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1. 发明授权

US5776068A Ultrasonic scanning of the eye using a stationary transducer 失效
标题翻译：使用固定式传感器对眼睛进行超声波扫描
公开(公告)号：US5776068A
公开(公告)日：1998-07-07
申请号：US879292
申请日：1997-06-19
申请人： Ronald H. Silverman , Donald Jackson Coleman , Dan Z. Reinstein , George Simoni , David Najafi
发明人： Ronald H. Silverman , Donald Jackson Coleman , Dan Z. Reinstein , George Simoni , David Najafi
IPC分类号： A61B8/10 , A61B8/00
CPC分类号： A61B8/10
摘要： Apparatus is provided for high frequency ultrasound examination of the anterior segment of a patient's eyes. A liquid bath is established about a first eye of the patient to be examined. A fixed ultrasound transducer is placed in contact with the liquid bath and directs the beam of ultrasound energy to the first eye and receives echoes of the ultrasound energy. A fixation source is juxtaposed to the second eye of the patient and displays a fixation target. A controller operates the fixation source to move the fixation target relative to the second eye, while the patient moves the second eye so as to remain focused on the fixation target. The movement of the second eye causes the first eye to move concurrently and enables relative movement between the beam of ultrasound energy and anterior segments of the first eye, while maintaining near orthogonality between the ultrasound beam and the surface of the eye. By tracking the position of the second eye, the position of the first eye, and hence of each pulse/echo sequence, is ascertained, enabling image construction and biometric determinations of the anterior segment anatomy to be performed.
摘要翻译：提供用于患者眼睛前段高频超声检查的装置。建立关于要检查的患者的第一只眼睛的液体浴。将固定的超声换能器放置成与液浴接触，并将超声能量束引导到第一只眼睛并接收超声能量的回波。固定源与患者的第二只眼并列并显示固定目标。控制器操作固定源以相对于第二只眼睛移动固定目标，同时患者移动第二只眼睛以保持聚焦在固定目标上。第二只眼睛的运动使得第一只眼睛同时移动，并且能够使超声能量束和第一只眼睛的前段之间的相对移动同时保持超声波束和眼睛表面之间的近似正交性。通过跟踪第二只眼睛的位置，确定第一只眼睛的位置，从而确定每个脉搏/回波序列的位置，从而能够进行前段解剖结构的图像构造和生物测定。

2. 发明授权

US06315727B1 Method and apparatus for ultrasound corneal scanning 有权
标题翻译：超声角膜扫描的方法和装置
公开(公告)号：US06315727B1
公开(公告)日：2001-11-13
申请号：US09408256
申请日：1999-09-29
申请人： D. Jackson Coleman , Dan Z. Reinstein , Ronald H. Silverman
发明人： D. Jackson Coleman , Dan Z. Reinstein , Ronald H. Silverman
IPC分类号： A61B802
CPC分类号： A61B8/10
摘要： An improved method and apparatus for conducting biometric high frequency ultrasound scanning of the human eye permits the subject to assume a seated position and to place the eye to be scanned in contact with the fluid medium contained in an eye cup. In a prefered embodiment, the eye cup is disposable after each use.
摘要翻译：用于进行人眼的生物测定高频超声波扫描的改进的方法和装置允许受试者呈现就座位置并且将要扫描的眼睛与包含在眼杯中的流体介质接触。在优选的实施例中，眼杯每次使用后是一次性的。

3. 发明授权

US5369454A System and method for producing and maintaining parallel and vertical fixation of visual axis 失效
标题翻译：用于生产和维护视轴平行和垂直固定的系统和方法
公开(公告)号：US5369454A
公开(公告)日：1994-11-29
申请号：US146214
申请日：1993-11-01
申请人： Dan Z. Reinstein , Ronald H. Silverman , Donald J. Coleman
发明人： Dan Z. Reinstein , Ronald H. Silverman , Donald J. Coleman
IPC分类号： A61B3/15 , A61B8/10 , A61B3/02
CPC分类号： A61B8/10 , A61B3/152
摘要： An apparatus for assuring vertical alignment of visual axes of a patient's eyes includes an eye cup that enables establishment of a liquid bath in which a surface of a cornea of a supine patient's first eye is completely submerged. A first light source is positioned above the liquid bath and directs a beam of alignment light to the submerged eye. A second light source is positioned above the patient's second eye and directs a beam of adjustment light to its corneal surface. Apparatus is provided that enables relative movement between the first and second light sources so as to enable the light sources to be moved into a position where the patient indicates a fusion of the light sources into a single spot, at which point it is known that the visual axis are vertical and aligned. The liquid bath assures that the beam of alignment light from the first light source is only in focus at the patient's eye when the first light source is directly coincident with the vertical axis of the first eye. Any deviation from that vertical axis results in blurring of the image due to refractive effects within the liquid bath.
摘要翻译：用于确保患者眼睛的视线的垂直对准的装置包括能够建立其中仰卧患者的第一只眼睛的角膜的表面被完全浸没的液体浴的眼杯。第一光源位于液槽上方，并将一束对准光引导到淹没的眼睛。第二个光源位于患者的第二只眼睛上方，并将一束调节光引导到其角膜表面。提供了能够实现第一和第二光源之间的相对移动的设备，以便使光源能够移动到患者将光源融合成单个位置的位置，此时已知视轴垂直并对齐。当第一光源与第一眼睛的垂直轴线直接一致时，液体浴确保来自第一光源的对准光束仅在患者眼睛处聚焦。与该垂直轴的任何偏离导致由于液槽内的折射效应造成的图像模糊。

