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1. 发明申请

US20100141682A1 Silhouette image acquisition 失效
标题翻译：剪影图像采集
公开(公告)号：US20100141682A1
公开(公告)日：2010-06-10
申请号：US12587107
申请日：2009-10-01
申请人： Cynthia B. Perz , Jose De La Torre-Bueno , Robert T. Ellis , Gina Marie McLaren , Mary Jean Smith
发明人： Cynthia B. Perz , Jose De La Torre-Bueno , Robert T. Ellis , Gina Marie McLaren , Mary Jean Smith
IPC分类号： G09G5/00 , G06K9/34
CPC分类号： G06K9/0014 , G06T7/11 , G06T2207/10056 , G06T2207/20016 , G06T2207/20021 , G06T2207/30024
摘要： Systems and techniques to acquire image data. In general, in one implementation, the technique includes: acquiring image data for a plurality of areas of a scan region. The technique may further include processing the image data to determine whether an area includes one or more desired features. The technique may further include designating an area as “interesting” if it includes a desired feature, and designating an area as non-interesting if it does not include the desired feature. The areas may be sub-divided one or more times, and subdivisions may be analyzed to determine if they include a desired feature.
摘要翻译：采集图像数据的系统和技术。通常，在一个实现中，该技术包括：获取扫描区域的多个区域的图像数据。该技术还可以包括处理图像数据以确定区域是否包括一个或多个期望的特征。该技术可以进一步包括将区域指定为“有趣的”，如果它包括期望的特征，并且如果区域不包括期望的特征，则将该区域指定为非有趣的。这些区域可以被细分一次或多次，并且可以分析细分以确定它们是否包括期望的特征。

2. 发明授权

US07873193B2 Serial section analysis for computer-controlled microscopic imaging 有权
标题翻译：计算机显微镜成像的序列分析
公开(公告)号：US07873193B2
公开(公告)日：2011-01-18
申请号：US11472820
申请日：2006-06-21
申请人： Jose De La Torre-Bueno , Cynthia B. Perz , Robert T. Ellis
发明人： Jose De La Torre-Bueno , Cynthia B. Perz , Robert T. Ellis
IPC分类号： G06K9/00
CPC分类号： G06T7/33 , G06T2207/10056 , G06T2207/30024
摘要： Automated projection of serial section images in microscopic imaging systems. A computer-controlled microscope that is connected electrically to a controller that has a display device. A batch of serial section slides includes a series of serial section slides, each of which has a microscope slide, a sample, and an interesting area. If one of the images is misregistered, then the images may be transformed.
摘要翻译：在显微镜成像系统中自动投影串联图像。一种与具有显示装置的控制器电连接的计算机控制的显微镜。一批连续片幻灯片包括一系列连续片段幻灯片，每个幻灯片都有一个显微镜幻灯片，一个样本和一个有趣的区域。如果其中一个图像被错误注册，则可能会转换图像。

