专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明申请

US20080255173A1 Novel Specific Caspase-10 Inhibitors 有权
标题翻译：新型特异性Caspase-10抑制剂
公开(公告)号：US20080255173A1
公开(公告)日：2008-10-16
申请号：US11791922
申请日：2005-11-02
申请人： Claude Lardy , Marc Lecomte , Catherine Vidal , Thierry Convard , Stephane Yvon , Marie Noelle Denuault , Denis Descours
发明人： Claude Lardy , Marc Lecomte , Catherine Vidal , Thierry Convard , Stephane Yvon , Marie Noelle Denuault , Denis Descours
IPC分类号： A61K31/44 , C07C57/38 , C07D213/55 , A61P27/02 , A61K31/192
CPC分类号： A61K31/192 , A61K31/44 , A61K31/50 , A61K31/505 , A61K31/53 , C07C57/38 , C07C57/58 , C07C59/64
摘要： The invention relates to compounds of the general formula (I), and to their use as caspase-10 inhibitors, especially for the treatment of diabetic retinopathy.
摘要翻译：本发明涉及通式（I）的化合物及其作为半胱天冬酶-10抑制剂的用途，特别是用于治疗糖尿病性视网膜病变。

2. 发明授权

US07829721B2 Specific caspase-10 inhibitors 有权
标题翻译：特异性半胱天冬酶-10抑制剂
公开(公告)号：US07829721B2
公开(公告)日：2010-11-09
申请号：US11791922
申请日：2005-11-02
申请人： Claude Lardy , Marc Lecomte , Catherine Vidal , Thierry Convard , Stéphane Yvon , Marie Noelle Denuault , Denis Descours
发明人： Claude Lardy , Marc Lecomte , Catherine Vidal , Thierry Convard , Stéphane Yvon , Marie Noelle Denuault , Denis Descours
IPC分类号： A61K31/44 , A61K31/192 , C07C57/38 , C07D213/55 , A61P27/02
CPC分类号： A61K31/192 , A61K31/44 , A61K31/50 , A61K31/505 , A61K31/53 , C07C57/38 , C07C57/58 , C07C59/64
摘要： The invention relates to compounds of the general formula (I), and to their use as caspase-10 inhibitors, especially for the treatment of diabetic retinopathy.
摘要翻译：本发明涉及通式（I）的化合物及其作为半胱天冬酶-10抑制剂的用途，特别是用于治疗糖尿病性视网膜病变。

