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1. 发明授权

US06809196B2 Molecular recognition at surfaces derivatized with self-assembled monolayers 失效
标题翻译：用自组装单层衍生的表面的分子识别
公开(公告)号：US06809196B2
公开(公告)日：2004-10-26
申请号：US09915187
申请日：2001-07-25
申请人： Cynthia C. Bamdad , George B. Sigal , Jack L. Strominger , George M. Whitesides
发明人： Cynthia C. Bamdad , George B. Sigal , Jack L. Strominger , George M. Whitesides
IPC分类号： C07H2104
CPC分类号： B82Y30/00 , B82Y15/00 , B82Y40/00 , C07H21/04 , C12Q1/6837 , G01N33/54353 , G01N33/54373 , G01N33/553 , G01N2610/00
摘要： An article suitable for use as a biosensor includes a molecule of a formula X—R—Ch adhered to a surface of the article as part of a self-assembled monolayer. X is a functionality that adheres to the surface, R is a spacer moiety, and Ch is a chelating agent. A metal ion can be coordinated by the chelating agent, and a polyamino acid-tagged biological binding partner of a target biological molecule coordinated to the metal ion. A method of the invention involves bringing the article into contact with a medium containing or suspected of containing the target biological molecule and allowing the biological molecule to biologically bind to the binding partner. The article is useful particularly as a surface plasmon resonance chip.
摘要翻译：适合用作生物传感器的制品包括作为自组装单层的一部分粘附到制品表面的式X-R-Ch分子。 X是附着于表面的官能团，R是间隔基，Ch是螯合剂。金属离子可以由螯合剂配位，并且靶向生物分子的聚氨基酸标记的生物结合配偶体与金属离子配位。本发明的方法包括使制品与含有或怀疑含有靶生物分子的培养基接触并允许生物分子与结合配偶体生物结合。该文章特别用作表面等离子体共振芯片。

2. 发明授权

US11202775B2 Methods for treatment of cancer 有权
公开(公告)号：US11202775B2
公开(公告)日：2021-12-21
申请号：US12238362
申请日：2008-09-25
申请人： Cynthia C. Bamdad
发明人： Cynthia C. Bamdad
IPC分类号： A61K31/437 , A61P35/00 , B82Y30/00
摘要： A method for treating or preventing cancer in a subject comprising administering a treatment effective amount of a chemotype 4 compound.

3. 发明申请

US20120135530A1 Detection of target analytes using particles and electrodes 有权
标题翻译：使用粒子和电极检测目标分析物
公开(公告)号：US20120135530A1
公开(公告)日：2012-05-31
申请号：US11982435
申请日：2007-10-31
申请人： Cynthia C. Bamdad , Robert C. Mucic
发明人： Cynthia C. Bamdad , Robert C. Mucic
IPC分类号： G01N27/00
CPC分类号： G01N27/3275 , B01J13/00 , B82Y15/00 , B82Y30/00 , C12Q1/6825 , G01N27/3277 , G01N27/48 , Y10S977/773 , Y10S977/92 , Y10T436/143333 , C12Q2565/1015 , C12Q2525/313 , C12Q2525/197 , C12Q2565/101 , C12Q2563/113
摘要： The invention relates to the use of particles comprising binding ligands and electron transfer moieties (ETMs). Upon binding of a target analyte, a particle and a reporter composition are associated and transported to an electrode surface. The ETMs are then detected, allowing the presence or absence of the target analyte to be determined.
摘要翻译：本发明涉及包含结合配体和电子转移部分（ETM）的颗粒的用途。当目标分析物结合时，颗粒和报道组合物被结合并传送到电极表面。然后检测ETM，允许确定目标分析物的存在或不存在。

