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1. 发明授权

US6027883A Optimal procedure for isolation of mutant mitochondrial alleles 失效
标题翻译：分离突变体线粒体等位基因的最佳方法
公开(公告)号：US6027883A
公开(公告)日：2000-02-22
申请号：US757438
申请日：1996-11-27
申请人： Corinna Herrnstadt , Soumitra Ghosh , Eoin D. Fahy , Robert E. Davis
发明人： Corinna Herrnstadt , Soumitra Ghosh , Eoin D. Fahy , Robert E. Davis
IPC分类号： C12N15/09 , C12Q1/68
CPC分类号： C12Q1/6883 , C12Q1/6806 , C12Q1/6858 , C12Q2600/156 , C12Q2600/16
摘要： A sample preparation procedure for mitochondrial (mt) DNA analysis is described. The present method for isolating mtDNA uses sedimentation techniques for separating erythrocytes from lymphocytes and platelets (crude buffy coat fraction), followed by DNA extraction from the crude buffy coat fraction by boiling in water. This approach improves the yield of mutant DNA, enhancing the sensitivity of subsequent mutation interrogation techniques and allowing for meaningful statistical treatment of the degree of heteroplasmy within the mitochondrial DNA.
摘要翻译：描述了线粒体（mt）DNA分析的样品制备程序。目前用于分离mtDNA的方法使用沉淀技术从淋巴细胞和血小板（粗血沉棕黄层级分离）中分离红细胞，然后通过在水中沸腾从粗血沉棕黄层级分提取DNA。这种方法提高了突变DNA的产量，提高了随后的突变询问技术的敏感性，并允许有意义的统计学处理线粒体DNA内的异质性程度。

2. 发明授权

US5976798A Methods for detecting mitochondrial mutations diagnostic for Alzheimer's disease and methods for determining heteroplasmy of mitochondrial nucleic acid 失效
标题翻译：检测线粒体突变诊断阿尔茨海默病的方法和线粒体核酸异质性检测方法
公开(公告)号：US5976798A
公开(公告)日：1999-11-02
申请号：US810599
申请日：1997-02-28
申请人： William Davis Parker , Corinna Herrnstadt , Soumitra Ghosh , Eoin D. Fahy
发明人： William Davis Parker , Corinna Herrnstadt , Soumitra Ghosh , Eoin D. Fahy
IPC分类号： C12N15/09 , C12Q1/68 , C07H21/04 , C12P19/34
CPC分类号： C12Q1/6883 , C12Q1/6806 , C12Q2600/156 , C12Q2600/16
摘要： The present invention relates to methods of detecting genetic mutations in mitochondrial cytochrome oxidase c genes that segregate with Alzheimer's Disease and methods for determining the amount of heteroplasmy of mitochondrial nucleic acid. The invention provides methods for detecting such mutations, as a diagnostic for Alzheimer's Disease, either before or after the onset of clinical symptoms.
摘要翻译：本发明涉及检测与阿尔茨海默氏病分离的线粒体细胞色素氧化酶c基因中的遗传突变的方法和确定线粒体核酸异质性量的方法。本发明提供了在临床症状发作之前或之后检测这种突变作为阿尔茨海默病诊断的方法。

3. 发明授权

US06268398B1 Compounds and methods for treating mitochondria-associated diseases 失效
标题翻译：用于治疗线粒体相关疾病的化合物和方法
公开(公告)号：US06268398B1
公开(公告)日：2001-07-31
申请号：US09299044
申请日：1999-04-23
申请人： Soumitra Ghosh , Robert E. Davis
发明人： Soumitra Ghosh , Robert E. Davis
IPC分类号： A61K31155
CPC分类号： A61K31/5375 , A61K31/155 , A61K31/196
摘要： Compounds, compositions and methods are disclosed for treating mitochondria-associated diseases, such as cancer, psoriasis, stroke, Alzheimer's Disease and diabetes. The compounds of this invention have structure (I) below, including stereoisomers, prodrugs and pharmaceutically acceptable salts thereof, wherein Ar and L are as defined herein. The methods of this invention are directed to treating a mitochondria-associated disease by administering to a warm-blooded animal in need thereof an effective amount of a compound of structure (I), typically in the form of a pharmaceutical composition.
摘要翻译：公开了用于治疗线粒体相关疾病如癌症，牛皮癣，中风，阿尔茨海默病和糖尿病的化合物，组合物和方法。本发明的化合物具有以下结构（I），包括其立体异构体，前药和药学上可接受的盐，其中Ar和L如本文所定义。本发明的方法涉及通过向有需要的温血动物施用有效量的通常为药物组合物形式的结构（I）的化合物来治疗线粒体相关疾病。

