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1. 发明授权

US4596808A Pharmacologically active 3-substituted beta-carbolines useful as tranquilizers 失效
标题翻译：药理活性的3-取代的β-咔啉可用作镇定剂
公开(公告)号：US4596808A
公开(公告)日：1986-06-24
申请号：US556869
申请日：1983-12-01
申请人： Claus T. Braestrup , Jogen A. Christensen , Mogens Engelstoft , Guenter Neef , Ulrich Eder , Ralph Schmiechen , Andreas Huth , Dieter Rahtz , Dieter Seidelmann , Wolfgang Kehr , Dieter Palenschat
发明人： Claus T. Braestrup , Jogen A. Christensen , Mogens Engelstoft , Guenter Neef , Ulrich Eder , Ralph Schmiechen , Andreas Huth , Dieter Rahtz , Dieter Seidelmann , Wolfgang Kehr , Dieter Palenschat
IPC分类号： A61K31/435 , A61K31/44 , A61K31/445 , A61K31/675 , A61P25/00 , A61P25/20 , C07D209/08 , C07D209/20 , C07D471/04 , C07F9/6561 , C07D487/14
CPC分类号： C07D471/04 , C07D209/08 , C07D209/20 , C07F9/6561
摘要： 3-Substituted beta-carbolines of the formula ##STR1## wherein R.sup.A is H, F, Cl, Br, I, NO.sub.2, CN, CH.sub.3, CF.sub.3, SCH.sub.3, NR.sup.16 R.sup.17 or NHCOR.sup.16,wherein R.sup.16 and R.sup.17 are the same or different and each is hydrogen or alkyl, alkenyl or alkynyl each of up to 6 C-atoms, aralkyl or cycloalkyl each of up to 10 C-atoms,or wherein R.sup.16 and R.sup.17 together form a saturated or unsaturated 3-7 membered heterocyclic ring;said compounds possess valuable psychotropic properties which make them useful for example as tranquilizers.

2. 发明授权

US4435403A Pharmacologically active 3-substituted beta-carbolines 失效
公开(公告)号：US4435403A
公开(公告)日：1984-03-06
申请号：US331740
申请日：1981-12-17
申请人： Claus T. Braestrup , Jogen A. Christensen , Mogens Engelstoft , Gunter Neef , Ulrich Eder , Ralph Schmiechen , Andreas Huth , Dieter Rahtz , Dieter Seidelmann , Wolfgang Kehr , Dieter Palenschat
发明人： Claus T. Braestrup , Jogen A. Christensen , Mogens Engelstoft , Gunter Neef , Ulrich Eder , Ralph Schmiechen , Andreas Huth , Dieter Rahtz , Dieter Seidelmann , Wolfgang Kehr , Dieter Palenschat
IPC分类号： A61K31/435 , A61K31/44 , A61K31/445 , A61K31/675 , A61P25/00 , A61P25/20 , C07D209/08 , C07D209/20 , C07D471/04 , C07F9/6561 , C07D487/14
CPC分类号： C07D471/04 , C07D209/08 , C07D209/20 , C07F9/6561
摘要： 3-substituted beta-carbolines of the formula ##STR1## wherein R.sup.C is hydrogen, lower alkyl, alkoxyalkyl of up to 6 C-atoms, cycloalkyl of 3-6 C-atoms, aralkyl of up to 8 C-atoms, or (CH.sub.2).sub.n OR.sup.20wherein R.sup.20 is alkyl of up to 6 C-atoms, cycloalkyl of 3-6 C-atoms or aralkyl of up to 8 C-atoms and n is an integer of 1 to 3;Y is oxygen, two hydrogen atoms or NOR.sup.1,wherein R.sup.1 is hydrogen, lower alkyl, aryl or aralkyl of up to 6 C-atoms, COR.sup.2, wherein R.sup.2 is lower alkyl of up to 6 C-atoms,or Y is CHCOOR.sup.3, wherein R.sup.3 is hydrogen or lower alkylor Y is NNR.sup.4 R.sup.5,wherein R.sup.4 and R.sup.5 can be the same or different and each is hydrogen, lower alkyl, C.sub.6-10 -aryl, C.sub.7-10 -aralkyl or CONR.sup.6 R.sup.7,wherein R.sup.6 and R.sup.7 can be the same or different and each is hydrogen or lower alkyl or R.sup.4 and R.sup.5 together with the connecting N-atom, for a 5- or 6-membered heterocyclic ring which optionally may also contain an O-atom or up to 3 N-atoms and which optionally may be substituted by a lower alkyl group;Z is hydrogen, or alkoxy or aralkoxy each of up to 10 C-atoms and each optionally substituted by hydroxy, or Z is alkyl of up to 6 C-atoms, C.sub.6-10 -aryl or C.sub.7-10 -aralkyl each of which may optionally be substituted by a COOR.sup.8 -- or a CONR.sup.9 R.sup.10 group,wherein R.sup.8 is alkyl of up to 6 C-atoms, and R.sup.9 and R.sup.10 can be the same or different and each is hydrogen or alkyl of up to 6 C-atoms;or Z is NR.sup.9 R.sup.10, wherein R.sup.9 and R.sup.10 are as defined above;or Z is NR.sup.11 CHR.sup.12 R.sup.13,wherein R.sup.11 and R.sup.12 each is hydrogen or together form a N.dbd.C double bond,wherein R.sup.13 is C.sub.1-10 -alkyl or NR.sup.14 R.sup.15,wherein R.sup.14 and R.sup.15 are the same or different and each is hydrogen, OH or alkyl or alkoxy each of up to 6 C-atoms,or wherein R.sup.12 and R.sup.13 together are oxygen, in which case, R.sup.11 is hydrogen;or Z is COOR.sup.2 wherein R.sup.2 is as defined above;or Y and Z, together with the connecting C-atom, may form a 5- or 6-membered heterocyclic ring which contains an O-atom, adjoining O- and N-atoms or up to 4 N atoms and which optionally may be substituted by a lower alkyl group, hydroxy or oxo have valuable psychotropic properties which make them useful for example as tranquilizers.

