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1. 发明授权

US07052251B2 Shape memory alloy wire driven positive displacement micropump with pulsatile output 有权
公开(公告)号：US07052251B2
公开(公告)日：2006-05-30
申请号：US10127094
申请日：2002-04-22
申请人： Clyde K. Nason , William H. Stutz, Jr. , Darren Y. Yap
发明人： Clyde K. Nason , William H. Stutz, Jr. , Darren Y. Yap
IPC分类号： F04B35/00
CPC分类号： F04B19/006 , A61M5/14216 , A61M5/14244 , A61M5/14248 , A61M2005/14268 , A61M2205/0266 , F04B17/00 , F05C2251/08
摘要： Apparatuses and methods for pumping fluid are disclosed. An exemplary apparatus is a miniature pump that includes a shape memory wire that obtains a plastic condition below a transformation temperature and has a memorized shape such that the shape memory wire produces a work stroke by returning to the memorize shape at least at the transformation temperature. A spring biased against the shape memory wire is deflected by the work stroke to deform the shape memory wire from the memorized shape below the transformation temperature. A fluid pump is coupled to the shape memory wire and driven by the biased spring and shape memory wire to produce a fluid flow. The miniature pump can be incorporated into a self-contained infusion device in the form of a compact self-adhesive patch including a fluid reservoir, control electronics and power supply that is place directly at the infusion site of a user.

2. 发明授权

US08574215B2 Shape memory alloy wire driven positive displacement micropump with pulsatile output 有权
公开(公告)号：US08574215B2
公开(公告)日：2013-11-05
申请号：US11726330
申请日：2007-03-21
申请人： Clyde K. Nason , William H. Stutz, Jr.
发明人： Clyde K. Nason , William H. Stutz, Jr.
IPC分类号： A61M31/00 , A61M37/00
CPC分类号： F04B19/006 , A61M5/14216 , A61M5/14244 , A61M5/14248 , A61M2005/14268 , A61M2205/0266 , F04B17/00 , F05C2251/08
摘要： Apparatuses and methods for pumping fluid are disclosed. An exemplary apparatus is a miniature pump that includes a shape memory wire that obtains a plastic condition below a transformation temperature and has a memorized shape such that the shape memory wire produces a work stroke by returning to the memorize shape at least at the transformation temperature. A spring biased against the shape memory wire is deflected by the work stroke to deform the shape memory wire from the memorized shape below the transformation temperature. A fluid pump is coupled to the shape memory wire and driven by the biased spring and shape memory wire to produce a fluid flow. The miniature pump can be incorporated into a self-contained infusion device in the form of a compact self-adhesive patch including a fluid reservoir, control electronics and power supply that is place directly at the infusion site of a user.

3. 发明授权

US07226278B2 Shape memory alloy wire driven positive displacement micropump with pulsatile output 有权
标题翻译：形状记忆合金丝驱动的正位移微型泵具有脉动输出
公开(公告)号：US07226278B2
公开(公告)日：2007-06-05
申请号：US11230142
申请日：2005-09-19
申请人： Clyde K. Nason , William H. Stutz, Jr.
发明人： Clyde K. Nason , William H. Stutz, Jr.
IPC分类号： F04B17/00 , F04B35/00 , F04B49/06
CPC分类号： F04B19/006 , A61M5/14216 , A61M5/14244 , A61M5/14248 , A61M2005/14268 , A61M2205/0266 , F04B17/00 , F05C2251/08
摘要： Apparatuses and methods for pumping fluid are disclosed. An exemplary apparatus is a miniature pump that includes a shape memory wire that obtains a plastic condition below a transformation temperature and has a memorized shape such that the shape memory wire produces a work stroke by returning to the memorize shape at least at the transformation temperature. A spring biased against the shape memory wire is deflected by the work stroke to deform the shape memory wire from the memorized shape below the transformation temperature. A fluid pump is coupled to the shape memory wire and driven by the biased spring and shape memory wire to produce a fluid flow. The miniature pump can be incorporated into a self-contained infusion device in the form of a compact self-adhesive patch including a fluid reservoir, control electronics and power supply that is place directly at the infusion site of a user.
摘要翻译：公开了用于泵送流体的装置和方法。示例性装置是一种微型泵，其包括形状记忆线，该形状记忆线获得低于相变温度的塑性状态，并且具有记忆形状，使得形状记忆线至少在相变温度下返回至记忆形状而产生工作行程。偏压在形状记忆线上的弹簧被工作冲程偏转，使形状记忆线从存储的形状变形到转变温度以下。流体泵联接到形状记忆线并由偏置的弹簧和形状记忆线驱动以产生流体流。微型泵可以以紧凑的自粘贴片的形式并入独立的输注装置，其包括流体储存器，控制电子器件和直接位于使用者的输注部位处的电源。

