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1. 发明授权

US5962411A Human growth hormone variants and methods of administering same 失效
标题翻译：人类生长激素变体及其施用方法
公开(公告)号：US5962411A
公开(公告)日：1999-10-05
申请号：US710324
申请日：1996-09-16
申请人： Craig A. Rosen , Timothy A. Coleman , Mark D. Adams , Jeannine D. Gocayne
发明人： Craig A. Rosen , Timothy A. Coleman , Mark D. Adams , Jeannine D. Gocayne
IPC分类号： G01N33/53 , A61K31/70 , A61K35/76 , A61K38/00 , A61K38/27 , A61K39/395 , A61K48/00 , A61P3/00 , A61P3/04 , A61P5/00 , A61P13/12 , A61P19/00 , A61P31/00 , A61P31/12 , A61P31/18 , A61P35/00 , A61P43/00 , C07H21/04 , C07K14/61 , C07K16/26 , C12N1/15 , C12N1/19 , C12N1/21 , C12N15/09 , C12N15/18 , C12P21/02 , C12R1/19 , C07K14/00 , A61K38/16
CPC分类号： C07K14/61 , A61K38/00
摘要： There is provided a DNA (or RNA) polynucleotide sequences encoding naturally occurring splice variants of human growth hormone, hGHV-2(88) and hGHV-3(53) as well as analogs and derivatives thereof, which both lack nucleotide sequences normally present in the gene which codes for wild-type hGH. The growth hormone variants of the present invention are of human origin and are useful for diagnostic preventative and therapeutic purposes with respect to certain human diseases. The present invention is also related to a method for producing the human growth hormone variants by recombinant DNA techniques. A method of generating an antibody directed against and therefore inhibiting the activity of wild-type growth hormone is also provided.
摘要翻译：提供了编码人生长激素，hGHV-2（88）和hGHV-3（53）的天然存在的剪接变体的DNA（或RNA）多核苷酸序列以及其类似物和衍生物，其缺乏通常存在于编码野生型hGH的基因。本发明的生长激素变体是人源的，并且对于某些人类疾病的诊断预防和治疗目的是有用的。本发明还涉及通过重组DNA技术生产人生长激素变体的方法。还提供了产生针对并因此抑制野生型生长激素的活性的抗体的方法。

2. 发明授权

US06566328B1 Human growth hormone 失效
标题翻译：人类生长激素
公开(公告)号：US06566328B1
公开(公告)日：2003-05-20
申请号：US09411657
申请日：1999-10-04
申请人： Craig A. Rosen , Timothy A. Coleman , Mark D. Adams , Jeannine D. Gocayne
发明人： Craig A. Rosen , Timothy A. Coleman , Mark D. Adams , Jeannine D. Gocayne
IPC分类号： A01N3718
CPC分类号： C07K14/61 , A61K38/00
摘要： The present invention relates to a method of treatment of patients by administration of human growth hormone. Also disclosed are DNA (or RNA) polynucleotide sequences that encode naturally occurring splice variants of human growth hormone, hGHV-2(88) and hGV-3(53), as well as analogs and derivatives thereof, which both lack nucleotide sequences normally present in the gene which codes for wild-type human growth hormone. The growth hormone variants of the present invention are of human origin and are useful for diagnostic, preventive and therapeutic purposes with respect to certain human diseases. Also disclosed is a method for producing the human growth hormone variants of the present invention by recombinant DNA techniques, as well as a method for generating antibodies directed against (and therefore inhibiting the activity of) wild-type growth hormone.
摘要翻译：本发明涉及通过给予人生长激素治疗患者的方法。还公开了编码人生长激素，hGHV-2（88）和hGV-3（53）的天然存在的剪接变体的DNA（或RNA）多核苷酸序列，以及其类似物和衍生物，其都缺乏通常存在的核苷酸序列在编码野生型人生长激素的基因中。本发明的生长激素变体是人源的，并且对于某些人类疾病的诊断，预防和治疗目的是有用的。还公开了通过重组DNA技术生产本发明的人生长激素变体的方法，以及用于产生针对（因此抑制）野生型生长激素的抗体的方法。