3. 发明授权

US4371536A .beta.-Carbolin-3-carboxylic acid derivatives 失效
标题翻译： β-链球蛋白-3-羧酸衍生物
公开(公告)号：US4371536A
公开(公告)日：1983-02-01
申请号：US182244
申请日：1980-08-28
申请人： Claus T. Braestrup , Mogens C. Nielsen , Joergen A. Christensen , Mogens Engelstoft , Henning Schou , Ulrich Eder , Gunter Neef , Andreas Huth , Dieter Rahtz , Ralph Schmiechen
发明人： Claus T. Braestrup , Mogens C. Nielsen , Joergen A. Christensen , Mogens Engelstoft , Henning Schou , Ulrich Eder , Gunter Neef , Andreas Huth , Dieter Rahtz , Ralph Schmiechen
IPC分类号： C07D471/04 , C07H13/10 , A61K31/435 , C07D487/14
CPC分类号： C07D471/04 , C07H13/10
摘要： A .beta.-carbolin-3-carboxylic acid derivative of the formula ##STR1## has valuable pharmacological properties when administered to patients, e.g. humans as a drug, have been shown to possess interesting tranquilizing activity.
摘要翻译：当向患者施用时，式“IMAGE”的β-咔啉-3-羧酸衍生物具有有价值的药理学性质。人类作为药物，已被证明具有有趣的镇静活动。

