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1. 发明授权

US5807826A Semaphorin gene family 失效
公开(公告)号：US5807826A
公开(公告)日：1998-09-15
申请号：US835268
申请日：1997-04-08
申请人： Corey S. Goodman , Alex L. Kolodkin , David Matthes , David R. Bentley , Timothy O'Connor
发明人： Corey S. Goodman , Alex L. Kolodkin , David Matthes , David R. Bentley , Timothy O'Connor
IPC分类号： A01K67/027 , A01K67/033 , A61K38/00 , A61K39/395 , A61P25/00 , A61P31/12 , A61P35/00 , A61P37/00 , C07H21/04 , C07K7/06 , C07K7/08 , C07K14/07 , C07K14/435 , C07K14/47 , C07K14/705 , C07K16/18 , C12N5/10 , C12N15/09 , C12N15/85 , C12P21/02 , C12Q1/00 , C12Q1/68 , C12R1/91 , G01N33/15 , G01N33/50 , G01N33/53 , G01N33/566 , A61K38/04 , A61K38/16
CPC分类号： C12N15/8509 , A01K67/0339 , C07K14/005 , C07K14/4703 , C07K14/705 , A01K2217/05 , A01K2217/075 , A01K2267/01 , A01K2267/03 , A01K2267/0318 , A61K38/00 , C12N2710/24122
摘要： A novel class of proteins, semaphorins, nucleic acids encoding semaphorins, semaphorin peptides, and methods of using semaphorins and semaphorin-encoding nucleic acids are disclosed. Semaphorin peptides and receptor agonists and antagonists provide potent modulators of nerve cell growth and regeneration. The invention provides pharmaceutical compositions, methods for screening chemical libraries for regulators of cell growth/differentiation; semaphorin gene-derived nucleic acids for use in genetic mapping, as probes for related genes, and as diagnostic reagents for genetic neurological disease; specific cellular and animal systems for the development of neurological disease therapy.

2. 发明授权

US5935865A Semaphorin gene family 失效
公开(公告)号：US5935865A
公开(公告)日：1999-08-10
申请号：US60692
申请日：1998-04-15
申请人： Corey S. Goodman , Alex L. Kolodkin , David Matthes , David R. Bentley , Timothy O'Connor
发明人： Corey S. Goodman , Alex L. Kolodkin , David Matthes , David R. Bentley , Timothy O'Connor
IPC分类号： A01K67/027 , A01K67/033 , A61K38/00 , A61K39/395 , A61P25/00 , A61P31/12 , A61P35/00 , A61P37/00 , C07H21/04 , C07K7/06 , C07K7/08 , C07K14/07 , C07K14/435 , C07K14/47 , C07K14/705 , C07K16/18 , C12N5/10 , C12N15/09 , C12N15/85 , C12P21/02 , C12Q1/00 , C12Q1/68 , C12R1/91 , G01N33/15 , G01N33/50 , G01N33/53 , G01N33/566
CPC分类号： C12N15/8509 , A01K67/0339 , C07K14/005 , C07K14/4703 , C07K14/705 , A01K2217/05 , A01K2217/075 , A01K2267/01 , A01K2267/03 , A01K2267/0318 , A61K38/00 , C12N2710/24122
摘要： A novel class of proteins, semaphorins, nucleic acids encoding semaphorins, semaphorin peptides, and methods of using semaphorins and semaphorin-encoding nucleic acids are disclosed. Semaphorin peptides and receptor agonists and antagonists provide potent modulators of nerve cell growth and regeneration. The invention provides pharmaceutical compositions, methods for screening chemical libraries for regulators of cell growth/differentiation; semaphorin gene-derived nucleic acids for use in genetic mapping, as probes for related genes, and as diagnostic reagents for genetic neurological disease; specific cellular and animal systems for the development of neurological disease therapy.

