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1. 发明授权

US06743570B2 Method of using heat-depolymerizable polycarbonate sacrificial layer to create nano-fluidic devices 失效
标题翻译：使用可热聚聚酰亚胺牺牲层制造纳米流体装置的方法
公开(公告)号：US06743570B2
公开(公告)日：2004-06-01
申请号：US10155855
申请日：2002-05-24
申请人： Cindy K. Harnett , Harold G. Craighead , Geoff Coates
发明人： Cindy K. Harnett , Harold G. Craighead , Geoff Coates
IPC分类号： G03C500
CPC分类号： G03F7/40 , G03F7/039 , Y10S430/143
摘要： A polycarbonate polymer such as poly(cyclohexene carbonate) acts as a positive electron beam resist, is substantially transparent to ultra violet light and that depolymerizes when heated. The polymer acts as a positive electron beam resist at 5 kV, and depolymerizes at temperatures between approximately 200-300° C. The polymer is removable from underneath other layers by heating, facilitating fabrication of overhanging structures such as tubes by depositing layers on top of the polymer.
摘要翻译：作为正电子束抗蚀剂的聚（碳酸环己酯）等聚碳酸酯聚合物对紫外线基本上是透明的，在加热时解聚。该聚合物作为5kV的正电子束抗蚀剂，并在约200-300℃之间的温度下解聚。聚合物可以通过加热从其它层的下方除去，从而有助于制造悬垂结构例如管，通过在聚合物。

2. 发明申请

US20090051372A1 3D fluid confined sample stream coulter flow cytometry 审中-公开
标题翻译： 3D流体限制样品流库仑流式细胞术
公开(公告)号：US20090051372A1
公开(公告)日：2009-02-26
申请号：US11978323
申请日：2007-10-29
申请人： Palaniappan Sethu , Cindy K. Harnett
发明人： Palaniappan Sethu , Cindy K. Harnett
IPC分类号： G01N27/02
CPC分类号： G01N15/12 , G01N2015/1062 , G01N2015/1236
摘要： A microfluidic flow cytometry device includes a substrate and transverse electrodes formed on the substrate. An elastomer microfluidic focusing channel system formed on the substrate focuses a sample stream onto the floor of an outlet channel that is substantially wider and taller than cells or particles of interest and that has the transverse electrodes disposed in its floor upstream of an exit site. A step in the outlet channel upstream of the transverse electrodes vertically confines sample stream flow onto the floor of the outlet channel over the transverse electrodes. Buffer inlet channels introduce a buffer stream for horizontal focusing of the sample stream into the central region of the outlet channel at the transverse electrodes. A sample inlet channel is smaller in vertical height than the buffer inlet channels for introducing a sample stream such that the buffer vertically focuses the sample stream away from the top of the outlet channel. Sensitivity of detection is good enough to conduct both qualitative and quantitative analysis. Detection and analysis circuitry can be optimized to conduct analyze real and imaginary impedance at frequencies optimized toward tagged particles and or cells, and assays are possible.
摘要翻译：微流体流式细胞术装置包括在基底上形成的基底和横向电极。形成在基材上的弹性体微流体聚焦通道系统将样品流聚焦到出口通道的地板上，该出口通道基本上比感兴趣的细胞或颗粒更宽和更高，并且其横向电极设置在其出口位置上游的地板中。横向电极上游出口通道的一个步骤将样品流垂直地限制在横向电极上的出口通道的地板上。缓冲器入口通道引入缓冲流，用于将样品流水平聚焦到横向电极处的出口通道的中心区域。样品入口通道的垂直高度小于用于引入样品流的缓冲器入口通道，使得缓冲器垂直地将样品流聚焦离开出口通道的顶部。检测灵敏度足以进行定性和定量分析。可以优化检测和分析电路以在针对标记的颗粒和或细胞优化的频率下分析实际和虚拟阻抗，并且测定是可能的。

