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1. 发明申请

US20060241742A1 Stent comprising a coating system 审中-公开
标题翻译：支架包括涂层系统
公开(公告)号：US20060241742A1
公开(公告)日：2006-10-26
申请号：US10562376
申请日：2004-06-14
申请人： Claus Harder , Stephane Delaloye , Bernd Heublein
发明人： Claus Harder , Stephane Delaloye , Bernd Heublein
IPC分类号： A61F2/82
CPC分类号： A61F2/82 , A61F2250/0035 , A61F2250/0067 , A61L31/10 , A61L31/16 , A61L2300/602
摘要： A stent comprises a tubular base body which is open on the front sides thereof and has a peripheral wall that is at least partially covered with a coating system consisting of at least one polymer carrier and at least one pharmacologically active substance, which is released into the surrounding tissue once the stent has been implanted in the human or animal body. The invention creates a coating system which enables an optimum local application of the active ingredient. A concentration of the substance, a morphological structure of the carrier(s), a material modification of the carrier(s), and/or a layer thickness of the carrier(s), are predetermined in the longitudinal direction of the stent, in such a way that the elution varies locally in the longitudinal direction of the stent and is determined according to the pathophysiological and/or rheological conditions to be expected during the application.
摘要翻译：支架包括在其前侧开口的管状基体，并且具有至少部分地覆盖有由至少一种聚合物载体和至少一种药理活性物质组成的涂层系统的周壁，其被释放到一旦将支架植入人体或动物体内，就会围绕组织。本发明产生一种涂覆系统，其能够最佳地局部施用活性成分。物质的浓度，载体的形态结构，载体的材料改性和/或载体的层厚度在支架的纵向上是预定的，在这样一种方式使得洗脱在支架的纵向上局部变化，并且根据在施用期间预期的病理生理学和/或流变学条件来确定。

2. 发明授权

US09480585B2 Implant of low radial strength 有权
标题翻译：植入物径向强度低
公开(公告)号：US09480585B2
公开(公告)日：2016-11-01
申请号：US11222595
申请日：2005-09-09
申请人： Bodo Gerold , Claus Harder , Bernd Heublein , Eva Heublein , Nora Heublein , Christoph Heublein , Heinz Mueller
发明人： Bodo Gerold , Claus Harder , Bernd Heublein , Heinz Mueller
IPC分类号： A61F2/06 , A61F2/86 , A61L31/02 , A61F2/90 , A61F2/91
CPC分类号： A61F2/86 , A61F2/90 , A61F2/91 , A61L31/022
摘要： The invention concerns an endovascular implant comprising a biodegradable material and having a tubular main body which is open at the ends and which is dilatable from an unexpanded condition into an expanded condition. The implant is so designed that when the implant in the expanded condition is subjected to a radially acting compression pressure in the range of between 5 and 30 kPa (0.05-0.3 bar) a cross-sectional area of the implant is reduced to 70% or less of the original cross-sectional area, or an internal volume of the implant is reduced to 70% or less of the original internal volume.

3. 发明授权

US08425835B2 Endoprosthesis 有权
标题翻译：内假体
公开(公告)号：US08425835B2
公开(公告)日：2013-04-23
申请号：US10706717
申请日：2003-11-11
申请人： Claus Harder , Bodo Gerold , Heinz Mueller , Bernd Heublein
发明人： Claus Harder , Bodo Gerold , Heinz Mueller , Bernd Heublein
IPC分类号： C22C23/00
CPC分类号： A61L31/022 , A61F2/91 , A61F2/915 , A61F2002/9155 , A61L31/148
摘要： An endoprosthesis includes a carrier structure which contains a metallic material. The metallic material contains a magnesium alloy of the following composition: magnesium: >90%, yttrium: 3.7%-5.5%, rare earths: 1.5%-4.4% and balance:
摘要翻译：内假体包括含有金属材料的载体结构。该金属材料含有以下组成的镁合金：镁：> 90％，钇：3.7％-5.5％，稀土：1.5％-4.4％，余量<1％。

4. 发明申请

US20060064160A1 Implant of low radial strength 有权
标题翻译：植入物径向强度低
公开(公告)号：US20060064160A1
公开(公告)日：2006-03-23
申请号：US11222595
申请日：2005-09-09
申请人： Bodo Gerold , Claus Harder , Bernd Heublein , Heinz Mueller , Eva Heublein , Nora Heublein , Christoph Heublein
发明人： Bodo Gerold , Claus Harder , Bernd Heublein , Heinz Mueller , Eva Heublein , Nora Heublein , Christoph Heublein
IPC分类号： A61F2/06
CPC分类号： A61F2/86 , A61F2/90 , A61F2/91 , A61L31/022
摘要： The invention concerns an endovascular implant comprising a biodegradable material and having a tubular main body which is open at the ends and which is dilatable from an unexpanded condition into an expanded condition. The implant is so designed that when the implant in the expanded condition is subjected to a radially acting compression pressure in the range of between 5 and 30 kPa (0.05-0.3 bar) a cross-sectional area of the implant is reduced to 70% or less of the original cross-sectional area, or an internal volume of the implant is reduced to 70% or less of the original internal volume.
摘要翻译：本发明涉及一种包括可生物降解材料的血管内植入物，并且具有管状主体，该管状主体在端部处是开口的，并且可从未膨胀状态扩张到膨胀状态。植入物的设计使得当处于膨胀状态的植入物经受5至30kPa（0.05-0.3巴）范围内的径向作用压缩压力时，植入物的横截面面积减小至70％或较小的原始横截面积或植入物的内部体积减少到原始内部体积的70％或更小。