4. 发明授权

US06752787B1 Cost-sensitive application infusion device 有权
标题翻译：成本敏感的应用输液装置
公开(公告)号：US06752787B1
公开(公告)日：2004-06-22
申请号：US09533578
申请日：2000-03-23
申请人： James D. Causey, III , William H. Stutz, Jr. , Clyde K. Nason , Sheldon B. Moberg , Jay Yonemoto
发明人： James D. Causey, III , William H. Stutz, Jr. , Clyde K. Nason , Sheldon B. Moberg , Jay Yonemoto
IPC分类号： A61M3700
CPC分类号： A61M5/14566 , A61M5/172 , A61M2205/0266 , A61M2205/6018 , G06F19/00
摘要： A reusable external infusion device infuses a fluid into an individual's body. The infusion device controls the rate that fluid flows from a reservoir inside a housing, through an external tube, and into the individual's body. Essentially, the infused fluid is insulin. However, many other fluids may be administered through infusion such as, HIV drugs, drugs to treat pulmonary hypertension, iron chelation drugs, pain medications, anti-cancer treatments, vitamins, hormones, and others.
摘要翻译：可重复使用的外部输液装置将流体注入个体的身体。输注装置控制流体从壳体内的储存器通过外部管流入个体的速度。基本上，输注的液体是胰岛素。然而，许多其它流体可以通过输注来施用，例如HIV药物，用于治疗肺动脉高压的药物，铁螯合药物，止痛药物，抗癌治疗剂，维生素，激素等。

