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1. 发明申请

US20100278921A1 SOLID ORAL FORMULATION OF ABT-263 审中-公开
标题翻译： ABT-263固体口服制剂
公开(公告)号：US20100278921A1
公开(公告)日：2010-11-04
申请号：US12770205
申请日：2010-04-29
申请人： Cristina M. Fischer , Rajeev Gokhale , Katherine Heemstra , David Hill , Kennan Marsh , Eric A. Schmitt , Yi Shi , Ping Tong , Deliang Zhou
发明人： Cristina M. Fischer , Rajeev Gokhale , Katherine Heemstra , David Hill , Kennan Marsh , Eric A. Schmitt , Yi Shi , Ping Tong , Deliang Zhou
IPC分类号： A61K31/5377 , A61K9/14 , A61P35/00
CPC分类号： A61K9/4866 , A61K9/1652 , A61K9/2054 , A61K31/5377
摘要： An orally deliverable pharmaceutical composition comprises (a) a pharmaceutically acceptable acid addition salt of ABT-263 in solid particulate form, and (b) a plurality of pharmaceutically acceptable excipients including at least a solid diluent and a solid disintegrant; wherein the salt is formed from more than one equivalent of acid per equivalent of ABT-263. The composition is suitable for oral administration to a subject in need thereof for treatment of a disease characterized by overexpression of one or more anti-apoptotic Bcl-2 family proteins, for example cancer.
摘要翻译：可口服递送的药物组合物包含（a）固体颗粒形式的ABT-263的药学上可接受的酸加成盐，和（b）至少包含固体稀释剂和固体崩解剂的多种药学上可接受的赋形剂; 其中所述盐由每当量ABT-263的多于一当量的酸形成。该组合物适合于有需要的受试者的口服给药，用于治疗以一种或多种抗凋亡Bcl-2家族蛋白（例如癌症）过表达为特征的疾病。

2. 发明申请

US20100297194A1 FORMULATION FOR ORAL ADMINISTRATION OF APOPTOSIS PROMOTER 审中-公开
标题翻译：制剂推荐药物的口服制剂
公开(公告)号：US20100297194A1
公开(公告)日：2010-11-25
申请号：US12770299
申请日：2010-04-29
申请人： Nathaniel Catron , Michael G. Fickes , Cristina M. Fischer , Rajeev Gokhale , Anthony R. Haight , Katherine Heemstra , David Hill , Martin Knobloch , Drazen Kostelac , Justin S. Lafountaine , Yanxia Li , Bernd Liepold , Kennan Marsh , Jonathan M. Miller , Claudia Packhaeuser , Yeshwant D. Sanzgiri , Eric A. Schmitt , Yi Shi , Norbert Steiger , Ping Tong , Huailiang Wu , Geoff G.Z. Zhang , Deliang Zhou
发明人： Nathaniel Catron , Michael G. Fickes , Cristina M. Fischer , Rajeev Gokhale , Anthony R. Haight , Katherine Heemstra , David Hill , Martin Knobloch , Drazen Kostelac , Justin S. Lafountaine , Yanxia Li , Bernd Liepold , Kennan Marsh , Jonathan M. Miller , Claudia Packhaeuser , Yeshwant D. Sanzgiri , Eric A. Schmitt , Yi Shi , Norbert Steiger , Ping Tong , Huailiang Wu , Geoff G.Z. Zhang , Deliang Zhou
IPC分类号： A61K31/5377 , A61K33/04 , A61K9/14 , A61P35/00
CPC分类号： A61K31/5377 , A61K9/08 , A61K9/10 , A61K9/146 , A61K9/2054 , A61K9/2077 , A61K9/4858 , A61K9/4866
摘要： An orally deliverable pharmaceutical composition comprises as a sole or first active ingredient a compound of Formula I defined herein or a pharmaceutically acceptable salt thereof, for example ABT-263 free base or ABT-263 bis-HCl salt, dispersed, in a free base equivalent amount of at least about 2.5% by weight of the composition, in a pharmaceutically acceptable carrier; wherein said active ingredient is in solid-state form and/or the composition further comprises, dispersed in the carrier, a pharmaceutically acceptable heavier-chalcogen antioxidant in an amount effective to inhibit oxidation of the active ingredient at a thioether linkage thereof. The composition is suitable for oral administration to a subject in need thereof for treatment of a disease characterized by overexpression of one or more anti-apoptotic Bcl-2 family proteins, for example cancer.
摘要翻译：可口服递送的药物组合物包含作为唯一或第一活性成分的本文定义的式I化合物或其药学上可接受的盐，例如ABT-263游离碱或ABT-263双-HCl盐，以游离碱当量至少约2.5重量％的组合物，在药学上可接受的载体中; 其中所述活性成分是固态形式和/或所述组合物还包含以有效抑制活性成分在其硫醚键的氧化的量分散在载体中的药学上可接受的较重硫族元素抗氧化剂。该组合物适合于有需要的受试者的口服给药，用于治疗以一种或多种抗凋亡Bcl-2家族蛋白（例如癌症）过表达为特征的疾病。

