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1. 发明申请

US20100141682A1 Silhouette image acquisition 失效
标题翻译：剪影图像采集
公开(公告)号：US20100141682A1
公开(公告)日：2010-06-10
申请号：US12587107
申请日：2009-10-01
申请人： Cynthia B. Perz , Jose De La Torre-Bueno , Robert T. Ellis , Gina Marie McLaren , Mary Jean Smith
发明人： Cynthia B. Perz , Jose De La Torre-Bueno , Robert T. Ellis , Gina Marie McLaren , Mary Jean Smith
IPC分类号： G09G5/00 , G06K9/34
CPC分类号： G06K9/0014 , G06T7/11 , G06T2207/10056 , G06T2207/20016 , G06T2207/20021 , G06T2207/30024
摘要： Systems and techniques to acquire image data. In general, in one implementation, the technique includes: acquiring image data for a plurality of areas of a scan region. The technique may further include processing the image data to determine whether an area includes one or more desired features. The technique may further include designating an area as “interesting” if it includes a desired feature, and designating an area as non-interesting if it does not include the desired feature. The areas may be sub-divided one or more times, and subdivisions may be analyzed to determine if they include a desired feature.
摘要翻译：采集图像数据的系统和技术。通常，在一个实现中，该技术包括：获取扫描区域的多个区域的图像数据。该技术还可以包括处理图像数据以确定区域是否包括一个或多个期望的特征。该技术可以进一步包括将区域指定为“有趣的”，如果它包括期望的特征，并且如果区域不包括期望的特征，则将该区域指定为非有趣的。这些区域可以被细分一次或多次，并且可以分析细分以确定它们是否包括期望的特征。

2. 发明授权

US08369591B2 Silhouette image acquisition 失效
标题翻译：剪影图像采集
公开(公告)号：US08369591B2
公开(公告)日：2013-02-05
申请号：US12587107
申请日：2009-10-01
申请人： Cynthia B. Perz , Jose De La Torre-Bueno , Robert T. Ellis , Gina Marie McLaren , Mary Jean Smith
发明人： Cynthia B. Perz , Jose De La Torre-Bueno , Robert T. Ellis , Gina Marie McLaren , Mary Jean Smith
IPC分类号： G06K9/00
CPC分类号： G06K9/0014 , G06T7/11 , G06T2207/10056 , G06T2207/20016 , G06T2207/20021 , G06T2207/30024
摘要： Systems and techniques to acquire image data. In general, in one implementation, the technique includes: acquiring image data for a plurality of areas of a scan region. The technique may further include processing the image data to determine whether an area includes one or more desired features. The technique may further include designating an area as “interesting” if it includes a desired feature, and designating an area as non-interesting if it does not include the desired feature. The areas may be sub-divided one or more times, and subdivisions may be analyzed to determine if they include a desired feature.
摘要翻译：采集图像数据的系统和技术。通常，在一个实现中，该技术包括：获取扫描区域的多个区域的图像数据。该技术还可以包括处理图像数据以确定区域是否包括一个或多个期望的特征。该技术可以进一步包括将区域指定为有意义的，如果其包括期望的特征，并且如果区域不包括期望的特征，则将该区域指定为非有趣的。这些区域可以被细分一次或多次，并且可以分析细分以确定它们是否包括期望的特征。

3. 发明授权

US07873193B2 Serial section analysis for computer-controlled microscopic imaging 有权
标题翻译：计算机显微镜成像的序列分析
公开(公告)号：US07873193B2
公开(公告)日：2011-01-18
申请号：US11472820
申请日：2006-06-21
申请人： Jose De La Torre-Bueno , Cynthia B. Perz , Robert T. Ellis
发明人： Jose De La Torre-Bueno , Cynthia B. Perz , Robert T. Ellis
IPC分类号： G06K9/00
CPC分类号： G06T7/33 , G06T2207/10056 , G06T2207/30024
摘要： Automated projection of serial section images in microscopic imaging systems. A computer-controlled microscope that is connected electrically to a controller that has a display device. A batch of serial section slides includes a series of serial section slides, each of which has a microscope slide, a sample, and an interesting area. If one of the images is misregistered, then the images may be transformed.
摘要翻译：在显微镜成像系统中自动投影串联图像。一种与具有显示装置的控制器电连接的计算机控制的显微镜。一批连续片幻灯片包括一系列连续片段幻灯片，每个幻灯片都有一个显微镜幻灯片，一个样本和一个有趣的区域。如果其中一个图像被错误注册，则可能会转换图像。