3. 发明授权

US5597709A Human growth hormone splice variants hGHV-2(88) and hGHV-3(53) 失效
标题翻译：人生长激素剪接变体hGHV-2（88）和hGHV-3（53）
公开(公告)号：US5597709A
公开(公告)日：1997-01-28
申请号：US187756
申请日：1994-01-27
申请人： Craig A. Rosen , Timothy A. Coleman , Mark D. Adams , Jeannine D. Gocayne
发明人： Craig A. Rosen , Timothy A. Coleman , Mark D. Adams , Jeannine D. Gocayne
IPC分类号： G01N33/53 , A61K31/70 , A61K35/76 , A61K38/00 , A61K38/27 , A61K39/395 , A61K48/00 , A61P3/00 , A61P3/04 , A61P5/00 , A61P13/12 , A61P19/00 , A61P31/00 , A61P31/12 , A61P31/18 , A61P35/00 , A61P43/00 , C07H21/04 , C07K14/61 , C07K16/26 , C12N1/15 , C12N1/19 , C12N1/21 , C12N15/09 , C12N15/18 , C12P21/02 , C12R1/19 , C07H21/02 , C12N15/63 , C12P21/06
CPC分类号： C07K14/61 , A61K38/00
摘要： There is provided a DNA (or RNA) polynucleotide sequences encoding naturally occurring splice variants of human growth hormone, hGHV-2(88) and hGHV-3(53) as well as analogs and derivatives thereof, which both lack nucleotide sequences normally present in the gene which codes for wild-type hGH. The growth hormone variants of the present invention are of human origin and are useful for diagnostic preventative and therapeutic purposes with respect to certain human diseases. The present invention is also related to a method for producing the human growth hormone variants by recombinant DNA techniques. A method of generating an antibody directed against and therefore inhibiting the activity of wild-type growth hormone is also provided.
摘要翻译：提供了编码人生长激素，hGHV-2（88）和hGHV-3（53）的天然存在的剪接变体的DNA（或RNA）多核苷酸序列以及其类似物和衍生物，其缺乏通常存在于编码野生型hGH的基因。本发明的生长激素变体是人源的，并且对于某些人类疾病的诊断预防和治疗目的是有用的。本发明还涉及通过重组DNA技术生产人生长激素变体的方法。还提供了产生针对并因此抑制野生型生长激素的活性的抗体的方法。

4. 发明授权

US07482326B2 Endothelial-monocyte activating polypeptide III 失效
标题翻译：内皮单核细胞激活多肽III
公开(公告)号：US07482326B2
公开(公告)日：2009-01-27
申请号：US11272757
申请日：2005-11-15
申请人： Timothy A. Coleman , Craig A. Rosen , Henrik S. Olsen
发明人： Timothy A. Coleman , Craig A. Rosen , Henrik S. Olsen
IPC分类号： C07K14/435 , C07K14/475 , C07K14/52 , C07K14/00 , A61K38/16 , A61K38/17 , A61K38/18 , A61K38/19
CPC分类号： C07K14/52
摘要： A human EMAP III polypeptide and DNA (RNA) encoding such polypeptide and a procedure for producing such polypeptide by recombinant techniques is disclosed. Also disclosed are methods for utilizing such polypeptide for preventing and/or treating neoplasia. Diagnostic assays for identifying mutations in nucleic acid sequence encoding a polypeptide of the present invention and for detecting altered levels of the polypeptide of the present invention for detecting diseases, for example, cancer, are also disclosed.
摘要翻译：公开了编码这种多肽的人类EMAP III多肽和DNA（RNA），以及通过重组技术产生此类多肽的方法。还公开了利用这种多肽预防和/或治疗瘤形成的方法。还公开了用于鉴定编码本发明多肽的核酸序列中的突变并用于检测用于检测疾病例如癌症的本发明多肽的改变水平的诊断测定法。