3. 发明授权

US09556238B2 Magnetosome gene expression in eukaryotic cells 有权
标题翻译：真核细胞中的磁粒子基因表达
公开(公告)号：US09556238B2
公开(公告)日：2017-01-31
申请号：US12303793
申请日：2007-06-08
申请人： Frank S Prato , Donna E Goldhawk , Cheryl R McCreary , Rebecca McGirr , Savita Dhanvantari , Terry R Thompson , Alex W Thomas , David Hill
发明人： Frank S Prato , Donna E Goldhawk , Cheryl R McCreary , Rebecca McGirr , Savita Dhanvantari , Terry R Thompson , Alex W Thomas , David Hill
IPC分类号： A61K49/06 , A61K35/12 , C12N15/63 , C12N5/10 , C12N1/00 , C07K14/195 , A61K49/14 , A61K49/18
CPC分类号： C07K14/195 , A61K49/14 , A61K49/1806 , A61K49/1896 , C12N2510/00
摘要： The invention is the production of magnetosome-like structures in cells. The invention provides in vitro and in vivo diagnostic and therapeutic methods using eukaryotic cells expressing magnetosome-like structures that act as contrast agents.
摘要翻译：本发明是细胞中磁小体样结构的生产。本发明提供使用表达作为造影剂的磁小体样结构的真核细胞的体外和体内诊断和治疗方法。

4. 发明授权

US09242551B2 Ventilation device for the fuel system of a hybrid vehicle 有权
标题翻译：混合动力汽车燃油系统通风装置
公开(公告)号：US09242551B2
公开(公告)日：2016-01-26
申请号：US14128170
申请日：2012-06-18
申请人： Bjorn Criel , Vincent Cuvelier , David Hill , Jules-Joseph Van Schaftingen
发明人： Bjorn Criel , Vincent Cuvelier , David Hill , Jules-Joseph Van Schaftingen
IPC分类号： F02M33/02 , B60K15/035 , F02M25/08 , B60K15/03
CPC分类号： B60K15/03504 , B60K15/03519 , B60K2015/03276 , B60K2015/03296 , B60K2015/03514 , B60K2015/03571 , B60K2015/03576 , F02M25/089 , Y10S903/902 , Y10T137/86324
摘要： A ventilation device including: a first enclosure including a first passage configured to be connected to a canister outlet and the atmosphere, and a normally closed shutter device configured to open to release the first passage; a second enclosure including a second passage configured to be connected to the canister inlet and a fuel tank, and a normally open shutter device configured to close to shut the second passage, the second passage being separate from and not in communication with the first passage; and a combined pressure/vacuum relief valve or OPR and UPR valve pair situated in or fastened to a bypass of the first passage configured to establish a connection between ends of the first passage when the shutter device is closed and when there is over- or under-pressure in the ends. A fuel system can include the device and a hybrid vehicle can include the fuel system.
摘要翻译：一种通风装置，包括：第一外壳，其包括构造成连接到罐出口和大气的第一通道，以及构造成打开以释放第一通道的常闭阀门装置; 第二壳体，包括构造成连接到所述罐入口的第二通道和燃料箱;以及构造成关闭所述第二通道的常开快门装置，所述第二通道与所述第一通道分离并且不与所述第一通道连通; 以及组合的压力/真空释放阀或OPR和UPR阀对，其位于或紧固到第一通道的旁路，其构造成当快门装置关闭时和当存在过度或过低时建立第一通道的端部之间的连接压在最后。燃料系统可以包括该装置，并且混合动力车辆可以包括燃料系统。

