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1. 发明授权

US06398739B1 Device and method for nonclinical monitoring of breathing during sleep, control of CPAP treatment and preventing apnea 失效
标题翻译：睡眠期间非临床监测呼吸的装置和方法，控制CPAP治疗和预防呼吸暂停
公开(公告)号：US06398739B1
公开(公告)日：2002-06-04
申请号：US09365643
申请日：1999-08-02
申请人： Colin E. Sullivan , Christopher Lynch
发明人： Colin E. Sullivan , Christopher Lynch
IPC分类号： A61B508
CPC分类号： A61B5/097 , A61B5/6814 , A61B7/003 , A61F5/56 , A61M16/0051 , A61M16/0069 , A61M16/024 , A61M16/06 , A61M2016/0024 , A61M2016/0036 , A61M2230/04 , A61M2230/10 , A61M2230/18 , A61M2230/205 , A61M2230/432 , A61M2230/60
摘要： Patient may operate a CPAP system to deliver appropriate airway pressure home. A patient's apnea problem can be diagnosed at home without supervision with a CPAP device which delivers a continuously minimum appropriate pressure for substantially the entire period of therapy.
摘要翻译：患者可以操作CPAP系统以在家中提供适当的气道压力。患者的呼吸暂停问题可以在家中进行诊断，而不用CPAP设备进行监督，CPAP设备在大体上整个治疗期间都能持续提供适当的压力。

2. 发明授权

US5522382A Device and method for treating obstructed breathing having a delay/ramp feature 失效
标题翻译：用于治疗具有延迟/斜坡特征的阻塞呼吸的装置和方法
公开(公告)号：US5522382A
公开(公告)日：1996-06-04
申请号：US371083
申请日：1995-01-10
申请人： Colin E. Sullivan , Christopher Lynch
发明人： Colin E. Sullivan , Christopher Lynch
IPC分类号： A61B5/097 , A61B7/00 , A61F5/56 , A61M16/00 , A61M16/06 , A62B7/00 , A61B5/08 , A62B7/04 , F16K31/02
CPC分类号： A61B5/097 , A61B5/6814 , A61B7/003 , A61F5/56 , A61M16/0051 , A61M16/0069 , A61M16/06 , A61M2016/0024 , A61M2016/0036 , A61M2230/04 , A61M2230/10 , A61M2230/18 , A61M2230/205 , A61M2230/432 , A61M2230/60
摘要： An air flow device and a method useful for the treatment of upper airway disordered breathing. The invention provides an airflow device having a means for delivering variable pressure levels of breathable air to a patient's respiratory system with a means for controlling the time during which the delivered pressurized air rises from an initial pressure level to a higher operating pressure level. The device increases the pressure level of gas delivered to the patient over a plurality of breaths taken by the patient. This type of device is useful for treating a wide variety of sleeping and breathing disorders.
摘要翻译：一种气流装置和用于治疗上呼吸道呼吸紊乱的方法。本发明提供了一种气流装置，其具有用于将输送可变压力水平的透气空气传送到患者呼吸系统的装置，该装置具有用于控制输送的加压空气从初始压力水平升高到较高工作压力水平的时间的装置。该装置增加了由患者采取的多次呼吸输送到患者的气体的压力水平。这种类型的装置可用于治疗各种睡眠和呼吸障碍。

