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1. 发明授权

US06547731B1 Method for assessing blood flow and apparatus thereof 有权
标题翻译：评估血流的方法及其装置
公开(公告)号：US06547731B1
公开(公告)日：2003-04-15
申请号：US09305593
申请日：1999-05-05
申请人： D. Jackson Coleman , Katherine W. Ferrara , Dustin E. Kruse , Ronald H. Silverman
发明人： D. Jackson Coleman , Katherine W. Ferrara , Dustin E. Kruse , Ronald H. Silverman
IPC分类号： A61B802
CPC分类号： G01S15/8981 , A61B8/06 , A61B8/10 , A61B8/13 , G01S15/8945 , G01S15/8956
摘要： A method for assessing blood flow in a tissue involving directing a beam through the tissue along overlapping lines of sight and then generating the blood flow data from where the ultrasonic beams overlap to evaluate blood flow in the tissue. More specifically, spatially overlapping beams are generated at a fixed temporal intervals. Spatial overlap allows the spatial distance between overlapping lines-of-sight to be ignored, while moving reflectors within any overlapping line-of-sight will cause detectable changes in range of the moving reflector from one line-of-sight to the next. The rate of motion is determined from the measured change in range and the known time interval between vectors. Processing of data includes alignment of data between lines-of-sight to suppress artifactual motion and a wall filter for isolation of flow-data from stationary structures. An apparatus for assessing blood flow includes a transmission system and a storage system. The transmission system generates a beam which is sequentially transmitted towards the tissue along a plurality of overlapping lines of sight and receives echo data from the transmission along each of the lines of sight. The storage system stores the echo data.
摘要翻译：一种用于评估组织中的血液流动的方法，包括将束穿过组织沿着重叠的视线引导，然后产生来自超声波束重叠的血流数据，以评估组织中的血流。更具体地，以固定的时间间隔产生空间重叠的光束。空间重叠允许重叠视线之间的空间距离被忽略，而在任何重叠的视线范围内移动反射器将导致移动反射器的范围从一个视线到下一个的可见变化。运动速率由测量的范围变化和向量之间的已知时间间隔确定。数据处理包括视线间的数据对齐以抑制人为运动，以及用于隔离静态结构的流量数据的壁式过滤器。用于评估血液流量的装置包括传输系统和存储系统。传输系统产生沿着多个重叠视线依次传送到组织的光束，并且沿着每条视线从传输接收回波数据。存储系统存储回波数据。

2. 发明授权

US4858124A Method for enhancement of ultrasonic image data 失效
标题翻译：超声图像数据增强方法
公开(公告)号：US4858124A
公开(公告)日：1989-08-15
申请号：US85289
申请日：1987-08-11
申请人： Frederic L. Lizzi , Mykola M. Yaremko , Ronald H. Silverman , D. Jackson Coleman
发明人： Frederic L. Lizzi , Mykola M. Yaremko , Ronald H. Silverman , D. Jackson Coleman
IPC分类号： G01N29/34 , G06T5/00
CPC分类号： G01N29/0645 , A61B8/10 , A61B8/5207 , G01N29/348 , G01S7/52036 , G01S7/52073 , G01S7/52074
摘要： Methods for enhancement of data obtained from scanning objects such as body tissue with ultrasonic wideband pulses to detect characteristics of the tissue and to identify the tissue. The methods include performing spectral analysis on selected time portions of signals obtained from ultrasonic scanning to derive spectral data which is representative of the received signal characteristics for spatial samples of a particular region of interest in the body. The characteristic values are selected to correlate with significant characteristics of the material. A display of the selected body region is generated, with the display characteristic for each of the spatial samples being selected in accordance with the derived spectral characteristic values. Examples of the spectral characteristic values include spectral amplitude, spectral slope, and spectral amplitude uncertainty. The spectral characteristic data can be used to derive periodicity data, such as cepstral data or spatial-correlation data, for each of the spatial samples. The spectral characteristic data obtained can be compared to data for tissue having known tissue characteristics to identify the tissue type. Related means for suppressing the display of noise, characterizing tissues using discriminent functions based on spectral data, and estimating scatter sizes are also shown.
摘要翻译：用于增强从具有超声宽带脉冲的身体组织扫描对象获得的数据的方法，以检测组织的特征并识别组织。这些方法包括对从超声波扫描获得的信号的选定时间部分执行光谱分析以导出代表身体中感兴趣的特定感兴趣区域的空间样本的接收信号特征的光谱数据。选择特征值以与材料的显着特性相关联。生成所选择的身体区域的显示，根据导出的光谱特征值选择每个空间样本的显示特性。光谱特征值的示例包括光谱幅度，光谱斜率和光谱幅度不确定度。频谱特征数据可以用于导出每个空间样本的周期性数据，例如倒谱数据或空间相关数据。可以将获得的光谱特征数据与具有已知组织特征的组织的数据进行比较，以识别组织类型。还示出了用于抑制噪声显示，基于光谱数据使用区分函数表征组织以及估计散射大小的相关装置。