5. 发明授权

US07045301B2 Endothelial-monocyte activating polypeptide III antibodies 失效
标题翻译：内皮单核细胞激活多肽III抗体
公开(公告)号：US07045301B2
公开(公告)日：2006-05-16
申请号：US10910403
申请日：2004-08-04
申请人： Timothy A. Coleman , Craig A. Rosen
发明人： Timothy A. Coleman , Craig A. Rosen
IPC分类号： C07K16/00 , C07K16/18 , C07K16/22 , C07K16/46
CPC分类号： C07K14/52
摘要： A human EMAP III polypeptide and DNA (RNA) encoding such polypeptide and a procedure for producing such polypeptide by recombinant techniques is disclosed. Also disclosed are methods for utilizing such polypeptide for preventing and/or treating neoplasia. Diagnostic assays for identifying mutations in nucleic acid sequence encoding a polypeptide of the present invention and for detecting altered levels of the polypeptide of the present invention for detecting diseases, for example, cancer, are also disclosed.
摘要翻译：公开了编码这种多肽的人类EMAP III多肽和DNA（RNA），以及通过重组技术产生此类多肽的方法。还公开了利用这种多肽预防和/或治疗瘤形成的方法。还公开了用于鉴定编码本发明多肽的核酸序列中的突变并用于检测用于检测疾病例如癌症的本发明多肽的改变水平的诊断测定法。

6. 发明授权

US6013483A DNA encoding endothelial monocyte activating polypeptide III 失效
标题翻译：编码内皮单核细胞活化多肽的DNA III
公开(公告)号：US6013483A
公开(公告)日：2000-01-11
申请号：US483534
申请日：1995-06-07
申请人： Timothy A. Coleman , Craig A. Rosen
发明人： Timothy A. Coleman , Craig A. Rosen
IPC分类号： C07K14/52 , C12P21/02 , C12N15/19 , C12N15/63
CPC分类号： C07K14/52
摘要： A human EMAP III polypeptide and DNA (RNA) encoding such polypeptide and a procedure for producing such polypeptide by recombinant techniques is disclosed. Also disclosed are methods for utilizing such polypeptide for preventing and/or treating neoplasia. Diagnostic assays for identifying mutations in nucleic acid sequence encoding a polypeptide of the present invention and for detecting altered levels of the polypeptide of the present invention for detecting diseases, for example, cancer, are also disclosed.
摘要翻译：公开了编码这种多肽的人类EMAP III多肽和DNA（RNA），以及通过重组技术产生此类多肽的方法。还公开了利用这种多肽预防和/或治疗瘤形成的方法。还公开了用于鉴定编码本发明多肽的核酸序列中的突变并用于检测用于检测疾病例如癌症的本发明多肽的改变水平的诊断测定法。

7. 发明授权

US06864226B1 Endothelial-monocyte activating polypeptide III 失效
公开(公告)号：US06864226B1
公开(公告)日：2005-03-08
申请号：US08972301
申请日：1997-11-18
申请人： Timothy A. Coleman , Craig A. Rosen
发明人： Timothy A. Coleman , Craig A. Rosen
IPC分类号： C07K14/52 , A61K38/16 , C07K14/435
CPC分类号： C07K14/52
摘要： A human EMAP III polypeptide and DNA (RNA) encoding such polypeptide and a procedure for producing such polypeptide by recombinant techniques is disclosed. Also disclosed are methods for utilizing such polypeptide for preventing and/or treating neoplasia. Diagnostic assays for identifying mutations in nucleic acid sequence encoding a polypeptide of the present invention and for detecting altered levels of the polypeptide of the present invention for detecting diseases, for example, cancer, are also disclosed.