3. 发明授权

US08116543B2 System for and method of intelligently directed segmentation analysis for automated microscope systems 失效
标题翻译：用于自动显微镜系统的智能定向分割分析系统和方法
公开(公告)号：US08116543B2
公开(公告)日：2012-02-14
申请号：US12460079
申请日：2009-07-13
申请人： Cynthia B. Perz , Robert T. Ellis , Jose De La Torre-Bueno
发明人： Cynthia B. Perz , Robert T. Ellis , Jose De La Torre-Bueno
IPC分类号： G06K9/00
CPC分类号： G06K9/0014 , G06T7/11 , G06T2207/10056 , G06T2207/20016 , G06T2207/20021 , G06T2207/20076 , G06T2207/20132 , G06T2207/30024
摘要： The present disclosure includes systems and techniques relating to intelligently directed segmentation analysis for automated microscope systems. In general, in one implementation, the technique includes obtaining an image of at least a portion of a scan region including a biological specimen, partitioning the obtained image into zelles, determining one or more parameters of the zelles, performing a cluster analysis on the one or more parameters of the zelles, differentiating tissue of greater interest from tissue of lesser interest in the obtained image based on the cluster analysis and based on a test being performed for the biological specimen, and storing more information for the tissue of greater interest than information for the tissue of lesser interest. The cluster analysis can be a multivariate statistical cluster analysis, and the zelles can be test-dependent zelles (e.g., having dimensions defined according to the test being performed for the biological specimen).
摘要翻译：本公开包括与用于自动显微镜系统的智能定向分割分析有关的系统和技术。通常，在一个实施方式中，该技术包括获得包括生物样本的扫描区域的至少一部分的图像，将获得的图像划分为zelles，确定zell的一个或多个参数，对该图像执行聚类分析或更多参数，基于聚类分析，并且基于对生物样本进行的测试，并且比信息存储更多的感兴趣的组织的信息，将获得的图像中较不感兴趣的组织感兴趣的组织区分为更多的组织对于较不感兴趣的组织。聚类分析可以是多变量统计聚类分析，并且zelles可以是测试依赖性zelles（例如，具有根据为生物样本进行的测试而定义的维度）。

4. 发明申请

US20100040266A1 System for and method of intelligently directed segmentation analysis for automated microscope systems 失效
标题翻译：用于自动显微镜系统的智能定向分割分析系统和方法
公开(公告)号：US20100040266A1
公开(公告)日：2010-02-18
申请号：US12460079
申请日：2009-07-13
申请人： Cynthia B. Perz , Robert T. Ellis , Jose De La Torre-Bueno
发明人： Cynthia B. Perz , Robert T. Ellis , Jose De La Torre-Bueno
IPC分类号： G06K9/00 , H04N7/18
CPC分类号： G06K9/0014 , G06T7/11 , G06T2207/10056 , G06T2207/20016 , G06T2207/20021 , G06T2207/20076 , G06T2207/20132 , G06T2207/30024
摘要： The present disclosure includes systems and techniques relating to intelligently directed segmentation analysis for automated microscope systems. In general, in one implementation, the technique includes obtaining an image of at least a portion of a scan region including a biological specimen, partitioning the obtained image into zelles, determining one or more parameters of the zelles, performing a cluster analysis on the one or more parameters of the zelles, differentiating tissue of greater interest from tissue of lesser interest in the obtained image based on the cluster analysis and based on a test being performed for the biological specimen, and storing more information for the tissue of greater interest than information for the tissue of lesser interest. The cluster analysis can be a multivariate statistical cluster analysis, and the zelles can be test-dependent zelles (e.g., having dimensions defined according to the test being performed for the biological specimen).
摘要翻译：本公开包括与用于自动显微镜系统的智能定向分割分析有关的系统和技术。通常，在一个实施方式中，该技术包括获得包括生物样本的扫描区域的至少一部分的图像，将获得的图像划分为zelles，确定zell的一个或多个参数，对该图像执行聚类分析或更多参数，基于聚类分析，并且基于对生物样本进行的测试，并且比信息存储更多的感兴趣的组织的信息，将获得的图像中较不感兴趣的组织感兴趣的组织区分为更多的组织对于较不感兴趣的组织。聚类分析可以是多变量统计聚类分析，并且zelles可以是测试依赖性zelles（例如，具有根据为生物样本进行的测试而定义的维度）。