3. 发明授权

US5082859A Derivatives of benzocycloalkenyldihydroxyalkanoic acids and medications containing them 失效
公开(公告)号：US5082859A
公开(公告)日：1992-01-21
申请号：US469121
申请日：1990-01-24
申请人： Didier Festal , Jean-Yves Nioche , Denis Descours , Robert Bellemin , Jacques Decerprit
发明人： Didier Festal , Jean-Yves Nioche , Denis Descours , Robert Bellemin , Jacques Decerprit
IPC分类号： A61K31/16 , A61K31/19 , A61K31/215 , A61K31/35 , A61K31/352 , A61K31/38 , A61K31/382 , A61K31/47 , A61K31/473 , A61P3/06 , A61P7/02 , A61P9/00 , A61P31/10 , C07C17/10 , C07C17/12 , C07C23/18 , C07C25/22 , C07C33/28 , C07C33/48 , C07C35/23 , C07C35/52 , C07C43/20 , C07C43/305 , C07C45/29 , C07C45/46 , C07C45/57 , C07C45/68 , C07C47/238 , C07C47/24 , C07C47/277 , C07C47/453 , C07C47/457 , C07C47/47 , C07C49/67 , C07C57/30 , C07C59/48 , C07C59/54 , C07C59/56 , C07C59/64 , C07C67/31 , C07C69/732 , C07C69/734 , C07C215/70 , C07C217/76 , C07C223/06 , C07C229/40 , C07C235/06 , C07C235/32 , C07C323/09 , C07C323/18 , C07C323/22 , C07C323/62 , C07D215/14 , C07D215/18 , C07D215/20 , C07D221/08 , C07D221/10 , C07D221/20 , C07D309/30 , C07D311/04 , C07D311/58 , C07D311/96 , C07D333/50 , C07D335/04 , C07D335/06 , C07D407/06 , C07D409/06
CPC分类号： C07D333/50 , C07C17/10 , C07C45/46 , C07C45/68 , C07C47/238 , C07C47/24 , C07C47/277 , C07C49/67 , C07C57/30 , C07D309/30 , C07D311/96 , C07D335/06 , C07D407/06 , C07D409/06 , C07C2102/10
摘要： Derivatives of benzocycloalkenyldihydroxyalkanoic acids, inhibitors of HMG CoA reductase, antagonists of thromoboxane A.sub.2 receptors and antifungals, denoted by the formula I ##STR1## in which X=CH.sub.2, O or S; R.sub.1 and R.sub.2, identical or different, =H, C.sub.1-3 alkyl or together from a --(CH.sub.2).sub.n -- chain (n=4,5) optionally substituted symmetrically by one or two C.sub.1-3 alkyl radicals.R.sub.3 and R.sub.4, identical or different, =H, CF.sub.3, halogen (Cl, F, Br), C.sub.1-5 N,N-dialkylamino, C.sub.1-4 alkyl, C.sub.1-5 -alkoxy, C.sub.1-3 alkylthio, or phenyl optionally substituted by at most two substitutents which may be identical or different and may denote C.sub.1-3 alkyl or C.sub.1-3 alkoxy radicals or halogens (F, Cl), it being understood that when one of R.sub.3 and R.sub.4 denotes the radicals: CF.sub.3, N,N-dialkylamino, C.sub.6 H.sub.5 or substituted phenyl, it is present at the vertices 3', 4'or 5' according to formula 1 and the other denotes a hydrogen atom.R.sub.5 and R.sub.6, (which may be identical or different)=H, halogen (F, Cl, Br), CF.sub.3, C.sub.1-3 alkyl, C.sub.1-3 alkoxy, C.sub.6 H.sub.5, optionally substituted by at most two substitutents which may be identical or different and may denote radicals: C.sub.1-3 alkyl or C.sub.1-3 alkoxy or halogen atoms (F, Cl), on condition that when one of R.sub.5 and R.sub.6 =CF.sub.3, C.sub.6 H.sub.5 or substituted phenyl, it is present at the vertex 6 or 7 and the other denotes a hydrogen atom.The substitutents R.sub.3 and R.sub.4 or R.sub.5 and R.sub.6 may also together form, on condition of being at two contiguous vertices, diradicals of formulae: --CH.dbd.CH--CH.dbd.CH--, --(CH.sub.2).sub.m -- and --O(CH.sub.2).sub.p O--, in which m=3 or 4, p=1 or 2, it being understood that when R.sub.3 and R.sub.4 or R.sub.5 and R.sub.6 form the chain sequence --O(CH.sub.2).sub.p O--, the latter is linked to the vertices 3' and 4' or 4' and 5' or 6 and 7 according to the formula 1.R.sub.7 and R.sub.8 =H or, together with the existing C--C bond, form a double bond of trans geometry; R.sub.9 and R.sub.10 =H or together form a C.sub.1-3 dialkylmethylene residue.In the form of free acids, salts, esters, amides or .delta.-lactones.Hypocholesterolaemiant, antithrombotic and antifungal medications containing them.

4. 发明授权

US5338849A Azaindoles, preparation processes and medicinal products containing them 失效
标题翻译：楝素，制备工艺和含有它们的药用产品
公开(公告)号：US5338849A
公开(公告)日：1994-08-16
申请号：US13427
申请日：1993-02-04
申请人： Didier Festal , Denis Descours , Jacques Decerprit
发明人： Didier Festal , Denis Descours , Jacques Decerprit
IPC分类号： A61K31/435 , A61K31/44 , A61P3/06 , A61P9/10 , A61P43/00 , C07C275/00 , C07D471/04 , A61K31/405
CPC分类号： C07D471/04
摘要： These compounds correspond to the formula ##STR1## in which one of the groups X.sub.1 to X.sub.4 represents nitrogen and the others a CH radical,R.sub.1 and R.sub.2 represent H, halogen, alkyl, hydroxymethyl, alkyloxymethyl, dialkylaminoalkyl, dialkylaminoalkyloxymethyl, carboxyl, ethyl carboxylate, piperidino, alkenyl, cycloalkyl, cycloalkenyl, alkylthio, benzyl, phenyl, thiophene or pyridine, optionally substituted,R.sub.3 and R.sub.4 represent H, halogen, alkyl, cycloalkyl, alkoxy or alkylthio,R.sub.5 and R.sub.6 denote H, alkyl, alkenyl, cycloalkyl, cycloalkenyl, alkoxyalkyl or alkylthioalkyl, or together form alkylene or alkyleneoxyalkylene chains,R.sub.7 denotes H, alkyl or cycloalkyl; one of the radicals R.sub.5 to R.sub.7 can also denote optionally substituted phenyl or benzyl,R.sub.8 represents H, alkyl, cycloalkyl or optionally substituted phenyl or benzyl,R.sub.9 denotes optionally substituted phenyl, naphthyl or heterocyclic,as well as their tautomeric forms, processes for preparing them and application as hypolipidaemic and antiatheromatous medicinal products.
摘要翻译：这些化合物对应于其中X 1至X 4中的一个表示氮并且其它基团为CH基团的式“IMAGE”，R 1和R 2表示H，卤素，烷基，羟甲基，烷氧基甲基，二烷基氨基烷基，二烷基氨基烷氧基甲基，羧基，乙基羧酸酯，哌啶基，烯基，环烷基，环烯基，烷硫基，苄基，苯基，噻吩或吡啶，任选取代，R 3和R 4表示H，卤素，烷基，环烷基，烷氧基或烷硫基，R 5和R 6表示H，烷基，烯基，环烷基，环烯基，烷氧基烷基或烷硫基烷基，或一起形成亚烷基或亚烷氧基亚烷基链，R7表示H，烷基或环烷基; R 5至R 7中的一个也可以表示任选取代的苯基或苄基，R 8表示H，烷基，环烷基或任选取代的苯基或苄基，R 9表示任选取代的苯基，萘基或杂环基，以及它们的互变异构形式，它们作为降血脂和抗动脉粥样硬化药物的应用。