5. 发明授权

US5951595A Setscrewless connector assembly for implantable medical devices 失效
标题翻译：用于可植入医疗设备的无螺丝连接器组件
公开(公告)号：US5951595A
公开(公告)日：1999-09-14
申请号：US852161
申请日：1997-05-06
申请人： Sheldon B. Moberg , Buehl E. Truex , Alfred D. Acken, deceased , Clyde K. Nason , William H. Stutz, Jr. , Edward Gene Rourke
发明人： Sheldon B. Moberg , Buehl E. Truex , Alfred D. Acken, deceased , Clyde K. Nason , William H. Stutz, Jr. , Edward Gene Rourke
IPC分类号： A61N1/375 , H01R13/52 , H01R24/58 , H01R17/18
CPC分类号： H01R13/5224 , A61N1/3752 , H01R24/58 , H01R2107/00 , H01R2201/12 , Y10S439/909
摘要： A connector assembly mounted on an implantable cardiac stimulation device has an actuator mechanism for fixing and sealing electrical leads inserted into lead receptacles within the connector assembly without the use of setscrews. Fixing and sealing of the leads is accomplished by compressing resilient lead lock seals of O-ring shape, disposed in annular recesses, with lip portions of a plunger drawn toward the molded support by the actuator mechanism. In a first embodiment of the actuator mechanism, rotation of a cam actuator transversely journaled within the support, using a torque wrench or similar tool, moves a cam slide attached to the plunger through a fixed displacement between lock and unlock positions as an offset camming portion of the actuator engages the surfaces of a slot within the cam slide. In a second embodiment, constant-force compression of the lead lock seals by the plunger is provided by using a torque wrench to rotate a screw actuator having one end coupled to the plunger and an opposite threaded end received within a screw block transversely disposed within the support. In a third embodiment, a rotatable toothed pinion engages a toothed slot within a slidable rack to provide incremental advancement of the rack, and thereby stepped displacement and force, with a resulting increased resolution. In a fourth embodiment, compliance provided by either a spring formed within the cam slide, or a spring nut mounted thereon, prevents excessive force from being exerted on leads of larger diameter.
摘要翻译：安装在可植入心脏刺激装置上的连接器组件具有致动器机构，用于固定和密封插入到连接器组件内的引线插座中的电引线，而不使用固定螺丝。引线的固定和密封是通过压缩环形形状的弹性引线锁定密封件来实现的，该密封件设置在环形凹槽中，其中柱塞的唇部通过致动器机构朝模制支撑件拉出。在致动器机构的第一实施例中，使用扭矩扳手或类似工具横向安装在支撑件内的凸轮致动器的旋转使附接到柱塞的凸轮滑块在锁定和解锁位置之间通过固定位移移动，作为偏移凸轮部分执行机构接合凸轮滑块内的槽的表面。在第二实施例中，通过使用扭矩扳手来旋转具有联接到柱塞的一端的螺钉致动器以及容纳在横向设置在所述柱塞内的螺纹块内的相对的螺纹端，由柱塞提供引线锁定密封件的恒定力压缩支持。在第三实施例中，可旋转的齿形小齿轮与可滑动齿条内的齿槽接合，以提供齿条的增量前进，并由此产生阶梯式的位移和力，从而产生增加的分辨率。在第四实施例中，由形成在凸轮滑块内的弹簧或安装在其上的弹簧螺母提供的顺应性防止过大的力施加在较大直径的引线上。

6. 发明申请

US20100160861A1 Control Tabs for Infusion Devices and Methods of Using the Same 有权
标题翻译：输液设备的控制选项卡及其使用方法
公开(公告)号：US20100160861A1
公开(公告)日：2010-06-24
申请号：US12689887
申请日：2010-01-19
申请人： James D. Causey, III , William H. Stutz, Jr. , Clyde K. Nason , Sheldon B. Moberg , Jay Yonemoto , Richard E. Purvis , Cary Talbot
发明人： James D. Causey, III , William H. Stutz, Jr. , Clyde K. Nason , Sheldon B. Moberg , Jay Yonemoto , Richard E. Purvis , Cary Talbot
IPC分类号： A61M5/14
CPC分类号： A61M5/14566 , A61M5/1456 , A61M5/172 , A61M2205/0266 , A61M2205/3331 , A61M2205/50 , A61M2205/6018
摘要： An external infusion device that infuses a fluid into an individual's body includes a housing, a reservoir, a drive system, a power supply, electrical elements, and a tab. The reservoir contains the fluid, and the drive system forces the fluid from the reservoir. The electrical elements control the power to the drive system to regulate the rate that fluid is forced from the reservoir. The tab mates with the housing, and contains at least one electrical element. The tab is removable, and may be replaced with a different tab. The different tab may change the rate fluid is forced from the reservoir. A tab may be removed from one external infusion device and installed in a different external infusion device. The tab may be limited to use in a predetermined number of external infusion devices and may include a power supply.
摘要翻译：将流体注入个体的外部输注装置包括壳体，储存器，驱动系统，电源，电气元件和突片。储存器包含流体，并且驱动系统迫使来自储存器的流体。电气元件控制驱动系统的功率，以调节流体从储存器被迫的速率。该卡舌与外壳配合，并且至少包含一个电气元件。标签是可移动的，可以用不同的标签替换。不同的标签可能会改变流体从储存器被迫的速率。可以从一个外部输注装置移除翼片并将其安装在不同的外部输注装置中。可以将突片限制为在预定数量的外部输注装置中使用，并且可以包括电源。