4. 发明授权

US5293871A System for ultrasonically determining corneal layer thicknesses and shape 失效
标题翻译：用于超声波测定角膜层厚度和形状的系统
公开(公告)号：US5293871A
公开(公告)日：1994-03-15
申请号：US89781
申请日：1993-07-09
申请人： Dan Z. Reinstein , Ronald H. Silverman , Donald J. Coleman , Frederic L. Lizzi
发明人： Dan Z. Reinstein , Ronald H. Silverman , Donald J. Coleman , Frederic L. Lizzi
IPC分类号： A61B8/10 , A61B18/12 , G01S7/52 , G01S15/89
CPC分类号： A61B18/1206 , A61B8/10 , G01S15/8938 , G01S7/52028 , A61B2018/00875
摘要： An ultrasound system that enables determination of layer thicknesses and contours of a multi-layer organic body includes a transmitter/receiver for obtaining a radio frequency signal from echoes over a plurality of points on the organic surface. Each radio frequency signal is then deconvolved to remove apparatus generated noise and filtered to create an analytic signal that exhibits a magnitude related to an instantaneous rate of arrival of total echo energy received by the transmitter/receiver. Analytic signals from adjacent parallel scans are then cross-correlated and magnitude detected to determine energy peaks to enable accurate determination of echo producing surfaces of each layer of the multi-layer organic body across the plurality of interrogation points. In the application of the invention to Corneal Epithelium Mapping, a pupil monitoring system is included that disables the measurement system if the pupil's gaze wanders so as to cause a diversion of the optical axis.
摘要翻译：能够确定多层有机物体的层厚度和轮廓的超声系统包括用于从有机表面上的多个点上的回波获得射频信号的发射器/接收器。然后对每个射频信号进行去卷积以去除设备产生的噪声并进行滤波以产生表现出与由发射机/接收机接收的总回波能量的瞬时到达速率相关的幅度的分析信号。然后对来自相邻并行扫描的分析信号进行交叉相关并且检测幅度以确定能量峰值，以便能够准确地确定多层有机物体在多个询问点上的各层的回波产生表面。在本发明应用于角膜上皮测绘中，包括一个瞳孔监测系统，如果瞳孔的视线漫游，导致测量系统导致光轴的转移，则该测量系统将被禁用。

5. 发明授权

US09107731B2 Method for increasing ocular depth of field 有权
标题翻译：增加眼球深度的方法
公开(公告)号：US09107731B2
公开(公告)日：2015-08-18
申请号：US13225590
申请日：2011-09-06
申请人： Dan Z. Reinstein , Hartmut Vogelsang , Michael Bergt
发明人： Dan Z. Reinstein , Hartmut Vogelsang , Michael Bergt
IPC分类号： A61F9/008
CPC分类号： A61F9/00804 , A61F9/00806 , A61F2009/00857 , A61F2009/00859 , A61F2009/00872 , A61F2009/0088 , A61F2009/00897
摘要： A method for performing a corneal ablation procedure on an eye of a patient including determining a refractive correction for the eye and determining a first parameter corresponding to the refractive correction or a condition of the patient. An ablation profile is selected that includes a refractive correction component and a pre-compensating component that is selected based on the first parameter. The ablation profile is configured to promote a controlled induction of a higher order aberration, where the pre-compensating component limits the induction of the higher order aberration to be within a predefined range. The cornea is ablated using the selected ablation profile.
摘要翻译：一种用于对患者的眼睛进行角膜消融手术的方法，包括确定眼睛的屈光矫正并确定对应于患者的屈光矫正或状况的第一参数。选择消融轮廓，其包括基于第一参数选择的折射校正部件和预补偿部件。消融轮廓被配置为促进高阶像差的受控感应，其中预补偿部件将较高阶像差的感应限制在预定范围内。使用所选择的消融轮廓消融角膜。

