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1. 发明申请

US20190383794A1 POLYMER MICROFILTERS, DEVICES COMPRISING THE SAME, METHODS OF MANUFACTURING THE SAME, AND USES THEREOF 审中-公开
公开(公告)号：US20190383794A1
公开(公告)日：2019-12-19
申请号：US16454937
申请日：2019-06-27
申请人： Creatv MicroTech, Inc.
发明人： Olga Makarova , Cha-Mei Tang , Peixuan Zhu , Shuhong Li , Daniel Adams , Platte T. Amstutz
IPC分类号： G01N33/50 , G01N1/40 , B01L3/00 , B01D39/16 , B01D29/00 , B01L9/00
摘要： A microfilter having a hydrophilic surface and suited for size-based capture and analysis of cells, such as circulating cancer cells, from whole blood and other human fluids is disclosed. The filter material is photo-definable, allowing the formation of precision pores by UV lithography. Exemplary embodiments provide a device that combines a microfilter with 3D nanotopography in culture scaffolds that mimic the 3D in vivo environment to better facilitate growth of captured cells.

2. 发明授权

US10368541B2 Urine preservative reagent for microfiltration 有权
公开(公告)号：US10368541B2
公开(公告)日：2019-08-06
申请号：US14776194
申请日：2014-03-13
申请人： Creatv MicroTech, Inc.
发明人： Peixuan Zhu , Daniel Adams , Cha-Mei Tang
IPC分类号： A01N1/02 , G01N33/493 , G01N33/574
摘要： A preservative reagent for urine is disclosed that increases the stability of cells, such as tumor cells, in urine for a period of several weeks. The preservative reagent comprises polyethylene glycol (PEG), ethanol, paraformaldehyde (PFA), and ethylenediaminetetraacetic acid (EDTA), and optionally pH stabilizing reagents.

3. 发明申请

US20140315295A1 POLYMER MICROFILTERS, DEVICES COMPRISING THE SAME, METHODS OF MANUFACTURING THE SAME, AND USES THEREOF 审中-公开
标题翻译：聚合物微滤膜，包含该聚合物的装置，其制造方法及其用途
公开(公告)号：US20140315295A1
公开(公告)日：2014-10-23
申请号：US14213183
申请日：2014-03-14
申请人： Creatv MicroTech, Inc.
发明人： Olga Makarova , Cha-Mei Tang , Peixuan Zhu , Shuhong Li , Daniel Adams , Platte T. Amstutz
IPC分类号： G01N1/34 , B01D39/16
CPC分类号： G01N1/34 , B01D39/1692 , B01D2239/0421 , G01N33/50
摘要： A microfilter having a hydrophilic surface and suited for size-based capture and analysis of cells, such as circulating cancer cells, from whole blood and other human fluids is disclosed. The filter material is photo-definable, allowing the formation of precision pores by UV lithography. Exemplary embodiments provide a device that combines a microfilter with 3D nanotopography in culture scaffolds that mimic the 3D in vivo environment to better facilitate growth of captured cells.
摘要翻译：公开了一种具有亲水表面并且适合于基于尺寸的捕获和分析来自全血和其它人体液体的细胞例如循环癌细胞的微过滤器。过滤材料是可光限定的，允许通过UV光刻形成精密孔。示例性实施方案提供了一种将微型过滤器与模拟3D体内环境的3D纳米形成相结合的装置，以更好地促进捕获的细胞的生长。

4. 发明申请

US20220074922A1 POLYMER MICROFILTERS, DEVICES COMPRISING THE SAME, METHODS OF MANUFACTURING THE SAME, AND USES THEREOF 有权
公开(公告)号：US20220074922A1
公开(公告)日：2022-03-10
申请号：US17526513
申请日：2021-11-15
申请人： Creatv MicroTech, Inc.
发明人： Olga Makarova , Cha-Mei Tang , Peixuan Zhu , Shuhong Li , Daniel Adams , Platte T. Amstutz
IPC分类号： G01N33/50 , G01N1/40 , B01L3/00 , B01D39/16 , B01D29/00 , B01L9/00 , B01D71/46
摘要： A microfilter having a hydrophilic surface and suited for size-based capture and analysis of cells, such as circulating cancer cells, from whole blood and other human fluids is disclosed. The filter material is photo-definable, allowing the formation of precision pores by UV lithography. Exemplary embodiments provide a device that combines a microfilter with 3D nanotopography in culture scaffolds that mimic the 3D in vivo environment to better facilitate growth of captured cells.