5. 发明授权

US5219859A Indole derivatives, preparation processes and medicinal products containing them 失效
标题翻译：内含衍生物，制剂工艺和含有它们的药物
公开(公告)号：US5219859A
公开(公告)日：1993-06-15
申请号：US855544
申请日：1992-03-20
申请人： Didier Festal , Denis Descours , Robert Bellemin , Jacques Decerprit
发明人： Didier Festal , Denis Descours , Robert Bellemin , Jacques Decerprit
IPC分类号： A61K31/40 , A61K31/403 , A61K31/404 , A61K31/4045 , A61K31/44 , A61K31/4427 , A61K31/443 , A61P3/06 , A61P3/08 , A61P3/10 , A61P9/10 , A61P31/10 , C07C237/52 , C07D209/04 , C07D209/08 , C07D209/14 , C07D209/16 , C07D401/02 , C07D401/06 , C07D401/12 , C07D405/04 , C07D405/06
CPC分类号： C07D209/14 , C07D209/16 , C07D401/12 , C07D405/06
摘要： The invention relates to indole derivatives of formula 1, ##STR1## in which: R.sub.1 and R.sub.2 represent H, alkyl, alkenyl, cycloalkyl, N-alkylamino- or N,N-dialkylaminoalkyl, benzyl, pyridylmethyl or phenyl, optionally substituted,R.sub.3 and R.sub.4 represent H, halogen, alkyl, alkoxy, alkylthio, CF.sub.3, NO.sub.2, N-alkylamino or N,N-dialkylamino, benzyl or phenyl, optionally substituted,R.sub.5 represents H, alkyl, cycloalkyl or optionally substituted benzyl,R.sub.6 denotes an alkyl, phenyl or heterocyclic radical, optionally substituted,Z denotes the bivalent radicals --(CH.sub.2).sub.n --C(R.sub.7 R.sub.8)--(CH.sub.2).sub.p --, --CH=CH--C(R.sub.7 R.sub.8)-- in which n=0--2, p=0--2 and n+p.ltoreq.2, R.sub.7 and R.sub.8 represent H, alkyl, alkenyl, cycloalkyl, N-alkylamino, N,N-dialkylamino, N-alkylamino- or N,N-dialkylaminoalkyl, benzyl or phenyl, where appropriate substituted, or together form polymethylene or oxa-, thia- or azapolymethylene chains,as well as their tautomeric forms, to processes for preparing them and to their application as hypolipidaemic, antiatheromatous and antidiabetic pharmaceutical products.
摘要翻译：本发明涉及式1的吲哚衍生物，其中：R1和R2代表H，烷基，烯基，环烷基，N-烷基氨基或N，N-二烷基氨基烷基，苄基，吡啶基甲基或苯基，任选取代的R 3 R 4表示氢，卤素，烷基，烷氧基，烷硫基，CF 3，NO 2，N-烷基氨基或N，N-二烷基氨基，苄基或苯基，任选地被取代，R 5表示H，烷基，环烷基或任选取代的苄基，，苯基或杂环基，任选取代的Z表示二价基团 - （CH 2）n C（R 7 R 8） - （CH 2）p - ， - CH = CH-C（R 7 R 8） - ，其中n = 0-2，p = 0 -2和n + p = 2，R7和R8代表H，烷基，烯基，环烷基，N-烷基氨基，N，N-二烷基氨基，N-烷基氨基或N，N-二烷基氨基烷基，苄基或苯基，取代或一起形成聚亚甲基或氧杂，硫杂或亚氨基亚甲基链，以及它们的互变异构形式，用于制备它们的方法和作为降血脂，抗动脉粥样硬化的应用 d抗糖尿病药品。