6. 发明授权

US12138115B1 System of determining the correct implantable collamer lens size from ultrasound images of the eye 有权
公开(公告)号：US12138115B1
公开(公告)日：2024-11-12
申请号：US17066473
申请日：2020-10-08
申请人： Dan Z Reinstein
发明人： Dan Z. Reinstein , Ryan Vida , Timothy James Archer
IPC分类号： A61B8/10 , A61B8/08 , A61F2/16
CPC分类号： A61B8/10 , A61B8/5215 , A61F2/16
摘要： A method for operating a data processing system to provide an estimate of a vault value for a PIOL to be inserted in a patient, a system for predicting the vault that will be realized for an implant, and computer readable medium that includes instructions that cause a data processing system to implement the method when the instructions are executed by a data processing system are disclosed. The method includes causing the data processing system to receive ultrasound-based anatomical measurements of the patient's eye, causing the data processing system to receive parameters specifying a power and size for the PIOL; and utilizing a calibrated model of a human eye to predict the vault based on the anatomical measurements and the parameters specifying the power and the size for the PIOL.

7. 发明授权

US08685007B2 Method and device for forming cut surfaces in a transparent material 有权
标题翻译：用于在透明材料中形成切割表面的方法和装置
公开(公告)号：US08685007B2
公开(公告)日：2014-04-01
申请号：US12936384
申请日：2009-04-02
申请人： Hartmut Vogelsang , Dan Z. Reinstein , Matthias Wottke , Andre Narr , Wilfried Bissmann
发明人： Hartmut Vogelsang , Dan Z. Reinstein , Matthias Wottke , Andre Narr , Wilfried Bissmann
IPC分类号： A61F9/01
CPC分类号： A61F9/008 , A61F9/00827 , A61F9/00836 , A61F2009/00872 , A61F2009/00897
摘要： A method and a device for forming cut surfaces in a transparent material, particularly in the cornea, by producing optical breakthroughs in the material by application of laser radiation focused into the material. The focal point is adjusted in three dimensions to form the cut surface by the sequential arrangement of optical perforations. The focal point is guided in such a manner that cutting is divided into at least two steps, and in at least one of the steps, the formation of the cut is carried out with a path radius that decreases in size, and in one of the steps, the cut formation is carried out with a path radius that increases in size.
摘要翻译：一种用于在透明材料（特别是角膜）中形成切割表面的方法和装置，通过施加聚焦到材料中的激光辐射在材料中产生光学突破。焦点通过光学穿孔的顺序布置三维调整形成切割面。焦点以这样的方式引导，即切割被分成至少两个步骤，并且在至少一个步骤中，以大小减小的路径半径进行切割的形成，并且在在步骤中，切割结构以尺寸增大的路径半径进行。

8. 发明授权

US08444632B2 Method of performing refractive laser eye surgery centered along the visual axis of a human eye 有权
$Method of performing refractive laser eye surgery centered along the visual axis of a human eye$
标题翻译：以人眼的视轴为中心进行折射激光眼部手术的方法
公开(公告)号：US08444632B2
公开(公告)日：2013-05-21
申请号：US12612898
申请日：2009-11-05
申请人： Dan Z. Reinstein , Hartmut Vogelsang , Daniel Neal
发明人： Dan Z. Reinstein , Hartmut Vogelsang , Daniel Neal
IPC分类号： A61B18/18 , A61B3/10
CPC分类号： A61F9/00806 , A61F9/00827 , A61F2009/00846 , A61F2009/00872 , A61F2009/0088 , A61F2009/00882
摘要： A method of performing refractive laser eye surgery on a human eye is provided wherein the ablation pattern is centered along the visual axis, rather than along the line of sight. First, a wavefront, either ocular, corneal or a combination thereof, is generated by a wavefront sensor centered along the line of sight. This measured wavefront is centered on and encompasses a patient's pupil. Then, an analysis pupil is determined which encompasses the measured pupil. The analysis pupil is centered along the visual axis at the point of intersection with the cornea. Consequently, the measured wavefront is reconstructed over the analysis pupil only using data taken over the area covered by the measured pupil. This reconstruction is done through a least squares fit of a series of slopes from the measured wavefront and/or through the transformation of aberration coefficients. Finally, an ablation pattern, or a lenticule generation pattern, to be performed by a refractive laser centered on the corneal intersect of the visual axis is produced in accordance with the reconstructed wavefront.
摘要翻译：提供了一种在人眼上执行折射激光眼外科手术的方法，其中消融图案沿视轴居中，而不是沿着视线。首先，通过以视线为中心的波前传感器产生波前，眼睛，角膜或其组合。这个测量的波前是以患者的瞳孔为中心并且包含患者的瞳孔。然后，确定包含测量瞳孔的分析瞳孔。分析瞳孔在与角膜交点处沿视轴居中。因此，仅使用在测量瞳孔覆盖的区域上拍摄的数据，通过分析瞳孔重建测量的波前。通过从测量的波前和/或通过像差系数的变换的一系列斜率的最小二乘拟合来完成该重建。最后，根据重建的波前产生由以视轴的角膜相交为中心的折射激光进行的消融图案或微透镜生成图案。