4. 发明授权

US07700715B2 Diagnostic tumor markers, drug screening for tumorigenesis inhibition, and compositions and methods for treatment of cancer 有权
标题翻译：诊断肿瘤标志物，用于肿瘤发生抑制的药物筛选，以及用于治疗癌症的组合物和方法
公开(公告)号：US07700715B2
公开(公告)日：2010-04-20
申请号：US09996069
申请日：2001-11-27
申请人： Cynthia C. Bamdad , R. Shoshana Bamdad
发明人： Cynthia C. Bamdad , R. Shoshana Bamdad
IPC分类号： C07K5/00
CPC分类号： G01N33/54313 , B82Y30/00 , C07K16/3092 , C07K2317/74 , G01N33/543 , G01N33/57407 , G01N33/57419 , G01N33/57423 , G01N33/57434 , G01N33/57449 , G01N33/57484 , G01N33/57488 , G01N33/57492 , G01N2333/4725 , G01N2500/02
摘要： The invention provides a series of compositions, methods, kits, articles and species associated primarily with the diagnosis and/or treatment of cell proliferation, specifically cancer. Cell proliferation associated with aberrant expression of MUC1 is particularly focused upon. Mechanisms associated with MUC1 cell proliferation are discussed.
摘要翻译：本发明提供了主要与细胞增殖的诊断和/或治疗特别是癌症相关的一系列组合物，方法，试剂盒，制品和物种。与MUC1异常表达相关的细胞增殖尤其重要。讨论与MUC1细胞增殖相关的机制。

5. 发明授权

US07615340B2 Electronic detection of interaction and detection of interaction based on the interruption of flow 有权
公开(公告)号：US07615340B2
公开(公告)日：2009-11-10
申请号：US09971056
申请日：2001-10-03
申请人： Cynthia C. Bamdad
发明人： Cynthia C. Bamdad
IPC分类号： C12Q1/68
CPC分类号： G01N33/54346 , B82Y30/00 , C12Q1/6816 , G01N33/54326 , G01N33/6803 , G01N2500/00 , Y10S436/806 , Y10T436/143333 , C12Q2565/629 , C12Q2563/155
摘要： Porous members can be positioned so as to partially or fully span channels in microfluidic systems. The porous members can be assembled and/or disassembled in situ. The porous members can be made such that pores are separated by connections including but a single molecule at one location, allowing for a high level of open area in a very small pore size member. The porous member can be made up of colloid particles interconnected with molecular species. These can be used to detect analytes qualitatively and/or quantitatively, or to selectively bind and/or release agents on command for a variety of purposes including first blocking, then opening a channel, concentrating analyte over time followed by release of analyte and detection downstream, etc. Porous members can define valves in multiple-channel systems and, with controlled binding and release of agents at the porous members, these valves can be opened and closed and fluid flow controlled in a multi-channel system. Fluidic systems of the invention can include multiple sensing locations at which different analytes are determined. Systems of the invention provide flexibility for overall microchemical analysis, sequentially, of a variety of agents.

6. 发明授权

US07585682B2 Magnetic in situ dilution 有权
公开(公告)号：US07585682B2
公开(公告)日：2009-09-08
申请号：US09971099
申请日：2001-10-03
申请人： Cynthia C. Bamdad
发明人： Cynthia C. Bamdad
IPC分类号： G01N33/553 , B05D5/12
CPC分类号： G01N33/54346 , B82Y30/00 , C12Q1/6816 , G01N33/54326 , G01N33/6803 , G01N2500/00 , Y10S436/806 , Y10T436/143333 , C12Q2565/629 , C12Q2563/155
摘要： The invention involves methods, assays, and components for the detection and analysis of binding between biological or chemical species, and can specifically be used for drug discovery. In an example where drug discovery is carried out, different candidate drugs can be attached to different articles such as magnetic beads. The beads can be exposed to colloid particles carrying signaling entities, or other signaling entities, immobilized with respect to protein targets of the drug candidates. After incubation, all beads are drawn to separate surface locations magnetically. Beads are released from surface locations where it is determined that signaling entities do not exist, and are removed from the assay. Beads held at other surface locations then are released, re-distributed, and re-attracted to surface locations. This is repeated with appropriate wash steps, until individual drug candidates can be isolated and identified.