3. 发明授权

US07094326B2 Electrodes for microfluidic applications 有权
标题翻译：用于微流控应用的电极
公开(公告)号：US07094326B2
公开(公告)日：2006-08-22
申请号：US10330607
申请日：2002-12-24
申请人： Robert W. Crocker , Cindy K. Harnett , Judith L. Rognlien
发明人： Robert W. Crocker , Cindy K. Harnett , Judith L. Rognlien
IPC分类号： G01N27/453 , B28B1/44
CPC分类号： G01N27/4473 , G01N27/30 , Y10T29/49002
摘要： An electrode device for high pressure applications. These electrodes, designed to withstand pressure of greater than 10,000 psi, are adapted for use in microfluidic devices that employ electrokinetic or electrophoretic flow. The electrode is composed, generally, of an outer electrically insulating tubular body having a porous ceramic frit material disposed in one end of the outer body. The pores of the porous ceramic material are filled with an ion conductive polymer resin. A conductive material situated on the upper surface of the porous ceramic frit material and, thus isolated from direct contact with the electrolyte, forms a gas diffusion electrode. A metal current collector, in contact with the gas diffusion electrode, provides connection to a voltage source.
摘要翻译：用于高压应用的电极装置。设计用于承受大于10,000psi的压力的这些电极适用于采用电动或电泳流动的微流体装置。电极通常由外电绝缘管状体构成，其具有设置在外体的一端的多孔陶瓷玻璃料。多孔陶瓷材料的孔被离子导电聚合物树脂填充。位于多孔陶瓷玻璃料材料的上表面上并因此与电解液直接接触隔离的导电材料形成气体扩散电极。与气体扩散电极接触的金属集流体提供与电压源的连接。

4. 发明授权

US06675660B1 Composition pulse time-of-flight mass flow sensor 有权
标题翻译：组成脉冲飞行时间质量流量传感器
公开(公告)号：US06675660B1
公开(公告)日：2004-01-13
申请号：US10210647
申请日：2002-07-31
申请人： Bruce P. Mosier , Robert W. Crocker , Cindy K. Harnett
发明人： Bruce P. Mosier , Robert W. Crocker , Cindy K. Harnett
IPC分类号： G01P518
CPC分类号： G01F1/7088 , Y10S977/955
摘要： A device for measuring fluid flow rates over a wide range of flow rates ( 10 &mgr;L/min) and at pressures at least as great as 10,000 psi. The invention is particularly adapted for use in microfluidic systems. The device operates by producing compositional variations in the fluid, or pulses, that are subsequently detected downstream from the point of creation to derive a flow rate. Each pulse, comprising a small fluid volume, whose composition is different from the mean composition of the fluid, can be created by electrochemical means, such as by electrolysis of a solvent, electrolysis of a dissolved species, or electrodialysis of a dissolved ionic species. Measurements of the conductivity of the fluid can be used to detect the arrival time of the pulses, from which the fluid flow rate can be determined
摘要翻译：用于在宽范围的流速（<1nL / min至>10μL/ min）和在至少高达10,000psi的压力下测量流体流速的装置。本发明特别适用于微流体系统。该装置通过产生流体或脉冲中的组成变化来操作，随后从创建点下游检测出流体或脉冲以导出流量。可以通过电化学方法，例如通过溶剂的电解，溶解的物质的电解或溶解的离子物质的电渗析来产生包含小的流体体积的每个脉冲，其组成不同于流体的平均组成。可以使用流体的电导率的测量来检测脉冲的到达时间，从而可以确定流体流速