4. 发明授权

US08116543B2 System for and method of intelligently directed segmentation analysis for automated microscope systems 失效
标题翻译：用于自动显微镜系统的智能定向分割分析系统和方法
公开(公告)号：US08116543B2
公开(公告)日：2012-02-14
申请号：US12460079
申请日：2009-07-13
申请人： Cynthia B. Perz , Robert T. Ellis , Jose De La Torre-Bueno
发明人： Cynthia B. Perz , Robert T. Ellis , Jose De La Torre-Bueno
IPC分类号： G06K9/00
CPC分类号： G06K9/0014 , G06T7/11 , G06T2207/10056 , G06T2207/20016 , G06T2207/20021 , G06T2207/20076 , G06T2207/20132 , G06T2207/30024
摘要： The present disclosure includes systems and techniques relating to intelligently directed segmentation analysis for automated microscope systems. In general, in one implementation, the technique includes obtaining an image of at least a portion of a scan region including a biological specimen, partitioning the obtained image into zelles, determining one or more parameters of the zelles, performing a cluster analysis on the one or more parameters of the zelles, differentiating tissue of greater interest from tissue of lesser interest in the obtained image based on the cluster analysis and based on a test being performed for the biological specimen, and storing more information for the tissue of greater interest than information for the tissue of lesser interest. The cluster analysis can be a multivariate statistical cluster analysis, and the zelles can be test-dependent zelles (e.g., having dimensions defined according to the test being performed for the biological specimen).
摘要翻译：本公开包括与用于自动显微镜系统的智能定向分割分析有关的系统和技术。通常，在一个实施方式中，该技术包括获得包括生物样本的扫描区域的至少一部分的图像，将获得的图像划分为zelles，确定zell的一个或多个参数，对该图像执行聚类分析或更多参数，基于聚类分析，并且基于对生物样本进行的测试，并且比信息存储更多的感兴趣的组织的信息，将获得的图像中较不感兴趣的组织感兴趣的组织区分为更多的组织对于较不感兴趣的组织。聚类分析可以是多变量统计聚类分析，并且zelles可以是测试依赖性zelles（例如，具有根据为生物样本进行的测试而定义的维度）。

5. 发明申请

US20100040266A1 System for and method of intelligently directed segmentation analysis for automated microscope systems 失效
标题翻译：用于自动显微镜系统的智能定向分割分析系统和方法
公开(公告)号：US20100040266A1
公开(公告)日：2010-02-18
申请号：US12460079
申请日：2009-07-13
申请人： Cynthia B. Perz , Robert T. Ellis , Jose De La Torre-Bueno
发明人： Cynthia B. Perz , Robert T. Ellis , Jose De La Torre-Bueno
IPC分类号： G06K9/00 , H04N7/18
CPC分类号： G06K9/0014 , G06T7/11 , G06T2207/10056 , G06T2207/20016 , G06T2207/20021 , G06T2207/20076 , G06T2207/20132 , G06T2207/30024
摘要： The present disclosure includes systems and techniques relating to intelligently directed segmentation analysis for automated microscope systems. In general, in one implementation, the technique includes obtaining an image of at least a portion of a scan region including a biological specimen, partitioning the obtained image into zelles, determining one or more parameters of the zelles, performing a cluster analysis on the one or more parameters of the zelles, differentiating tissue of greater interest from tissue of lesser interest in the obtained image based on the cluster analysis and based on a test being performed for the biological specimen, and storing more information for the tissue of greater interest than information for the tissue of lesser interest. The cluster analysis can be a multivariate statistical cluster analysis, and the zelles can be test-dependent zelles (e.g., having dimensions defined according to the test being performed for the biological specimen).
摘要翻译：本公开包括与用于自动显微镜系统的智能定向分割分析有关的系统和技术。通常，在一个实施方式中，该技术包括获得包括生物样本的扫描区域的至少一部分的图像，将获得的图像划分为zelles，确定zell的一个或多个参数，对该图像执行聚类分析或更多参数，基于聚类分析，并且基于对生物样本进行的测试，并且比信息存储更多的感兴趣的组织的信息，将获得的图像中较不感兴趣的组织感兴趣的组织区分为更多的组织对于较不感兴趣的组织。聚类分析可以是多变量统计聚类分析，并且zelles可以是测试依赖性zelles（例如，具有根据为生物样本进行的测试而定义的维度）。