3. 发明授权

US06705315B2 Device for monitoring breathing during sleep and ramped control of CPAP treatment 失效
标题翻译：在睡眠期间监测呼吸和CPAP治疗的控制的装置
公开(公告)号：US06705315B2
公开(公告)日：2004-03-16
申请号：US09875326
申请日：2001-06-06
申请人： Colin E. Sullivan , Christopher Lynch
发明人： Colin E. Sullivan , Christopher Lynch
IPC分类号： A61M1600
CPC分类号： A61B5/097 , A61B5/6814 , A61B7/003 , A61F5/56 , A61M16/0051 , A61M16/0069 , A61M16/024 , A61M16/06 , A61M2016/0024 , A61M2016/0036 , A61M2230/04 , A61M2230/10 , A61M2230/18 , A61M2230/205 , A61M2230/432 , A61M2230/60
摘要： A CPAP apparatus including: a variable pressured air source and means to vary the air pressure delivered therefrom; a nose piece for sealed air communication with a patient's respiratory system; an air communication line from the air source to the nose piece; a sound transducer adapted to be in sound communication with the patient's respiratory system; and a feedback system controlling the output pressure of the air source in response to an output from the transducer so as to increase the output air pressure from said air source, in response to detection of sound indicative of snoring, in accordance with a predefined procedure. The sound transducer, in its most general form, comprises a pressure transducer which, in addition to detecting snoring sounds, can detect other respiratory parameters such as the rate of breathing, inhaled air flow volume, and inhaled air flow rate. Output air pressure from air source is increased in response to one or more of these parameters in accordance with a pre-defined procedure.
摘要翻译：一种CPAP设备，包括：可变压力空气源和改变从其传送的空气压力的装置; 用于与患者的呼吸系统进行密封空气通信的鼻片; 从空气源到鼻片的空气通信线; 适于与患者呼吸系统进行声音通信的声音换能器; 以及反馈系统，其响应于来自换能器的输出来控制空气源的输出压力，以响应于根据预定义的过程检测到指示打鼾的声音来增加来自所述空气源的输出空气压力。声音传感器在其最通用的形式中包括一个压力传感器，除了检测打鼾的声音之外，还可以检测其他呼吸参数，例如呼吸速率，吸入空气流量和吸入空气流速。响应于根据预定义过程的这些参数中的一个或多个，来自空气源的输出空气压力增加。

4. 发明授权

US5245995A Device and method for monitoring breathing during sleep, control of CPAP treatment, and preventing of apnea 失效
标题翻译：睡眠期间监测呼吸的装置和方法，CPAP治疗的控制和防止呼吸暂停
公开(公告)号：US5245995A
公开(公告)日：1993-09-21
申请号：US892692
申请日：1992-05-27
申请人： Colin E. Sullivan , Christopher Lynch
发明人： Colin E. Sullivan , Christopher Lynch
IPC分类号： A61B5/097 , A61B7/00 , A61F5/56 , A61M16/00 , A61M16/06 , A62B7/00
CPC分类号： A61B5/097 , A61B5/6814 , A61B7/003 , A61F5/56 , A61M16/0051 , A61M16/0069 , A61M16/06 , A61M2016/0024 , A61M2016/0036 , A61M2230/04 , A61M2230/10 , A61M2230/18 , A61M2230/205 , A61M2230/432 , A61M2230/60
摘要： A CPAP apparatus including: a variable pressured air source and means to vary the air pressure delivered therefrom; a nose piece for sealed air communication with a patient's respiratory system; an air communication line from the air source to the nose piece; a sound transducer adapted to be in sound communication with the patient's respiratory system; and a feedback system controlling the output pressure of the air source in response to an output from the transducer so as to increase the output air pressure from said air source, in response to detection of sound indicative of snoring, in accordance with a predefined procedure. The sound transducer, in its most general form, comprises a pressure transducer which, in addition to detecting snoring sounds, can detect other respiratory parameters such as the rate of breathing, inhaled air flow volume, and inhaled air flow rate. Output air pressure from air source is increased in response to one or more of these parameters in accordance with a pre-defined procedure.
摘要翻译：一种CPAP设备，包括：可变压力空气源和改变从其传送的空气压力的装置; 用于与患者的呼吸系统进行密封空气通信的鼻片; 从空气源到鼻片的空气通信线; 适于与患者呼吸系统进行声音通信的声音换能器; 以及反馈系统，其响应于来自换能器的输出控制空气源的输出压力，以响应于根据预定义的过程检测到指示打鼾的声音，来增加来自所述空气源的输出空气压力。声音传感器在其最通用的形式中包括压力传感器，除了检测打鼾音之外，还可以检测呼吸参数，例如呼吸速率，吸入空气流量和吸入空气流速。响应于根据预定义过程的这些参数中的一个或多个，来自空气源的输出空气压力增加。