4. 发明授权

US5010077A .beta.-carbolin-3-carboxylic acid derivatives useful for treating anxiety and related disorders 失效
标题翻译：可用于治疗焦虑和相关疾病的β-咔啉-3-羧酸衍生物
公开(公告)号：US5010077A
公开(公告)日：1991-04-23
申请号：US188145
申请日：1988-04-25
申请人： Claus T. Braestrup , Mogens C. Nielsen , Joergen A. Christensen , Mogens Engelstoft , Henning Schou , Ulrich Eder , Gunter Neef , Andreas Huth , Dieter Rahtz , Ralph Schmiechen
发明人： Claus T. Braestrup , Mogens C. Nielsen , Joergen A. Christensen , Mogens Engelstoft , Henning Schou , Ulrich Eder , Gunter Neef , Andreas Huth , Dieter Rahtz , Ralph Schmiechen
IPC分类号： C07D471/04 , C07H13/10
CPC分类号： C07D471/04 , C07H13/10
摘要： A .beta.-carbolin-3-carboxylic acid derivative of the formula ##STR1## wherein: X is oxygen, sulphur or NR.sup.10, wherein R.sup.10 is hydrogen, C.sub.1-6 -alkyl, C.sub.1-6 -alkenyl, C.sub.3-7 -cycloalkyl or C.sub.3-7 -cycloalkenyl;R.sup.3 is (a) C.sub.1-10 -alkoxy, C.sub.1-10 -alkenyloxy, C.sub.6-10 -aryloxy, C.sub.7-11 -aralkoxy or C.sub.8-12 -aralkenyloxy, each optionally substituted with one or more hydroxy groups, halogen atoms, CF.sub.3 groups, C.sub.1-10 -alkoxy groups or C.sub.2-4 -alkenyloxy groups or each optionally substituted with an amino, di-C.sub.1-6 -alkylamino, C.sub.1-10 -alkoxycarbonyl or C.sub.1-10 -alkenyloxycarbonyl group; or (b) NR.sup.11 R.sup.12, wherein R.sup.11 and R.sup.12 are the same or different and each is (i) hydrogen, (ii) hydroxy, (iii) C.sub.1-10 -alkyl, (iv) C.sub.2-10 -alkenyl, (v) C.sub.6-10 -aryl, (vi) C.sub.7-11 -aralkyl, (vii) C.sub.8-12 -aralkenyl, (viii) C.sub.3-7 -cycloalkyl, or (ix) C.sub.3-7 -cycloalkenyl, each of groups (iii)-(ix) optionally substituted with hydroxy, carboxamido, carboxy, C.sub.1-10 -alkoxycarbonyl or C.sub.1-10 -alkenyloxycarbonyl; or (x) amino optionally substituted with C.sub.1-10 -alkyl, C.sub.2-10 -alkenyl, C.sub.6-10 -aryl, C.sub.7-11 -aralkyl, C.sub.8-12 -aralkenyl, C.sub.3-7 -cycloalkyl or C.sub.3-7 -cycloalkenyl; or wherein R.sup.11 and R.sup.12 together with the connecting nitrogen atom form a 5-, 6- or 7-membered heterocyclic ring, which may also contain one additional N or one O atom, and which may be optionally substituted with the same groups of substituents listed for groups (iii)-(ix) above, with the proviso that R.sup.11 and R.sup.12 cannot both be hydroxy; or wherein X and R.sup.3 together represent a single nitrogen atom;R.sup.4 is hydrogen, C.sub.1-10 -alkyl, C.sub.2-10 -alkenyl, C.sub.3-7 -cycloalkyl, C.sub.3-7 -cycloalkenyl, C.sub.7-10 -aralkyl, C.sub.8-10 -aralkenyl, phenyl, C.sub.7-10 -alkoxyphenyl or C.sub.8-10 -alkenyloxyphenyl;R.sup.A is F, Cl, Br, I, NO.sub.2, NR.sup.13 R.sup.14, NHCOR.sup.13, CN, COOR.sup.13, OR.sup.13, SCH.sub.3 or SO.sub.2 NR.sup.11 R.sup.12, wherein R.sup.13 and R.sup.14 each is hydrogen or C.sub.1-6 -alkyl optionally substituted with hydroxy or halogen; and wherein R.sup.11 and R.sup.12 are as defined above, and wherein there may be 1-4 identical or different R.sup.A 's; andR.sup.9 is hydrogen, C.sub.1-8 -alkyl, C.sub.1-8 -alkenyl, C.sub.1-8 -alkoxycarbonyl, C.sub.1-8 -alkenyloxycarbonyl, or C.sub.1-8 -alkenyloxy;with the proviso that R.sup.11 and R.sup.12 are not both hydrogen, when X is oxygen and when R.sup.4, R.sup.A and R.sup.9 each is hydrogen; that one of R.sup.11 and R.sup.12 is not hydrogen when the other is amino and when X is oxygen and R.sup.4, R.sup.A and R.sup.9 each are hydrogen; and that R.sup.4, R.sup.A and R.sup.9 each is not hydrogen when X is oxygen and R.sup.3 is OCH.sub.3.have valuable pharmacological properties.