6. 发明授权

US07627153B2 Repositioning inaccuracies in an automated imaging system 有权
标题翻译：在自动化成像系统中重新定位不准确
公开(公告)号：US07627153B2
公开(公告)日：2009-12-01
申请号：US11198018
申请日：2005-08-04
申请人： Cynthia B. Perz , Robert T. Ellis
发明人： Cynthia B. Perz , Robert T. Ellis
IPC分类号： G06K9/00
CPC分类号： G03B5/00
摘要： Systems and techniques for reducing repositioning inaccuracies in imaging systems. Initial image data and positional information is received and cross-correlated with additional image data and positional information. An offset may be determined based on the cross-correlation.
摘要翻译：用于减少成像系统中重新定位不准确度的系统和技术。初始图像数据和位置信息被接收并与附加图像数据和位置信息相互关联。可以基于互相关来确定偏移。

7. 发明授权

US07428325B2 Method and apparatus for automated image analysis of biological specimens 有权
标题翻译：生物样本自动图像分析的方法和装置
公开(公告)号：US07428325B2
公开(公告)日：2008-09-23
申请号：US11685717
申请日：2007-03-13
申请人： James W. Douglass , Thomas J. Riding , James E. Ring , Gina McLaren , William J. Decker , Robert T. Ellis
发明人： James W. Douglass , Thomas J. Riding , James E. Ring , Gina McLaren , William J. Decker , Robert T. Ellis
IPC分类号： G06K9/00
CPC分类号： G06K9/3233 , G01N15/1475 , G02B21/367 , G06K9/00127 , G06K9/00134 , G06K9/20 , G06K9/342 , G06K9/4609 , G06K9/4652 , G06T5/002 , G06T5/005 , G06T5/30 , G06T7/136 , G06T2207/10024 , G06T2207/10056 , G06T2207/20012 , G06T2207/20016 , G06T2207/30024
摘要： A method and apparatus for automated cell analysis of biological specimens automatically scans at a low magnification to acquire images which are analyzed to determine candidate cell objects of interest. The low magnification images are converted from a first color space to a second color space. The color space converted image is then filtered. The candidate interest pixels are morphologically processed and compared to blob parameters to identify candidate objects of interest which correspond to cells or other structures relevant to medical diagnosis of the biological specimen. The location coordinates of the objects of interest are stored and additional images of the candidate cell objects are acquired at high magnification.
摘要翻译：用于生物标本的自动细胞分析的方法和装置以低倍率自动扫描以获取被分析以确定感兴趣的候选细胞对象的图像。低倍率图像从第一颜色空间转换为第二颜色空间。然后过滤颜色空间转换的图像。候选兴趣像素被形态地处理并与斑点参数进行比较，以识别对应于与生物样本的医学诊断相关的细胞或其他结构的候选对象。存储感兴趣对象的位置坐标，并以高倍率获取候选单元对象的附加图像。

