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1. 发明申请

US20090247569A1 Process for Preparing Clopidogrel Bisulphate 审中-公开
标题翻译：硫酸氯吡格雷制备方法
公开(公告)号：US20090247569A1
公开(公告)日：2009-10-01
申请号：US12083128
申请日：2007-08-03
申请人： Claude Singer , Basem Masarwa , Greta Sterimbaum , Paola Daverio , Eran Turgeman
发明人： Claude Singer , Basem Masarwa , Greta Sterimbaum , Paola Daverio , Eran Turgeman
IPC分类号： A61K31/4743 , C07D491/02
CPC分类号： C07D495/04
摘要： Provided are processes for the preparation of clopidogrel bisulphate Form I.
摘要翻译：提供了制备硫酸氯吡格雷I型的方法。

2. 发明授权

US07589128B2 Process for preparation of amorphous form of a drug 失效
标题翻译：制备无定形形式药物的方法
公开(公告)号：US07589128B2
公开(公告)日：2009-09-15
申请号：US11143312
申请日：2005-06-01
申请人： Csaba Szabo , Szabolcs Szoke , Lorant Gyuricza , Claude Singer , Valerie Niddam-Hildesheim , Greta Sterimbaum
发明人： Csaba Szabo , Szabolcs Szoke , Lorant Gyuricza , Claude Singer , Valerie Niddam-Hildesheim , Greta Sterimbaum
IPC分类号： A61K47/00
CPC分类号： C07D215/18 , C07D407/06 , F26B5/041 , F26B11/12
摘要： Provided is a process for preparation of amorphous form of an active pharmaceutical ingredient.
摘要翻译：提供了制备活性药物成分的无定形形式的方法。

3. 发明申请

US20090012047A1 Crystalline forms of ibandronate sodium 审中-公开
公开(公告)号：US20090012047A1
公开(公告)日：2009-01-08
申请号：US11985857
申请日：2007-11-16
申请人： Eran Turgeman , Revital Lifshitz-Liron , Claude Singer , Tamas Koltai
发明人： Eran Turgeman , Revital Lifshitz-Liron , Claude Singer , Tamas Koltai
IPC分类号： A61K31/663 , C07F9/28 , A61P19/10
CPC分类号： C07F9/3873
摘要： Provided are crystalline forms of ibandronate sodium, as well as processes for the preparation thereof.

4. 发明授权

US07737177B2 Processes for preparing crystalline and amorphous mupirocin calcium 失效
标题翻译：制备结晶和无定形莫匹罗星钙的方法
公开(公告)号：US07737177B2
公开(公告)日：2010-06-15
申请号：US10289919
申请日：2002-11-06
申请人： Lorant Gyuricza , Erszebet Meszaros-Sos , Csaba Szabo , Claude Singer
发明人： Lorant Gyuricza , Erszebet Meszaros-Sos , Csaba Szabo , Claude Singer
IPC分类号： A61K31/335
CPC分类号： C07D407/06
摘要： Processes are provided for preparing mupirocin calcium dihydrate from pseudomonic acid in a two phase system by using an organic carboxylate. A highly pure composition of amorphous mupirocin calcium is provided, and processes for its preparation by solvent removal, lyophilization and precipitation with use of an anti-solvent. Pharmaceutical compositions of amorphous form, and methods of using them to treat infections are also provided. Also provided are combined processes for preparing mupirocin calcium dihydrate and amorphous, by producing amorphous form first, followed by conversion of amorphous form into the dihydrate through crystallization from an aqueous solution. Also provided are processes for removing the water of crystallization of the dihydrate to obtain mupirocin calcium anhydrate.
摘要翻译：提供了通过使用有机羧酸盐在两相体系中由假单胞菌酸制备莫匹罗星二水合钙的方法。提供了一种高纯度非晶莫匹罗星钙组合物，以及通过溶剂去除，冻干和使用抗溶剂沉淀制备的方法。还提供了无定形形式的药物组合物，以及使用它们治疗感染的方法。还提供了通过首先产生无定形形式，然后通过从水溶液中结晶将无定形形式转化为二水合物，制备莫匹罗星二水合物和无定形物的组合方法。还提供了去除二水合物结晶水以获得莫匹罗星钙无水物的方法。