3. 发明授权

US06315727B1 Method and apparatus for ultrasound corneal scanning 有权
标题翻译：超声角膜扫描的方法和装置
公开(公告)号：US06315727B1
公开(公告)日：2001-11-13
申请号：US09408256
申请日：1999-09-29
申请人： D. Jackson Coleman , Dan Z. Reinstein , Ronald H. Silverman
发明人： D. Jackson Coleman , Dan Z. Reinstein , Ronald H. Silverman
IPC分类号： A61B802
CPC分类号： A61B8/10
摘要： An improved method and apparatus for conducting biometric high frequency ultrasound scanning of the human eye permits the subject to assume a seated position and to place the eye to be scanned in contact with the fluid medium contained in an eye cup. In a prefered embodiment, the eye cup is disposable after each use.
摘要翻译：用于进行人眼的生物测定高频超声波扫描的改进的方法和装置允许受试者呈现就座位置并且将要扫描的眼睛与包含在眼杯中的流体介质接触。在优选的实施例中，眼杯每次使用后是一次性的。

4. 发明申请

US20080004527A1 High-resolution ultrasound spectral and wavelet analysis of vascular tissue 审中-公开
标题翻译：血管组织的高分辨率超声波和小波分析
公开(公告)号：US20080004527A1
公开(公告)日：2008-01-03
申请号：US11784270
申请日：2007-04-05
申请人： D. Jackson Coleman , Ronald H. Silverman , Mark Rondeau
发明人： D. Jackson Coleman , Ronald H. Silverman , Mark Rondeau
IPC分类号： G01N29/34
CPC分类号： G01N29/46 , G01N29/043 , G01N29/4418 , G01N2291/02475 , G01N2291/02836
摘要： Images that map statistics of ultrasound backscatter obtained from wavelet decomposition of ultrasound parameter images are used to highlight spatial variation in scattering related to changes in the choroid's vascular conformation. Wavelet analysis ultrasound parameter images are used to identify changes in the scattering structure. The technique can also be applied to other vascular beds and other tissue, as well as non-biological material that can be interrogated with high frequency ultrasound.
摘要翻译：利用超声参数图像小波分解获得的超声后向散射图的图像，用于突出脉络膜血管构象变化的散射空间变异。小波分析超声参数图像用于识别散射结构的变化。该技术也可以应用于其他血管床和其他组织，以及可以用高频超声波询问的非生物材料。

5. 发明申请

US20140268036A1 METHODS FOR DIAGNOSING VITREO-RETINAL DISEASE 有权
标题翻译：诊断病毒性疾病的方法
公开(公告)号：US20140268036A1
公开(公告)日：2014-09-18
申请号：US14209864
申请日：2014-03-13
申请人： Jeffrey A. Ketterling , Jonathan Mamou , Ronald H. Silverman , Jerry Sebag
发明人： Jeffrey A. Ketterling , Jonathan Mamou , Ronald H. Silverman , Jerry Sebag
IPC分类号： A61B8/10
CPC分类号： A61B8/10 , A61B8/5223
摘要： A quantitative method to analyze phase-resolved, raw backscatter echo data or the envelope of phase-resolved, raw backscatter echo data to characterize vitreous inhomogeneities as they relate to normal aging and vitreo-retinal disease. The technique can be applied to 2D or 3D data acquired from the vitreous. The approach provides an objective end value to characterize the vitreous and provide a tool for early diagnosis, monitoring and planning treatment of vitreo-retinal diseases.
摘要翻译：分析相分离，原始反向散射回波数据或相位解析的原始反向散射回波数据的包络的定量方法，以表征与正常老化和玻璃体视网膜疾病相关的玻璃体不均匀性。该技术可以应用于从玻璃体获取的2D或3D数据。该方法提供了客观的最终价值来表征玻璃体，并提供了早期诊断，监测和规划治疗玻璃体视网膜疾病的工具。