5. 发明申请

US20100034899A1 USE OF ONE OR MORE OF THE ELEMENTS FROM THE GROUP YTTRIUM, NEODYMIUM AND ZIRCONIUM, AND PHARMACEUTICAL COMPOSITIONS WHICH CONTAIN THOSE ELEMENTS 审中-公开
公开(公告)号：US20100034899A1
公开(公告)日：2010-02-11
申请号：US12575596
申请日：2009-10-08
申请人： Claus Harder , Bernd Heublein , Eva Heublein , Nora Heublein , Christoph Heublein
发明人： Claus Harder , Bernd Heublein , Eva Heublein , Nora Heublein , Christoph Heublein
IPC分类号： A61K33/24 , A61P35/00
CPC分类号： A61L31/022 , A61F2/91 , A61F2/915 , A61F2002/9155 , A61L31/148
摘要： A method of treating a patient includes the medical use of one or more of the elements from the group yttrium, neodymium and zirconium, pharmaceutical formulations which contain said elements and implants which are at least region-wise made up of such formulations. It has been found inter alia that a formulation containing one or more of the elements has an action of inhibiting the proliferation of human smooth muscle cells.

6. 发明申请

US20090182290A1 IMPLANT FOR RELEASING AN ACTIVE SUBSTANCE INTO A VESSEL THROUGH WHICH A BODY MEDIUM FLOWS 有权
标题翻译：通过身体中流量将活性物质释放到血管内的植入物
公开(公告)号：US20090182290A1
公开(公告)日：2009-07-16
申请号：US10597099
申请日：2005-02-04
申请人： Claus Harder , Roland Rohde , Bernd Heublein , Eva Heublein , Nora Heublein , Christoph Heublein , Erhard Flach , Wolfgang Geistert , Gernot Kolberg , Heinz Müller
发明人： Claus Harder , Roland Rohde , Bernd Heublein , Eva Heublein , Nora Heublein , Christoph Heublein , Erhard Flach , Wolfgang Geistert , Gernot Kolberg , Heinz Müller
IPC分类号： A61M5/00
CPC分类号： A61L31/022 , A61F2/86 , A61F2210/0004 , A61F2250/0068 , A61L31/08 , A61L31/148 , A61L31/16 , A61L2300/604
摘要： The aim of the invention is to provide an implant for releasing an active substance into a vessel through which a body medium flows. This aim is achieved by the inventive implant for releasing an active substance into a vessel through which a body medium flows. Said implant comprises a base that consists of a biodegradable material as the carrier of the active substance to be released. The body medium flows around said base on the inside and/or outside thereof.
摘要翻译：本发明的目的是提供一种用于将活性物质释放到体媒体通过其流动的容器中的植入物。该目的通过本发明的用于将活性物质释放到体介质通过其流动的容器中来实现。所述植入物包括由作为要释放的活性物质的载体的生物可降解材料组成的基底。身体介质在其内部和/或外部围绕所述基座流动。

7. 发明申请

US20070191708A1 Radio-opaque marker for medical implants 有权
标题翻译：用于医疗植入物的无线电不透明标记
公开(公告)号：US20070191708A1
公开(公告)日：2007-08-16
申请号：US10596797
申请日：2004-03-31
申请人： Bodo Gerold , Claus Harder , Bernd Heublein , Heinz Muller , Eva Heublein , Nora Heublein , Christoph Heublein
发明人： Bodo Gerold , Claus Harder , Bernd Heublein , Heinz Muller , Eva Heublein , Nora Heublein , Christoph Heublein
IPC分类号： A61B6/12 , A61F2/06
CPC分类号： A61L31/18 , A61F2/82 , A61F2250/0098 , A61L27/047 , A61L27/58 , A61L31/148
摘要： The invention relates to a radio-opaque marker for medical implants. Said marker contains between 10 and 90 weight percent of a biodegradable base component, between 10 and 90 weight percent of one or more radio-opaque elements from the group containing I, Au, Ta, Y, Nb, Mo, Ru, Rh, Ba, La, Ce, Pr, Nd, Sm, Eu, Gd, Tb, Dy, Ho, Er, Tm, Yb, Lu, Hf, Ta, W, Re, Os, Ir and Bi as a marker component and 10 weight percent oF residual components, the aforementioned components amounting to 100 weight percent.
摘要翻译：本发明涉及用于医疗植入物的不透射线标记物。所述标记包含10至90重量％的可生物降解的基础组分，10至90重量％的一种或多种不透明元素来自含有I，Au，Ta，Y，Nb，Mo，Ru，Rh，Ba ，La，Ce，Pr，Nd，Sm，Eu，Gd，Tb，Dy，Ho，Er，Tm，Yb，Lu，Hf，Ta，W，Re，Os，Ir和Bi作为标记成分，10重量％ oF残留组分，上述组分总计为100重量％。