8. 发明申请

US20090060303A1 METHOD AND APPARATUS FOR AUTOMATED IMAGE ANALYSIS OF BIOLOGICAL SPECIMENS 有权
标题翻译：用于生物样本自动图像分析的方法和装置
公开(公告)号：US20090060303A1
公开(公告)日：2009-03-05
申请号：US12201800
申请日：2008-08-29
申请人： James W. Douglass , Thomas J. Riding , James E. Ring , Gina McLaren , William J. Decker , Robert T. Ellis
发明人： James W. Douglass , Thomas J. Riding , James E. Ring , Gina McLaren , William J. Decker , Robert T. Ellis
IPC分类号： G06K9/00 , G06K9/40
CPC分类号： G01N1/312 , G01N15/1468 , G01N15/1475 , G01N2015/1472 , G01N2015/1488 , G01N2015/1497 , G02B21/244 , G02B21/367 , G06K9/00127 , G06K9/00134 , G06T7/60
摘要： A method including acquiring images of medical slides at a plurality of different focus positions, determining a position which produces a maximum value of pixel values relative to a pixel value mean, wherein said determining comprises using a pixel value mean as a coarse estimate of coarse focus position, and subsequently refining said coarse focus position to find a fine focus position, and wherein said refining comprises fitting to a polynomial, and using a specified portion of the polynomial as a fine estimate of focus position, and producing a focus control signal that is related to said maximum value to control a focus position.
摘要翻译：一种方法，包括在多个不同焦点位置获取医疗幻灯片的图像，确定相对于像素值平均值产生像素值的最大值的位置，其中所述确定包括使用像素值均值作为粗略焦点的粗略估计位置，随后精炼所述粗焦点位置以找到精细对焦位置，并且其中所述精炼包括拟合到多项式，并且使用多项式的指定部分作为焦点位置的精细估计，并且产生聚焦控制信号与所述最大值有关以控制焦点位置。

9. 外观设计

USD394088S Sailing training aide 失效
公开(公告)号：USD394088S
公开(公告)日：1998-05-05
申请号：US66908
申请日：1997-02-24
申请人： Robert T. Ellis
设计人： Robert T. Ellis

10. 发明授权

US07783098B2 Method and apparatus for automated image analysis of biological specimens 有权
标题翻译：生物标本自动图像分析的方法和装置
公开(公告)号：US07783098B2
公开(公告)日：2010-08-24
申请号：US12201800
申请日：2008-08-29
申请人： James W. Douglass , Thomas J. Riding , James E. Ring , Gina McLaren , William J. Decker , Robert T. Ellis
发明人： James W. Douglass , Thomas J. Riding , James E. Ring , Gina McLaren , William J. Decker , Robert T. Ellis
IPC分类号： G06K9/00 , G06K9/40
CPC分类号： G01N1/312 , G01N15/1468 , G01N15/1475 , G01N2015/1472 , G01N2015/1488 , G01N2015/1497 , G02B21/244 , G02B21/367 , G06K9/00127 , G06K9/00134 , G06T7/60
摘要： A method including acquiring images of medical slides at a plurality of different focus positions, determining a position which produces a maximum value of pixel values relative to a pixel value mean, wherein said determining comprises using a pixel value mean as a coarse estimate of coarse focus position, and subsequently refining said coarse focus position to find a fine focus position, and wherein said refining comprises fitting to a polynomial, and using a specified portion of the polynomial as a fine estimate of focus position, and producing a focus control signal that is related to said maximum value to control a focus position.
摘要翻译：一种方法，包括在多个不同焦点位置获取医疗幻灯片的图像，确定相对于像素值平均值产生像素值的最大值的位置，其中所述确定包括使用像素值均值作为粗略焦点的粗略估计位置，随后精炼所述粗焦点位置以找到精细对焦位置，并且其中所述精炼包括拟合到多项式，并且使用多项式的指定部分作为焦点位置的精细估计，并且产生聚焦控制信号与所述最大值有关以控制焦点位置。

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