6. 发明授权

US5331962A Ultrasound system for corneal biometry 失效
标题翻译：超声系统用于角膜生物测定
公开(公告)号：US5331962A
公开(公告)日：1994-07-26
申请号：US48786
申请日：1993-04-16
申请人： Donald J. Coleman , Ronald H. Silverman
发明人： Donald J. Coleman , Ronald H. Silverman
IPC分类号： A61B3/10 , A61B8/10
CPC分类号： A61B8/4461 , A61B3/1005 , A61B8/10
摘要： An ultrasonic biometer images an eye structure and enables measurement of a cornea's thickness at various points about the cornea's surface curvature. The biometer employs a liquid bath in contact with the corneal surface and includes a curved track positioned above the liquid bath, the curved track having a path that closely approximates the surface curvature of the corneal surface. An ultrasonic transducer (having a central axis) is movably mounted by a connector structure along the track and is positioned in communication with the liquid bath. The connector structure operates to maintain the central axis of the ultrasonic transducer perpendicular to a tangent drawn to the curved track, at a plurality of locations along the track. When the connector structure is moved along the curved track, it enables an ultrasonic beam, generated by the transducer, to interrogate areas of the corneal surface, with the angle of incidence of the beam being substantially orthogonal to the surface.
摘要翻译：超声波生物计图像眼结构，能够在角膜表面曲率的各个点处测量角膜的厚度。生物计量器采用与角膜表面接触的液体浴，并且包括位于液浴上方的弯曲轨道，弯曲轨道具有紧密接近角膜表面的曲率的路径。超声波换能器（具有中心轴）通过连接器结构沿轨道可移动地安装并定位成与液槽连通。连接器结构用于在超声波振子的沿着轨道的多个位置处保持超声波换能器的中心轴线垂直于弯曲轨道上的切线。当连接器结构沿着弯曲的轨道移动时，其能够使由换能器产生的超声波束询问角膜表面的区域，其中束的入射角基本上与表面正交。

7. 发明授权

US09295448B2 Methods for diagnosing vitreo-retinal disease 有权
标题翻译：诊断玻璃体视网膜疾病的方法
公开(公告)号：US09295448B2
公开(公告)日：2016-03-29
申请号：US14209864
申请日：2014-03-13
申请人： Jeffrey A. Ketterling , Jonathan Mamou , Ronald H. Silverman , Jerry Sebag
发明人： Jeffrey A. Ketterling , Jonathan Mamou , Ronald H. Silverman , Jerry Sebag
IPC分类号： A61B3/10 , A61B3/00 , A61B8/10 , A61B8/08
CPC分类号： A61B8/10 , A61B8/5223
摘要： A quantitative method to analyze phase-resolved, raw backscatter echo data or the envelope of phase-resolved, raw backscatter echo data to characterize vitreous inhomogeneities as they relate to normal aging and vitreo-retinal disease. The technique can be applied to 2D or 3D data acquired from the vitreous. The approach provides an objective end value to characterize the vitreous and provide a tool for early diagnosis, monitoring and planning treatment of vitreo-retinal diseases.
摘要翻译：分析相分离，原始反向散射回波数据或相位解析的原始反向散射回波数据的包络的定量方法，以表征与正常老化和玻璃体视网膜疾病相关的玻璃体不均匀性。该技术可以应用于从玻璃体获取的2D或3D数据。该方法提供了客观的最终价值来表征玻璃体，并提供了早期诊断，监测和规划治疗玻璃体视网膜疾病的工具。

8. 发明申请

US20080228073A1 SYSTEM AND METHOD FOR OPTOACOUSTIC IMAGING OF PERIPHERAL TISSUES 审中-公开
标题翻译：用于外周组织光学成像的系统和方法
公开(公告)号：US20080228073A1
公开(公告)日：2008-09-18
申请号：US12046975
申请日：2008-03-12
申请人： Ronald H. Silverman , Jeffrey A. Ketterling
发明人： Ronald H. Silverman , Jeffrey A. Ketterling
IPC分类号： A61B8/00 , A61B6/00
CPC分类号： A61B5/0073 , A61B5/0066 , A61B5/0097 , A61B8/4281
摘要： The system and method for optoacoustic imaging of peripheral tissues provides an assembly for emitting radiation on a tissue and an OCT system coupled to said assembly. The OCT system images tissue concurrent with the emission of radiation on the tissue.
摘要翻译：用于外周组织的光声成像的系统和方法提供了用于在组织和耦合到所述组件的OCT系统上发射辐射的组件。 OCT系统与组织上辐射的辐射同时成像组织。