6. 发明授权

US5183924A Derivatives of benzocycloalkenyldihydroxyalkanoic acids, processes of preparation and medications containing them 失效
公开(公告)号：US5183924A
公开(公告)日：1993-02-02
申请号：US782195
申请日：1991-10-24
申请人： Didier Festal , Jean-Yves Nioche , Denis Descours , Robert Bellemin , Jacques Decerprit
发明人： Didier Festal , Jean-Yves Nioche , Denis Descours , Robert Bellemin , Jacques Decerprit
IPC分类号： C07C1/20 , C07C17/10 , C07C45/46 , C07C45/68 , C07C47/232 , C07C47/238 , C07C47/24 , C07C47/277 , C07C49/67 , C07C57/30 , C07D309/30 , C07D311/96 , C07D333/50 , C07D335/06 , C07D407/06 , C07D409/06
CPC分类号： C07D333/50 , C07C1/20 , C07C17/10 , C07C45/46 , C07C45/68 , C07C47/232 , C07C47/238 , C07C47/24 , C07C47/277 , C07C49/67 , C07C57/30 , C07D309/30 , C07D311/96 , C07D335/06 , C07D407/06 , C07D409/06 , C07C2102/10
摘要： Derivatives of benzocycloalkenyldihydroxyalkanoic acids, inhibitors of HMG CoA reductase, antagonists of thromboxane A.sub.2 receptors and antifungals, denoted by the formula I ##STR1## in which X=CH.sub.2, O or S; R.sub.1 and R.sub.2, identical or different, =H, C.sub.1-3 alkyl or together form a --(CH.sub.2).sub.n -- chain (n=4,5) optionally substituted symmetrically by one or two C.sub.1-3 alkyl radicals.R.sub.3 and R.sub.4, identical or different, =H, CF.sub.3, halogen (Cl, F, Br), C.sub.1-5 N,N-dialkylamino, C.sub.1-4 alkyl, C.sub.1-5 -alkoxy, C.sub.1-3 alkylthio, or phenyl optionally substituted by at most substituents which may be identical or different and may denote C.sub.1-3 alkyl or C.sub.1-3 alkoxy radicals or halogens (F, Cl), it being understood that when one of R.sub.3 and R.sub.4 denotes the radicals: CF.sub.3, N,N-dialkylamino, C.sub.6 H.sub.5 or substituted phenyl, it is present at the vertices 3', R' or 5' according to formula 1 and the other denotes a hydrogen atom.R.sub.5 and R.sub.6, (which may be identical or different) =H, halogen (F, Cl, Br), CF.sub.3, C.sub.1-3 alkoxy, C.sub.8 H.sub.5, optionally substituted by at most two substituents which may be identical or different and may denote radicals: C.sub.1-3 alkyl or C.sub.1-3 alkoxy or halogen atoms (F, Cl), on condition that when one of R.sub.5 and R.sub.6 =CF.sub.3, C.sub.6 H.sub.5 or substituted phenyl, it is present at the vertex 6 or 7 and the other denotes a hydrogen atom.The substituents R.sub.3 and R.sub.4 or R.sub.5 and R.sub.6 may also together form, on condition of being at two contiguous vertices, diradicals of formulae: --CH.dbd.CH--CH.dbd.CH--, --(CH.sub.2).sub.m -- and --O(CH.sub.2).sub.p O--, in which m=3 or 4, p=1 or 2, it being understood that when R.sub.3 and R.sub.4 or R.sub.5 and R.sub.6 form the chain sequence --O(CH.sub.2).sub.p O--, the latter is linked to the vertices 3' and 4' and 5' or 6 and 7 according to the formula 1.R.sub.7 and R.sub.8 =H or, together with the existing C-C bond, form a double bond of trans geometry; R.sub.9 and R.sub.10 =H or together form a C.sub.1-3 dialkylmethylene residue.In the form of free acids, salts, esters, amides or .delta.-lactones.Hypocholesterolaemiant, antithrombotic and antifungal medications containing them.

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式