5. 发明授权

US4066674A Process for the preparation of 1,3-oxygenated 8.alpha.-estratrienes and novel intermediates obtained therefrom 失效
标题翻译：制备1,3-氧化的8'-离子的方法及其获得的新型中间体
公开(公告)号：US4066674A
公开(公告)日：1978-01-03
申请号：US741497
申请日：1976-11-12
申请人： Ulrich Eder , Gerhard Sauer , Gregor Haffer , Guenter Neef , Rudolf Wiechert
发明人： Ulrich Eder , Gerhard Sauer , Gregor Haffer , Guenter Neef , Rudolf Wiechert
IPC分类号： C07C59/52 , C07J1/00 , C07J15/00
CPC分类号： C07C59/52 , C07J1/0074 , C07J15/00
摘要： Novel 1,3-dialkoxy 8.alpha.-estratriene compounds of the formula ##STR1## WHEREIN R.sub.1 is alkyl of 1-18 carbon atoms, R.sub.2 is alkyl of 1-5 carbon atoms and Ac is alkanoyl of 1-8 carbon atoms, are obtained by a three-step synthesis from a tetrahydroindane-5-one compound.

6. 发明授权

US4379790A (Erolinyl)-N,N-diethylurea derivatives, and their preparation and use 失效
标题翻译：（Erolinyl）-N，N-二乙基脲衍生物及其制备和用途
公开(公告)号：US4379790A
公开(公告)日：1983-04-12
申请号：US337355
申请日：1982-01-06
申请人： Reinhard Horowski , Wolfgang Kehr , Gerhard Sauer , Ulrich Eder , Hans P. Lorenz
发明人： Reinhard Horowski , Wolfgang Kehr , Gerhard Sauer , Ulrich Eder , Hans P. Lorenz
IPC分类号： C07D457/02 , A61K31/48 , A61P25/00 , C07D457/12 , A61K31/475
CPC分类号： C07D457/12
摘要： Compounds of the formula ##STR1## or a pharmaceutically acceptable salt thereof, wherein R.sub.1 is alkyl of 2-6 carbon atoms, ##STR2## n is 1, or 2, m is 0 or 1,R.sub.2 is alkyl of 1-6 carbon atoms, ##STR3## is a CC single bond or a CC double bond, and the 8-positioned urea residue can be in the .alpha.- or .beta.-position, have valuable pharmacological properties, e.g., lactation inhibition and anti-Parkinsonism.
摘要翻译：其中R 1是2-6个碳原子的烷基，（CH 2）n CHCH 2，（CH 2）n CCH，（CH 2）n COOR 2，+ TR，n是1或者其药学上可接受的盐， 2，m为0或1，R2为1-6个碳原子的烷基，IMA图为CC单键或CC双键，8位尿素残基可为α或β位，具有宝贵的药理性质，如哺乳期抑制和抗帕金森综合征。

7. 发明授权

US4826852A Novel ergolinyl compounds nitrogen-substituted in the 8-position, useful for treating dopamine deficiency 失效
标题翻译：在8-位氮取代的新型麦角酰基化合物，可用于治疗多巴胺缺乏症
公开(公告)号：US4826852A
公开(公告)日：1989-05-02
申请号：US878762
申请日：1986-06-26
申请人： Gregor Haffer , Gerhard Sauer , Helmut Wachtel , Herbert Schneider , Ulrich Eder
发明人： Gregor Haffer , Gerhard Sauer , Helmut Wachtel , Herbert Schneider , Ulrich Eder
IPC分类号： A61K31/48 , A61P9/12 , A61P25/00 , A61P25/18 , A61P25/28 , A61P43/00 , C07D457/04 , C07D457/06 , C07D457/12 , A61K31/44 , A61K31/54 , C07D417/14
CPC分类号： C07D457/04 , C07D457/06 , C07D457/12
摘要： Ergolinyl compounds which are nitrogen-substituted in the 8-position and have Formula (I) ##STR1## and physiologically compatible salts thereof, wherein (a) R.sup.1 is hydrogen, the 8-substituent can be in the .alpha.- or .beta.-position and ##STR2## represents a single or a double bond, R.sup.2 is hydrogen, C.sub.1-4 -alkyl or C.sub.1-7 -acyl,R.sup.3 is hydrogen, chlorine or bromine, andR.sup.4 is C.sub.1-6 -alkyl, C.sub.3-6 -cycloalkyl-C.sub.1-3 -alkyl, C.sub.3-6 -alkenyl, or C.sub.3-6 -alkynyl; or(b) R.sup.1 is ##STR3## and the 8-substituent can be in the .alpha.- or .beta.-position, ##STR4## represents a single or double bond, R.sup.2, R.sup.3 are as defined above,R.sup.4, is C.sub.1.varies.6 -alkyl, C.sub.3-6 -cycloalkyl-C.sub.1-3 -alkyl, C.sub.3-6 -alkenyl, or C.sub.3-6 -alkynyl; andR.sup.5 is hydrogen, C.sub.-10 -alkyl, C.sub.3-10 -alkenyl, or C.sub.3-10 -alkynyl, andR.sup.6 is C.sub.1-10 -alkyl, C.sub.3-10 -alkenyl, C.sub.3-10 -alkynyl, or aryl, orR.sup.5 and R.sup.6 together with the connecting N-atom form a 5- to 10-membered heterocyclic ring, preferably 5- or 6-membered, which optionally can contain further heteroatoms.
摘要翻译：在8-位上被氮取代且具有式（I）的化合物和其生理上相容的盐，其中（a）R 1是氢，所述8-取代基可以是α-或β- - 位和表示单键或双键，R 2为氢，C 1-4 - 烷基或C 1-7 - 酰基，R 3为氢，氯或溴，且R 4为C 1-6 - 烷基，C 3-6 环烷基-C 1-3 - 烷基，C 3-6 - 烯基或C 3-6 - 炔基; 或（b）R 1是，并且8-取代基可以是α-或β-位，表示单键或双键，R2，R3如上所定义，R4是C1，烷基，C 3-6 - 环烷基-C 1-3 - 烷基，C 3-6 - 烯基或C 3-6 - 炔基; 和R 5是氢，C 1-10烷基，C 3-10 - 烯基或C 3-10 - 炔基，R 6是C 1-10烷基，C 3-10 - 烯基，C 3-10 - 炔基或芳基或R 5 和R6连同连接的N-原子形成5-至10-元杂环，优选5-或6-元，其任选地可含有其它杂原子。