5. 发明授权

US07622588B2 Method for the purification of lansoprazole 失效
标题翻译：兰索拉唑纯化方法
公开(公告)号：US07622588B2
公开(公告)日：2009-11-24
申请号：US11083485
申请日：2005-03-18
申请人： Claude Singer , Anita Liberman , Irena Veinberg , Nina Finkelstein , Tamar Nidam
发明人： Claude Singer , Anita Liberman , Irena Veinberg , Nina Finkelstein , Tamar Nidam
IPC分类号： C07D401/12
CPC分类号： C07D401/12
摘要： The present invention provides a method for preparing a substantially pure lansoprazole containing less than about 0.2% (wt/wt) impurities including sulfone/sulfide derivatives. The present invention also provides a process for recrystallizing lansoprazole to obtain a lansoprazole containing less than about 0.1% (wt/wt) water.
摘要翻译：本发明提供一种制备基本上纯的兰索拉唑的方法，该兰索拉唑含有少于约0.2％（重量/重量）的杂质，包括砜/硫化物衍生物。本发明还提供了使兰索拉唑重结晶以获得含有少于约0.1％（wt / wt）水的兰索拉唑的方法。

6. 发明授权

US07262293B2 Aztreonam L-lysine and methods for the preparation thereof 有权
标题翻译：氨基曲坦L-赖氨酸及其制备方法
公开(公告)号：US07262293B2
公开(公告)日：2007-08-28
申请号：US10882591
申请日：2004-07-01
申请人： Viktor Gyollai , Csaba Szabo , Claude Singer , Istvan Bodi
发明人： Viktor Gyollai , Csaba Szabo , Claude Singer , Istvan Bodi
IPC分类号： C07D417/12
CPC分类号： C07D417/12 , C07C229/26 , Y10T436/145555
摘要： The present invention relates to the L-lysine salt of aztreonam and methods for making the L-lysine salt of aztreonam.
摘要翻译：本发明涉及氨曲南的L-赖氨酸盐和制备氨曲南的L-赖氨酸盐的方法。

7. 发明申请

US20070167424A1 Aztreonam L-lysine and methods for the preparation thereof 有权
公开(公告)号：US20070167424A1
公开(公告)日：2007-07-19
申请号：US11723867
申请日：2007-03-22
申请人： Viktor Gyollai , Csaba Szabo , Claude Singer , Istvan Bodi
发明人： Viktor Gyollai , Csaba Szabo , Claude Singer , Istvan Bodi
IPC分类号： A61K31/427 , C07D417/02
CPC分类号： C07D417/12 , C07C229/26 , Y10T436/145555
摘要： The present invention relates to the L-lysine salt of aztreonam and methods for making the L-lysine salt of aztreonam.

8. 发明申请

US20070073085A1 Method for the preparation of pregabalin and salts thereof 失效
标题翻译：普瑞巴林及其盐的制备方法
公开(公告)号：US20070073085A1
公开(公告)日：2007-03-29
申请号：US11432721
申请日：2006-05-10
申请人： Lilach Hedvati , Ziv Dee Noor , Claude Singer , Gideon Pilarski
发明人： Lilach Hedvati , Ziv Dee Noor , Claude Singer , Gideon Pilarski
IPC分类号： C07C229/02
CPC分类号： C07C227/16 , C07C227/20 , C07C227/32 , C07C229/08
摘要： Processes for preparing and purifying Pregabalin and salts thereof are provided.
摘要翻译：提供了制备和纯化普瑞巴林及其盐的方法。

9. 发明申请

US20050250773A1 Process for preparation of mycophenolate mofetil and other esters of mycophenolic acid 审中-公开
标题翻译：霉酚酸酯和麦考酚酸的其他酯的制备方法
公开(公告)号：US20050250773A1
公开(公告)日：2005-11-10
申请号：US11115820
申请日：2005-04-26
申请人： Sandor Molnar , Csaba Szabo , Tivadar Tamas , Janos Hajko , Claude Singer , Beata Kosztya
发明人： Sandor Molnar , Csaba Szabo , Tivadar Tamas , Janos Hajko , Claude Singer , Beata Kosztya
IPC分类号： A61K31/365 , A61K31/5377 , C07B63/00 , C07D307/88 , C07D413/02 , C07D413/14
CPC分类号： C07D307/88 , Y10T436/141111
摘要： Provided are processes for the preparation of mycophenolate mofetil and other esters of mycophenolic acid.
摘要翻译：提供了制备霉酚酸酯和麦考酚酸的其它酯的方法。

10. 发明申请

US20050165061A1 Method for the purification of lansoprazole 失效
公开(公告)号：US20050165061A1
公开(公告)日：2005-07-28
申请号：US11084269
申请日：2005-03-18
申请人： Claude Singer , Anita Liberman , Irena Veinberg , Nina Finkelstein , Tamar Nidam
发明人： Claude Singer , Anita Liberman , Irena Veinberg , Nina Finkelstein , Tamar Nidam
IPC分类号： C07D401/12 , A61K31/4439 , C07D43/02
CPC分类号： C07D401/12
摘要： The present invention provides a method for preparing a substantially pure lansoprazole containing less than about 0.2% (wt/wt) impurities including sulfone/sulfide derivatives. The present invention also provides a process for recrystallizing lansoprazole to obtain a lansoprazole containing less than about 0.1% (wt/wt) water.

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