9. 发明申请

US20110208171A1 METHOD AND DEVICE FOR FORMING CUT SURFACES IN A TRANSPARENT MATERIAL 有权
标题翻译：在透明材料中形成切割表面的方法和装置
公开(公告)号：US20110208171A1
公开(公告)日：2011-08-25
申请号：US12936384
申请日：2009-04-02
申请人： Hartmut Vogelsang , Dan Z. Reinstein , Matthias Wottke , André Narr , Wilfried Bissmann
发明人： Hartmut Vogelsang , Dan Z. Reinstein , Matthias Wottke , André Narr , Wilfried Bissmann
IPC分类号： A61F9/01
CPC分类号： A61F9/008 , A61F9/00827 , A61F9/00836 , A61F2009/00872 , A61F2009/00897
摘要： A method and a device for forming cut surfaces in a transparent material, particularly in the cornea, by producing optical breakthroughs in the material by application of laser radiation focused into the material. The focal point is adjusted in three dimensions to form the cut surface by the sequential arrangement of optical perforations. The focal point is guided in such a manner that cutting is divided into at least two steps, and in at least one of the steps, the formation of the cut is carried out with a path radius that decreases in size, and in one of the steps, the cut formation is carried out with a path radius that increases in size.
摘要翻译：一种用于在透明材料（特别是角膜）中形成切割表面的方法和装置，通过施加聚焦到材料中的激光辐射在材料中产生光学突破。焦点通过光学穿孔的顺序布置三维调整形成切割面。焦点以这样的方式引导，即切割被分成至少两个步骤，并且在至少一个步骤中，以大小减小的路径半径进行切割的形成，并且在在步骤中，切割结构以尺寸增大的路径半径进行。

10. 发明申请

US20100114076A1 METHOD OF PERFORMING REFRACTIVE LASER EYE SURGERY CENTERED ALONG THE VISUAL AXIS OF A HUMAN EYE 有权
标题翻译：在人眼可见轴上进行折射激光眼手术的方法
公开(公告)号：US20100114076A1
公开(公告)日：2010-05-06
申请号：US12612898
申请日：2009-11-05
申请人： Dan Z. Reinstein , Hartmut Vogelsang , Daniel Neal
发明人： Dan Z. Reinstein , Hartmut Vogelsang , Daniel Neal
IPC分类号： A61F9/008 , A61B3/10
CPC分类号： A61F9/00806 , A61F9/00827 , A61F2009/00846 , A61F2009/00872 , A61F2009/0088 , A61F2009/00882
摘要： A method of performing refractive laser eye surgery on a human eye is provided wherein the ablation pattern is centered along the visual axis, rather than along the line of sight. First, a wavefront, either ocular, corneal or a combination thereof, is generated by a wavefront sensor centered along the line of sight. This measured wavefront is centered on and encompasses a patient's pupil. Then, an analysis pupil is determined which encompasses the measured pupil. The analysis pupil is centered along the visual axis at the point of intersection with the cornea. Consequently, the measured wavefront is reconstructed over the analysis pupil only using data taken over the area covered by the measured pupil. This reconstruction is done through a least squares fit of a series of slopes from the measured wavefront and/or through the transformation of aberration coefficients. Finally, an ablation pattern, or a lenticule generation pattern, to be performed by a refractive laser centered on the corneal intersect of the visual axis is produced in accordance with the reconstructed wavefront.
摘要翻译：提供了一种在人眼上执行折射激光眼外科手术的方法，其中消融图案沿视轴居中，而不是沿着视线。首先，通过以视线为中心的波前传感器产生波前，眼睛，角膜或其组合。这个测量的波前是以患者的瞳孔为中心并且包含患者的瞳孔。然后，确定包含测量瞳孔的分析瞳孔。分析瞳孔在与角膜交点处沿视轴居中。因此，仅使用在测量瞳孔覆盖的区域上拍摄的数据，通过分析瞳孔重建测量的波前。通过从测量的波前和/或通过像差系数的变换的一系列斜率的最小二乘拟合来完成该重建。最后，根据重建的波前产生由以视轴的角膜相交为中心的折射激光进行的消融图案或微透镜生成图案。

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