5. 发明授权

US5199424A Device for monitoring breathing during sleep and control of CPAP treatment that is patient controlled 失效
标题翻译：睡眠期间呼吸监测和患者控制的CPAP治疗控制装置
公开(公告)号：US5199424A
公开(公告)日：1993-04-06
申请号：US806157
申请日：1991-12-12
申请人： Colin E. Sullivan , Christopher Lynch
发明人： Colin E. Sullivan , Christopher Lynch
IPC分类号： A61B5/097 , A61B7/00 , A61F5/56 , A61M16/00 , A61M16/06 , A62B7/00
CPC分类号： A61B5/097 , A61B5/6814 , A61B7/003 , A61F5/56 , A61M16/0051 , A61M16/0069 , A61M16/06 , A61M2016/0024 , A61M2016/0036 , A61M2230/04 , A61M2230/10 , A61M2230/18 , A61M2230/205 , A61M2230/432 , A61M2230/60
摘要： A CPAP apparatus including: a variable pressured air source and means to vary the air pressure delivered therefrom; a nose piece for sealed air communication with a patient's respiratory system; an air communication line from the air source to the nose piece; a sound transducer adapted to be in sound communication with the patient's respiratory system; and a feedback system controlling the output pressure of the air source in response to an output from the transducer so as to increase the output air pressure from said air source, in response to detection of sound indicative of snoring, in accordance with a predefined procedure. The sound transducer, in its most general form, comprises a pressure transducer which, in addition to detecting snoring sounds, can detect other respiratory parameters such as the rate of breathing, inhaled air flow volume, and inhaled air flow rate. Output air pressure from air source is increased in response to one or more of these parameters in accordance with a pre-defined procedure.
摘要翻译：一种CPAP设备，包括：可变压力空气源和改变从其传送的空气压力的装置; 用于与患者的呼吸系统进行密封空气通信的鼻片; 从空气源到鼻片的空气通信线; 适于与患者呼吸系统进行声音通信的声音换能器; 以及响应于来自换能器的输出控制空气源的输出压力的反馈系统，以响应于根据预定义的过程检测到指示打鼾的声音，来增加来自所述空气源的输出空气压力。声音传感器在其最通用的形式中包括压力传感器，除了检测打鼾音之外，还可以检测呼吸参数，例如呼吸速率，吸入空气流量和吸入空气流速。响应于根据预定义过程的这些参数中的一个或多个，来自空气源的输出空气压力增加。

7. 发明申请

US20070051371A1 METHOD AND APPARATUS USEFUL IN THE DIAGNOSIS OF OBSTRUCTIVE SLEEP APNEA OF A PATIENT 审中-公开
标题翻译：患者阻塞性睡眠障碍诊断中使用的方法和装置
公开(公告)号：US20070051371A1
公开(公告)日：2007-03-08
申请号：US11554378
申请日：2006-10-30
申请人： Colin SULLIVAN , Christopher Lynch
发明人： Colin SULLIVAN , Christopher Lynch
IPC分类号： A62B18/08 , A61B5/08
CPC分类号： A61B5/097 , A61B5/6814 , A61B7/003 , A61F5/56 , A61M16/0051 , A61M16/0069 , A61M16/024 , A61M16/06 , A61M2016/0024 , A61M2016/0036 , A61M2230/04 , A61M2230/10 , A61M2230/18 , A61M2230/205 , A61M2230/432 , A61M2230/60
摘要： Patients may operate a CPAP system to deliver appropriate airway pressure at their home. A patient's apnea problem can be diagnosed at home without supervision with a CPAP device which delivers a continuously minimum appropriate pressure for substantially the entire period of therapy.
摘要翻译：患者可以运用CPAP系统在家中提供适当的气道压力。患者的呼吸暂停问题可以在家中进行诊断，而不用CPAP设备进行监督，CPAP设备在大体上整个治疗期间都能持续提供适当的压力。