5. 发明授权

US08369591B2 Silhouette image acquisition 失效
标题翻译：剪影图像采集
公开(公告)号：US08369591B2
公开(公告)日：2013-02-05
申请号：US12587107
申请日：2009-10-01
申请人： Cynthia B. Perz , Jose De La Torre-Bueno , Robert T. Ellis , Gina Marie McLaren , Mary Jean Smith
发明人： Cynthia B. Perz , Jose De La Torre-Bueno , Robert T. Ellis , Gina Marie McLaren , Mary Jean Smith
IPC分类号： G06K9/00
CPC分类号： G06K9/0014 , G06T7/11 , G06T2207/10056 , G06T2207/20016 , G06T2207/20021 , G06T2207/30024
摘要： Systems and techniques to acquire image data. In general, in one implementation, the technique includes: acquiring image data for a plurality of areas of a scan region. The technique may further include processing the image data to determine whether an area includes one or more desired features. The technique may further include designating an area as “interesting” if it includes a desired feature, and designating an area as non-interesting if it does not include the desired feature. The areas may be sub-divided one or more times, and subdivisions may be analyzed to determine if they include a desired feature.
摘要翻译：采集图像数据的系统和技术。通常，在一个实现中，该技术包括：获取扫描区域的多个区域的图像数据。该技术还可以包括处理图像数据以确定区域是否包括一个或多个期望的特征。该技术可以进一步包括将区域指定为有意义的，如果其包括期望的特征，并且如果区域不包括期望的特征，则将该区域指定为非有趣的。这些区域可以被细分一次或多次，并且可以分析细分以确定它们是否包括期望的特征。

6. 发明授权

US07653260B2 System and method of registering field of view 失效
标题翻译：登记视野的系统和方法
公开(公告)号：US07653260B2
公开(公告)日：2010-01-26
申请号：US10872138
申请日：2004-06-17
申请人： Cynthia B. Perz , Jose De La Torre-Bueno
发明人： Cynthia B. Perz , Jose De La Torre-Bueno
IPC分类号： G06K9/36
CPC分类号： G02B21/365
摘要： Disclosed is a system for and a method of registering images captured by a computer-controlled microscope. The imaging system of the present invention includes a computer-controlled microscope electrically connected to a controller having a display device. The microscope further includes a barcode reader, a camera, a serial interface, one or more sensors, one or more motors, a light source, a turret, and a data interface. The method of image registration includes the steps of defining areas of interest on a microscope slide, creating a database of microscopic image locations, commanding a microscope to each location, capturing and storing an image, calculating correlation with neighbors, registering correlation scores and offsets, determining an anchor, and attaching neighbors using correlation scores and offsets.
摘要翻译：公开了一种用于记录由计算机控制的显微镜捕获的图像的系统和方法。本发明的成像系统包括电连接到具有显示装置的控制器的计算机控制的显微镜。显微镜还包括条形码读取器，照相机，串行接口，一个或多个传感器，一个或多个电动机，光源，转塔和数据接口。图像配准的方法包括以下步骤：在显微镜幻灯片上定义感兴趣区域，创建微观图像位置的数据库，对每个位置指示显微镜，捕获和存储图像，计算与邻居的相关性，记录相关分数和偏移量，确定锚点，并使用相关分数和偏移量来附加邻居。

7. 发明授权

US08582924B2 Data structure of an image storage and retrieval system 有权
标题翻译：图像存储和检索系统的数据结构
公开(公告)号：US08582924B2
公开(公告)日：2013-11-12
申请号：US10882661
申请日：2004-06-30
申请人： Jose De La Torre-Bueno , Cynthia B. Perz
发明人： Jose De La Torre-Bueno , Cynthia B. Perz
IPC分类号： G06K9/60
CPC分类号： G02B21/367
摘要： Disclosed is an imaging system that stores and retrieves very large scanned digital images, as in applications that automatically scan biological samples using a computer-controlled digital camera microscope. Slide data is entered, zelle data is captured and compressed and a zelle database file is loaded. Furthermore, an image database file is loaded and it is determined whether another zelle is to be stored. The image can be retrieved by accessing the zelle database, reading a zelle record, reading an image file, loading the display buffer, and determining whether another zelle is to be loaded.
摘要翻译：公开了一种成像系统，其存储和检索非常大的扫描数字图像，如在使用计算机控制的数码相机显微镜自动扫描生物样品的应用中。输入幻灯片数据，捕获并压缩zelle数据，并加载zelle数据库文件。此外，加载图像数据库文件，并且确定是否存储另外的zelle。可以通过访问zelle数据库，读取zelle记录，读取图像文件，加载显示缓冲区以及确定是否要加载另一个zelle来检索图像。