3. 发明授权

US6013781A Semaphorin gene family 失效
公开(公告)号：US6013781A
公开(公告)日：2000-01-11
申请号：US833391
申请日：1997-04-08
申请人： Corey S. Goodman , Alex L. Kolodkin , David Matthes , David R. Bentley , Timothy O'Connor
发明人： Corey S. Goodman , Alex L. Kolodkin , David Matthes , David R. Bentley , Timothy O'Connor
IPC分类号： A01K67/027 , A01K67/033 , A61K38/00 , A61K39/395 , A61P25/00 , A61P31/12 , A61P35/00 , A61P37/00 , C07H21/04 , C07K7/06 , C07K7/08 , C07K14/07 , C07K14/435 , C07K14/47 , C07K14/705 , C07K16/18 , C12N5/10 , C12N15/09 , C12N15/85 , C12P21/02 , C12Q1/00 , C12Q1/68 , C12R1/91 , G01N33/15 , G01N33/50 , G01N33/53 , G01N33/566 , C12N15/11
CPC分类号： C12N15/8509 , A01K67/0339 , C07K14/005 , C07K14/4703 , C07K14/705 , A01K2217/05 , A01K2217/075 , A01K2267/01 , A01K2267/03 , A01K2267/0318 , A61K38/00 , C12N2710/24122
摘要： A novel class of proteins, semaphorins, nucleic acids encoding semaphorins, semaphorin peptides, and methods of using semaphorins and semaphorin-encoding nucleic acids are disclosed. Semaphorin peptides and receptor agonists and antagonists provide potent modulators of nerve cell growth and regeneration. The invention provides pharmaceutical compositions, methods for screening chemical libraries for regulators of cell growth/differentiation; semaphorin gene-derived nucleic acids for use in genetic mapping, as probes for related genes, and as diagnostic reagents for genetic neurological disease; specific cellular and animal systems for the development of neurological disease therapy.

4. 发明授权

US5639856A Semaphorin gene family 失效
标题翻译：信号素基因家族
公开(公告)号：US5639856A
公开(公告)日：1997-06-17
申请号：US121713
申请日：1993-09-13
申请人： Corey S. Goodman , Alex L. Kolodkin , David Matthes , David R. Bentley , Timothy O'Connor
发明人： Corey S. Goodman , Alex L. Kolodkin , David Matthes , David R. Bentley , Timothy O'Connor
IPC分类号： A01K67/027 , A01K67/033 , A61K38/00 , A61K39/395 , A61P25/00 , A61P31/12 , A61P35/00 , A61P37/00 , C07H21/04 , C07K7/06 , C07K7/08 , C07K14/07 , C07K14/435 , C07K14/47 , C07K14/705 , C07K16/18 , C12N5/10 , C12N15/09 , C12N15/85 , C12P21/02 , C12Q1/00 , C12Q1/68 , C12R1/91 , G01N33/15 , G01N33/50 , G01N33/53 , G01N33/566 , A61K38/04 , A61K38/16 , C07K14/005
CPC分类号： C12N15/8509 , A01K67/0339 , C07K14/005 , C07K14/4703 , C07K14/705 , A01K2217/05 , A01K2217/075 , A01K2267/01 , A01K2267/03 , A01K2267/0318 , A61K38/00 , C12N2710/24122
摘要： A novel class of proteins, semaphorins, nucleic acids encoding semaphorins, semaphorin peptides, and methods of using semaphorins and semaphorin-encoding nucleic acids are disclosed. Semaphorin peptides and receptor agonists and antagonists provide potent modulators of nerve cell growth and regeneration. The invention provides pharmaceutical compositions, methods for screening chemical libraries for regulators of cell growth/differentiation; semaphorin gene-derived nucleic acids for use in genetic mapping, as probes for related genes, and as diagnostic reagents for genetic neurological disease; specific cellular and animal systems for the development of neurological disease therapy.
摘要翻译：公开了一类新颖的蛋白质，信号素，编码信号素的核酸，信号素肽，以及使用信号素和信号素编码核酸的方法。信号肽和受体激动剂和拮抗剂提供神经细胞生长和再生的有效调节剂。本发明提供药物组合物，用于筛选细胞生长/分化调节物的化学文库的方法; 用于遗传作图的信号素基因衍生的核酸，作为相关基因的探针，以及作为遗传神经疾病的诊断试剂; 特异性细胞和动物系统用于神经疾病治疗的发展。