8. 发明申请

US20100119576A1 USE OF ONE OR MORE OF THE ELEMENTS FROM THE GROUP YTTRIUM, NEODYMIUM AND ZIRCONIUM, AND PHARMACEUTICAL COMPOSITIONS WHICH CONTAIN THOSE ELEMENTS 审中-公开
标题翻译：使用来自集团YTTRIUM，NEODYMIUM和ZIRCONIUM的元素中的一种或多种元素，以及含有元素的药物组合物
公开(公告)号：US20100119576A1
公开(公告)日：2010-05-13
申请号：US12575613
申请日：2009-10-08
申请人： Claus Harder , Bernd Heublein , Eva Heublein , Nora Heublein , Christoph Heublein
发明人： Claus Harder , Bernd Heublein , Eva Heublein , Nora Heublein , Christoph Heublein
IPC分类号： A61K9/00 , A61K33/24 , A61P9/00
CPC分类号： A61L31/022 , A61F2/91 , A61F2/915 , A61F2002/9155 , A61L31/148
摘要： A method of treating a patient includes the medical use of one or more of the elements from the group yttrium, neodymium and zirconium, pharmaceutical formulations which contain said elements and implants which are at least region-wise made up of such formulations. It has been found inter alia that a formulation containing one or more of the elements has an action of inhibiting the proliferation of human smooth muscle cells.
摘要翻译：治疗患者的方法包括来自钇，钕和锆组的一种或多种元素的医学用途，含有所述元件的药物制剂和至少由这些制剂区域地构成的植入物。已经发现，含有一种或多种元件的制剂具有抑制人平滑肌细胞增殖的作用。

9. 发明申请

US20060246107A1 Use of one or more elements from the group containing yttrium, neodymium and zirconium and pharmaceutical compositions containing said elements 审中-公开
标题翻译：使用一种或多种含有钇，钕和锆的元素以及含有所述元素的药物组合物
公开(公告)号：US20060246107A1
公开(公告)日：2006-11-02
申请号：US10535084
申请日：2003-10-11
申请人： Claus Harder , Bernd Heublein , Eva Heublein , Nora Heublein , Christoph Heublein
发明人： Claus Harder , Bernd Heublein , Eva Heublein , Nora Heublein , Christoph Heublein
IPC分类号： A61K33/24 , A61F2/00
CPC分类号： A61L31/022 , A61F2/91 , A61F2/915 , A61F2002/9155 , A61L31/148
摘要： A method of treating a patient includes the medical use of one or more of the elements from the group yttrium, neodymium and zirconium, pharmaceutical formulations which contain said elements and implants which are at least region-wise made up of such formulations. It has been found inter alia that a formulation containing one or more of the elements has an action of inhibiting the proliferation of human smooth muscle cells.
摘要翻译：治疗患者的方法包括来自钇，钕和锆组的一种或多种元素的医学用途，含有所述元件的药物制剂和至少由这些制剂区域地构成的植入物。已经发现，含有一种或多种元件的制剂具有抑制人平滑肌细胞增殖的作用。

10. 发明申请

US20050266041A1 IMPLANT FOR VESSEL LIGATURE 审中-公开
标题翻译：船体用植物
公开(公告)号：US20050266041A1
公开(公告)日：2005-12-01
申请号：US10908729
申请日：2005-05-24
申请人： Bodo Gerold , Claus Harder , Heinz Mueller , Bernd Heublein , Eva Heublein , Nora Heublein , Christoph Heublein
发明人： Bodo Gerold , Claus Harder , Heinz Mueller , Bernd Heublein , Eva Heublein , Nora Heublein , Christoph Heublein
IPC分类号： A61L31/02 , A61L31/14 , A61F2/06 , A61F2/00
CPC分类号： A61L31/022 , A61L31/148
摘要： The invention concerns inter alia an implant for vessel ligature, the implant which comprises an alloy, wherein the alloy is at least partially biodegradable, and wherein the alloy comprises: greater than 87% magnesium; from about 3% to about 6% yttrium; from about 1% to about 5% lanthanide; and a balance of about 0.0% to about 2%.
摘要翻译：本发明特别涉及用于血管结扎的植入物，包括合金的植入物，其中所述合金至少部分可生物降解，并且其中所述合金包括：大于87％的镁; 约3％至约6％的钇; 约1％至约5％的镧系元素; 余量约为0.0％至约2％。

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