8. 发明授权

US4024166A Process for the preparation of 13.beta.-alkyl-4-gonene-3,17-diones 失效
标题翻译：制备13 {62-烷基-4-锑烯-3,17-二酮的方法
公开(公告)号：US4024166A
公开(公告)日：1977-05-17
申请号：US621384
申请日：1975-10-10
申请人： Gerhard Sauer , Ulrich Eder , Gregor Haffer , Gunter Neef , Rudolf Wiechert
发明人： Gerhard Sauer , Ulrich Eder , Gregor Haffer , Gunter Neef , Rudolf Wiechert
IPC分类号： B01J23/00 , C07B61/00 , C07C317/14 , C07D317/26 , C07D317/72 , C07J1/00
CPC分类号： C07C317/00 , C07D317/26 , C07D317/72 , C07J1/0059
摘要： Novel process for the preparation of 13.beta.-alkyl-4-gonene-3,17-diones of the formula ##STR1## wherein R.sub.1 is methyl or ethyl, consists of REACTING A 7A.beta.-ALKYL,5,6,7,7A-TETRAHYDROINDANE-1,5-DIONE WITH FORMALDEHYDE AND AN ARYLSULFINIC ACID OR AN ADDUCT OF FORMALDEHYDE AND ARYLSULFINIC ACID TO PRODUCE A TETRAHYDROINDANE DERIVATIVE;Hydrogenating the tetrahydroindane derivative with hydrogen in the presence of a palladium-, platinum-, or rhodium-containing hydrogenation catalyst to produce a perhydroindane derivative;Condensing the perhydroindane derivative in the presence of a proton-accepting agent with a 7,7-alkylenedioxy-3-oxooctanoic acid ester;Treating the product obtained with a strong aqueous base and then heating the product in an inert solvent to produce a 4,5-secosteroid;Hydrogenating the 4,5-secosteroid in the presence of a palladium-, platinum-, rhodium-, or nickel-containing hydrogenation catalyst; andHydrolyzing and cyclizing the hydrogenated 4,5-secosteroid by treatment with a strong acid.
摘要翻译：用于制备式“IMAGE”的13β-烷基-4-单宁-3,17-二酮的新方法，其中R 1是甲基或乙基，由反应A7Aβ-烷基，5,6,7,7a- 四氢呋喃-1,5-二酮与甲醛和氨基磺酸或甲醛和芳香酸的添加以生产四氢衍生物衍生物; 在含有氢氧化钯，或含氢氧化铑的氢化催化剂存在下氢化四氢呋喃衍生物生成四氢呋喃衍生物; 在具有7,7-亚甲基氧化亚硝酸酯酸酯的接受原料的情况下，冷凝该衍生物衍生物; 处理用强碱性基质获得的产品，然后加入产品中的产品用于生产4,5代谢物; 在含有钯，铑，铑，或含镍的氢化催化剂存在下氢化4,5-二氧化硫; 并通过用强酸处理氢化和循环氢化的4,5代谢物。