8. 发明申请

US20070043014A1 3,5-Aryl, heteroaryl or cycloalkyl substituted-1,2,4-oxadiazoles as s1p receptor agonists 审中-公开
标题翻译： 3,5-芳基，杂芳基或环烷基取代的-1,2,4-恶二唑作为s1p受体激动剂
公开(公告)号：US20070043014A1
公开(公告)日：2007-02-22
申请号：US10571334
申请日：2004-09-27
申请人： George Doherty , Jeffrey Hale , Irene Legiec , Christopher Lynch , Leslie Toth
发明人： George Doherty , Jeffrey Hale , Irene Legiec , Christopher Lynch , Leslie Toth
IPC分类号： A61K31/506 , A61K31/501 , A61K31/497 , A61K31/4709 , A61K31/4745 , A61K31/4439 , A61K31/4245 , C07D413/04
CPC分类号： C07D413/04 , C07D271/06
摘要： The present invention encompasses compounds of Formula I: (I) as well as the pharmaceutically acceptable salts thereof. The compounds are useful for treating immune mediated diseases and conditions, such as bone marrow, organ and tissue transplant rejection. Pharmaceutical compositions and methods of use are included.
摘要翻译：本发明包括式I化合物：（I）及其药学上可接受的盐。该化合物可用于治疗免疫介导的疾病和病症，例如骨髓，器官和组织移植排斥反应。包括药物组合物和使用方法。

9. 发明授权

US06770037B2 Method and apparatus useful in the diagnosis of obstructive sleep apnea of a patient 失效
标题翻译：用于诊断患者阻塞性睡眠呼吸暂停的方法和装置
公开(公告)号：US06770037B2
公开(公告)日：2004-08-03
申请号：US10086444
申请日：2002-03-04
申请人： Colin Edward Sullivan , Christopher Lynch
发明人： Colin Edward Sullivan , Christopher Lynch
IPC分类号： A21B508
CPC分类号： A61B5/097 , A61B5/6814 , A61B7/003 , A61F5/56 , A61M16/0051 , A61M16/0069 , A61M16/024 , A61M16/06 , A61M2016/0024 , A61M2016/0036 , A61M2230/04 , A61M2230/10 , A61M2230/18 , A61M2230/205 , A61M2230/432 , A61M2230/60
摘要： Patients may operate a CPAP system to deliver appropriate airway pressure at their home. A patient's apnea problem ca be diagnosed at home without supervision with a CPAP device which delivers a continuously minimum appropriate pressure for substantially the entire period of therapy.
摘要翻译：患者可以运用CPAP系统在家中提供适当的气道压力。患者的呼吸暂停问题可以在家中进行诊断，无需监护，CPAP装置可在整个治疗期间持续提供最低限度的适当压力。

10. 发明申请

US20080064695A1 PYRROLE DERIVATIVES AND THEIR METHODS OF USE 有权
标题翻译：吡咯衍生物及其使用方法
公开(公告)号：US20080064695A1
公开(公告)日：2008-03-13
申请号：US11769395
申请日：2007-06-27
申请人： Ramin Faghih , Gregory Gfesser , Christopher Lynch , Murali Gopalakrishnan , Sujatha Gopalakrishnan , John Malysz , Earl Gubbins , Rachid El Kouhen , Jinhe Li
发明人： Ramin Faghih , Gregory Gfesser , Christopher Lynch , Murali Gopalakrishnan , Sujatha Gopalakrishnan , John Malysz , Earl Gubbins , Rachid El Kouhen , Jinhe Li
IPC分类号： A61K31/4025 , A61K31/40 , A61K31/404 , A61K31/4439 , A61K31/454 , A61K31/496 , A61K31/5377 , A61P25/00 , A61P29/00 , A61P9/00 , C07D207/00 , C07D401/02 , C07D403/02 , C07D405/02 , C07D409/02 , C07D413/02 , C12Q1/02 , C12Q1/48
CPC分类号： C07D207/34 , C07D401/10 , C07D403/10 , C07D405/10 , C07D409/10
摘要： The invention relates to a series of substituted pyrrole derivatives, compositions comprising the same, and methods of treating conditions and disorders using such compounds and compositions.
摘要翻译：本发明涉及一系列取代的吡咯衍生物，包含其的组合物，以及使用这些化合物和组合物治疗病症和病症的方法。

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