5. 发明授权

US07153936B2 Semaphorin gene family 失效
公开(公告)号：US07153936B2
公开(公告)日：2006-12-26
申请号：US10067632
申请日：2002-02-04
申请人： Corey S. Goodman , Alex L. Kolodkin , David Matthes , David R. Bentley , Timothy O'Connor
发明人： Corey S. Goodman , Alex L. Kolodkin , David Matthes , David R. Bentley , Timothy O'Connor
IPC分类号： C07K1/00 , C07K14/00 , A61K38/00
CPC分类号： C12N15/8509 , A01K67/0339 , A01K2217/05 , A01K2217/075 , A01K2267/01 , A01K2267/03 , A01K2267/0318 , A61K38/00 , C07K14/005 , C07K14/4703 , C07K14/705 , C12N2710/24122
摘要： A novel class of proteins, semaphorins, nucleic acids encoding semaphorins, semaphorin peptides, and methods of using semaphorins and semaphorin-encoding nucleic acids are disclosed. Semaphorin peptides and receptor agonists and antagonists provide potent modulators of nerve cell growth and regeneration. The invention provides pharmaceutical compositions, methods for screening chemical libraries for regulators of cell growth/differentiation; semaphorin gene-derived nucleic acids for use in genetic mapping, as probes for related genes, and as diagnostic reagents for genetic neurological disease; specific cellular and animal systems for the development of neurological disease therapy.

6. 发明申请

US20080312158A1 Semaphorin Gene Family 审中-公开
标题翻译：信噪比基因家族
公开(公告)号：US20080312158A1
公开(公告)日：2008-12-18
申请号：US11763394
申请日：2007-06-14
申请人： Corey S. Goodman , Alex L. Kolodkin , David Matthes , David R. Bentley , Timothy O'Connor
发明人： Corey S. Goodman , Alex L. Kolodkin , David Matthes , David R. Bentley , Timothy O'Connor
IPC分类号： A61K38/00 , C07K7/00 , C07K16/18 , C12N15/11 , C12N5/06 , A61P25/00 , A01K67/027 , C12P21/04 , G01N33/566 , C12Q1/68
CPC分类号： C12N15/8509 , A01K67/0339 , A01K2217/05 , A01K2217/075 , A01K2267/01 , A01K2267/03 , A01K2267/0318 , A61K38/00 , C07K14/005 , C07K14/4703 , C07K14/705 , C12N2710/24122
摘要： A novel class of proteins, semaphorins, nucleic acids encoding semaphorins, semaphorin peptides, and methods of using semaphorins and semaphorin-encoding nucleic acids are disclosed. Semaphorin peptides and receptor agonists and antagonists provide potent modulators of nerve cell growth and regeneration. The invention provides pharmaceutical compositions, methods for screening chemical libraries for regulators of cell growth/differentiation; semaphorin gene-derived nucleic acids for use in genetic mapping, as probes for related genes, and as diagnostic reagents for genetic neurological disease; specific cellular and animal systems for the development of neurological disease therapy.
摘要翻译：公开了一类新颖的蛋白质，信号素，编码信号素的核酸，信号素肽，以及使用信号素和信号素编码核酸的方法。信号肽和受体激动剂和拮抗剂提供神经细胞生长和再生的有效调节剂。本发明提供药物组合物，用于筛选细胞生长/分化调节物的化学文库的方法; 用于遗传作图的信号素基因衍生的核酸，作为相关基因的探针，以及作为遗传神经疾病的诊断试剂; 特异性细胞和动物系统用于神经疾病治疗的发展。

7. 发明授权

US06344544B1 Semaphorin-specific antibodies 失效
标题翻译：信号素特异性抗体
公开(公告)号：US06344544B1
公开(公告)日：2002-02-05
申请号：US09060610
申请日：1998-04-15
申请人： Corey S. Goodman , Alex L. Kolodkin , David Matthes , David R. Bentley , Timothy O'Connor
发明人： Corey S. Goodman , Alex L. Kolodkin , David Matthes , David R. Bentley , Timothy O'Connor
IPC分类号： A61K39395
CPC分类号： C12N15/8509 , A01K67/0339 , A01K2217/05 , A01K2217/075 , A01K2267/01 , A01K2267/03 , A01K2267/0318 , A61K38/00 , C07K14/005 , C07K14/4703 , C07K14/705 , C12N2710/24122
摘要： A novel class of proteins, semaphorins, nucleic acids encoding semaphorins, semaphorin peptides, and methods of using semaphorins and semaphorin-encoding nucleic acids are disclosed. Semaphorin peptides and receptor agonists and antagonists provide potent modulators of nerve cell growth and regeneration. The invention provides pharmaceutical compositions, methods for screening chemical libraries for regulators of cell growth/differentiation; semaphorin gene-derived nucleic acids for use in genetic mapping, as probes for related genes, and as diagnostic reagents for genetic neurological disease; specific cellular and animal systems for the development of neurological disease therapy.
摘要翻译：公开了一类新颖的蛋白质，信号素，编码信号素的核酸，信号素肽，以及使用信号素和信号素编码核酸的方法。信号肽和受体激动剂和拮抗剂提供神经细胞生长和再生的有效调节剂。本发明提供药物组合物，用于筛选细胞生长/分化调节物的化学文库的方法; 用于遗传作图的信号素基因衍生的核酸，作为相关基因的探针，以及作为遗传神经疾病的诊断试剂; 特异性细胞和动物系统用于神经疾病治疗的发展。

