01N35/08 , G01N2500/10 , G01N2500/20
摘要： A method for the detection of cell contents, the method comprising the steps of, introducing a cell into a channel in a microchip; lysing the cell to release cell contents into the channel; moving the cell contents towards a detection zone; and detecting the cell contents at the detection zone. An apparatus for the detection of cell contents, the apparatus comprising: a microchip; a cell mobilization channel formed in the microchip, the cell mobilization channel having a cell introduction end and a detection end; a cell mobilizer operably connected with the cell introduction end for moving cells from the cell introduction end to the detection end; means for lysing cells in the cell mobilization channel at a lysing zone, the lysing zone being located between the cell introduction end and the detection end; and a detector, disposed adjacent the detector end, arranged to detect cell contents appearing at the detector end that have been moved from the lysing zone to the detector end by the cell mobilizer.
摘要翻译：一种用于检测小区内容的方法，所述方法包括以下步骤：将小区引入到微芯片中的信道中; 裂解细胞以将细胞内容物释放到通道中; 将细胞内容物移动到检测区域; 并检测检测区的细胞内容。一种用于检测细胞内容物的装置，所述装置包括：微芯片; 形成在所述微芯片上的细胞移动通道，所述细胞移动通道具有细胞介导端和检测端; 与细胞引入端可操作地连接的用于将细胞从细胞引入端移动到检测端的细胞移动器; 用于在裂解区裂解细胞移动通道中的细胞的装置，裂解区位于细胞介导端和检测端之间; 以及设置在所述检测器端附近的检测器，被布置成检测由所述细胞迁移器已经从所述裂解区移动到所述检测器端的出现在所述检测器端的细胞内容物。

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