5. 发明授权

US08648734B2 System and method for collecting data using wired sensors connected to wireless nodes 有权
标题翻译：使用连接到无线节点的有线传感器收集数据的系统和方法
公开(公告)号：US08648734B2
公开(公告)日：2014-02-11
申请号：US12676450
申请日：2008-09-12
申请人： Cindy K. Harnett
发明人： Cindy K. Harnett
IPC分类号： G08C17/00 , G08C19/12
CPC分类号： H04Q9/00 , H04L67/12 , H04Q2209/43 , H04Q2209/75
摘要： A system for collecting data includes a remote sensor assembly and a central data collection device. The remote sensor assembly has a data bus, a remote wireless node, and a plurality of remote sensor modules in wired communication with the remote wireless node via the data bus. Each of the remote sensor modules converts a sensed condition into data in response to a request from the remote wireless node. The central data collection device has a master wireless node for periodically wirelessly communicating with the remote wireless node. The remote wireless node collects data from each of the plurality of remote sensor modules and periodically transmits the data to the master wireless node. The remote sensor modules are interchangeable and new remote sensor modules may be added. The remote wireless node may detect the sequence of the attached remote sensor modules to enable three-dimensional mapping of the sensed conditions.
摘要翻译：用于收集数据的系统包括远程传感器组件和中央数据收集装置。远程传感器组件具有数据总线，远程无线节点和经由数据总线与远程无线节点进行有线通信的多个远程传感器模块。每个远程传感器模块响应于来自远程无线节点的请求将感测到的条件转换成数据。中央数据采集装置具有用于与远程无线节点周期性无线通信的主无线节点。远程无线节点从多个远程传感器模块中的每一个收集数据，并且周期地将数据发送到主无线节点。远程传感器模块是可互换的，可以添加新的远程传感器模块。远程无线节点可以检测所连接的远程传感器模块的顺序，以便能够对感测到的条件进行三维映射。

6. 发明申请

US20100201542A1 SYSTEM AND METHOD FOR REMOTE SAMPLING OF CONDITIONS USING WIRED SENSORS CONNECTED TO WIRELESS NODES 有权
标题翻译：使用连接到无线节点的有线传感器远程采样条件的系统和方法
公开(公告)号：US20100201542A1
公开(公告)日：2010-08-12
申请号：US12676450
申请日：2008-09-12
申请人： Cindy K. Harnett
发明人： Cindy K. Harnett
IPC分类号： G08C17/00
CPC分类号： H04Q9/00 , H04L67/12 , H04Q2209/43 , H04Q2209/75
摘要： A system for collecting data includes a remote sensor assembly and a central data collection device. The remote sensor assembly has a data bus, a remote wireless node, and a plurality of remote sensor modules in wired communication with the remote wireless node via the data bus. Each of the remote sensor modules converts a sensed condition into data in response to a request from the remote wireless node. The central data collection device has a master wireless node for periodically wirelessly communicating with the remote wireless node. The remote wireless node collects data from each of the plurality of remote sensor modules and periodically transmits the data to the master wireless node. The remote sensor modules are interchangeable and new remote sensor modules may be added. The remote wireless node may detect the sequence of the attached remote sensor modules to enable three-dimensional mapping of the sensed conditions.
摘要翻译：用于收集数据的系统包括远程传感器组件和中央数据收集装置。远程传感器组件具有数据总线，远程无线节点和经由数据总线与远程无线节点进行有线通信的多个远程传感器模块。每个远程传感器模块响应于来自远程无线节点的请求将感测到的条件转换成数据。中央数据采集装置具有用于与远程无线节点周期性无线通信的主无线节点。远程无线节点从多个远程传感器模块中的每一个收集数据，并且周期地将数据发送到主无线节点。远程传感器模块是可互换的，可以添加新的远程传感器模块。远程无线节点可以检测所连接的远程传感器模块的顺序，以便能够对感测到的条件进行三维映射。