8. 发明授权

US06383737B1 Human oxalyl-CoA Decarboxylase 有权
公开(公告)号：US06383737B1
公开(公告)日：2002-05-07
申请号：US09732020
申请日：2000-12-08
申请人： Henrik S. Olsen , Timothy A. Coleman , Mark D. Adams
发明人： Henrik S. Olsen , Timothy A. Coleman , Mark D. Adams
IPC分类号： C12Q1527
摘要： A human oxalyl-CoA decarboxylase polypeptide and DNA(RNA) encoding such polypeptide and a procedure for producing such polypeptide by recombinant techniques and for producing an antibody against such polypeptide are disclosed. Also disclosed is a combination of the polypeptide of the present invention and a suitable pharmaceutical carrier for providing a therapeutically effective amount of the polypeptide for the treatment of urolithiasis and hyperoxaluria. Also disclosed are assays for identifying mutations in nucleic acid sequence encoding a polypeptide of the present invention and for detecting altered levels of the polypeptide of the present invention.

9. 发明授权

US5635616A Human oxalyl-CoA decarboxylase 失效
标题翻译：人类草酰辅酶A脱羧酶
公开(公告)号：US5635616A
公开(公告)日：1997-06-03
申请号：US458120
申请日：1995-06-02
申请人： Henrik S. Olsen , Timothy A. Coleman , Mark D. Adams
发明人： Henrik S. Olsen , Timothy A. Coleman , Mark D. Adams
IPC分类号： A61K38/00 , C12N9/88 , C12Q1/68 , C07H21/02 , C07H21/04 , C12P21/04
CPC分类号： C12N9/88 , C12Q1/6883 , A61K38/00 , C12Q2600/156
摘要： A human oxalyl-CoA decarboxylase polypeptide and DNA(RNA) encoding such polypeptide and a procedure for producing such polypeptide by recombinant techniques and for producing an antibody against such polypeptide are disclosed. Also disclosed is a combination of the polypeptide of the present invention and a suitable pharmaceutical carrier for providing a therapeutically effective amount of the polypeptide for the treatment of urolithiasis and hyperoxaluria. Also disclosed are assays for identifying mutations in nucleic acid sequence encoding a polypeptide of the present invention and for detecting altered levels of the polypeptide of the present invention.
摘要翻译：公开了人草酰-CoA脱羧酶多肽和编码这种多肽的DNA（RNA），以及通过重组技术产生此类多肽的方法和用于产生抗这种多肽的抗体。还公开了本发明的多肽与合适的药物载体的组合，用于提供治疗有效量的多肽用于治疗尿石症和高硫酸尿症。还公开了用于鉴定编码本发明多肽的核酸序列中的突变并检测本发明多肽的改变水平的测定。

10. 发明授权

US06200796B1 Human oxalyl-CoA decarboxylase 有权
标题翻译：人类草酰辅酶A脱羧酶
公开(公告)号：US06200796B1
公开(公告)日：2001-03-13
申请号：US09326217
申请日：1999-06-03
申请人： Henrik S. Olsen , Timothy A. Coleman , Mark D. Adams
发明人： Henrik S. Olsen , Timothy A. Coleman , Mark D. Adams
IPC分类号： C12N988
CPC分类号： C12Q1/6883 , A61K38/00 , C12N9/88
摘要： A human oxalyl-CoA decarboxylase polypeptide and DNA (RNA) encoding such polypeptide and a procedure for producing such polypeptide by recombinant techniques and for producing an antibody against such polypeptide are disclosed. Also disclosed is a combination of the polypeptide of the present invention and a suitable pharmaceutical carrier for providing a therapeutically effective amount of the polypeptide for the treatment of urolithiasis and hyperoxaluria. Also disclosed are assays for identifying mutations in nucleic acid sequence encoding a polypeptide of the present invention and for detecting altered levels of the polypeptide of the present invention.
摘要翻译：公开了人草酰-CoA脱羧酶多肽和编码这种多肽的DNA（RNA），以及通过重组技术产生此类多肽的方法和用于产生抗这种多肽的抗体。还公开了本发明的多肽与合适的药物载体的组合，用于提供治疗有效量的多肽用于治疗尿石症和高硫尿症。还公开了用于鉴定编码本发明多肽的核酸序列中的突变并检测本发明多肽的改变水平的测定。

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