8. 发明授权

US06428965B1 Screening assays for the interaction of semaphorins and neuropilins 失效
标题翻译： semaphorins和神经丝氨酸相互作用的筛选分析
公开(公告)号：US06428965B1
公开(公告)日：2002-08-06
申请号：US09116473
申请日：1998-07-16
申请人： David D. Ginty , Alex L. Kolodkin
发明人： David D. Ginty , Alex L. Kolodkin
IPC分类号： G01N3353
CPC分类号： G01N33/6896 , G01N33/566 , G01N33/68
摘要： The semaphorin family contains a large number of plylogenetically conserved proteins and includes several members that have been shown to function in repulsive axon guidance. Semaplorin III (Sema III) is a secreted protein that in vitro causes neuronal growth cone collapse and chemorepulsion of neurites, and is required in vivo for correct sensory afferent innervation and other aspects of development. The mechanism of Sema III function, however, is unknown. Here, we report that neuropilin, a type I transmembrane protein, is a Sema III receptor. We also describe the identification of neuropiln-2, a related neuropilin family member, and show that neuropilin and neuropilin-2 are expressed in overlapping, yet distinct, populations of neurons in the rat embryonic nervous system.
摘要翻译：信号素家族含有大量的蛋白质保守蛋白质，包括已被证明在排斥性轴突指导中起作用的几个成员。 Semaplorin III（Sema III）是一种分泌蛋白质，其体外引起神经元生长锥形塌陷和神经突的化学反应，并且在体内需要正确的感觉传入神经支配和其他发展方面。然而，Sema III功能的机制是未知的。在这里，我们报道，I型跨膜蛋白的神经蛋白是Sema III受体。我们还描述了相关的神经系蛋白家族成员神经iln醇2的鉴定，并且显示神经纤维蛋白和神经纤维蛋白-2在大鼠胚胎神经系统中的重叠但不同的神经元群体中表达。

9. 发明申请

US20110256544A1 MOLECULES INTERACTING WITH CASL (MICAL) POLYNUCLEOTIDES, POLYPEPTIDES, AND METHODS OF USING THE SAME 审中-公开
标题翻译：与CASL（MICAL）POLYNUCLEOTIDES，POLYPEPTIDES及其使用方法相互作用的分子
公开(公告)号：US20110256544A1
公开(公告)日：2011-10-20
申请号：US12882975
申请日：2010-09-15
申请人： Alex L. Kolodkin , Jon R. Terman , Tiany Mao , Ronald J. Pasterkamp , Hung-Hsiang Yu
发明人： Alex L. Kolodkin , Jon R. Terman , Tiany Mao , Ronald J. Pasterkamp , Hung-Hsiang Yu
IPC分类号： C12Q1/68 , C07K14/47 , C12N9/96 , C12N1/00 , C12N15/63 , C12N5/10 , C12Q1/26 , C12N9/02 , C07H21/00
CPC分类号： C12N9/0071 , C07K14/47
摘要： The present invention provides MICAL and MICAL-Like polypeptides and polynucleotides. Also provided are methods that for identifying agents that affect axon growth and placement. Furthermore, provided herein are methods for affecting axon growth and placement.
摘要翻译：本发明提供MICAL和MICAL-like多肽和多核苷酸。还提供了用于鉴定影响轴突生长和放置的试剂的方法。此外，本文提供了影响轴突生长和放置的方法。

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