7. 发明授权

US07225683B2 Composition pulse time-of-flight mass flow sensor 有权
标题翻译：组成脉冲飞行时间质量流量传感器
公开(公告)号：US07225683B2
公开(公告)日：2007-06-05
申请号：US10661401
申请日：2003-09-11
申请人： Cindy K. Harnett , Robert W. Crocker , Bruce P. Mosier , Pamela F. Caton , James F. Stamps
发明人： Cindy K. Harnett , Robert W. Crocker , Bruce P. Mosier , Pamela F. Caton , James F. Stamps
IPC分类号： G01F1/58
CPC分类号： G01F1/7088
摘要： A device for measuring fluid flow rates over a wide range of flow rates ( 10 μL/min) and at pressures at least as great as 2,000 psi. The invention is particularly adapted for use in microfluidic systems. The device operates by producing compositional variations in the fluid, or pulses, that are subsequently detected downstream from the point of creation to derive a flow rate. Each pulse, comprising a small fluid volume, whose composition is different from the mean composition of the fluid, can be created by electrochemical means, such as by electrolysis of a solvent, electrolysis of a dissolved species, or electrodialysis of a dissolved ionic species. Measurements of the conductivity of the fluid can be used to detect the arrival time of the pulses, from which the fluid flow rate can be determined. A pair of spaced apart electrodes can be used to produce the electrochemical pulse. In those instances where it is desired to measure a wide range of fluid flow rates a three electrode configuration in which the electrodes are spaced at unequal distances has been found to be desirable.
摘要翻译：用于在宽的流量范围（<1nL / min至>10μL/ min）和至少高达2,000psi的压力下测量流体流速的装置。本发明特别适用于微流体系统。该装置通过产生流体或脉冲中的组成变化来操作，随后从创建点下游检测出流体或脉冲以导出流量。可以通过电化学方法，例如通过溶剂的电解，溶解的物质的电解或溶解的离子物质的电渗析来产生包含小的流体体积的每个脉冲，其组成不同于流体的平均组成。可以使用流体的电导率的测量来检测脉冲的到达时间，从而可以确定流体流速。可以使用一对间隔开的电极来产生电化学脉冲。在需要测量各种流体流速的情况下，已经发现其中电极以不等距离间隔开的三电极配置是期望的。

8. 发明授权

US07213473B2 Sample preparation system for microfluidic applications 有权
标题翻译：用于微流控应用的样品制备系统
公开(公告)号：US07213473B2
公开(公告)日：2007-05-08
申请号：US11016310
申请日：2004-12-15
申请人： Bruce P. Mosier , Robert W. Crocker , Kamlesh D. Patel , Cindy K. Harnett
发明人： Bruce P. Mosier , Robert W. Crocker , Kamlesh D. Patel , Cindy K. Harnett
IPC分类号： G01F1/37
CPC分类号： F04B19/006 , B01L3/0293 , B01L3/5027 , B01L2200/143 , B01L2400/0415 , G01N35/1016 , G01N2030/285 , G01N2030/326 , G01N2035/1034
摘要： An apparatus that couples automated injection with flow feedback to provide nanoliter accuracy in controlling microliter volumes. The apparatus comprises generally a source of hydraulic fluid pressure, a fluid isolator joined to the outlet of the hydraulic pressure source and a flow sensor to provide pressure-driven analyte metering. For operation generally and particularly in microfluidic systems the hydraulic pressure source is typically an electrokinetic (EK) pump that incorporates gasless electrodes. The apparatus is capable of metering sub-microliter volumes at flowrates of 1–100 μL/min into microsystem load pressures of up to 1000–50 psi, respectively. Flowrates can be specified within 0.5 μL/min and volumes as small as 80 nL can be metered.
摘要翻译：将自动注射与流量反馈相结合的装置，以提供纳升精度来控制微升体积。该装置通常包括液压流体压力源，连接到液压源的出口的流体隔离器和用于提供压力驱动的分析物计量的流量传感器。对于一般而且特别是在微流体系统中的操作，液压源通常是包含无气体电极的电动（EK）泵。该装置能够以1-100μL/ min的流量计量分数达到1000-50psi的微系统负荷压力的亚微升体积。流量可以在0.5 muL / min范围内，体积小至80 nL可以计量。

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