5. 发明授权

US11150245B2 Use of circulating tumor cell mitotic index in cancer stratification and diagnostics 有权
公开(公告)号：US11150245B2
公开(公告)日：2021-10-19
申请号：US15576472
申请日：2016-05-26
申请人： CREATV MICROTECH INC.
发明人： Daniel Adams , Cha-Mei Tang
IPC分类号： G01N33/574 , G01N33/50
摘要： Circulating tumor cells (CTCs) are associated with metastasis of malignant solid tumors in a patient. Presented here is evidence that CTCs exhibit cell cycle phase variability and that there is a strong correlation between the number of CTCs in a mitotic cell cycle phase and the prospects for long term survival of the subject from which the cells were obtained. Also presented herein are methods of determining the mitotic cell cycle phase of CTCs from a patient having cancer and using the information in grading malignant solid tumors and predicting the likelihood of survival of the patient.

6. 发明申请

US20170199194A1 MULTI-PHENOTYPIC SUBTYPING OF BIOLOGICAL SAMPLES USING SEQUENTIAL FLUORESCENT QUENCHING AND RESTAINING 审中-公开
公开(公告)号：US20170199194A1
公开(公告)日：2017-07-13
申请号：US15400962
申请日：2017-01-06
申请人： Creatv MicroTech, Inc.
发明人： Daniel Adams , Cha-Mei Tang
IPC分类号： G01N33/574 , G01N33/50 , G01N33/58
CPC分类号： G01N33/574 , G01N1/30 , G01N33/5091 , G01N33/582
摘要： A simple and accurate method for characterizing biomarkers in a biological sample using multiple rounds of fluorescent staining is described. The method involves the steps of quenching underrivatizing, amine stripping and regaining (QUAS-R) of cells, tissue or any biological sample.

7. 发明授权

US11353459B2 Methods of using PD-L1 expression in treatment decisions for cancer therapy 有权
公开(公告)号：US11353459B2
公开(公告)日：2022-06-07
申请号：US16092998
申请日：2017-04-14
申请人： Creatv MicroTech, Inc.
发明人： Daniel Adams , Cha-Mei Tang
IPC分类号： A61K45/06 , A61P35/00 , G01N33/574 , A61K39/395 , C07K16/28
摘要： Methods of using detection of PD-L1 expression by circulating cancer cells in the screening, monitoring, treatment and diagnosis of cancer in subjects are disclosed. The methods are based on assaying one or more of circulating tumor cells (CTCs), epithelial to mesenchymal transition CTCs (EMTCTCs), cancer associated macrophage-like cells (CAMLs), and cancer associated vascular endothelial cells (CAVEs) isolated from a subject having cancer for PD-L1 expression.

8. 发明授权

US09658207B2 Polymer microfiltration devices, methods of manufacturing the same and the uses of the microfiltration devices 有权
公开(公告)号：US09658207B2
公开(公告)日：2017-05-23
申请号：US14359467
申请日：2012-11-21
申请人： Creatv Microtech, Inc.
发明人： Cha-Mei Tang , Yunqi Zhang
IPC分类号： B01D39/16 , G01N33/50 , B01D29/00 , G01N1/40 , B01L3/00 , B01L9/00
CPC分类号： G01N33/5005 , B01D29/00 , B01D39/16 , B01D39/1692 , B01L3/50 , B01L3/502 , B01L3/5635 , B01L9/00 , B01L2300/0681 , G01N1/4005 , G01N1/4077 , G01N2001/4088 , Y10T29/49826 , Y10T29/49963
摘要： A microfilter comprising a polymer layer formed from epoxy-based photo-definable dry film, and a plurality of apertures each extending through the polymer layer. A microfilter comprising two or more polymer layers formed from epoxy-based photo-definable dry film, and a plurality of apertures or open areas each extending through the polymer layer. A method of forming a microfilter is also disclosed. The method includes providing a first layer of epoxy-based photo-definable dry film disposed on a substrate, exposing the first layer to energy through a mask to form a pattern, defined by the mask, in the first layer of dry film, forming, from the exposed first layer of dry film, a polymer layer having a plurality of apertures extending therethrough, the plurality of apertures having a distribution defined by the pattern, and removing the polymer layer from the substrate. Unique filter holder designs and methods appropriate to hold microfilters to collect the rare cells and allow performing assays in the filter holder are provided. The invention also describes the use of the microfilter and filter holder to collect rare cells from body fluids and perform assays. Rare cells collected on the microfilter in accordance with embodiments of the present invention can be used for medical and biological research applications.