4. 发明授权

US07928060B2 Amylin family polypeptide-6 (AFP-6) analogs and methods of making and using them 失效
标题翻译：胰岛淀粉样多肽多肽-6（AFP-6）类似物及其制备和使用方法
公开(公告)号：US07928060B2
公开(公告)日：2011-04-19
申请号：US11664750
申请日：2005-10-11
申请人： Mary Erickson , Ved Srivastava , Sarah McQuaid , Andrew Young , Richard Pittner , Soumitra Ghosh
发明人： Mary Erickson , Ved Srivastava , Sarah McQuaid , Andrew Young , Richard Pittner , Soumitra Ghosh
IPC分类号： A61K38/22 , C07K14/575
CPC分类号： C07K14/575 , A61K38/00
摘要： The present invention relates to Amylin Family Polypeptide-6 (AFP-6) analogs, which include derivatives and fragments, related nucleic acids, expression constructs, host cells, and processes for recombinant production of the AFP-6 analogs. The AFP-6 analogs of the invention include one or more amino acid sequence modifications. In addition, methods and compositions are disclosed to treat and prevent conditions such as metabolic and cardiovascular disorders, e.g., obesity, diabetes, metabolic syndrome, myocardial ischemia, and increased cardiovascular risk.
摘要翻译：本发明涉及淀粉蛋白家族多肽-6（AFP-6）类似物，其包括衍生物和片段，相关核酸，表达构建体，宿主细胞和用于重组生产AFP-6类似物的方法。本发明的AFP-6类似物包括一个或多个氨基酸序列修饰。此外，公开了治疗和预防诸如代谢和心血管疾病如肥胖症，糖尿病，代谢综合征，心肌缺血和增加的心血管风险的病症的方法和组合物。

5. 发明申请

US20060194825A1 Ligands of adenine nucleotide translocase (ant) and compositions and methods related thereto 审中-公开
标题翻译：腺嘌呤核苷酸转位酶（蚂蚁）的配体及其相关的组合物和方法
公开(公告)号：US20060194825A1
公开(公告)日：2006-08-31
申请号：US10539539
申请日：2003-12-19
申请人： Soumitra Ghosh , Yazhong Pei , Xiao-Qing Tang , Spiros Liras , Michael Ahlijanian
发明人： Soumitra Ghosh , Yazhong Pei , Xiao-Qing Tang , Spiros Liras , Michael Ahlijanian
IPC分类号： A61K31/44 , A61K31/40 , A61K31/277 , A61K31/235 , A61K31/192 , A61K31/195
CPC分类号： C07D263/57 , A61K31/185 , C07C65/24 , C07C65/30 , C07C65/40 , C07C69/94 , C07D277/66 , C07D307/80 , C07D333/16 , C07D333/24 , C07D333/56 , C07D333/60
摘要： Compounds which have utility in the treatment of conditions associated with altered mitochondrial function. The compounds having structure (I), including stereoisomers, prodrugs, and pharmaceutically acceptable salts thereof, wherein R1, R2, R3, R4, R5 and R6 are as defined herein. Pharmaceutical compositions containing a compound of structure (I), as well as methods relating to the use thereof, are also disclosed.
摘要翻译：可用于治疗与改变的线粒体功能相关的病症的化合物。具有结构（I）的化合物，包括立体异构体，前药和药学上可接受的盐，其中R 1，R 2，R 3， R 4，R 5和R 6如本文所定义。还公开了含有结构（I）化合物的药物组合物，以及与其使用有关的方法。

6. 发明申请

US20050148768A1 Cobalt-porphyrin complexes and use thereof as an anti-obesity agent 审中-公开
标题翻译：钴 - 卟啉络合物及其作为抗肥胖剂的用途
公开(公告)号：US20050148768A1
公开(公告)日：2005-07-07
申请号：US10984557
申请日：2004-11-08
申请人： Tomas Szabo , Soumitra Ghosh , Robert Davis
发明人： Tomas Szabo , Soumitra Ghosh , Robert Davis
IPC分类号： A61K31/409 , A61K33/24 , A61P3/04 , C07D487/22 , C07F15/06
CPC分类号： C07D487/22
摘要： Cobalt-porphyrin (Co-P) complexes for use as anti-obesity agents, and compositions and methods related thereto. The Co-P complexes exhibit reduced redox activity compared to cobalt mesoporphyrin (Co-MP) and cobalt protoporphyrin (Co-PP), which alleviates the deleterious effects associated with administration of Co-P associated with oxidative stress, particularly in the context of injection site toxicity.
摘要翻译：用作抗肥胖剂的钴卟啉（Co-P）络合物，以及与其相关的组合物和方法。 Co-P配合物与钴中卟啉（Co-MP）和钴原卟啉（Co-PP）相比显示出降低的氧化还原活性，其减轻了与施用与氧化应激相关的Co-P相关的有害作用，特别是在注射的情况下现场毒性。