9. 发明授权

US4012420A 9,10-Secoestrane derivatives and their production 失效
标题翻译： 9,10-Secoestrane衍生物及其生产
公开(公告)号：US4012420A
公开(公告)日：1977-03-15
申请号：US570072
申请日：1975-04-21
申请人： Ulrich Eder , Gregor Haffer , Jurgen Ruppert , Gerhard Sauer , Rudolf Wiechert
发明人： Ulrich Eder , Gregor Haffer , Jurgen Ruppert , Gerhard Sauer , Rudolf Wiechert
IPC分类号： C07C49/84 , C07C69/01 , C07C401/00 , C07D317/46 , C07D319/08
CPC分类号： C07D317/46 , C07C49/84 , C07C69/01
摘要： 9,10-Secoestranes, useful as intermediates in the total synthesis of steroids, of the formula ##STR1## WHEREIN N IS 1 OR 2, R.sub.1 is lower alkyl, R.sub.2, R.sub.3 and R.sub.4 are hydrogen, alkoxy or acyloxy, X is free or ketalized carbonyl or free, esterified or etherified hydroxymethylene, and Y is carbonyl or dialkoxymethylene are produced by condensing, in the presence of a basic catalyst, ##STR2## WHEREIN X, n, R.sub.1, R.sub.2, R.sub.3, R.sub.4 have the values given above, and Z is Cl, Br or I, to produce a 9,10-secoestrane of the above formula wherein Y is a free carbonyl group, which can then, if desired, be ketalized to a corresponding compound wherein Y is dialkoxymethylene or like ketal group.
摘要翻译： 9,10-Secoestranes，用作类固醇总合成中的中间体，式为“IMAGE”，其中N为1或2，R 1为低级烷基，R 2，R 3和R 4为氢，烷氧基或酰氧基，X为游离或缩酮化的羰基或游离的，酯化的或醚化的羟基亚甲基，Y是羰基或二烷氧基亚甲基，是在碱性催化剂存在下，通过在上述给定的值下，并且Z是Cl，Br或I，以产生上式的9,10-隔离子，其中Y是游离羰基，如果需要，其可以被缩醛化成相应的化合物，其中Y是二烷氧基亚甲基或类似的缩酮基。

10. 发明授权

US4072716A Bicycloalkane derivatives 失效
标题翻译：双环烷烃衍生物
公开(公告)号：US4072716A
公开(公告)日：1978-02-07
申请号：US754000
申请日：1976-12-27
申请人： Gerhard Sauer , Helmut Hauser , Gregor Haffer , Juergen Ruppert , Ulrich Eder , Rudolf Wiechert
发明人： Gerhard Sauer , Helmut Hauser , Gregor Haffer , Juergen Ruppert , Ulrich Eder , Rudolf Wiechert
IPC分类号： C07D317/30 , C07D317/46 , C07C49/54
CPC分类号： C07D317/46 , C07D317/30
摘要： Bicycloalkane derivatives of the formula ##STR1## WHEREIN N IS 1 OR 2, R.sub.1 is lower alkyl, X is carbonyl or free or etherified hydroxymethylene, and Y is --S--R.sub.2, --SO.sub.m --R.sub.2, or ##STR2## wherein m is 1 or 2, R.sub.2 is alkyl, R.sub.3 is hydrogen or lower alkyl, R.sub.4 is aliphatic acyl and Z is nitro, lower alkanoyl, lower alkylsulfinyl, or lower alkylsulfonyl are useful intermediates in the total synthesis of steroids. The compounds are prepared by reacting a corresponding compound lacking the CH.sub.2 Y substituent with formaldehyde and a mercaptan or a sulfinic acid, followed if desired by oxidation and optional salt condensation.
摘要翻译：式中，R 1为低级烷基，X为羰基或游离的或醚化的羟基亚甲基，Y为-S-R 2，-SO m-R 2或其中m为1的双环烷烃衍生物或2，R2是烷基，R3是氢或低级烷基，R4是脂族酰基，Z是硝基，低级烷酰基，低级烷基亚磺酰基或低级烷基磺酰基是在类固醇的总合成中的有用的中间体。通过使相应的缺少CH 2 Y取代基的化合物与甲醛和硫醇或亚磺酸反应来制备化合物，随后如果需要，通过氧化和任选的盐缩合。

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