9. 发明授权

US10247725B2 Capture, identification and use of a new biomarker of solid tumors in body fluids 有权
公开(公告)号：US10247725B2
公开(公告)日：2019-04-02
申请号：US14404403
申请日：2013-05-31
申请人： CREATV MICROTECH, INC.
发明人： Daniel Adams , Cha-Mei Tang
IPC分类号： G01N33/50 , G01N33/574
摘要： A new sensitive cell biomarker of solid tumors is identified in blood. This biomarker can be used to determine presence of carcinomas, rapid determination of treatment response, early detection of cancer, early detection of cancer recurrence, and may be used to determine therapy.

10. 发明申请

US20140322743A1 POLYMER MICROFILTRATION DEVICES, METHODS OF MANUFACTURING THE SAME AND THE USES OF THE MICROFILTRATION DEVICES 审中-公开
标题翻译：聚合物微滤装置，其制造方法和微滤装置的用途
公开(公告)号：US20140322743A1
公开(公告)日：2014-10-30
申请号：US14359467
申请日：2012-11-21
申请人： Creatv Microtech, Inc.
发明人： Cha-Mei Tang , Yunqi Zhang
IPC分类号： G01N33/50 , B01D39/16 , B01L3/00 , B01L9/00
CPC分类号： G01N33/5005 , B01D29/00 , B01D39/16 , B01D39/1692 , B01L3/50 , B01L3/502 , B01L3/5635 , B01L9/00 , B01L2300/0681 , G01N1/4005 , G01N1/4077 , G01N2001/4088 , Y10T29/49826 , Y10T29/49963
摘要： A microfilter comprising a polymer layer formed from epoxy-based photo-definable dry film, and a plurality of apertures each extending through the polymer layer. A microfilter comprising two or more polymer layers formed from epoxy-based photo-definable dry film, and a plurality of apertures or open areas each extending through the polymer layer. A method of forming a microfilter is also disclosed. The method includes providing a first layer of epoxy-based photo-definable dry film disposed on a substrate, exposing the first layer to energy through a mask to form a pattern, defined by the mask, in the first layer of dry film, forming, from the exposed first layer of dry film, a polymer layer having a plurality of apertures extending therethrough, the plurality of apertures having a distribution defined by the pattern, and removing the polymer layer from the substrate. Unique filter holder designs and methods appropriate to hold microfilters to collect the rare cells and allow performing assays in the filter holder are provided. The invention also describes the use of the microfilter and filter holder to collect rare cells from body fluids and perform assays. Rare cells collected on the microfilter in accordance with embodiments of the present invention can be used for medical and biological research applications.
摘要翻译：一种包含由环氧基可光定影干膜形成的聚合物层的微过滤器，以及遍及聚合物层的多个孔。一种包含由环氧基可光限制的干膜形成的两个或更多个聚合物层的微过滤器，以及各自延伸穿过聚合物层的多个孔或开口区域。还公开了一种形成微过滤器的方法。该方法包括提供设置在基底上的第一层环氧基光可定义干膜，将第一层暴露于能量通过掩模，以在第一层干膜中形成由掩模限定的图案，从曝光的第一层干膜，具有延伸穿过其中的多个孔的聚合物层，所述多个孔具有由图案限定的分布，以及从基底去除聚合物层。提供了独特的过滤器支架设计和适用于容纳微过滤器以收集稀有细胞并允许在过滤器保持器中进行测定的方法。本发明还描述了微过滤器和过滤器保持器从体液中收集稀有细胞并进行测定的用途。根据本发明的实施方案收集在微过滤器上的稀有细胞可用于医学和生物研究应用。

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