5. 发明申请

US20140110038A1 PROCESS FOR MANUFACTURING A PLASTIC FUEL TANK 有权
标题翻译：制造塑料燃料油罐的工艺
公开(公告)号：US20140110038A1
公开(公告)日：2014-04-24
申请号：US14111076
申请日：2012-04-04
申请人： Bjorn Criel , Vincent Cuvelier , David Hill
发明人： Bjorn Criel , Vincent Cuvelier , David Hill
IPC分类号： B29D22/00
CPC分类号： B29D22/003 , B29C49/04 , B29C51/12 , B29C51/267 , B29C2049/0057 , B29C2049/2008 , B29C2049/2047 , B29C2049/2065 , B29C2049/2078 , B29C2791/001 , B29C2793/0081 , B29C2793/009 , B29K2023/065 , B29K2023/086 , B29K2623/065 , B29K2709/08 , B29L2031/7172 , B60K15/03177
摘要： A process for manufacturing a fuel tank, including: inserting a plastic parison including two distinct parts into an open two-cavity mold; inserting a core inside the parison, the core including two parts of a reinforcing element capable of securing two different locations inside the parison; pressing the parison firmly against the mold cavities; fixing the two reinforcing element parts at the two locations of the parison using the core; withdrawing the core; closing the mold, bringing its two cavities together to grip the two parison parts around their periphery to weld them together; injecting a pressurized fluid into the mold and/or creating a vacuum behind the mold cavities to press the parison firmly against the mold cavities; opening the mold and extracting the tank; making an opening into the tank wall; and through the opening, putting at least a third reinforcing element part to link/connect the two first parts together.
摘要翻译：一种用于制造燃料箱的方法，包括：将包括两个不同部分的塑料型坯插入开放的双腔模具中; 将型芯插入型坯内部，该芯部包括能够固定型坯内部两个不同位置的加强元件的两部分; 将型坯牢固地压在模腔上; 使用芯将两个增强元件部件固定在型坯的两个位置处; 撤回核心; 关闭模具，将其两个腔体一起夹在其周围的两个型坯部分以将它们焊接在一起; 将加压流体注入模具和/或在模腔后面产生真空以将型坯牢固地压靠在模腔上; 打开模具并取出罐; 打开坦克墙; 并且通过开口，至少放置第三加强元件部分以将两个第一部分连接/连接在一起。