8. 发明授权

US07627153B2 Repositioning inaccuracies in an automated imaging system 有权
标题翻译：在自动化成像系统中重新定位不准确
公开(公告)号：US07627153B2
公开(公告)日：2009-12-01
申请号：US11198018
申请日：2005-08-04
申请人： Cynthia B. Perz , Robert T. Ellis
发明人： Cynthia B. Perz , Robert T. Ellis
IPC分类号： G06K9/00
CPC分类号： G03B5/00
摘要： Systems and techniques for reducing repositioning inaccuracies in imaging systems. Initial image data and positional information is received and cross-correlated with additional image data and positional information. An offset may be determined based on the cross-correlation.
摘要翻译：用于减少成像系统中重新定位不准确度的系统和技术。初始图像数据和位置信息被接收并与附加图像数据和位置信息相互关联。可以基于互相关来确定偏移。

9. 发明申请

US20100265323A1 SYSTEM FOR AND METHOD OF FOCUSING IN AUTOMATED MICROSCOPE SYSTEMS 有权
标题翻译：用于自动显微系统聚焦的系统和方法
公开(公告)号：US20100265323A1
公开(公告)日：2010-10-21
申请号：US12763854
申请日：2010-04-20
申请人： Cynthia B. Perz
发明人： Cynthia B. Perz
IPC分类号： H04N7/18
CPC分类号： G02B21/244 , G06K9/00127
摘要： The present disclosure includes systems and techniques relating to focusing in automated microscope systems. In general, in one implementation, the technique includes obtaining an image of at least a portion of a scan region, analyzing the image to find an area in the image representing a sample, determining a nature of the sample at a selected focus point location in the area in the image, selecting an automated focusing process for use at the selected focus point location based on the determined nature of the sample at the selected focus point location, and focusing the selected automated focusing process. The selecting can include selecting different automated focusing processes for different focus point locations based on different tissue characteristics at the locations.
摘要翻译：本公开包括与在自动显微镜系统中聚焦有关的系统和技术。通常，在一个实现中，该技术包括获得扫描区域的至少一部分的图像，分析图像以找到表示样本的图像中的区域，在所选择的焦点位置确定样本的性质基于所选择的焦点位置处的样本的确定的性质，选择在所选焦点位置处使用的自动聚焦处理，并且聚焦所选择的自动聚焦处理。该选择可以包括基于位置处的不同组织特征为不同焦点位置选择不同的自动对焦过程。

10. 发明授权

US08000511B2 System for and method of focusing in automated microscope systems 有权
标题翻译：自动显微镜系统和聚焦方法
公开(公告)号：US08000511B2
公开(公告)日：2011-08-16
申请号：US12763854
申请日：2010-04-20
申请人： Cynthia B. Perz
发明人： Cynthia B. Perz
IPC分类号： G06K9/00
CPC分类号： G02B21/244 , G06K9/00127
摘要： The present disclosure includes systems and techniques relating to focusing in automated microscope systems. In general, in one implementation, the technique includes obtaining an image of at least a portion of a scan region, analyzing the image to find an area in the image representing a sample, determining a nature of the sample at a selected focus point location in the area in the image, selecting an automated focusing process for use at the selected focus point location based on the determined nature of the sample at the selected focus point location, and focusing the selected automated focusing process. The selecting can include selecting different automated focusing processes for different focus point locations based on different tissue characteristics at the locations.
摘要翻译：本公开包括与在自动显微镜系统中聚焦有关的系统和技术。通常，在一个实现中，该技术包括获得扫描区域的至少一部分的图像，分析图像以找到表示样本的图像中的区域，在所选择的焦点位置确定样本的性质基于所选择的焦点位置处的样本的确定的性质，选择在所选焦点位置处使用的自动聚焦处理，并且聚焦所选择的自动聚焦处理。该选择可以包括基于位置处的不同组织特征为不同焦点位置选择不同的自动对焦过程。

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