9. 发明授权

US5776068A Ultrasonic scanning of the eye using a stationary transducer 失效
标题翻译：使用固定式传感器对眼睛进行超声波扫描
公开(公告)号：US5776068A
公开(公告)日：1998-07-07
申请号：US879292
申请日：1997-06-19
申请人： Ronald H. Silverman , Donald Jackson Coleman , Dan Z. Reinstein , George Simoni , David Najafi
发明人： Ronald H. Silverman , Donald Jackson Coleman , Dan Z. Reinstein , George Simoni , David Najafi
IPC分类号： A61B8/10 , A61B8/00
CPC分类号： A61B8/10
摘要： Apparatus is provided for high frequency ultrasound examination of the anterior segment of a patient's eyes. A liquid bath is established about a first eye of the patient to be examined. A fixed ultrasound transducer is placed in contact with the liquid bath and directs the beam of ultrasound energy to the first eye and receives echoes of the ultrasound energy. A fixation source is juxtaposed to the second eye of the patient and displays a fixation target. A controller operates the fixation source to move the fixation target relative to the second eye, while the patient moves the second eye so as to remain focused on the fixation target. The movement of the second eye causes the first eye to move concurrently and enables relative movement between the beam of ultrasound energy and anterior segments of the first eye, while maintaining near orthogonality between the ultrasound beam and the surface of the eye. By tracking the position of the second eye, the position of the first eye, and hence of each pulse/echo sequence, is ascertained, enabling image construction and biometric determinations of the anterior segment anatomy to be performed.
摘要翻译：提供用于患者眼睛前段高频超声检查的装置。建立关于要检查的患者的第一只眼睛的液体浴。将固定的超声换能器放置成与液浴接触，并将超声能量束引导到第一只眼睛并接收超声能量的回波。固定源与患者的第二只眼并列并显示固定目标。控制器操作固定源以相对于第二只眼睛移动固定目标，同时患者移动第二只眼睛以保持聚焦在固定目标上。第二只眼睛的运动使得第一只眼睛同时移动，并且能够使超声能量束和第一只眼睛的前段之间的相对移动同时保持超声波束和眼睛表面之间的近似正交性。通过跟踪第二只眼睛的位置，确定第一只眼睛的位置，从而确定每个脉搏/回波序列的位置，从而能够进行前段解剖结构的图像构造和生物测定。

10. 发明授权

US5369454A System and method for producing and maintaining parallel and vertical fixation of visual axis 失效
标题翻译：用于生产和维护视轴平行和垂直固定的系统和方法
公开(公告)号：US5369454A
公开(公告)日：1994-11-29
申请号：US146214
申请日：1993-11-01
申请人： Dan Z. Reinstein , Ronald H. Silverman , Donald J. Coleman
发明人： Dan Z. Reinstein , Ronald H. Silverman , Donald J. Coleman
IPC分类号： A61B3/15 , A61B8/10 , A61B3/02
CPC分类号： A61B8/10 , A61B3/152
摘要： An apparatus for assuring vertical alignment of visual axes of a patient's eyes includes an eye cup that enables establishment of a liquid bath in which a surface of a cornea of a supine patient's first eye is completely submerged. A first light source is positioned above the liquid bath and directs a beam of alignment light to the submerged eye. A second light source is positioned above the patient's second eye and directs a beam of adjustment light to its corneal surface. Apparatus is provided that enables relative movement between the first and second light sources so as to enable the light sources to be moved into a position where the patient indicates a fusion of the light sources into a single spot, at which point it is known that the visual axis are vertical and aligned. The liquid bath assures that the beam of alignment light from the first light source is only in focus at the patient's eye when the first light source is directly coincident with the vertical axis of the first eye. Any deviation from that vertical axis results in blurring of the image due to refractive effects within the liquid bath.
摘要翻译：用于确保患者眼睛的视线的垂直对准的装置包括能够建立其中仰卧患者的第一只眼睛的角膜的表面被完全浸没的液体浴的眼杯。第一光源位于液槽上方，并将一束对准光引导到淹没的眼睛。第二个光源位于患者的第二只眼睛上方，并将一束调节光引导到其角膜表面。提供了能够实现第一和第二光源之间的相对移动的设备，以便使光源能够移动到患者将光源融合成单个位置的位置，此时已知视轴垂直并对齐。当第一光源与第一眼睛的垂直轴线直接一致时，液体浴确保来自第一光源的对准光束仅在患者眼睛处聚焦。与该垂直轴的任何偏离导致由于液槽内的折射效应造成的图像模糊。

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