7. 发明授权

US5210203A Sulfonamide-derivative compounds for tagging nucleic acid probes 失效
标题翻译：用于标记核酸探针的磺酰胺衍生化合物
公开(公告)号：US5210203A
公开(公告)日：1993-05-11
申请号：US879593
申请日：1992-05-07
申请人： Gary F. Musso , Soumitra Ghosh , Emil T. Kaiser
发明人： Gary F. Musso , Soumitra Ghosh , Emil T. Kaiser
IPC分类号： C07F7/18 , C07H21/00 , C12Q1/68
CPC分类号： C07H21/00 , C07F7/1852 , C07F7/1856 , C12Q1/6816
摘要： Nucleic acid hybridization probes are provided which comprise an N.sup.4 -(substituted amino)cytosine moiety, wherein the substituted amino group comprises a tag moiety, whereby the probe is detected. Methods of preparing probes of the invention, intermediates used in such methods, and methods of using the probes of the invention in hybridization assays are also provided. Typical tag moieties employed with the probes of the invention are biotinyl, aminothiadiazole and fluorescein derivatives, connected to N.sup.4 -amino groups of modified cytosines of the probe through linker moieties. Probes tagged with biotin are typically detected by binding to the biotinyl moieties, through a streptavidin or avidin molecule, a reporter group which includes streptavidin or avidin and then detecting a signal due to the reporter group. Probes tagged with aminothiadiazole derivatives are typically detected by essentially the same method as those tagged with biotinyl but employing as reporter group one which binds to the derivative through a carbonic anhydrase molecule. Probes tagged with fluorescein derivatives are detected by a fluorescence spectroscopic method without binding of a reporter group to the tag.
摘要翻译：提供了包含N4-（取代氨基）胞嘧啶部分的核酸杂交探针，其中取代的氨基包括标签部分，由此检测探针。还提供了制备本发明的探针的方法，在这些方法中使用的中间体以及在杂交测定中使用本发明的探针的方法。与本发明的探针一起使用的典型标签部分是通过接头部分连接到探针的修饰胞嘧啶的N4-氨基的生物素，氨基噻二唑和荧光素衍生物。用生物素标记的探针通常通过结合生物素部分，通过链霉抗生物素蛋白或抗生物素蛋白分子，包括链霉抗生物素蛋白或抗生物素蛋白的报道基团检测，然后检测由于报告基团引起的信号。用氨基噻二唑衍生物标记的探针通常用与生物素标记的那些基本上相同的方法来检测，但采用作为通过碳酸酐酶分子与衍生物结合的报告基团。用荧光素衍生物标记的探针通过荧光光谱法检测，而不将报道基团与标签结合。

8. 发明申请

US20080032981A1 ARYL N-CYANOGUANIDINES AND METHODS RELATED THERETO 审中-公开
标题翻译： ARYL N-烷基甘氨酸及其相关方法
公开(公告)号：US20080032981A1
公开(公告)日：2008-02-07
申请号：US11744532
申请日：2007-05-04
申请人： Soumitra Ghosh , Tomas Szabo
发明人： Soumitra Ghosh , Tomas Szabo
IPC分类号： A61K31/155 , A61K31/16 , A61K31/44 , A61K31/535 , A61K31/537 , A61P19/02 , C07C279/28 , C07D207/46 , C07D213/57 , C07D265/30 , C07D279/00
CPC分类号： A61K31/5375 , A61K31/155 , C07C279/28
摘要： Compounds, compositions and methods treating arthritic disorders such as osteoarthritis or rheumatoid arthritis, and for treating other diseases associated with altered mitochondrial function, such as cancer, psoriasis, stroke, Alzheimer's Disease and diabetes. The compounds of this invention have the following structure (I): including stereoisomers, prodrugs and pharmaceutically acceptable salts thereof, wherein R1-5 are as defined herein. The methods of this invention are directed to administering to a warm-blooded animal in need thereof an effective amount of a compound of structure (I), typically in the form of a pharmaceutical composition.
摘要翻译：治疗关节炎疾病如骨关节炎或类风湿性关节炎的化合物，组合物和方法，以及用于治疗与线粒体功能改变相关的其它疾病，例如癌症，牛皮癣，中风，阿尔茨海默氏病和糖尿病。本发明的化合物具有以下结构（I）：包括其立体异构体，前药和药学上可接受的盐，其中R 1-5如本文所定义。本发明的方法涉及向有需要的温血动物施用有效量的结构式（I）的化合物，通常为药物组合物的形式。