7. 发明授权

US08613726B2 Control tabs for infusion devices and methods of using the same 有权
标题翻译：输液装置的控制标签及其使用方法
公开(公告)号：US08613726B2
公开(公告)日：2013-12-24
申请号：US12689887
申请日：2010-01-19
申请人： James D. Causey, III , William H. Stutz, Jr. , Clyde K. Nason , Sheldon B. Moberg , Jay Yonemoto , Richard E. Purvis , Cary Talbot
发明人： James D. Causey, III , William H. Stutz, Jr. , Clyde K. Nason , Sheldon B. Moberg , Jay Yonemoto , Richard E. Purvis , Cary Talbot
IPC分类号： A61M37/00
CPC分类号： A61M5/14566 , A61M5/1456 , A61M5/172 , A61M2205/0266 , A61M2205/3331 , A61M2205/50 , A61M2205/6018
摘要： An external infusion device that infuses a fluid into an individual's body includes a housing, a reservoir, a drive system, a power supply, electrical elements, and a tab. The reservoir contains the fluid, and the drive system forces the fluid from the reservoir. The electrical elements control the power to the drive system to regulate the rate that fluid is forced from the reservoir. The tab mates with the housing, and contains at least one electrical element. The tab is removable, and may be replaced with a different tab. The different tab may change the rate fluid is forced from the reservoir. A tab may be removed from one external infusion device and installed in a different external infusion device. The tab may be limited to use in a predetermined number of external infusion devices and may include a power supply.
摘要翻译：将流体注入个体的外部输注装置包括壳体，储存器，驱动系统，电源，电气元件和突片。储存器包含流体，并且驱动系统迫使来自储存器的流体。电气元件控制驱动系统的功率，以调节流体从储存器被迫的速率。该卡舌与外壳配合，并且至少包含一个电气元件。标签是可移动的，可以用不同的标签替换。不同的标签可能会改变流体从储存器被迫的速率。可以从一个外部输注装置移除翼片并将其安装在不同的外部输注装置中。可以将突片限制为在预定数量的外部输注装置中使用，并且可以包括电源。

8. 发明授权

US5873899A Implantable medical device having compliant support for internal components 失效
标题翻译：可植入医疗器械具有内部部件的兼容支撑
公开(公告)号：US5873899A
公开(公告)日：1999-02-23
申请号：US586527
申请日：1996-01-16
申请人： William H. Stutz, Jr. , Clyde K. Nason
发明人： William H. Stutz, Jr. , Clyde K. Nason
IPC分类号： A61N1/375
CPC分类号： A61N1/375 , A61N1/3758
摘要： An implantable medical device, in the form of a cardiac defibrillator, has a support structure of molded thermoplastic foam surrounding the components of the device within a case to provide the components with shock and vibration resistance. The thermoplastic foam is produced by a process using dry nitrogen blowing, so as to be chemically inert. This prevents harmful outgassing of chemicals from the foam. The thermoplastic foam is a low density, crosslinked foam of polyethylene or polypropylene composition. The support structure includes an opposite pair of supports molded from the thermoplastic foam, so as to have facing portions configured to the irregular shape and size of the components. Each support is made by preheating an opposing pair of dies and a thermoplastic foam element, compressing the preheated foam element between the opposing dies, and heating for a predetermined time at a predetermined temperature, cooling the dies, and then removing the formed support from the dies.
摘要翻译：心脏除颤器形式的可植入医疗装置具有模制的热塑性泡沫的支撑结构，其围绕壳体内的装置的部件，以使组件具有抗冲击和抗振动性。热塑性泡沫是通过使用干燥氮吹的方法制备的，以便是化学惰性的。这可以防止泡沫中有害的化学物质脱气。热塑性泡沫是聚乙烯或聚丙烯组合物的低密度交联泡沫体。支撑结构包括由热塑性泡沫模制的相对的一对支撑件，以便具有构造成部件的不规则形状和尺寸的面对部分。每个支撑件通过预热相对的一对模具和热塑性泡沫元件，在相对的模具之间压缩预热的泡沫元件，并在预定温度下加热预定时间，冷却模具，然后从形成的支撑件死了