6. 发明申请

US20140027958A1 PROCESS FOR MANUFACTURING A FUEL TANK 有权
标题翻译：制造燃油箱的过程
公开(公告)号：US20140027958A1
公开(公告)日：2014-01-30
申请号：US13983067
申请日：2012-01-26
申请人： David Hill , James Edward Thompson , Bjorn Criel
发明人： David Hill , James Edward Thompson , Bjorn Criel
IPC分类号： B29D22/00
CPC分类号： B29D22/003 , B29C49/04 , B29C49/4252 , B29C51/12 , B29C51/267 , B29C2049/2073 , B29C2791/006 , B29C2791/007 , B29C2793/0081 , B29L2031/7172
摘要： A process for manufacturing a plastic fuel tank including at least one component, by molding a parison using a mold including two impressions and a core, the process including: introducing a parison into the mold impressions; introducing a core inside the parison, the core having a moving device including the at least one component closing the mold so that the impressions come into leaktight contact with the core; pressing the parison against the impressions by blowing through the core and/or applying a vacuum behind the impressions; fastening the at least one component on an inner wall of the parison; opening the mold to withdraw the core; and final molding the parison by blow-molding and/or thermoforming; and to enable its fastening to the parison, the component is moved away from the core by the moving device through a combination of a rotational motion and a linear motion.
摘要翻译：一种制造包括至少一个部件的塑料燃料箱的方法，通过使用包括两个印模和芯的模具成型型坯，所述方法包括：将型坯引入模压印模; 在型坯内部引入芯，芯具有移动装置，该移动装置包括至少一个关闭模具的部件，使得印模与芯部密封接触; 通过吹过核心和/或在印象之后施加真空来压制型坯抵抗印象; 将所述至少一个部件紧固在所述型坯的内壁上; 打开模具取出核心; 并通过吹塑和/或热成型最终成型型坯; 并且为了使其能够紧固到型坯，通过旋转运动和线性运动的组合，通过移动装置将部件移动离开芯部。

7. 发明申请

US20130192702A1 PLASTIC FUEL TANK WITH INCREASED DEFORMATION STABILITY 有权
标题翻译：塑料燃料罐具有增加的变形稳定性
公开(公告)号：US20130192702A1
公开(公告)日：2013-08-01
申请号：US13807475
申请日：2011-06-22
申请人： Joseph Douglas Chiasson , Paul Daniel Reuther , David Hill
发明人： Joseph Douglas Chiasson , Paul Daniel Reuther , David Hill
IPC分类号： B60K15/035
CPC分类号： B60K15/035 , B29C49/00 , B29C49/04 , B29C2049/0057 , B29C2791/006 , B29C2791/007 , B29L2031/7172 , B60K15/03177 , B60K15/06 , B60K15/073 , B60K2015/03105 , B60K2015/03111 , B60K2015/03453 , B60K2015/0777 , Y10T29/4998 , Y10T137/86035
摘要： A plastic fuel tank and a process for manufacturing a fuel tank, the fuel tank including an upper wall, a lower wall, and at least one kiss point formed by welding together a multiplicity of contact points of the upper and lower walls and an accessory. Both the upper and lower walls show a concave recess in the kiss point area so that the weld of the kiss point is located in between planes defined by the upper and lower walls respectively; a bottom of the upper concave recess extends substantially beyond the weld of the kiss point, while a bottom of the lower concave recess does not; the accessory is at least partially located under the extension of the bottom of the upper concave recess.
摘要翻译：一种塑料燃料箱和用于制造燃料箱的方法，所述燃料箱包括上壁，下壁和通过将上壁和下壁的多个接触点与附件焊接在一起而形成的至少一个吻点。上壁和下壁都在接触点区域中显示凹凹槽，使得接吻点的焊缝分别位于由上壁和下壁限定的平面之间; 上凹凹槽的底部基本上延伸超过接触点的焊缝，而下凹凹槽的底部不是; 附件至少部分地位于上凹凹槽的底部的延伸部下方。