9. 发明申请

US20050064530A1 PRODUCTION OF ADENINE NUCLEOTIDE TRANSLOCATOR (ANT), NOVEL ANT LIGANDS AND SCREENING ASSAYS THEREFOR 失效
公开(公告)号：US20050064530A1
公开(公告)日：2005-03-24
申请号：US09811132
申请日：2001-03-14
申请人： Christen Anderson , Robert Davis , Tomas Szabo , Soumitra Ghosh , Walter Moos , Yazhong Pei
发明人： Christen Anderson , Robert Davis , Tomas Szabo , Soumitra Ghosh , Walter Moos , Yazhong Pei
IPC分类号： G01N33/50 , A61K31/704 , A61K31/7048 , A61K31/7056 , A61K31/7064 , A61K45/00 , A61P3/00 , A61P3/10 , A61P17/06 , A61P25/08 , A61P25/14 , A61P25/16 , A61P25/18 , A61P25/28 , A61P27/16 , A61P35/00 , A61P43/00 , C07H15/256 , C07H15/26 , C07K1/22 , C07K14/47 , C07K19/00 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N15/09 , C12N15/12 , C12N15/62 , C12P21/02 , C12Q1/02 , C12Q1/68 , G01N33/15 , G01N33/53 , G01N33/566 , C12Q1/48 , C07J17/00
CPC分类号： C07K14/47 , C07K2319/00 , C07K2319/07 , C07K2319/21 , C07K2319/23 , C12N15/62 , C12N2799/021
摘要： Compositions and methods are provided for producing adenine nucleotide translocator (ANT) polypeptides and fusion proteins, including the production and use of recombinant expression constructs having a regulated promoter. ANT ligands and compositions and methods for identifying ANT ligands, agents that bind ANT and agents that interact with ANT are also disclosed.

10. 发明授权

US4780405A Carbonic anhydrase inhibitor-tagged nucleic acid probes 失效
标题翻译：碳酸酐酶抑制剂标记的核酸探针
公开(公告)号：US4780405A
公开(公告)日：1988-10-25
申请号：US753176
申请日：1985-07-09
申请人： Emil T. Kaiser , Gary F. Musso , Soumitra Ghosh , Leslie E. Orgel , Geoffrey M. Wahl
发明人： Emil T. Kaiser , Gary F. Musso , Soumitra Ghosh , Leslie E. Orgel , Geoffrey M. Wahl
IPC分类号： G01N33/58 , C07F7/18 , C07H21/00 , C12N15/09 , C12Q1/68 , C12Q1/70 , G01N33/532 , G01N33/535
CPC分类号： G01N33/535 , C07F7/1852 , C07F7/1856 , C07H21/00 , G01N33/532
摘要： Nucleic acid hybridization probes are provided which comprise nucleoside bases or terminal nucleotide phosphates chemically linked to aromatic sulfonamide inhibitors of carbonic anhydrase. Methods of preparing probes of the invention, intermediates used in such methods, and methods of using the probes of the invention in hybridization assays are also provided. A probe of the invention is detected by binding to it a reporter group, such as a homopolymer or heteropolymer of enzymes, which includes a carbonic anhydrase which binds to the inhibitor linked to the probe, and then detecting the bound reporter group, as by production of a fluorescent or colored product in a reaction catalyzed by an enzyme component of the reporter group. Also provided are enzyme immunoassays wherein detection of antibody is by a process which comprises a chemical reaction catalyzed by a carbonic anhydrase.
摘要翻译：提供核酸杂交探针，其包含与碳酸酐酶的芳族磺酰胺抑制剂化学连接的核苷碱基或末端核苷酸磷酸酯。还提供了制备本发明的探针的方法，在这些方法中使用的中间体以及在杂交测定中使用本发明的探针的方法。本发明的探针通过与其结合的报道基团如酶的均聚物或异源聚合物来检测，所述报告基团包括结合与探针连接的抑制剂的碳酸酐酶，然后通过生产检测结合的报道基团的荧光或着色产物在由报道基团的酶组分催化的反应中。还提供了酶免疫测定，其中抗体的检测是通过包含由碳酸酐酶催化的化学反应的方法。

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