9. 发明授权

US5741313A Implantable medical device with a reduced volumetric configuration and improved shock stabilization 失效
标题翻译：植入式医疗器械具有减小的体积结构和改善的震动稳定性
公开(公告)号：US5741313A
公开(公告)日：1998-04-21
申请号：US711012
申请日：1996-09-09
申请人： Dion Frank Davis , Buehl E. Truex , Clyde K. Nason , William H. Stutz, Jr.
发明人： Dion Frank Davis , Buehl E. Truex , Clyde K. Nason , William H. Stutz, Jr.
IPC分类号： A61N1/375
CPC分类号： A61N1/375 , A61N1/3758
摘要： A cardiac stimulation device having a reduced volumetric configuration contains a pair of high-voltage cylindrical discharge capacitors positioned at rounded edges within a device container. The capacitors have electrical contact tabs at one end which are inserted directly through apertures formed within an associated electronic module. The capacitor tabs are connected directly to the electronic module eliminating the need for secondary connectors or point to point wiring, thus reducing the number of connections. Direct connection of the capacitors to the electronic module allows for optimal positioning of the module within the container. Specifically, the generally planar module is oriented perpendicular to planar cover surfaces of the container. Irregularly shaped components attached to the surface of the module advantageously extend away from the surface into remaining voids within the container. Adhesive compressible foam is placed around and between the internal components of the stimulation device to stabilize the device against shock and vibration.
摘要翻译：具有减小的体积配置的心脏刺激装置包含位于装置容器内的圆形边缘处的一对高压圆柱形放电电容器。这些电容器在一端具有电接触片，其直接通过形成在相关联的电子模块内的孔插入。电容器接头直接连接到电子模块，无需辅助连接器或点对点接线，从而减少连接数量。将电容器直接连接到电子模块允许模块在容器内的最佳定位。具体而言，大致平面的模块垂直于容器的平面盖表面定向。附接到模块表面的不规则形状的部件有利地从表面延伸到容器内的剩余空隙中。粘合剂可压缩泡沫放置在刺激装置的内部部件之间并且在刺激装置的内部部件之间，以使装置抵抗冲击和振动。

10. 发明授权

US5080653A Infusion pump with dual position syringe locator 失效
标题翻译：双位置灌注定位器输液泵
公开(公告)号：US5080653A
公开(公告)日：1992-01-14
申请号：US509933
申请日：1990-04-16
申请人： Laveille Voss , Clyde K. Nason
发明人： Laveille Voss , Clyde K. Nason
IPC分类号： A61M1/00 , A61M5/145 , A61M5/168
CPC分类号： A61M5/1456 , Y10S128/12
摘要： An improved infusion pump is provided for controlled delivery of medication from a syringe to a patient, wherein a pump housing includes a syringe chamber and associated lock members for receiving and supporting the syringe in one of two different positions. The syringe includes a medication-containing barrel connected to a luer fitting at a nose end thereof by a luer neck of reduced cross sectional size. In one position, the syringe seats into the chamber with the luer neck protruding through an outlet port of mating size and with the luer fitting disposed outside the housing, such that the housing defines a lock member engaged axially between the syringe barrel and luer fitting to secure the barrel against axial displacement. In another position, a retainer key is adapted for installation into the syringe chamber at a position spaced inboard from the outlet port and defines an alternative lock member for axially securing the syringe with the luer fitting disposed inside the housing. In either position, a syringe piston plunger is controllably advanced by the pump into the barrel to deliver medication from the nose end of the syringe for administration to a patient via the luer fitting and infusion tubing or the like connected thereto.

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