8. 发明申请

US20110175809A1 Tracking Groups Of Users In Motion Capture System 有权
标题翻译：跟踪运动捕捉系统中的用户组
公开(公告)号：US20110175809A1
公开(公告)日：2011-07-21
申请号：US12688793
申请日：2010-01-15
申请人： Relja Markovic , Stephen G. Latta , Kevin A. Geisner , David Hill , Darren A. Bennett , David C. Haley, JR. , Brian S. Murphy , Shawn C. Wright
发明人： Relja Markovic , Stephen G. Latta , Kevin A. Geisner , David Hill , Darren A. Bennett , David C. Haley, JR. , Brian S. Murphy , Shawn C. Wright
IPC分类号： G06F3/033
CPC分类号： A63F13/424 , A63F13/06 , A63F13/10 , A63F13/213 , A63F13/803 , A63F2300/1093 , A63F2300/6045 , A63F2300/6072 , A63F2300/8017 , A63F2300/8023 , G06F3/017 , G06F3/038
摘要： In a motion capture system, a unitary input is provided to an application based on detected movement and/or location of a group of people. Audio information from the group can also be used as an input. The application can provide real-time feedback to the person or group via a display and audio output. The group can control the movement of an avatar in a virtual space based on the movement of each person in the group, such as in a steering or balancing game. To avoid a discontinuous or confusing output by the application, missing data can be generated for a person who is occluded or partially out of the field of view. A wait time can be set for activating a new person and deactivating a currently-active person. The wait time can be adaptive based on a first detected position or a last detected position of the person.
摘要翻译：在运动捕捉系统中，基于检测到的一组人的移动和/或位置，向应用提供单一输入。组中的音频信息也可以用作输入。应用程序可以通过显示和音频输出向人员或组提供实时反馈。该组可以基于每个人在组中的移动来控制虚拟空间中的化身的移动，诸如在转向或平衡游戏中。为了避免应用程序的不连续或混乱的输出，可以为被遮挡或部分超出视野的人员生成丢失的数据。可以设置等待时间来激活新人员并停用当前活跃的人员。等待时间可以基于人的第一检测位置或最后检测到的位置来适应。

9. 发明申请

US20110094658A1 Method for manufacturing a storage tank 有权
标题翻译：储罐的制造方法
公开(公告)号：US20110094658A1
公开(公告)日：2011-04-28
申请号：US12997368
申请日：2009-06-24
申请人： David Hill , James Edward Thompson
发明人： David Hill , James Edward Thompson
IPC分类号： B29C70/86
CPC分类号： B29C49/04 , B29C53/602 , B29C63/24 , B29C2791/001 , B29L2031/7156 , F17C2205/0305
摘要： Method for manufacturing a storage tank comprising an inner liner, an outer filament winding and a connecting part. The method comprises the steps of: blow molding the inner liner by extruding a parison, pinching the inner liner at least at one extremity to create a pinch and then blowing the parison; providing the connecting part with a slot of appropriate shape and size to receive a part of the pinch; inserting the part of the pinch in the slot so as to secure the inner liner and the connecting part; and applying the outer filament winding around the liner and the connecting part.
摘要翻译：一种储罐的制造方法，其特征在于，包括内衬，外筒丝和连接部。该方法包括以下步骤：通过挤压型坯来吹塑内衬，至少在一个末端夹住内衬，产生夹紧，然后吹出型坯; 为连接部分提供适当形状和尺寸的狭槽，以容纳部分捏合物; 将夹头的一部分插入槽中，以固定内衬和连接部分; 以及将所述外部细丝缠绕在所述衬套和所述连接部件周围。

10. 发明授权

US07926860B2 Adjustable strap with handles for lifting objects safely 有权
标题翻译：带手柄的可调节带子，用于安全地提升物体
公开(公告)号：US07926860B2
公开(公告)日：2011-04-19
申请号：US11895336
申请日：2007-08-24
申请人： Brad Hill , David Hill
发明人： Brad Hill , David Hill
IPC分类号： A45F5/00
CPC分类号： A45F3/14
摘要： A manual lifting apparatus for providing adjustable handles that allow a person to more effectively, efficiently, and safely lift objects. The present invention provides a webbing attached to two ergonomic handles that assists a user in lifting objects. The handles are adjustable to allow a user to adjust the height from which the user must lift the object thus allowing the user to effectively lift an object from the power zone to more effectively and safely lift objects.
摘要翻译：一种用于提供可调节手柄的手动提升装置，其允许人们更有效，高效和安全地提起物体。本发明提供了一种连接到两个人体工程学手柄上的织带，其帮助使用者提起物体。手柄是可调节的，以允许使用者调整用户必须提起物体的高度，从而允许使用者有效地从动力区提升物体以更有效和安全地提升物体。

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