7. 发明授权

US06306584B1 Electronic-property probing of biological molecules at surfaces 失效
标题翻译：表面生物分子的电子特性探测
公开(公告)号：US06306584B1
公开(公告)日：2001-10-23
申请号：US08843623
申请日：1997-04-10
申请人： Cynthia C. Bamdad
发明人： Cynthia C. Bamdad
IPC分类号： C12Q168
CPC分类号： B82Y30/00 , B01J2219/00653 , B82Y15/00 , C12Q1/6825 , G01N2610/00 , C12Q2565/607
摘要： A technique for immobilizing biological molecules, in particular nucleic acid strands, is described. Biological molecules immobilized at surfaces can be used in electron-transfer detection techniques in which a binding partner of a biological molecule is brought into proximity of the surface-immobilized biological molecule, an electrical potential created between the two biologically-binding species, and electron transfer through the species determined. Another technique involves immobilizing a bioligical molecule such as a protein, DNA, etc. at a surface via a self-assembled monolayer, affecting the biological molecule via, for example, biological binding, inducing a change in conformation via a prion, etc., and detecting an electronic property change in the molecule via a change in inpedence associated with an electronic circuit addressed by the biological molecule. These technique facilitates combinatorial array detection articles.
摘要翻译：描述了用于固定生物分子，特别是核酸链的技术。固定在表面的生物分子可用于电子转移检测技术，其中生物分子的结合配偶体被附着在表面固定的生物分子附近，在两个生物结合物质之间产生的电势和电子转移通过物种确定。另一技术涉及通过自组装单层将表面上的诸如蛋白质，DNA等的生物学分子固定化，通过例如生物结合影响生物分子，通过朊病毒等引起构象变化，以及通过与由生物分子寻址的电子电路相关联的衰减的变化来检测分子中的电子特性变化。这些技术有助于组合阵列检测文章。

8. 发明授权

US11898160B2 Method for maintaining pluripotency in cells 有权
公开(公告)号：US11898160B2
公开(公告)日：2024-02-13
申请号：US12577103
申请日：2009-10-09
申请人： Cynthia C. Bamdad , Shawn P. Fessler
发明人： Cynthia C. Bamdad , Shawn P. Fessler
IPC分类号： C12N5/0735 , C12N5/074
CPC分类号： C12N5/0606 , C12N5/0696 , C12N2501/40 , C12N2501/50 , C12N2501/602 , C12N2501/603 , C12N2501/604 , C12N2501/998
摘要： The present application describes a method for inducing or maintaining pluripotency in a cell by contacting the cell with a biological or chemical species that increases MUC1* activity.

9. 发明授权

US08859495B2 Methods for stimulating or enhancing proliferation of non-tumorous cells expressing MUC1 receptors 有权
标题翻译：刺激或增强表达MUC1受体的非肿瘤细胞增殖的方法
公开(公告)号：US08859495B2
公开(公告)日：2014-10-14
申请号：US11278122
申请日：2006-03-30
申请人： Cynthia C. Bamdad
发明人： Cynthia C. Bamdad
IPC分类号： A61K38/18 , C07K14/475 , A61K38/00 , C07K14/47 , A61K38/48 , A61K38/19 , C07K16/28 , A61K38/45 , A61K38/17
CPC分类号： C07K16/3092 , A61K38/1709 , A61K38/193 , A61K38/45 , A61K38/488 , A61K38/4886 , A61K48/00 , C07K16/2863 , C07K16/468 , C07K2317/31 , C07K2317/35 , C07K2317/75 , A61K2300/00
摘要： The present application discloses a method for stimulating or enhancing proliferation of a population of cells by activating MUC1 receptor on the cells.
摘要翻译：本申请公开了通过激活细胞上的MUC1受体来刺激或增强细胞群增殖的方法。

10. 发明授权

US08535944B2 Culturing embryonic stem cells, embryonic stem-like cells, or induced pluripotent stem cells with a Muc1 or Muc1* ligand 有权
标题翻译：用Muc1或Muc1 *配体培养胚胎干细胞，胚胎干样细胞或诱导多能干细胞
公开(公告)号：US08535944B2
公开(公告)日：2013-09-17
申请号：US12814420
申请日：2010-06-11
申请人： Cynthia C. Bamdad
发明人： Cynthia C. Bamdad
IPC分类号： C12N5/00
CPC分类号： G01N33/57492 , C12N5/0606 , C12N5/0647 , C12N5/0695 , C12N2501/998 , C12N2502/30 , C12N2533/90 , G01N33/56966
摘要： The present application describes a method of culturing, expanding or growing stem or stem-like cells or induced pluripotent stem cells on a surface, including attaching the cells to the surface through a ligand that binds to the surface and the cells.
摘要翻译：本申请描述了在表面上培养，扩增或培养茎或干样细胞或诱导的多能干细胞的方法，包括通过与表面和细胞结合的配体将细胞附着到表面。

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